Amino acid dipepetide frequency for Hubei picorna-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.988AlaAla: 5.988 ± 1.31
1.198AlaCys: 1.198 ± 0.019
3.992AlaAsp: 3.992 ± 0.947
2.794AlaGlu: 2.794 ± 0.247
2.794AlaPhe: 2.794 ± 0.247
3.992AlaGly: 3.992 ± 0.947
1.996AlaHis: 1.996 ± 0.437
3.194AlaIle: 3.194 ± 0.456
2.794AlaLys: 2.794 ± 0.247
6.786AlaLeu: 6.786 ± 1.307
3.194AlaMet: 3.194 ± 0.759
3.992AlaAsn: 3.992 ± 2.161
5.19AlaPro: 5.19 ± 0.321
2.395AlaGln: 2.395 ± 0.039
2.794AlaArg: 2.794 ± 0.36
7.585AlaSer: 7.585 ± 2.71
5.19AlaThr: 5.19 ± 0.321
8.782AlaVal: 8.782 ± 0.263
1.198AlaTrp: 1.198 ± 0.019
4.79AlaTyr: 4.79 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
0.798CysAla: 0.798 ± 0.417
0.0CysCys: 0.0 ± 0.0
0.798CysAsp: 0.798 ± 0.189
1.597CysGlu: 1.597 ± 0.835
1.996CysPhe: 1.996 ± 0.17
0.399CysGly: 0.399 ± 0.209
0.0CysHis: 0.0 ± 0.0
1.198CysIle: 1.198 ± 0.019
0.798CysLys: 0.798 ± 0.417
1.198CysLeu: 1.198 ± 0.626
1.198CysMet: 1.198 ± 0.626
0.0CysAsn: 0.0 ± 0.0
1.198CysPro: 1.198 ± 0.019
0.0CysGln: 0.0 ± 0.0
0.399CysArg: 0.399 ± 0.209
0.399CysSer: 0.399 ± 0.209
1.198CysThr: 1.198 ± 0.019
2.395CysVal: 2.395 ± 1.252
0.0CysTrp: 0.0 ± 0.0
0.798CysTyr: 0.798 ± 0.417
0.0CysXaa: 0.0 ± 0.0
Asp
3.992AspAla: 3.992 ± 0.266
1.198AspCys: 1.198 ± 0.626
3.593AspAsp: 3.593 ± 1.271
3.194AspGlu: 3.194 ± 0.456
1.597AspPhe: 1.597 ± 0.835
3.593AspGly: 3.593 ± 0.665
0.399AspHis: 0.399 ± 0.209
4.391AspIle: 4.391 ± 0.475
2.794AspLys: 2.794 ± 0.854
7.585AspLeu: 7.585 ± 2.145
1.597AspMet: 1.597 ± 0.228
4.391AspAsn: 4.391 ± 0.739
1.597AspPro: 1.597 ± 0.986
1.198AspGln: 1.198 ± 0.019
0.798AspArg: 0.798 ± 0.417
3.194AspSer: 3.194 ± 0.758
2.794AspThr: 2.794 ± 0.966
4.391AspVal: 4.391 ± 1.082
0.798AspTrp: 0.798 ± 0.189
1.597AspTyr: 1.597 ± 0.379
0.0AspXaa: 0.0 ± 0.0
Glu
6.387GluAla: 6.387 ± 2.126
1.198GluCys: 1.198 ± 0.626
2.794GluAsp: 2.794 ± 0.247
3.593GluGlu: 3.593 ± 0.665
5.19GluPhe: 5.19 ± 0.893
1.996GluGly: 1.996 ± 0.17
1.198GluHis: 1.198 ± 0.626
3.992GluIle: 3.992 ± 0.873
2.395GluLys: 2.395 ± 0.645
2.395GluLeu: 2.395 ± 0.039
3.194GluMet: 3.194 ± 0.151
1.597GluAsn: 1.597 ± 0.228
1.198GluPro: 1.198 ± 0.626
1.597GluGln: 1.597 ± 0.835
2.794GluArg: 2.794 ± 1.461
4.79GluSer: 4.79 ± 0.077
2.395GluThr: 2.395 ± 0.568
1.996GluVal: 1.996 ± 0.17
0.399GluTrp: 0.399 ± 0.209
1.996GluTyr: 1.996 ± 0.17
0.0GluXaa: 0.0 ± 0.0
Phe
2.794PheAla: 2.794 ± 0.247
1.198PheCys: 1.198 ± 0.626
3.593PheAsp: 3.593 ± 0.665
3.194PheGlu: 3.194 ± 0.758
3.194PhePhe: 3.194 ± 0.456
1.597PheGly: 1.597 ± 0.986
2.395PheHis: 2.395 ± 0.039
1.198PheIle: 1.198 ± 0.019
3.194PheLys: 3.194 ± 1.67
3.593PheLeu: 3.593 ± 0.058
0.399PheMet: 0.399 ± 0.398
3.194PheAsn: 3.194 ± 0.151
1.597PhePro: 1.597 ± 0.835
2.395PheGln: 2.395 ± 0.568
1.597PheArg: 1.597 ± 0.228
3.194PheSer: 3.194 ± 0.456
3.992PheThr: 3.992 ± 1.554
4.79PheVal: 4.79 ± 0.53
0.399PheTrp: 0.399 ± 0.209
1.198PheTyr: 1.198 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
7.585GlyAla: 7.585 ± 2.71
0.399GlyCys: 0.399 ± 0.209
4.391GlyAsp: 4.391 ± 0.475
3.593GlyGlu: 3.593 ± 0.665
1.198GlyPhe: 1.198 ± 0.019
2.395GlyGly: 2.395 ± 0.645
1.597GlyHis: 1.597 ± 0.228
2.794GlyIle: 2.794 ± 0.854
2.794GlyLys: 2.794 ± 0.854
2.794GlyLeu: 2.794 ± 0.247
1.996GlyMet: 1.996 ± 0.437
1.198GlyAsn: 1.198 ± 0.588
1.597GlyPro: 1.597 ± 0.835
1.996GlyGln: 1.996 ± 0.437
3.194GlyArg: 3.194 ± 0.456
5.988GlySer: 5.988 ± 1.117
3.593GlyThr: 3.593 ± 2.976
2.794GlyVal: 2.794 ± 0.247
0.798GlyTrp: 0.798 ± 0.417
2.794GlyTyr: 2.794 ± 0.36
0.0GlyXaa: 0.0 ± 0.0
His
1.198HisAla: 1.198 ± 0.019
0.399HisCys: 0.399 ± 0.209
2.395HisAsp: 2.395 ± 1.252
0.798HisGlu: 0.798 ± 0.189
1.996HisPhe: 1.996 ± 0.437
2.395HisGly: 2.395 ± 1.252
0.0HisHis: 0.0 ± 0.0
1.198HisIle: 1.198 ± 0.626
1.597HisLys: 1.597 ± 0.379
1.597HisLeu: 1.597 ± 0.228
0.399HisMet: 0.399 ± 0.209
0.798HisAsn: 0.798 ± 0.189
1.198HisPro: 1.198 ± 0.019
0.399HisGln: 0.399 ± 0.209
0.0HisArg: 0.0 ± 0.0
0.798HisSer: 0.798 ± 0.417
0.798HisThr: 0.798 ± 0.189
2.794HisVal: 2.794 ± 0.36
0.0HisTrp: 0.0 ± 0.0
0.399HisTyr: 0.399 ± 0.209
0.0HisXaa: 0.0 ± 0.0
Ile
8.383IleAla: 8.383 ± 1.079
0.798IleCys: 0.798 ± 0.417
2.794IleAsp: 2.794 ± 0.854
1.597IleGlu: 1.597 ± 0.228
1.996IlePhe: 1.996 ± 0.437
2.794IleGly: 2.794 ± 0.966
1.198IleHis: 1.198 ± 0.626
4.391IleIle: 4.391 ± 0.475
2.794IleLys: 2.794 ± 1.461
6.387IleLeu: 6.387 ± 0.305
1.198IleMet: 1.198 ± 0.019
2.395IleAsn: 2.395 ± 1.175
2.395IlePro: 2.395 ± 0.039
3.992IleGln: 3.992 ± 0.266
1.996IleArg: 1.996 ± 0.437
3.992IleSer: 3.992 ± 2.161
3.593IleThr: 3.593 ± 1.271
2.794IleVal: 2.794 ± 0.36
0.0IleTrp: 0.0 ± 0.0
0.798IleTyr: 0.798 ± 0.417
0.0IleXaa: 0.0 ± 0.0
Lys
1.597LysAla: 1.597 ± 0.228
0.399LysCys: 0.399 ± 0.209
2.794LysAsp: 2.794 ± 1.461
3.194LysGlu: 3.194 ± 1.063
2.395LysPhe: 2.395 ± 0.039
2.794LysGly: 2.794 ± 0.247
1.597LysHis: 1.597 ± 0.835
1.996LysIle: 1.996 ± 0.437
3.194LysLys: 3.194 ± 1.67
3.593LysLeu: 3.593 ± 0.549
1.597LysMet: 1.597 ± 0.228
2.395LysAsn: 2.395 ± 0.039
2.794LysPro: 2.794 ± 1.461
3.194LysGln: 3.194 ± 1.063
4.391LysArg: 4.391 ± 1.689
1.996LysSer: 1.996 ± 1.044
2.794LysThr: 2.794 ± 0.854
1.996LysVal: 1.996 ± 1.044
0.798LysTrp: 0.798 ± 0.189
2.794LysTyr: 2.794 ± 0.854
0.0LysXaa: 0.0 ± 0.0
Leu
6.786LeuAla: 6.786 ± 0.7
1.996LeuCys: 1.996 ± 0.437
3.194LeuAsp: 3.194 ± 0.456
4.391LeuGlu: 4.391 ± 1.082
1.597LeuPhe: 1.597 ± 0.228
3.194LeuGly: 3.194 ± 1.67
1.996LeuHis: 1.996 ± 0.437
4.391LeuIle: 4.391 ± 0.132
7.186LeuLys: 7.186 ± 1.329
5.988LeuLeu: 5.988 ± 1.31
3.194LeuMet: 3.194 ± 0.151
4.79LeuAsn: 4.79 ± 1.744
4.79LeuPro: 4.79 ± 0.53
2.794LeuGln: 2.794 ± 0.36
3.992LeuArg: 3.992 ± 0.266
6.786LeuSer: 6.786 ± 0.7
5.988LeuThr: 5.988 ± 1.117
5.988LeuVal: 5.988 ± 0.096
0.399LeuTrp: 0.399 ± 0.209
3.593LeuTyr: 3.593 ± 1.271
0.0LeuXaa: 0.0 ± 0.0
Met
1.597MetAla: 1.597 ± 0.379
0.0MetCys: 0.0 ± 0.0
1.597MetAsp: 1.597 ± 0.228
2.794MetGlu: 2.794 ± 1.461
1.996MetPhe: 1.996 ± 1.384
2.794MetGly: 2.794 ± 0.854
1.198MetHis: 1.198 ± 0.626
1.597MetIle: 1.597 ± 0.228
1.198MetLys: 1.198 ± 0.626
3.194MetLeu: 3.194 ± 1.67
0.0MetMet: 0.0 ± 0.0
0.798MetAsn: 0.798 ± 0.417
1.597MetPro: 1.597 ± 0.379
1.198MetGln: 1.198 ± 0.019
1.996MetArg: 1.996 ± 0.777
0.399MetSer: 0.399 ± 0.209
0.399MetThr: 0.399 ± 0.209
1.597MetVal: 1.597 ± 0.228
0.0MetTrp: 0.0 ± 0.0
0.798MetTyr: 0.798 ± 0.189
0.0MetXaa: 0.0 ± 0.0
Asn
3.194AsnAla: 3.194 ± 0.456
1.198AsnCys: 1.198 ± 0.588
1.597AsnAsp: 1.597 ± 0.228
1.597AsnGlu: 1.597 ± 0.379
2.395AsnPhe: 2.395 ± 1.782
2.395AsnGly: 2.395 ± 0.568
1.597AsnHis: 1.597 ± 0.379
3.194AsnIle: 3.194 ± 1.365
1.198AsnLys: 1.198 ± 0.019
4.391AsnLeu: 4.391 ± 1.345
1.198AsnMet: 1.198 ± 0.019
3.992AsnAsn: 3.992 ± 1.554
3.593AsnPro: 3.593 ± 0.549
0.798AsnGln: 0.798 ± 0.796
2.794AsnArg: 2.794 ± 0.854
3.593AsnSer: 3.593 ± 1.156
5.589AsnThr: 5.589 ± 0.719
1.198AsnVal: 1.198 ± 0.588
1.198AsnTrp: 1.198 ± 1.194
1.597AsnTyr: 1.597 ± 0.986
0.0AsnXaa: 0.0 ± 0.0
Pro
3.194ProAla: 3.194 ± 0.151
0.399ProCys: 0.399 ± 0.209
1.597ProAsp: 1.597 ± 0.228
3.593ProGlu: 3.593 ± 1.878
3.593ProPhe: 3.593 ± 0.549
3.194ProGly: 3.194 ± 0.758
0.399ProHis: 0.399 ± 0.398
2.794ProIle: 2.794 ± 0.36
1.597ProLys: 1.597 ± 0.835
5.589ProLeu: 5.589 ± 0.494
0.0ProMet: 0.0 ± 0.0
3.194ProAsn: 3.194 ± 0.758
1.597ProPro: 1.597 ± 0.228
3.194ProGln: 3.194 ± 0.758
1.198ProArg: 1.198 ± 0.626
3.194ProSer: 3.194 ± 0.151
2.794ProThr: 2.794 ± 0.36
5.988ProVal: 5.988 ± 1.724
1.198ProTrp: 1.198 ± 0.019
2.395ProTyr: 2.395 ± 1.782
0.0ProXaa: 0.0 ± 0.0
Gln
2.794GlnAla: 2.794 ± 0.36
1.996GlnCys: 1.996 ± 0.437
1.597GlnAsp: 1.597 ± 0.835
0.798GlnGlu: 0.798 ± 0.796
0.399GlnPhe: 0.399 ± 0.398
0.798GlnGly: 0.798 ± 0.189
0.399GlnHis: 0.399 ± 0.209
2.395GlnIle: 2.395 ± 0.645
1.198GlnLys: 1.198 ± 0.019
3.194GlnLeu: 3.194 ± 0.456
1.597GlnMet: 1.597 ± 0.379
1.597GlnAsn: 1.597 ± 0.228
2.794GlnPro: 2.794 ± 0.36
0.798GlnGln: 0.798 ± 0.189
3.593GlnArg: 3.593 ± 0.665
5.589GlnSer: 5.589 ± 1.933
2.794GlnThr: 2.794 ± 0.854
3.194GlnVal: 3.194 ± 1.365
1.597GlnTrp: 1.597 ± 0.228
0.399GlnTyr: 0.399 ± 0.209
0.0GlnXaa: 0.0 ± 0.0
Arg
4.391ArgAla: 4.391 ± 0.475
1.198ArgCys: 1.198 ± 0.626
3.593ArgAsp: 3.593 ± 0.665
2.794ArgGlu: 2.794 ± 1.461
4.79ArgPhe: 4.79 ± 0.684
1.996ArgGly: 1.996 ± 0.17
0.0ArgHis: 0.0 ± 0.0
3.194ArgIle: 3.194 ± 0.758
1.996ArgLys: 1.996 ± 1.044
1.198ArgLeu: 1.198 ± 0.626
0.399ArgMet: 0.399 ± 0.209
2.794ArgAsn: 2.794 ± 0.247
3.194ArgPro: 3.194 ± 1.365
1.597ArgGln: 1.597 ± 0.379
1.597ArgArg: 1.597 ± 0.228
3.194ArgSer: 3.194 ± 0.456
1.996ArgThr: 1.996 ± 1.044
4.391ArgVal: 4.391 ± 0.739
0.798ArgTrp: 0.798 ± 0.417
2.395ArgTyr: 2.395 ± 0.645
0.0ArgXaa: 0.0 ± 0.0
Ser
6.786SerAla: 6.786 ± 3.127
0.399SerCys: 0.399 ± 0.209
4.79SerAsp: 4.79 ± 1.744
3.992SerGlu: 3.992 ± 0.266
3.593SerPhe: 3.593 ± 0.549
5.589SerGly: 5.589 ± 1.326
1.198SerHis: 1.198 ± 0.626
4.79SerIle: 4.79 ± 0.53
1.996SerLys: 1.996 ± 0.437
5.19SerLeu: 5.19 ± 1.499
1.198SerMet: 1.198 ± 0.019
2.794SerAsn: 2.794 ± 1.573
3.194SerPro: 3.194 ± 1.365
1.597SerGln: 1.597 ± 0.379
5.19SerArg: 5.19 ± 0.286
4.79SerSer: 4.79 ± 1.744
6.786SerThr: 6.786 ± 1.914
7.984SerVal: 7.984 ± 1.894
0.0SerTrp: 0.0 ± 0.0
3.194SerTyr: 3.194 ± 0.758
0.0SerXaa: 0.0 ± 0.0
Thr
5.19ThrAla: 5.19 ± 0.321
0.399ThrCys: 0.399 ± 0.398
2.395ThrAsp: 2.395 ± 0.039
2.794ThrGlu: 2.794 ± 0.966
4.391ThrPhe: 4.391 ± 0.475
4.391ThrGly: 4.391 ± 1.345
0.399ThrHis: 0.399 ± 0.398
2.794ThrIle: 2.794 ± 0.36
2.794ThrLys: 2.794 ± 0.247
6.786ThrLeu: 6.786 ± 1.914
1.198ThrMet: 1.198 ± 0.626
4.79ThrAsn: 4.79 ± 1.744
5.19ThrPro: 5.19 ± 0.928
1.996ThrGln: 1.996 ± 0.437
2.395ThrArg: 2.395 ± 0.645
6.387ThrSer: 6.387 ± 3.336
5.19ThrThr: 5.19 ± 0.928
4.79ThrVal: 4.79 ± 0.077
1.198ThrTrp: 1.198 ± 0.019
2.794ThrTyr: 2.794 ± 0.854
0.0ThrXaa: 0.0 ± 0.0
Val
5.988ValAla: 5.988 ± 0.511
1.597ValCys: 1.597 ± 0.835
2.794ValAsp: 2.794 ± 0.966
3.992ValGlu: 3.992 ± 0.266
2.395ValPhe: 2.395 ± 0.039
4.79ValGly: 4.79 ± 0.077
1.597ValHis: 1.597 ± 0.228
4.391ValIle: 4.391 ± 0.132
5.19ValLys: 5.19 ± 2.106
4.79ValLeu: 4.79 ± 0.077
1.198ValMet: 1.198 ± 0.626
2.395ValAsn: 2.395 ± 0.568
3.992ValPro: 3.992 ± 1.554
5.988ValGln: 5.988 ± 0.511
2.794ValArg: 2.794 ± 0.36
5.988ValSer: 5.988 ± 0.096
4.79ValThr: 4.79 ± 1.137
3.593ValVal: 3.593 ± 0.549
1.198ValTrp: 1.198 ± 0.019
3.593ValTyr: 3.593 ± 1.763
0.0ValXaa: 0.0 ± 0.0
Trp
1.597TrpAla: 1.597 ± 0.986
0.0TrpCys: 0.0 ± 0.0
0.798TrpAsp: 0.798 ± 0.417
0.798TrpGlu: 0.798 ± 0.417
0.798TrpPhe: 0.798 ± 0.417
0.0TrpGly: 0.0 ± 0.0
0.798TrpHis: 0.798 ± 0.189
1.198TrpIle: 1.198 ± 0.019
0.0TrpLys: 0.0 ± 0.0
1.996TrpLeu: 1.996 ± 0.777
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.399TrpPro: 0.399 ± 0.209
0.0TrpGln: 0.0 ± 0.0
1.996TrpArg: 1.996 ± 0.437
1.198TrpSer: 1.198 ± 0.019
1.198TrpThr: 1.198 ± 0.588
0.399TrpVal: 0.399 ± 0.209
0.0TrpTrp: 0.0 ± 0.0
0.399TrpTyr: 0.399 ± 0.209
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.798TyrAla: 0.798 ± 0.796
0.399TyrCys: 0.399 ± 0.209
3.593TyrAsp: 3.593 ± 0.058
1.996TyrGlu: 1.996 ± 1.044
0.399TyrPhe: 0.399 ± 0.209
4.391TyrGly: 4.391 ± 1.082
1.198TyrHis: 1.198 ± 0.019
1.198TyrIle: 1.198 ± 0.019
1.597TyrLys: 1.597 ± 0.379
4.79TyrLeu: 4.79 ± 0.53
1.597TyrMet: 1.597 ± 0.835
1.198TyrAsn: 1.198 ± 0.588
1.597TyrPro: 1.597 ± 0.835
2.395TyrGln: 2.395 ± 0.568
1.996TyrArg: 1.996 ± 1.991
1.996TyrSer: 1.996 ± 0.777
4.391TyrThr: 4.391 ± 0.132
1.198TyrVal: 1.198 ± 0.626
1.597TyrTrp: 1.597 ± 0.379
1.198TyrTyr: 1.198 ± 0.588
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski