Amino acid dipepetide frequency for Lysinibacillus sp. 2017

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.177AlaAla: 6.177 ± 0.121	0.544AlaCys: 0.544 ± 0.024	3.565AlaAsp: 3.565 ± 0.077	4.699AlaGlu: 4.699 ± 0.076	3.471AlaPhe: 3.471 ± 0.063	5.166AlaGly: 5.166 ± 0.093	1.371AlaHis: 1.371 ± 0.041	6.731AlaIle: 6.731 ± 0.096	5.126AlaLys: 5.126 ± 0.087	7.601AlaLeu: 7.601 ± 0.098	2.212AlaMet: 2.212 ± 0.05	3.175AlaAsn: 3.175 ± 0.06	2.173AlaPro: 2.173 ± 0.051	2.945AlaGln: 2.945 ± 0.052	2.674AlaArg: 2.674 ± 0.056	4.302AlaSer: 4.302 ± 0.069	4.463AlaThr: 4.463 ± 0.104	5.376AlaVal: 5.376 ± 0.073	0.526AlaTrp: 0.526 ± 0.023	2.494AlaTyr: 2.494 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.449CysAla: 0.449 ± 0.02	0.1CysCys: 0.1 ± 0.01	0.347CysAsp: 0.347 ± 0.018	0.484CysGlu: 0.484 ± 0.022	0.325CysPhe: 0.325 ± 0.02	0.594CysGly: 0.594 ± 0.026	0.168CysHis: 0.168 ± 0.013	0.567CysIle: 0.567 ± 0.022	0.336CysLys: 0.336 ± 0.02	0.582CysLeu: 0.582 ± 0.024	0.192CysMet: 0.192 ± 0.015	0.269CysAsn: 0.269 ± 0.017	0.282CysPro: 0.282 ± 0.018	0.202CysGln: 0.202 ± 0.013	0.23CysArg: 0.23 ± 0.016	0.438CysSer: 0.438 ± 0.02	0.416CysThr: 0.416 ± 0.023	0.415CysVal: 0.415 ± 0.022	0.072CysTrp: 0.072 ± 0.008	0.271CysTyr: 0.271 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.879AspAla: 3.879 ± 0.07	0.343AspCys: 0.343 ± 0.018	2.352AspAsp: 2.352 ± 0.061	4.608AspGlu: 4.608 ± 0.066	2.567AspPhe: 2.567 ± 0.053	3.433AspGly: 3.433 ± 0.078	0.933AspHis: 0.933 ± 0.032	3.909AspIle: 3.909 ± 0.071	2.833AspLys: 2.833 ± 0.059	4.695AspLeu: 4.695 ± 0.072	1.219AspMet: 1.219 ± 0.037	1.94AspAsn: 1.94 ± 0.05	1.632AspPro: 1.632 ± 0.04	1.73AspGln: 1.73 ± 0.044	1.862AspArg: 1.862 ± 0.051	2.524AspSer: 2.524 ± 0.058	2.613AspThr: 2.613 ± 0.053	3.912AspVal: 3.912 ± 0.064	0.566AspTrp: 0.566 ± 0.024	2.25AspTyr: 2.25 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.486GluAla: 5.486 ± 0.093	0.342GluCys: 0.342 ± 0.02	3.615GluAsp: 3.615 ± 0.066	6.284GluGlu: 6.284 ± 0.094	2.62GluPhe: 2.62 ± 0.055	4.006GluGly: 4.006 ± 0.07	1.545GluHis: 1.545 ± 0.046	5.814GluIle: 5.814 ± 0.091	5.977GluLys: 5.977 ± 0.085	7.189GluLeu: 7.189 ± 0.092	2.263GluMet: 2.263 ± 0.044	3.884GluAsn: 3.884 ± 0.07	1.933GluPro: 1.933 ± 0.053	4.496GluGln: 4.496 ± 0.084	3.286GluArg: 3.286 ± 0.066	3.455GluSer: 3.455 ± 0.058	3.822GluThr: 3.822 ± 0.069	5.358GluVal: 5.358 ± 0.084	0.716GluTrp: 0.716 ± 0.031	2.055GluTyr: 2.055 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.396PheAla: 3.396 ± 0.064	0.356PheCys: 0.356 ± 0.019	2.587PheAsp: 2.587 ± 0.051	3.425PheGlu: 3.425 ± 0.063	2.257PhePhe: 2.257 ± 0.056	3.169PheGly: 3.169 ± 0.064	0.9PheHis: 0.9 ± 0.031	4.14PheIle: 4.14 ± 0.09	2.591PheLys: 2.591 ± 0.054	4.278PheLeu: 4.278 ± 0.096	1.242PheMet: 1.242 ± 0.035	2.075PheAsn: 2.075 ± 0.043	1.497PhePro: 1.497 ± 0.042	1.476PheGln: 1.476 ± 0.04	1.39PheArg: 1.39 ± 0.041	3.215PheSer: 3.215 ± 0.067	2.849PheThr: 2.849 ± 0.059	3.505PheVal: 3.505 ± 0.07	0.418PheTrp: 0.418 ± 0.024	1.814PheTyr: 1.814 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.827GlyAla: 4.827 ± 0.101	0.53GlyCys: 0.53 ± 0.025	3.146GlyAsp: 3.146 ± 0.061	4.359GlyGlu: 4.359 ± 0.07	3.249GlyPhe: 3.249 ± 0.069	4.357GlyGly: 4.357 ± 0.086	1.326GlyHis: 1.326 ± 0.043	5.703GlyIle: 5.703 ± 0.081	4.455GlyLys: 4.455 ± 0.059	5.929GlyLeu: 5.929 ± 0.084	1.947GlyMet: 1.947 ± 0.043	2.651GlyAsn: 2.651 ± 0.064	1.483GlyPro: 1.483 ± 0.04	2.262GlyGln: 2.262 ± 0.046	2.333GlyArg: 2.333 ± 0.054	3.707GlySer: 3.707 ± 0.066	4.038GlyThr: 4.038 ± 0.088	4.785GlyVal: 4.785 ± 0.074	0.628GlyTrp: 0.628 ± 0.032	2.731GlyTyr: 2.731 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.386HisAla: 1.386 ± 0.042	0.196HisCys: 0.196 ± 0.014	0.942HisAsp: 0.942 ± 0.031	1.465HisGlu: 1.465 ± 0.037	1.072HisPhe: 1.072 ± 0.038	1.255HisGly: 1.255 ± 0.038	0.554HisHis: 0.554 ± 0.025	1.517HisIle: 1.517 ± 0.042	0.994HisLys: 0.994 ± 0.032	1.999HisLeu: 1.999 ± 0.048	0.487HisMet: 0.487 ± 0.023	0.854HisAsn: 0.854 ± 0.025	0.96HisPro: 0.96 ± 0.03	0.764HisGln: 0.764 ± 0.029	0.724HisArg: 0.724 ± 0.025	1.105HisSer: 1.105 ± 0.034	1.064HisThr: 1.064 ± 0.032	1.444HisVal: 1.444 ± 0.041	0.172HisTrp: 0.172 ± 0.014	0.937HisTyr: 0.937 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.747IleAla: 6.747 ± 0.094	0.653IleCys: 0.653 ± 0.025	4.451IleAsp: 4.451 ± 0.073	6.54IleGlu: 6.54 ± 0.092	3.537IlePhe: 3.537 ± 0.077	5.825IleGly: 5.825 ± 0.09	1.69IleHis: 1.69 ± 0.044	6.412IleIle: 6.412 ± 0.101	4.296IleLys: 4.296 ± 0.066	7.483IleLeu: 7.483 ± 0.114	1.782IleMet: 1.782 ± 0.047	3.244IleAsn: 3.244 ± 0.061	3.132IlePro: 3.132 ± 0.058	3.265IleGln: 3.265 ± 0.059	2.978IleArg: 2.978 ± 0.063	5.099IleSer: 5.099 ± 0.081	4.607IleThr: 4.607 ± 0.08	6.199IleVal: 6.199 ± 0.081	0.611IleTrp: 0.611 ± 0.028	2.581IleTyr: 2.581 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.588LysAla: 4.588 ± 0.077	0.313LysCys: 0.313 ± 0.019	3.462LysAsp: 3.462 ± 0.061	5.804LysGlu: 5.804 ± 0.079	2.326LysPhe: 2.326 ± 0.046	3.934LysGly: 3.934 ± 0.065	1.163LysHis: 1.163 ± 0.031	4.7LysIle: 4.7 ± 0.069	5.163LysLys: 5.163 ± 0.08	6.099LysLeu: 6.099 ± 0.083	2.444LysMet: 2.444 ± 0.053	3.408LysAsn: 3.408 ± 0.06	2.004LysPro: 2.004 ± 0.048	3.246LysGln: 3.246 ± 0.064	2.978LysArg: 2.978 ± 0.048	3.63LysSer: 3.63 ± 0.065	3.66LysThr: 3.66 ± 0.07	4.552LysVal: 4.552 ± 0.075	0.769LysTrp: 0.769 ± 0.028	2.275LysTyr: 2.275 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	7.753LeuAla: 7.753 ± 0.101	0.695LeuCys: 0.695 ± 0.027	4.558LeuAsp: 4.558 ± 0.072	6.426LeuGlu: 6.426 ± 0.089	4.905LeuPhe: 4.905 ± 0.113	5.94LeuGly: 5.94 ± 0.089	1.976LeuHis: 1.976 ± 0.044	7.257LeuIle: 7.257 ± 0.116	6.515LeuLys: 6.515 ± 0.094	9.987LeuLeu: 9.987 ± 0.161	2.598LeuMet: 2.598 ± 0.053	4.607LeuAsn: 4.607 ± 0.071	3.69LeuPro: 3.69 ± 0.062	4.13LeuGln: 4.13 ± 0.071	3.432LeuArg: 3.432 ± 0.065	6.182LeuSer: 6.182 ± 0.091	5.995LeuThr: 5.995 ± 0.09	6.45LeuVal: 6.45 ± 0.1	0.741LeuTrp: 0.741 ± 0.031	3.11LeuTyr: 3.11 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.99MetAla: 1.99 ± 0.046	0.139MetCys: 0.139 ± 0.012	1.482MetAsp: 1.482 ± 0.043	1.864MetGlu: 1.864 ± 0.047	1.081MetPhe: 1.081 ± 0.037	1.612MetGly: 1.612 ± 0.043	0.522MetHis: 0.522 ± 0.023	2.106MetIle: 2.106 ± 0.053	2.492MetLys: 2.492 ± 0.048	2.603MetLeu: 2.603 ± 0.055	0.875MetMet: 0.875 ± 0.035	1.72MetAsn: 1.72 ± 0.04	1.075MetPro: 1.075 ± 0.033	1.162MetGln: 1.162 ± 0.039	1.139MetArg: 1.139 ± 0.036	1.658MetSer: 1.658 ± 0.044	1.824MetThr: 1.824 ± 0.05	1.622MetVal: 1.622 ± 0.034	0.178MetTrp: 0.178 ± 0.013	0.866MetTyr: 0.866 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.293AsnAla: 3.293 ± 0.067	0.311AsnCys: 0.311 ± 0.018	2.323AsnAsp: 2.323 ± 0.054	3.89AsnGlu: 3.89 ± 0.07	1.952AsnPhe: 1.952 ± 0.041	3.421AsnGly: 3.421 ± 0.066	0.943AsnHis: 0.943 ± 0.036	3.404AsnIle: 3.404 ± 0.065	2.873AsnLys: 2.873 ± 0.062	4.1AsnLeu: 4.1 ± 0.069	1.243AsnMet: 1.243 ± 0.036	2.159AsnAsn: 2.159 ± 0.059	2.103AsnPro: 2.103 ± 0.049	1.715AsnGln: 1.715 ± 0.041	1.916AsnArg: 1.916 ± 0.048	2.595AsnSer: 2.595 ± 0.065	2.49AsnThr: 2.49 ± 0.066	3.278AsnVal: 3.278 ± 0.067	0.515AsnTrp: 0.515 ± 0.025	1.825AsnTyr: 1.825 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.211ProAla: 2.211 ± 0.058	0.19ProCys: 0.19 ± 0.015	1.604ProAsp: 1.604 ± 0.045	2.575ProGlu: 2.575 ± 0.065	1.95ProPhe: 1.95 ± 0.051	1.936ProGly: 1.936 ± 0.052	0.721ProHis: 0.721 ± 0.029	2.892ProIle: 2.892 ± 0.063	2.119ProLys: 2.119 ± 0.044	3.181ProLeu: 3.181 ± 0.063	0.874ProMet: 0.874 ± 0.036	1.731ProAsn: 1.731 ± 0.05	0.823ProPro: 0.823 ± 0.033	1.226ProGln: 1.226 ± 0.038	0.945ProArg: 0.945 ± 0.026	2.074ProSer: 2.074 ± 0.049	2.238ProThr: 2.238 ± 0.057	2.587ProVal: 2.587 ± 0.056	0.263ProTrp: 0.263 ± 0.015	1.352ProTyr: 1.352 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.107GlnAla: 3.107 ± 0.07	0.178GlnCys: 0.178 ± 0.015	1.653GlnAsp: 1.653 ± 0.041	2.573GlnGlu: 2.573 ± 0.058	1.982GlnPhe: 1.982 ± 0.051	2.058GlnGly: 2.058 ± 0.051	0.9GlnHis: 0.9 ± 0.034	3.11GlnIle: 3.11 ± 0.057	2.691GlnLys: 2.691 ± 0.052	4.99GlnLeu: 4.99 ± 0.072	1.26GlnMet: 1.26 ± 0.039	1.846GlnAsn: 1.846 ± 0.05	1.314GlnPro: 1.314 ± 0.05	2.6GlnGln: 2.6 ± 0.069	1.412GlnArg: 1.412 ± 0.039	2.291GlnSer: 2.291 ± 0.05	2.19GlnThr: 2.19 ± 0.052	2.643GlnVal: 2.643 ± 0.05	0.423GlnTrp: 0.423 ± 0.021	1.462GlnTyr: 1.462 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.628ArgAla: 2.628 ± 0.054	0.206ArgCys: 0.206 ± 0.017	1.927ArgAsp: 1.927 ± 0.04	2.942ArgGlu: 2.942 ± 0.057	1.842ArgPhe: 1.842 ± 0.052	2.202ArgGly: 2.202 ± 0.048	0.713ArgHis: 0.713 ± 0.027	3.017ArgIle: 3.017 ± 0.055	2.812ArgLys: 2.812 ± 0.059	3.597ArgLeu: 3.597 ± 0.061	1.101ArgMet: 1.101 ± 0.029	1.744ArgAsn: 1.744 ± 0.043	1.188ArgPro: 1.188 ± 0.036	1.513ArgGln: 1.513 ± 0.039	1.528ArgArg: 1.528 ± 0.048	1.889ArgSer: 1.889 ± 0.048	1.914ArgThr: 1.914 ± 0.045	2.458ArgVal: 2.458 ± 0.051	0.332ArgTrp: 0.332 ± 0.019	1.49ArgTyr: 1.49 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.959SerAla: 3.959 ± 0.068	0.366SerCys: 0.366 ± 0.018	2.739SerAsp: 2.739 ± 0.06	3.816SerGlu: 3.816 ± 0.074	3.134SerPhe: 3.134 ± 0.063	3.98SerGly: 3.98 ± 0.07	1.1SerHis: 1.1 ± 0.031	5.307SerIle: 5.307 ± 0.081	3.973SerLys: 3.973 ± 0.067	5.71SerLeu: 5.71 ± 0.082	1.626SerMet: 1.626 ± 0.042	2.821SerAsn: 2.821 ± 0.063	1.874SerPro: 1.874 ± 0.047	1.855SerGln: 1.855 ± 0.043	1.995SerArg: 1.995 ± 0.05	3.753SerSer: 3.753 ± 0.078	3.507SerThr: 3.507 ± 0.082	4.076SerVal: 4.076 ± 0.057	0.554SerTrp: 0.554 ± 0.027	2.351SerTyr: 2.351 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.35ThrAla: 4.35 ± 0.095	0.337ThrCys: 0.337 ± 0.019	2.855ThrAsp: 2.855 ± 0.068	3.849ThrGlu: 3.849 ± 0.07	2.816ThrPhe: 2.816 ± 0.058	4.057ThrGly: 4.057 ± 0.11	1.151ThrHis: 1.151 ± 0.034	5.212ThrIle: 5.212 ± 0.082	3.776ThrLys: 3.776 ± 0.071	5.547ThrLeu: 5.547 ± 0.082	1.53ThrMet: 1.53 ± 0.038	2.922ThrAsn: 2.922 ± 0.069	2.307ThrPro: 2.307 ± 0.053	1.826ThrGln: 1.826 ± 0.046	1.774ThrArg: 1.774 ± 0.036	3.529ThrSer: 3.529 ± 0.075	3.596ThrThr: 3.596 ± 0.094	4.444ThrVal: 4.444 ± 0.097	0.483ThrTrp: 0.483 ± 0.024	2.083ThrTyr: 2.083 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.592ValAla: 5.592 ± 0.088	0.554ValCys: 0.554 ± 0.026	3.704ValAsp: 3.704 ± 0.064	5.226ValGlu: 5.226 ± 0.091	3.081ValPhe: 3.081 ± 0.06	4.628ValGly: 4.628 ± 0.079	1.305ValHis: 1.305 ± 0.042	5.811ValIle: 5.811 ± 0.074	4.715ValLys: 4.715 ± 0.082	6.887ValLeu: 6.887 ± 0.085	1.934ValMet: 1.934 ± 0.048	3.113ValAsn: 3.113 ± 0.063	2.52ValPro: 2.52 ± 0.055	2.678ValGln: 2.678 ± 0.053	2.65ValArg: 2.65 ± 0.062	4.315ValSer: 4.315 ± 0.068	4.641ValThr: 4.641 ± 0.104	5.387ValVal: 5.387 ± 0.079	0.534ValTrp: 0.534 ± 0.021	2.248ValTyr: 2.248 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.519TrpAla: 0.519 ± 0.024	0.07TrpCys: 0.07 ± 0.008	0.442TrpAsp: 0.442 ± 0.022	0.471TrpGlu: 0.471 ± 0.025	0.446TrpPhe: 0.446 ± 0.021	0.567TrpGly: 0.567 ± 0.027	0.219TrpHis: 0.219 ± 0.016	0.752TrpIle: 0.752 ± 0.028	0.611TrpLys: 0.611 ± 0.025	1.049TrpLeu: 1.049 ± 0.032	0.294TrpMet: 0.294 ± 0.016	0.46TrpAsn: 0.46 ± 0.024	0.236TrpPro: 0.236 ± 0.018	0.408TrpGln: 0.408 ± 0.021	0.347TrpArg: 0.347 ± 0.018	0.573TrpSer: 0.573 ± 0.025	0.501TrpThr: 0.501 ± 0.026	0.595TrpVal: 0.595 ± 0.023	0.098TrpTrp: 0.098 ± 0.01	0.291TrpTyr: 0.291 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.456TyrAla: 2.456 ± 0.05	0.316TyrCys: 0.316 ± 0.016	2.045TyrAsp: 2.045 ± 0.05	2.846TyrGlu: 2.846 ± 0.055	1.968TyrPhe: 1.968 ± 0.045	2.307TyrGly: 2.307 ± 0.055	0.692TyrHis: 0.692 ± 0.025	2.773TyrIle: 2.773 ± 0.058	2.173TyrLys: 2.173 ± 0.05	3.44TyrLeu: 3.44 ± 0.065	0.887TyrMet: 0.887 ± 0.03	1.727TyrAsn: 1.727 ± 0.044	1.267TyrPro: 1.267 ± 0.038	1.182TyrGln: 1.182 ± 0.03	1.448TyrArg: 1.448 ± 0.043	2.16TyrSer: 2.16 ± 0.058	2.016TyrThr: 2.016 ± 0.042	2.436TyrVal: 2.436 ± 0.048	0.35TyrTrp: 0.35 ± 0.018	1.534TyrTyr: 1.534 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3417 proteins (1001123 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---