Amino acid dipepetide frequency for Erysipelotrichaceae bacterium OH741_COT-311

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.88AlaAla: 2.88 ± 0.105
0.891AlaCys: 0.891 ± 0.04
2.443AlaAsp: 2.443 ± 0.078
2.65AlaGlu: 2.65 ± 0.101
2.852AlaPhe: 2.852 ± 0.074
3.287AlaGly: 3.287 ± 0.109
1.011AlaHis: 1.011 ± 0.046
5.721AlaIle: 5.721 ± 0.125
4.813AlaLys: 4.813 ± 0.118
6.739AlaLeu: 6.739 ± 0.148
1.865AlaMet: 1.865 ± 0.074
3.208AlaAsn: 3.208 ± 0.092
1.283AlaPro: 1.283 ± 0.055
1.837AlaGln: 1.837 ± 0.06
2.019AlaArg: 2.019 ± 0.08
4.389AlaSer: 4.389 ± 0.096
3.089AlaThr: 3.089 ± 0.095
3.476AlaVal: 3.476 ± 0.093
0.37AlaTrp: 0.37 ± 0.029
2.887AlaTyr: 2.887 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
0.574CysAla: 0.574 ± 0.042
0.213CysCys: 0.213 ± 0.039
0.583CysAsp: 0.583 ± 0.035
0.433CysGlu: 0.433 ± 0.031
0.659CysPhe: 0.659 ± 0.037
0.82CysGly: 0.82 ± 0.049
0.265CysHis: 0.265 ± 0.031
1.076CysIle: 1.076 ± 0.052
0.974CysLys: 0.974 ± 0.048
1.041CysLeu: 1.041 ± 0.051
0.296CysMet: 0.296 ± 0.023
0.676CysAsn: 0.676 ± 0.037
0.361CysPro: 0.361 ± 0.029
0.363CysGln: 0.363 ± 0.03
0.335CysArg: 0.335 ± 0.027
0.728CysSer: 0.728 ± 0.043
0.478CysThr: 0.478 ± 0.034
0.674CysVal: 0.674 ± 0.041
0.048CysTrp: 0.048 ± 0.01
0.485CysTyr: 0.485 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.361AspAla: 3.361 ± 0.091
0.659AspCys: 0.659 ± 0.037
2.706AspAsp: 2.706 ± 0.079
4.326AspGlu: 4.326 ± 0.097
2.785AspPhe: 2.785 ± 0.076
3.482AspGly: 3.482 ± 0.11
1.165AspHis: 1.165 ± 0.054
4.778AspIle: 4.778 ± 0.104
3.528AspLys: 3.528 ± 0.092
5.389AspLeu: 5.389 ± 0.104
1.339AspMet: 1.339 ± 0.049
2.317AspAsn: 2.317 ± 0.065
1.574AspPro: 1.574 ± 0.061
1.913AspGln: 1.913 ± 0.071
1.743AspArg: 1.743 ± 0.069
2.932AspSer: 2.932 ± 0.09
2.813AspThr: 2.813 ± 0.076
4.661AspVal: 4.661 ± 0.116
0.385AspTrp: 0.385 ± 0.032
3.226AspTyr: 3.226 ± 0.086
0.0AspXaa: 0.0 ± 0.0
Glu
4.124GluAla: 4.124 ± 0.108
0.654GluCys: 0.654 ± 0.047
4.132GluAsp: 4.132 ± 0.112
6.137GluGlu: 6.137 ± 0.135
2.826GluPhe: 2.826 ± 0.081
3.272GluGly: 3.272 ± 0.088
1.619GluHis: 1.619 ± 0.069
5.747GluIle: 5.747 ± 0.131
5.641GluLys: 5.641 ± 0.14
6.602GluLeu: 6.602 ± 0.12
1.909GluMet: 1.909 ± 0.064
3.511GluAsn: 3.511 ± 0.088
1.224GluPro: 1.224 ± 0.053
2.302GluGln: 2.302 ± 0.079
1.959GluArg: 1.959 ± 0.074
3.087GluSer: 3.087 ± 0.084
3.522GluThr: 3.522 ± 0.096
5.776GluVal: 5.776 ± 0.114
0.389GluTrp: 0.389 ± 0.031
3.478GluTyr: 3.478 ± 0.087
0.0GluXaa: 0.0 ± 0.0
Phe
2.665PheAla: 2.665 ± 0.084
0.376PheCys: 0.376 ± 0.027
3.054PheAsp: 3.054 ± 0.088
3.078PheGlu: 3.078 ± 0.087
2.156PhePhe: 2.156 ± 0.081
2.752PheGly: 2.752 ± 0.089
1.096PheHis: 1.096 ± 0.057
4.393PheIle: 4.393 ± 0.123
4.261PheLys: 4.261 ± 0.099
4.411PheLeu: 4.411 ± 0.134
1.213PheMet: 1.213 ± 0.051
2.445PheAsn: 2.445 ± 0.078
1.252PhePro: 1.252 ± 0.057
1.567PheGln: 1.567 ± 0.061
1.233PheArg: 1.233 ± 0.055
2.824PheSer: 2.824 ± 0.082
2.572PheThr: 2.572 ± 0.08
3.328PheVal: 3.328 ± 0.084
0.35PheTrp: 0.35 ± 0.031
2.265PheTyr: 2.265 ± 0.081
0.0PheXaa: 0.0 ± 0.0
Gly
3.198GlyAla: 3.198 ± 0.096
0.841GlyCys: 0.841 ± 0.044
2.593GlyAsp: 2.593 ± 0.093
2.648GlyGlu: 2.648 ± 0.081
3.137GlyPhe: 3.137 ± 0.087
3.435GlyGly: 3.435 ± 0.123
1.18GlyHis: 1.18 ± 0.051
5.626GlyIle: 5.626 ± 0.139
4.574GlyLys: 4.574 ± 0.117
5.554GlyLeu: 5.554 ± 0.121
1.565GlyMet: 1.565 ± 0.061
2.865GlyAsn: 2.865 ± 0.089
1.115GlyPro: 1.115 ± 0.062
1.832GlyGln: 1.832 ± 0.062
1.896GlyArg: 1.896 ± 0.07
3.7GlySer: 3.7 ± 0.088
2.728GlyThr: 2.728 ± 0.095
4.1GlyVal: 4.1 ± 0.106
0.472GlyTrp: 0.472 ± 0.032
3.487GlyTyr: 3.487 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
1.146HisAla: 1.146 ± 0.048
0.289HisCys: 0.289 ± 0.028
1.078HisAsp: 1.078 ± 0.055
1.269HisGlu: 1.269 ± 0.053
1.087HisPhe: 1.087 ± 0.05
1.367HisGly: 1.367 ± 0.061
0.711HisHis: 0.711 ± 0.043
1.83HisIle: 1.83 ± 0.065
1.467HisLys: 1.467 ± 0.051
2.341HisLeu: 2.341 ± 0.075
0.409HisMet: 0.409 ± 0.032
1.083HisAsn: 1.083 ± 0.048
1.02HisPro: 1.02 ± 0.054
1.163HisGln: 1.163 ± 0.05
0.889HisArg: 0.889 ± 0.047
1.174HisSer: 1.174 ± 0.054
1.054HisThr: 1.054 ± 0.053
1.45HisVal: 1.45 ± 0.059
0.17HisTrp: 0.17 ± 0.023
1.143HisTyr: 1.143 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
5.547IleAla: 5.547 ± 0.129
0.959IleCys: 0.959 ± 0.045
5.426IleAsp: 5.426 ± 0.115
6.089IleGlu: 6.089 ± 0.11
3.628IlePhe: 3.628 ± 0.112
4.882IleGly: 4.882 ± 0.103
2.056IleHis: 2.056 ± 0.071
6.678IleIle: 6.678 ± 0.163
6.913IleLys: 6.913 ± 0.133
8.349IleLeu: 8.349 ± 0.173
2.009IleMet: 2.009 ± 0.075
4.387IleAsn: 4.387 ± 0.106
2.767IlePro: 2.767 ± 0.081
3.158IleGln: 3.158 ± 0.092
2.8IleArg: 2.8 ± 0.079
5.287IleSer: 5.287 ± 0.125
4.528IleThr: 4.528 ± 0.113
6.539IleVal: 6.539 ± 0.124
0.478IleTrp: 0.478 ± 0.034
3.776IleTyr: 3.776 ± 0.1
0.0IleXaa: 0.0 ± 0.0
Lys
4.804LysAla: 4.804 ± 0.136
0.583LysCys: 0.583 ± 0.038
5.304LysAsp: 5.304 ± 0.111
8.595LysGlu: 8.595 ± 0.147
2.393LysPhe: 2.393 ± 0.074
4.445LysGly: 4.445 ± 0.13
2.05LysHis: 2.05 ± 0.071
6.124LysIle: 6.124 ± 0.111
7.228LysLys: 7.228 ± 0.154
6.691LysLeu: 6.691 ± 0.12
2.6LysMet: 2.6 ± 0.079
4.274LysAsn: 4.274 ± 0.108
2.259LysPro: 2.259 ± 0.075
3.85LysGln: 3.85 ± 0.101
2.976LysArg: 2.976 ± 0.083
3.745LysSer: 3.745 ± 0.094
4.385LysThr: 4.385 ± 0.107
5.804LysVal: 5.804 ± 0.127
0.556LysTrp: 0.556 ± 0.031
3.404LysTyr: 3.404 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
6.154LeuAla: 6.154 ± 0.104
1.009LeuCys: 1.009 ± 0.048
5.478LeuAsp: 5.478 ± 0.119
6.13LeuGlu: 6.13 ± 0.134
4.713LeuPhe: 4.713 ± 0.127
5.447LeuGly: 5.447 ± 0.135
2.0LeuHis: 2.0 ± 0.076
7.319LeuIle: 7.319 ± 0.138
9.391LeuLys: 9.391 ± 0.17
9.967LeuLeu: 9.967 ± 0.227
2.676LeuMet: 2.676 ± 0.077
5.774LeuAsn: 5.774 ± 0.119
3.219LeuPro: 3.219 ± 0.082
3.678LeuGln: 3.678 ± 0.093
2.939LeuArg: 2.939 ± 0.082
6.513LeuSer: 6.513 ± 0.131
5.076LeuThr: 5.076 ± 0.109
6.608LeuVal: 6.608 ± 0.14
0.683LeuTrp: 0.683 ± 0.044
3.874LeuTyr: 3.874 ± 0.112
0.0LeuXaa: 0.0 ± 0.0
Met
1.674MetAla: 1.674 ± 0.06
0.25MetCys: 0.25 ± 0.024
1.719MetAsp: 1.719 ± 0.059
1.748MetGlu: 1.748 ± 0.054
1.215MetPhe: 1.215 ± 0.057
1.3MetGly: 1.3 ± 0.061
0.615MetHis: 0.615 ± 0.038
2.543MetIle: 2.543 ± 0.08
2.848MetLys: 2.848 ± 0.079
2.556MetLeu: 2.556 ± 0.086
0.92MetMet: 0.92 ± 0.049
1.611MetAsn: 1.611 ± 0.062
0.835MetPro: 0.835 ± 0.042
1.039MetGln: 1.039 ± 0.046
0.815MetArg: 0.815 ± 0.044
1.483MetSer: 1.483 ± 0.062
1.128MetThr: 1.128 ± 0.051
1.685MetVal: 1.685 ± 0.071
0.137MetTrp: 0.137 ± 0.018
1.083MetTyr: 1.083 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
3.28AsnAla: 3.28 ± 0.102
0.489AsnCys: 0.489 ± 0.033
2.924AsnAsp: 2.924 ± 0.098
3.987AsnGlu: 3.987 ± 0.106
2.098AsnPhe: 2.098 ± 0.066
3.145AsnGly: 3.145 ± 0.101
1.472AsnHis: 1.472 ± 0.058
4.345AsnIle: 4.345 ± 0.102
4.302AsnLys: 4.302 ± 0.112
4.363AsnLeu: 4.363 ± 0.101
1.361AsnMet: 1.361 ± 0.057
2.713AsnAsn: 2.713 ± 0.098
2.059AsnPro: 2.059 ± 0.064
2.687AsnGln: 2.687 ± 0.078
1.998AsnArg: 1.998 ± 0.07
2.478AsnSer: 2.478 ± 0.073
2.722AsnThr: 2.722 ± 0.086
3.643AsnVal: 3.643 ± 0.102
0.389AsnTrp: 0.389 ± 0.027
2.615AsnTyr: 2.615 ± 0.071
0.0AsnXaa: 0.0 ± 0.0
Pro
1.272ProAla: 1.272 ± 0.051
0.365ProCys: 0.365 ± 0.03
1.256ProAsp: 1.256 ± 0.053
1.761ProGlu: 1.761 ± 0.068
1.704ProPhe: 1.704 ± 0.063
1.326ProGly: 1.326 ± 0.056
0.526ProHis: 0.526 ± 0.033
2.665ProIle: 2.665 ± 0.084
2.163ProLys: 2.163 ± 0.079
2.752ProLeu: 2.752 ± 0.076
0.806ProMet: 0.806 ± 0.042
1.674ProAsn: 1.674 ± 0.062
0.433ProPro: 0.433 ± 0.036
0.789ProGln: 0.789 ± 0.046
0.785ProArg: 0.785 ± 0.044
2.072ProSer: 2.072 ± 0.077
1.696ProThr: 1.696 ± 0.063
1.917ProVal: 1.917 ± 0.071
0.228ProTrp: 0.228 ± 0.022
1.537ProTyr: 1.537 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
2.569GlnAla: 2.569 ± 0.082
0.387GlnCys: 0.387 ± 0.031
2.046GlnAsp: 2.046 ± 0.071
3.472GlnGlu: 3.472 ± 0.082
1.585GlnPhe: 1.585 ± 0.058
2.017GlnGly: 2.017 ± 0.066
0.959GlnHis: 0.959 ± 0.054
2.489GlnIle: 2.489 ± 0.081
2.687GlnLys: 2.687 ± 0.087
3.676GlnLeu: 3.676 ± 0.091
0.993GlnMet: 0.993 ± 0.048
1.563GlnAsn: 1.563 ± 0.059
0.911GlnPro: 0.911 ± 0.047
1.869GlnGln: 1.869 ± 0.081
1.539GlnArg: 1.539 ± 0.064
1.961GlnSer: 1.961 ± 0.071
1.765GlnThr: 1.765 ± 0.07
2.409GlnVal: 2.409 ± 0.075
0.378GlnTrp: 0.378 ± 0.03
1.961GlnTyr: 1.961 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
1.509ArgAla: 1.509 ± 0.064
0.426ArgCys: 0.426 ± 0.036
1.441ArgAsp: 1.441 ± 0.053
1.78ArgGlu: 1.78 ± 0.07
1.891ArgPhe: 1.891 ± 0.064
1.604ArgGly: 1.604 ± 0.065
0.622ArgHis: 0.622 ± 0.035
3.211ArgIle: 3.211 ± 0.09
2.909ArgLys: 2.909 ± 0.088
3.474ArgLeu: 3.474 ± 0.099
1.067ArgMet: 1.067 ± 0.052
1.963ArgAsn: 1.963 ± 0.069
0.872ArgPro: 0.872 ± 0.049
1.106ArgGln: 1.106 ± 0.048
1.402ArgArg: 1.402 ± 0.059
1.887ArgSer: 1.887 ± 0.069
1.239ArgThr: 1.239 ± 0.055
2.228ArgVal: 2.228 ± 0.071
0.274ArgTrp: 0.274 ± 0.029
1.835ArgTyr: 1.835 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
2.93SerAla: 2.93 ± 0.084
0.556SerCys: 0.556 ± 0.036
2.832SerAsp: 2.832 ± 0.082
3.354SerGlu: 3.354 ± 0.094
3.513SerPhe: 3.513 ± 0.083
3.713SerGly: 3.713 ± 0.104
1.113SerHis: 1.113 ± 0.056
5.756SerIle: 5.756 ± 0.114
5.156SerLys: 5.156 ± 0.114
6.384SerLeu: 6.384 ± 0.127
1.732SerMet: 1.732 ± 0.061
3.437SerAsn: 3.437 ± 0.084
1.272SerPro: 1.272 ± 0.052
1.872SerGln: 1.872 ± 0.069
1.752SerArg: 1.752 ± 0.07
3.813SerSer: 3.813 ± 0.121
2.88SerThr: 2.88 ± 0.088
3.937SerVal: 3.937 ± 0.095
0.443SerTrp: 0.443 ± 0.032
2.893SerTyr: 2.893 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
2.532ThrAla: 2.532 ± 0.095
0.648ThrCys: 0.648 ± 0.038
2.317ThrAsp: 2.317 ± 0.079
2.298ThrGlu: 2.298 ± 0.078
2.717ThrPhe: 2.717 ± 0.096
3.039ThrGly: 3.039 ± 0.095
1.076ThrHis: 1.076 ± 0.054
5.134ThrIle: 5.134 ± 0.118
3.689ThrLys: 3.689 ± 0.096
5.782ThrLeu: 5.782 ± 0.109
1.45ThrMet: 1.45 ± 0.056
2.778ThrAsn: 2.778 ± 0.086
1.687ThrPro: 1.687 ± 0.06
1.389ThrGln: 1.389 ± 0.059
1.487ThrArg: 1.487 ± 0.065
3.402ThrSer: 3.402 ± 0.078
3.215ThrThr: 3.215 ± 0.104
3.515ThrVal: 3.515 ± 0.094
0.42ThrTrp: 0.42 ± 0.035
2.615ThrTyr: 2.615 ± 0.093
0.0ThrXaa: 0.0 ± 0.0
Val
4.378ValAla: 4.378 ± 0.104
0.872ValCys: 0.872 ± 0.045
4.421ValAsp: 4.421 ± 0.11
4.934ValGlu: 4.934 ± 0.121
3.348ValPhe: 3.348 ± 0.089
4.104ValGly: 4.104 ± 0.111
1.137ValHis: 1.137 ± 0.049
6.347ValIle: 6.347 ± 0.113
5.719ValLys: 5.719 ± 0.125
7.043ValLeu: 7.043 ± 0.147
1.778ValMet: 1.778 ± 0.067
3.798ValAsn: 3.798 ± 0.096
1.802ValPro: 1.802 ± 0.062
1.78ValGln: 1.78 ± 0.067
1.919ValArg: 1.919 ± 0.061
4.878ValSer: 4.878 ± 0.105
3.598ValThr: 3.598 ± 0.112
5.876ValVal: 5.876 ± 0.16
0.467ValTrp: 0.467 ± 0.035
3.167ValTyr: 3.167 ± 0.083
0.0ValXaa: 0.0 ± 0.0
Trp
0.391TrpAla: 0.391 ± 0.028
0.078TrpCys: 0.078 ± 0.014
0.4TrpAsp: 0.4 ± 0.029
0.33TrpGlu: 0.33 ± 0.027
0.452TrpPhe: 0.452 ± 0.032
0.361TrpGly: 0.361 ± 0.027
0.146TrpHis: 0.146 ± 0.016
0.717TrpIle: 0.717 ± 0.038
0.517TrpLys: 0.517 ± 0.03
0.765TrpLeu: 0.765 ± 0.037
0.226TrpMet: 0.226 ± 0.024
0.515TrpAsn: 0.515 ± 0.04
0.17TrpPro: 0.17 ± 0.02
0.28TrpGln: 0.28 ± 0.028
0.176TrpArg: 0.176 ± 0.022
0.359TrpSer: 0.359 ± 0.028
0.307TrpThr: 0.307 ± 0.028
0.441TrpVal: 0.441 ± 0.032
0.061TrpTrp: 0.061 ± 0.012
0.317TrpTyr: 0.317 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.722TyrAla: 2.722 ± 0.074
0.535TyrCys: 0.535 ± 0.041
2.926TyrAsp: 2.926 ± 0.073
2.891TyrGlu: 2.891 ± 0.079
2.532TyrPhe: 2.532 ± 0.092
2.745TyrGly: 2.745 ± 0.086
1.322TyrHis: 1.322 ± 0.056
3.756TyrIle: 3.756 ± 0.097
3.291TyrLys: 3.291 ± 0.095
4.767TyrLeu: 4.767 ± 0.109
0.987TyrMet: 0.987 ± 0.051
2.478TyrAsn: 2.478 ± 0.076
1.615TyrPro: 1.615 ± 0.061
2.759TyrGln: 2.759 ± 0.09
2.078TyrArg: 2.078 ± 0.068
2.63TyrSer: 2.63 ± 0.08
2.398TyrThr: 2.398 ± 0.068
3.302TyrVal: 3.302 ± 0.097
0.313TyrTrp: 0.313 ± 0.031
2.35TyrTyr: 2.35 ± 0.104
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1436 proteins (460030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski