Amino acid dipepetide frequency for Ruminococcus sp. CAG:177

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.213AlaAla: 10.213 ± 0.201
1.457AlaCys: 1.457 ± 0.049
5.701AlaAsp: 5.701 ± 0.11
5.951AlaGlu: 5.951 ± 0.133
3.65AlaPhe: 3.65 ± 0.095
6.301AlaGly: 6.301 ± 0.127
1.386AlaHis: 1.386 ± 0.049
5.252AlaIle: 5.252 ± 0.111
5.488AlaLys: 5.488 ± 0.123
8.09AlaLeu: 8.09 ± 0.164
2.47AlaMet: 2.47 ± 0.069
2.699AlaAsn: 2.699 ± 0.073
2.702AlaPro: 2.702 ± 0.083
2.89AlaGln: 2.89 ± 0.08
3.527AlaArg: 3.527 ± 0.073
4.616AlaSer: 4.616 ± 0.096
3.262AlaThr: 3.262 ± 0.082
7.91AlaVal: 7.91 ± 0.145
0.588AlaTrp: 0.588 ± 0.033
2.822AlaTyr: 2.822 ± 0.078
0.005AlaXaa: 0.005 ± 0.003
Cys
1.784CysAla: 1.784 ± 0.06
0.37CysCys: 0.37 ± 0.029
1.167CysAsp: 1.167 ± 0.045
1.195CysGlu: 1.195 ± 0.047
0.689CysPhe: 0.689 ± 0.033
1.84CysGly: 1.84 ± 0.065
0.278CysHis: 0.278 ± 0.022
1.182CysIle: 1.182 ± 0.048
0.841CysLys: 0.841 ± 0.042
1.185CysLeu: 1.185 ± 0.043
0.437CysMet: 0.437 ± 0.027
0.563CysAsn: 0.563 ± 0.033
0.843CysPro: 0.843 ± 0.041
0.273CysGln: 0.273 ± 0.021
0.93CysArg: 0.93 ± 0.048
1.154CysSer: 1.154 ± 0.048
0.863CysThr: 0.863 ± 0.037
1.368CysVal: 1.368 ± 0.054
0.131CysTrp: 0.131 ± 0.014
0.496CysTyr: 0.496 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
4.999AspAla: 4.999 ± 0.106
1.133AspCys: 1.133 ± 0.053
3.427AspAsp: 3.427 ± 0.1
5.213AspGlu: 5.213 ± 0.109
2.964AspPhe: 2.964 ± 0.074
5.401AspGly: 5.401 ± 0.104
0.766AspHis: 0.766 ± 0.038
5.226AspIle: 5.226 ± 0.089
3.956AspLys: 3.956 ± 0.083
4.131AspLeu: 4.131 ± 0.078
1.886AspMet: 1.886 ± 0.053
2.378AspAsn: 2.378 ± 0.066
2.172AspPro: 2.172 ± 0.061
0.835AspGln: 0.835 ± 0.037
2.962AspArg: 2.962 ± 0.085
3.946AspSer: 3.946 ± 0.084
3.125AspThr: 3.125 ± 0.085
3.92AspVal: 3.92 ± 0.081
0.594AspTrp: 0.594 ± 0.032
2.579AspTyr: 2.579 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
4.702GluAla: 4.702 ± 0.099
0.969GluCys: 0.969 ± 0.045
3.535GluAsp: 3.535 ± 0.072
4.535GluGlu: 4.535 ± 0.109
2.615GluPhe: 2.615 ± 0.07
3.684GluGly: 3.684 ± 0.088
1.331GluHis: 1.331 ± 0.049
4.997GluIle: 4.997 ± 0.101
6.062GluLys: 6.062 ± 0.111
6.549GluLeu: 6.549 ± 0.115
1.941GluMet: 1.941 ± 0.058
4.303GluAsn: 4.303 ± 0.077
2.205GluPro: 2.205 ± 0.086
2.138GluGln: 2.138 ± 0.063
3.689GluArg: 3.689 ± 0.091
3.658GluSer: 3.658 ± 0.082
3.203GluThr: 3.203 ± 0.073
3.707GluVal: 3.707 ± 0.096
0.556GluTrp: 0.556 ± 0.03
2.805GluTyr: 2.805 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.881PheAla: 3.881 ± 0.085
0.941PheCys: 0.941 ± 0.04
3.231PheAsp: 3.231 ± 0.07
2.879PheGlu: 2.879 ± 0.064
2.131PhePhe: 2.131 ± 0.068
3.588PheGly: 3.588 ± 0.086
0.625PheHis: 0.625 ± 0.033
3.056PheIle: 3.056 ± 0.08
2.478PheLys: 2.478 ± 0.068
3.273PheLeu: 3.273 ± 0.086
1.095PheMet: 1.095 ± 0.045
1.712PheAsn: 1.712 ± 0.056
1.422PhePro: 1.422 ± 0.047
0.681PheGln: 0.681 ± 0.031
1.696PheArg: 1.696 ± 0.053
3.45PheSer: 3.45 ± 0.073
2.491PheThr: 2.491 ± 0.07
3.092PheVal: 3.092 ± 0.081
0.383PheTrp: 0.383 ± 0.025
1.676PheTyr: 1.676 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
6.035GlyAla: 6.035 ± 0.129
1.411GlyCys: 1.411 ± 0.058
4.329GlyAsp: 4.329 ± 0.088
5.339GlyGlu: 5.339 ± 0.1
3.305GlyPhe: 3.305 ± 0.072
5.629GlyGly: 5.629 ± 0.124
1.286GlyHis: 1.286 ± 0.05
5.766GlyIle: 5.766 ± 0.093
5.679GlyLys: 5.679 ± 0.107
5.776GlyLeu: 5.776 ± 0.093
2.288GlyMet: 2.288 ± 0.07
2.596GlyAsn: 2.596 ± 0.065
1.157GlyPro: 1.157 ± 0.047
1.561GlyGln: 1.561 ± 0.051
3.58GlyArg: 3.58 ± 0.084
4.578GlySer: 4.578 ± 0.094
4.293GlyThr: 4.293 ± 0.087
5.742GlyVal: 5.742 ± 0.103
0.697GlyTrp: 0.697 ± 0.044
3.193GlyTyr: 3.193 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.27HisAla: 1.27 ± 0.047
0.357HisCys: 0.357 ± 0.028
0.961HisAsp: 0.961 ± 0.045
0.998HisGlu: 0.998 ± 0.045
0.774HisPhe: 0.774 ± 0.04
1.412HisGly: 1.412 ± 0.048
0.327HisHis: 0.327 ± 0.024
1.298HisIle: 1.298 ± 0.041
0.831HisLys: 0.831 ± 0.04
1.264HisLeu: 1.264 ± 0.044
0.484HisMet: 0.484 ± 0.027
0.663HisAsn: 0.663 ± 0.03
0.831HisPro: 0.831 ± 0.038
0.345HisGln: 0.345 ± 0.024
0.777HisArg: 0.777 ± 0.038
1.098HisSer: 1.098 ± 0.04
0.921HisThr: 0.921 ± 0.044
0.848HisVal: 0.848 ± 0.043
0.177HisTrp: 0.177 ± 0.015
0.66HisTyr: 0.66 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.445IleAla: 6.445 ± 0.112
1.426IleCys: 1.426 ± 0.043
4.774IleAsp: 4.774 ± 0.097
4.555IleGlu: 4.555 ± 0.071
3.092IlePhe: 3.092 ± 0.081
5.0IleGly: 5.0 ± 0.117
1.033IleHis: 1.033 ± 0.038
5.382IleIle: 5.382 ± 0.126
4.735IleLys: 4.735 ± 0.094
5.588IleLeu: 5.588 ± 0.1
1.959IleMet: 1.959 ± 0.062
3.164IleAsn: 3.164 ± 0.085
2.944IlePro: 2.944 ± 0.072
1.16IleGln: 1.16 ± 0.038
2.892IleArg: 2.892 ± 0.069
5.159IleSer: 5.159 ± 0.098
4.156IleThr: 4.156 ± 0.086
4.884IleVal: 4.884 ± 0.107
0.555IleTrp: 0.555 ± 0.033
2.457IleTyr: 2.457 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
5.357LysAla: 5.357 ± 0.102
0.838LysCys: 0.838 ± 0.04
3.607LysAsp: 3.607 ± 0.075
4.254LysGlu: 4.254 ± 0.088
2.326LysPhe: 2.326 ± 0.062
3.882LysGly: 3.882 ± 0.089
0.974LysHis: 0.974 ± 0.047
5.157LysIle: 5.157 ± 0.076
5.946LysLys: 5.946 ± 0.109
5.604LysLeu: 5.604 ± 0.088
2.174LysMet: 2.174 ± 0.062
3.656LysAsn: 3.656 ± 0.078
2.267LysPro: 2.267 ± 0.057
1.581LysGln: 1.581 ± 0.057
3.241LysArg: 3.241 ± 0.07
3.814LysSer: 3.814 ± 0.08
3.882LysThr: 3.882 ± 0.088
4.116LysVal: 4.116 ± 0.086
0.511LysTrp: 0.511 ± 0.027
2.985LysTyr: 2.985 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
7.018LeuAla: 7.018 ± 0.116
1.858LeuCys: 1.858 ± 0.054
5.265LeuAsp: 5.265 ± 0.093
5.238LeuGlu: 5.238 ± 0.091
3.897LeuPhe: 3.897 ± 0.098
6.378LeuGly: 6.378 ± 0.112
1.37LeuHis: 1.37 ± 0.049
5.827LeuIle: 5.827 ± 0.116
5.411LeuLys: 5.411 ± 0.091
7.838LeuLeu: 7.838 ± 0.146
2.362LeuMet: 2.362 ± 0.067
3.431LeuAsn: 3.431 ± 0.071
3.714LeuPro: 3.714 ± 0.084
1.57LeuGln: 1.57 ± 0.053
4.332LeuArg: 4.332 ± 0.097
6.445LeuSer: 6.445 ± 0.114
4.861LeuThr: 4.861 ± 0.11
5.288LeuVal: 5.288 ± 0.102
0.737LeuTrp: 0.737 ± 0.036
2.764LeuTyr: 2.764 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
2.231MetAla: 2.231 ± 0.064
0.486MetCys: 0.486 ± 0.028
1.447MetAsp: 1.447 ± 0.051
1.38MetGlu: 1.38 ± 0.046
1.142MetPhe: 1.142 ± 0.044
1.966MetGly: 1.966 ± 0.067
0.501MetHis: 0.501 ± 0.03
1.9MetIle: 1.9 ± 0.062
2.144MetLys: 2.144 ± 0.056
2.899MetLeu: 2.899 ± 0.073
0.73MetMet: 0.73 ± 0.035
1.34MetAsn: 1.34 ± 0.048
1.355MetPro: 1.355 ± 0.046
0.879MetGln: 0.879 ± 0.033
1.424MetArg: 1.424 ± 0.049
1.959MetSer: 1.959 ± 0.064
1.815MetThr: 1.815 ± 0.047
1.388MetVal: 1.388 ± 0.052
0.196MetTrp: 0.196 ± 0.018
0.828MetTyr: 0.828 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.655AsnAla: 3.655 ± 0.089
0.705AsnCys: 0.705 ± 0.036
2.327AsnAsp: 2.327 ± 0.066
2.522AsnGlu: 2.522 ± 0.073
1.843AsnPhe: 1.843 ± 0.056
3.796AsnGly: 3.796 ± 0.08
0.62AsnHis: 0.62 ± 0.037
3.496AsnIle: 3.496 ± 0.08
2.301AsnLys: 2.301 ± 0.06
3.1AsnLeu: 3.1 ± 0.071
1.223AsnMet: 1.223 ± 0.047
1.619AsnAsn: 1.619 ± 0.056
1.809AsnPro: 1.809 ± 0.06
0.812AsnGln: 0.812 ± 0.042
1.93AsnArg: 1.93 ± 0.058
2.671AsnSer: 2.671 ± 0.073
2.205AsnThr: 2.205 ± 0.06
2.82AsnVal: 2.82 ± 0.067
0.329AsnTrp: 0.329 ± 0.025
1.534AsnTyr: 1.534 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
3.29ProAla: 3.29 ± 0.084
0.56ProCys: 0.56 ± 0.032
2.907ProAsp: 2.907 ± 0.076
3.373ProGlu: 3.373 ± 0.085
1.57ProPhe: 1.57 ± 0.052
2.372ProGly: 2.372 ± 0.067
0.674ProHis: 0.674 ± 0.031
2.142ProIle: 2.142 ± 0.063
1.985ProLys: 1.985 ± 0.063
2.966ProLeu: 2.966 ± 0.062
0.915ProMet: 0.915 ± 0.039
1.357ProAsn: 1.357 ± 0.046
0.876ProPro: 0.876 ± 0.044
1.134ProGln: 1.134 ± 0.042
1.267ProArg: 1.267 ± 0.052
2.008ProSer: 2.008 ± 0.058
1.81ProThr: 1.81 ± 0.059
2.985ProVal: 2.985 ± 0.072
0.306ProTrp: 0.306 ± 0.023
1.288ProTyr: 1.288 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.856GlnAla: 1.856 ± 0.059
0.318GlnCys: 0.318 ± 0.024
1.007GlnAsp: 1.007 ± 0.037
1.311GlnGlu: 1.311 ± 0.054
0.912GlnPhe: 0.912 ± 0.04
1.561GlnGly: 1.561 ± 0.047
0.373GlnHis: 0.373 ± 0.024
1.755GlnIle: 1.755 ± 0.053
1.83GlnLys: 1.83 ± 0.059
2.208GlnLeu: 2.208 ± 0.07
0.746GlnMet: 0.746 ± 0.037
1.198GlnAsn: 1.198 ± 0.046
0.799GlnPro: 0.799 ± 0.035
0.732GlnGln: 0.732 ± 0.039
1.268GlnArg: 1.268 ± 0.047
1.524GlnSer: 1.524 ± 0.053
1.457GlnThr: 1.457 ± 0.064
1.273GlnVal: 1.273 ± 0.045
0.214GlnTrp: 0.214 ± 0.022
0.971GlnTyr: 0.971 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
3.797ArgAla: 3.797 ± 0.073
0.756ArgCys: 0.756 ± 0.036
2.74ArgAsp: 2.74 ± 0.079
3.822ArgGlu: 3.822 ± 0.085
2.103ArgPhe: 2.103 ± 0.053
3.113ArgGly: 3.113 ± 0.081
0.818ArgHis: 0.818 ± 0.033
3.426ArgIle: 3.426 ± 0.079
2.962ArgLys: 2.962 ± 0.073
4.306ArgLeu: 4.306 ± 0.086
1.296ArgMet: 1.296 ± 0.046
1.812ArgAsn: 1.812 ± 0.05
1.542ArgPro: 1.542 ± 0.053
1.303ArgGln: 1.303 ± 0.068
3.069ArgArg: 3.069 ± 0.092
2.832ArgSer: 2.832 ± 0.069
2.373ArgThr: 2.373 ± 0.058
3.169ArgVal: 3.169 ± 0.073
0.391ArgTrp: 0.391 ± 0.027
1.72ArgTyr: 1.72 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.463SerAla: 6.463 ± 0.125
0.956SerCys: 0.956 ± 0.039
4.208SerAsp: 4.208 ± 0.09
4.292SerGlu: 4.292 ± 0.102
3.034SerPhe: 3.034 ± 0.074
5.712SerGly: 5.712 ± 0.113
1.046SerHis: 1.046 ± 0.047
3.882SerIle: 3.882 ± 0.081
3.481SerLys: 3.481 ± 0.082
5.591SerLeu: 5.591 ± 0.109
1.599SerMet: 1.599 ± 0.056
2.19SerAsn: 2.19 ± 0.065
2.167SerPro: 2.167 ± 0.067
1.612SerGln: 1.612 ± 0.048
3.085SerArg: 3.085 ± 0.077
4.151SerSer: 4.151 ± 0.101
3.026SerThr: 3.026 ± 0.082
5.116SerVal: 5.116 ± 0.103
0.54SerTrp: 0.54 ± 0.031
2.19SerTyr: 2.19 ± 0.058
0.002SerXaa: 0.002 ± 0.002
Thr
5.406ThrAla: 5.406 ± 0.121
0.653ThrCys: 0.653 ± 0.035
3.706ThrAsp: 3.706 ± 0.098
3.234ThrGlu: 3.234 ± 0.077
2.247ThrPhe: 2.247 ± 0.064
4.365ThrGly: 4.365 ± 0.075
0.897ThrHis: 0.897 ± 0.041
2.835ThrIle: 2.835 ± 0.068
2.851ThrLys: 2.851 ± 0.075
4.873ThrLeu: 4.873 ± 0.092
1.18ThrMet: 1.18 ± 0.041
1.71ThrAsn: 1.71 ± 0.056
2.381ThrPro: 2.381 ± 0.059
1.319ThrGln: 1.319 ± 0.048
2.056ThrArg: 2.056 ± 0.051
2.815ThrSer: 2.815 ± 0.079
2.581ThrThr: 2.581 ± 0.086
5.491ThrVal: 5.491 ± 0.097
0.396ThrTrp: 0.396 ± 0.025
1.859ThrTyr: 1.859 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
5.224ValAla: 5.224 ± 0.116
1.596ValCys: 1.596 ± 0.056
4.064ValAsp: 4.064 ± 0.081
4.226ValGlu: 4.226 ± 0.087
3.301ValPhe: 3.301 ± 0.076
4.815ValGly: 4.815 ± 0.094
1.136ValHis: 1.136 ± 0.037
5.465ValIle: 5.465 ± 0.099
4.362ValLys: 4.362 ± 0.09
6.511ValLeu: 6.511 ± 0.11
2.002ValMet: 2.002 ± 0.056
2.796ValAsn: 2.796 ± 0.067
2.928ValPro: 2.928 ± 0.078
1.417ValGln: 1.417 ± 0.045
3.453ValArg: 3.453 ± 0.087
5.226ValSer: 5.226 ± 0.101
4.095ValThr: 4.095 ± 0.076
4.65ValVal: 4.65 ± 0.109
0.573ValTrp: 0.573 ± 0.03
2.565ValTyr: 2.565 ± 0.066
0.002ValXaa: 0.002 ± 0.002
Trp
0.612TrpAla: 0.612 ± 0.029
0.188TrpCys: 0.188 ± 0.019
0.535TrpAsp: 0.535 ± 0.033
0.488TrpGlu: 0.488 ± 0.035
0.414TrpPhe: 0.414 ± 0.029
0.673TrpGly: 0.673 ± 0.04
0.205TrpHis: 0.205 ± 0.017
0.543TrpIle: 0.543 ± 0.032
0.48TrpLys: 0.48 ± 0.031
0.822TrpLeu: 0.822 ± 0.037
0.242TrpMet: 0.242 ± 0.019
0.381TrpAsn: 0.381 ± 0.03
0.18TrpPro: 0.18 ± 0.017
0.324TrpGln: 0.324 ± 0.023
0.429TrpArg: 0.429 ± 0.024
0.512TrpSer: 0.512 ± 0.03
0.381TrpThr: 0.381 ± 0.029
0.463TrpVal: 0.463 ± 0.027
0.087TrpTrp: 0.087 ± 0.013
0.354TrpTyr: 0.354 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.738TyrAla: 2.738 ± 0.061
0.612TyrCys: 0.612 ± 0.032
2.674TyrAsp: 2.674 ± 0.071
2.381TyrGlu: 2.381 ± 0.067
1.771TyrPhe: 1.771 ± 0.058
2.751TyrGly: 2.751 ± 0.075
0.651TyrHis: 0.651 ± 0.032
2.774TyrIle: 2.774 ± 0.082
2.347TyrLys: 2.347 ± 0.06
3.03TyrLeu: 3.03 ± 0.065
0.98TyrMet: 0.98 ± 0.04
1.748TyrAsn: 1.748 ± 0.063
1.486TyrPro: 1.486 ± 0.046
0.745TyrGln: 0.745 ± 0.035
1.743TyrArg: 1.743 ± 0.052
2.728TyrSer: 2.728 ± 0.076
2.056TyrThr: 2.056 ± 0.075
2.175TyrVal: 2.175 ± 0.064
0.352TyrTrp: 0.352 ± 0.024
1.707TyrTyr: 1.707 ± 0.068
0.002TyrXaa: 0.002 ± 0.002
Xaa
0.003XaaAla: 0.003 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.005XaaPro: 0.005 ± 0.003
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.016XaaXaa: 0.016 ± 0.009
Statistics based on 1937 proteins (610976 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski