Amino acid dipepetide frequency for Rhodanobacter lindaniclasticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.637AlaAla: 18.637 ± 0.222	1.25AlaCys: 1.25 ± 0.033	7.287AlaAsp: 7.287 ± 0.081	6.666AlaGlu: 6.666 ± 0.103	3.982AlaPhe: 3.982 ± 0.061	11.244AlaGly: 11.244 ± 0.153	2.935AlaHis: 2.935 ± 0.057	5.585AlaIle: 5.585 ± 0.071	3.279AlaLys: 3.279 ± 0.072	15.264AlaLeu: 15.264 ± 0.146	3.447AlaMet: 3.447 ± 0.065	2.979AlaAsn: 2.979 ± 0.064	6.272AlaPro: 6.272 ± 0.104	5.489AlaGln: 5.489 ± 0.085	9.602AlaArg: 9.602 ± 0.133	6.828AlaSer: 6.828 ± 0.081	6.463AlaThr: 6.463 ± 0.097	8.886AlaVal: 8.886 ± 0.104	2.189AlaTrp: 2.189 ± 0.049	2.421AlaTyr: 2.421 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.084CysAla: 1.084 ± 0.034	0.111CysCys: 0.111 ± 0.011	0.466CysAsp: 0.466 ± 0.021	0.424CysGlu: 0.424 ± 0.018	0.297CysPhe: 0.297 ± 0.018	0.903CysGly: 0.903 ± 0.032	0.266CysHis: 0.266 ± 0.016	0.354CysIle: 0.354 ± 0.019	0.199CysLys: 0.199 ± 0.013	0.783CysLeu: 0.783 ± 0.023	0.185CysMet: 0.185 ± 0.013	0.216CysAsn: 0.216 ± 0.017	0.398CysPro: 0.398 ± 0.017	0.224CysGln: 0.224 ± 0.013	0.629CysArg: 0.629 ± 0.027	0.49CysSer: 0.49 ± 0.021	0.467CysThr: 0.467 ± 0.019	0.68CysVal: 0.68 ± 0.027	0.126CysTrp: 0.126 ± 0.01	0.234CysTyr: 0.234 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.183AspAla: 8.183 ± 0.105	0.465AspCys: 0.465 ± 0.023	3.552AspAsp: 3.552 ± 0.068	3.272AspGlu: 3.272 ± 0.062	2.11AspPhe: 2.11 ± 0.046	5.775AspGly: 5.775 ± 0.105	1.348AspHis: 1.348 ± 0.041	2.319AspIle: 2.319 ± 0.052	1.685AspLys: 1.685 ± 0.048	5.461AspLeu: 5.461 ± 0.07	1.154AspMet: 1.154 ± 0.031	1.425AspAsn: 1.425 ± 0.039	3.483AspPro: 3.483 ± 0.058	1.844AspGln: 1.844 ± 0.041	3.758AspArg: 3.758 ± 0.058	2.581AspSer: 2.581 ± 0.053	2.781AspThr: 2.781 ± 0.057	4.104AspVal: 4.104 ± 0.061	1.088AspTrp: 1.088 ± 0.033	1.711AspTyr: 1.711 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.284GluAla: 6.284 ± 0.087	0.377GluCys: 0.377 ± 0.016	2.134GluAsp: 2.134 ± 0.058	2.116GluGlu: 2.116 ± 0.057	1.601GluPhe: 1.601 ± 0.038	3.474GluGly: 3.474 ± 0.059	1.621GluHis: 1.621 ± 0.041	2.197GluIle: 2.197 ± 0.053	1.506GluLys: 1.506 ± 0.045	6.428GluLeu: 6.428 ± 0.09	1.034GluMet: 1.034 ± 0.03	1.117GluAsn: 1.117 ± 0.029	2.552GluPro: 2.552 ± 0.045	2.767GluGln: 2.767 ± 0.059	4.643GluArg: 4.643 ± 0.07	2.45GluSer: 2.45 ± 0.045	2.255GluThr: 2.255 ± 0.05	3.839GluVal: 3.839 ± 0.062	0.647GluTrp: 0.647 ± 0.021	1.096GluTyr: 1.096 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.341PheAla: 4.341 ± 0.057	0.324PheCys: 0.324 ± 0.016	2.607PheAsp: 2.607 ± 0.046	1.77PheGlu: 1.77 ± 0.037	1.204PhePhe: 1.204 ± 0.037	3.407PheGly: 3.407 ± 0.061	0.815PheHis: 0.815 ± 0.03	1.271PheIle: 1.271 ± 0.032	0.947PheLys: 0.947 ± 0.03	2.889PheLeu: 2.889 ± 0.054	0.706PheMet: 0.706 ± 0.023	1.068PheAsn: 1.068 ± 0.034	1.437PhePro: 1.437 ± 0.038	0.967PheGln: 0.967 ± 0.025	2.178PheArg: 2.178 ± 0.045	1.964PheSer: 1.964 ± 0.045	1.707PheThr: 1.707 ± 0.041	2.654PheVal: 2.654 ± 0.049	0.469PheTrp: 0.469 ± 0.026	0.854PheTyr: 0.854 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.303GlyAla: 9.303 ± 0.14	0.842GlyCys: 0.842 ± 0.029	4.732GlyAsp: 4.732 ± 0.077	4.741GlyGlu: 4.741 ± 0.08	3.29GlyPhe: 3.29 ± 0.056	7.154GlyGly: 7.154 ± 0.136	2.242GlyHis: 2.242 ± 0.052	3.913GlyIle: 3.913 ± 0.063	3.326GlyLys: 3.326 ± 0.068	8.405GlyLeu: 8.405 ± 0.098	2.329GlyMet: 2.329 ± 0.049	2.493GlyAsn: 2.493 ± 0.081	2.932GlyPro: 2.932 ± 0.047	3.2GlyGln: 3.2 ± 0.057	5.752GlyArg: 5.752 ± 0.079	5.054GlySer: 5.054 ± 0.094	4.524GlyThr: 4.524 ± 0.135	6.643GlyVal: 6.643 ± 0.08	1.659GlyTrp: 1.659 ± 0.039	2.509GlyTyr: 2.509 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	3.601HisAla: 3.601 ± 0.066	0.28HisCys: 0.28 ± 0.015	1.657HisAsp: 1.657 ± 0.041	1.297HisGlu: 1.297 ± 0.034	0.925HisPhe: 0.925 ± 0.028	2.729HisGly: 2.729 ± 0.056	0.69HisHis: 0.69 ± 0.025	0.848HisIle: 0.848 ± 0.028	0.537HisLys: 0.537 ± 0.022	2.363HisLeu: 2.363 ± 0.048	0.554HisMet: 0.554 ± 0.023	0.494HisAsn: 0.494 ± 0.023	1.579HisPro: 1.579 ± 0.04	0.793HisGln: 0.793 ± 0.025	1.703HisArg: 1.703 ± 0.041	1.064HisSer: 1.064 ± 0.03	1.061HisThr: 1.061 ± 0.028	1.804HisVal: 1.804 ± 0.043	0.5HisTrp: 0.5 ± 0.02	0.813HisTyr: 0.813 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.958IleAla: 5.958 ± 0.083	0.35IleCys: 0.35 ± 0.019	3.274IleAsp: 3.274 ± 0.053	2.946IleGlu: 2.946 ± 0.052	1.175IlePhe: 1.175 ± 0.033	4.362IleGly: 4.362 ± 0.069	0.973IleHis: 0.973 ± 0.03	1.412IleIle: 1.412 ± 0.04	1.167IleLys: 1.167 ± 0.031	3.029IleLeu: 3.029 ± 0.06	0.553IleMet: 0.553 ± 0.023	1.326IleAsn: 1.326 ± 0.04	2.01IlePro: 2.01 ± 0.045	1.02IleGln: 1.02 ± 0.032	2.701IleArg: 2.701 ± 0.051	2.186IleSer: 2.186 ± 0.041	2.275IleThr: 2.275 ± 0.043	3.336IleVal: 3.336 ± 0.055	0.454IleTrp: 0.454 ± 0.021	0.94IleTyr: 0.94 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.45LysAla: 3.45 ± 0.078	0.13LysCys: 0.13 ± 0.011	1.415LysAsp: 1.415 ± 0.047	1.101LysGlu: 1.101 ± 0.038	0.836LysPhe: 0.836 ± 0.029	1.978LysGly: 1.978 ± 0.052	0.696LysHis: 0.696 ± 0.026	1.164LysIle: 1.164 ± 0.032	0.974LysLys: 0.974 ± 0.046	3.389LysLeu: 3.389 ± 0.059	0.59LysMet: 0.59 ± 0.026	0.726LysAsn: 0.726 ± 0.028	1.952LysPro: 1.952 ± 0.045	1.257LysGln: 1.257 ± 0.037	2.027LysArg: 2.027 ± 0.045	1.476LysSer: 1.476 ± 0.037	1.443LysThr: 1.443 ± 0.043	2.142LysVal: 2.142 ± 0.048	0.282LysTrp: 0.282 ± 0.017	0.663LysTyr: 0.663 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	16.036LeuAla: 16.036 ± 0.151	1.04LeuCys: 1.04 ± 0.029	7.012LeuAsp: 7.012 ± 0.09	4.994LeuGlu: 4.994 ± 0.079	3.454LeuPhe: 3.454 ± 0.057	9.195LeuGly: 9.195 ± 0.104	2.751LeuHis: 2.751 ± 0.045	4.121LeuIle: 4.121 ± 0.073	3.282LeuLys: 3.282 ± 0.066	12.807LeuLeu: 12.807 ± 0.163	2.027LeuMet: 2.027 ± 0.048	2.425LeuAsn: 2.425 ± 0.058	6.666LeuPro: 6.666 ± 0.098	4.289LeuGln: 4.289 ± 0.072	8.559LeuArg: 8.559 ± 0.111	5.572LeuSer: 5.572 ± 0.067	5.073LeuThr: 5.073 ± 0.092	7.74LeuVal: 7.74 ± 0.097	1.396LeuTrp: 1.396 ± 0.04	2.246LeuTyr: 2.246 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.68MetAla: 2.68 ± 0.053	0.134MetCys: 0.134 ± 0.011	1.149MetAsp: 1.149 ± 0.029	0.898MetGlu: 0.898 ± 0.03	0.669MetPhe: 0.669 ± 0.024	1.475MetGly: 1.475 ± 0.037	0.564MetHis: 0.564 ± 0.023	0.911MetIle: 0.911 ± 0.03	0.765MetLys: 0.765 ± 0.032	2.639MetLeu: 2.639 ± 0.056	0.431MetMet: 0.431 ± 0.019	0.773MetAsn: 0.773 ± 0.024	1.46MetPro: 1.46 ± 0.041	0.99MetGln: 0.99 ± 0.031	1.726MetArg: 1.726 ± 0.044	1.491MetSer: 1.491 ± 0.032	1.246MetThr: 1.246 ± 0.032	1.542MetVal: 1.542 ± 0.036	0.218MetTrp: 0.218 ± 0.015	0.37MetTyr: 0.37 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.137AsnAla: 3.137 ± 0.058	0.187AsnCys: 0.187 ± 0.014	1.497AsnAsp: 1.497 ± 0.042	1.161AsnGlu: 1.161 ± 0.033	0.873AsnPhe: 0.873 ± 0.033	2.341AsnGly: 2.341 ± 0.078	0.555AsnHis: 0.555 ± 0.021	1.081AsnIle: 1.081 ± 0.033	0.623AsnLys: 0.623 ± 0.027	2.7AsnLeu: 2.7 ± 0.057	0.458AsnMet: 0.458 ± 0.02	0.676AsnAsn: 0.676 ± 0.03	1.734AsnPro: 1.734 ± 0.038	0.871AsnGln: 0.871 ± 0.028	1.71AsnArg: 1.71 ± 0.041	1.074AsnSer: 1.074 ± 0.038	1.353AsnThr: 1.353 ± 0.051	1.831AsnVal: 1.831 ± 0.049	0.377AsnTrp: 0.377 ± 0.02	0.717AsnTyr: 0.717 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.949ProAla: 7.949 ± 0.097	0.361ProCys: 0.361 ± 0.021	3.459ProAsp: 3.459 ± 0.061	2.811ProGlu: 2.811 ± 0.051	1.667ProPhe: 1.667 ± 0.032	4.81ProGly: 4.81 ± 0.068	1.229ProHis: 1.229 ± 0.033	1.85ProIle: 1.85 ± 0.043	1.277ProLys: 1.277 ± 0.04	5.611ProLeu: 5.611 ± 0.074	1.263ProMet: 1.263 ± 0.038	1.148ProAsn: 1.148 ± 0.033	3.11ProPro: 3.11 ± 0.068	2.116ProGln: 2.116 ± 0.042	3.458ProArg: 3.458 ± 0.069	2.644ProSer: 2.644 ± 0.045	2.493ProThr: 2.493 ± 0.051	4.077ProVal: 4.077 ± 0.056	0.899ProTrp: 0.899 ± 0.03	1.227ProTyr: 1.227 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.475GlnAla: 5.475 ± 0.08	0.244GlnCys: 0.244 ± 0.013	1.521GlnAsp: 1.521 ± 0.035	1.354GlnGlu: 1.354 ± 0.035	1.184GlnPhe: 1.184 ± 0.029	2.668GlnGly: 2.668 ± 0.057	1.104GlnHis: 1.104 ± 0.031	1.559GlnIle: 1.559 ± 0.044	0.895GlnLys: 0.895 ± 0.027	4.891GlnLeu: 4.891 ± 0.076	0.809GlnMet: 0.809 ± 0.027	0.733GlnAsn: 0.733 ± 0.026	2.442GlnPro: 2.442 ± 0.047	2.096GlnGln: 2.096 ± 0.049	3.736GlnArg: 3.736 ± 0.076	1.877GlnSer: 1.877 ± 0.041	1.672GlnThr: 1.672 ± 0.047	3.018GlnVal: 3.018 ± 0.05	0.629GlnTrp: 0.629 ± 0.026	0.855GlnTyr: 0.855 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.461ArgAla: 8.461 ± 0.103	0.598ArgCys: 0.598 ± 0.024	4.218ArgAsp: 4.218 ± 0.059	4.603ArgGlu: 4.603 ± 0.068	2.729ArgPhe: 2.729 ± 0.054	5.235ArgGly: 5.235 ± 0.074	2.325ArgHis: 2.325 ± 0.05	3.608ArgIle: 3.608 ± 0.064	2.041ArgLys: 2.041 ± 0.044	8.538ArgLeu: 8.538 ± 0.105	1.903ArgMet: 1.903 ± 0.044	1.774ArgAsn: 1.774 ± 0.038	3.341ArgPro: 3.341 ± 0.066	3.204ArgGln: 3.204 ± 0.055	6.331ArgArg: 6.331 ± 0.108	3.595ArgSer: 3.595 ± 0.061	3.129ArgThr: 3.129 ± 0.045	5.225ArgVal: 5.225 ± 0.072	1.378ArgTrp: 1.378 ± 0.035	2.105ArgTyr: 2.105 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.314SerAla: 6.314 ± 0.077	0.439SerCys: 0.439 ± 0.02	2.71SerAsp: 2.71 ± 0.059	2.298SerGlu: 2.298 ± 0.046	1.954SerPhe: 1.954 ± 0.042	5.265SerGly: 5.265 ± 0.089	1.25SerHis: 1.25 ± 0.031	2.349SerIle: 2.349 ± 0.049	1.302SerLys: 1.302 ± 0.041	5.616SerLeu: 5.616 ± 0.075	1.252SerMet: 1.252 ± 0.029	1.314SerAsn: 1.314 ± 0.034	2.76SerPro: 2.76 ± 0.05	1.697SerGln: 1.697 ± 0.039	3.567SerArg: 3.567 ± 0.055	3.065SerSer: 3.065 ± 0.065	2.787SerThr: 2.787 ± 0.047	3.84SerVal: 3.84 ± 0.058	0.864SerTrp: 0.864 ± 0.029	1.454SerTyr: 1.454 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.892ThrAla: 5.892 ± 0.091	0.366ThrCys: 0.366 ± 0.018	2.65ThrAsp: 2.65 ± 0.05	2.067ThrGlu: 2.067 ± 0.047	1.577ThrPhe: 1.577 ± 0.039	4.455ThrGly: 4.455 ± 0.103	1.173ThrHis: 1.173 ± 0.032	2.072ThrIle: 2.072 ± 0.046	0.97ThrLys: 0.97 ± 0.036	6.309ThrLeu: 6.309 ± 0.123	0.952ThrMet: 0.952 ± 0.031	1.121ThrAsn: 1.121 ± 0.047	3.382ThrPro: 3.382 ± 0.059	1.618ThrGln: 1.618 ± 0.034	3.577ThrArg: 3.577 ± 0.054	2.564ThrSer: 2.564 ± 0.064	2.726ThrThr: 2.726 ± 0.097	4.067ThrVal: 4.067 ± 0.09	0.665ThrTrp: 0.665 ± 0.026	1.099ThrTyr: 1.099 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.627ValAla: 9.627 ± 0.114	0.666ValCys: 0.666 ± 0.024	4.599ValAsp: 4.599 ± 0.065	3.98ValGlu: 3.98 ± 0.063	2.531ValPhe: 2.531 ± 0.045	5.511ValGly: 5.511 ± 0.075	1.714ValHis: 1.714 ± 0.033	3.378ValIle: 3.378 ± 0.06	1.907ValLys: 1.907 ± 0.053	8.518ValLeu: 8.518 ± 0.105	1.639ValMet: 1.639 ± 0.041	2.004ValAsn: 2.004 ± 0.053	3.946ValPro: 3.946 ± 0.054	2.562ValGln: 2.562 ± 0.047	5.16ValArg: 5.16 ± 0.071	3.943ValSer: 3.943 ± 0.062	3.907ValThr: 3.907 ± 0.065	6.007ValVal: 6.007 ± 0.079	0.937ValTrp: 0.937 ± 0.028	1.652ValTyr: 1.652 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.305TrpAla: 1.305 ± 0.038	0.146TrpCys: 0.146 ± 0.011	0.701TrpAsp: 0.701 ± 0.024	0.506TrpGlu: 0.506 ± 0.019	0.602TrpPhe: 0.602 ± 0.026	0.886TrpGly: 0.886 ± 0.029	0.483TrpHis: 0.483 ± 0.02	0.696TrpIle: 0.696 ± 0.024	0.43TrpLys: 0.43 ± 0.02	2.401TrpLeu: 2.401 ± 0.052	0.427TrpMet: 0.427 ± 0.019	0.52TrpAsn: 0.52 ± 0.019	0.794TrpPro: 0.794 ± 0.029	0.87TrpGln: 0.87 ± 0.027	1.455TrpArg: 1.455 ± 0.035	0.937TrpSer: 0.937 ± 0.03	0.701TrpThr: 0.701 ± 0.023	0.951TrpVal: 0.951 ± 0.029	0.331TrpTrp: 0.331 ± 0.019	0.369TrpTyr: 0.369 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.988TyrAla: 2.988 ± 0.051	0.225TyrCys: 0.225 ± 0.015	1.458TyrAsp: 1.458 ± 0.051	1.132TyrGlu: 1.132 ± 0.032	0.92TyrPhe: 0.92 ± 0.031	2.177TyrGly: 2.177 ± 0.042	0.555TyrHis: 0.555 ± 0.019	0.761TyrIle: 0.761 ± 0.026	0.579TyrLys: 0.579 ± 0.024	2.642TyrLeu: 2.642 ± 0.054	0.415TyrMet: 0.415 ± 0.018	0.625TyrAsn: 0.625 ± 0.03	1.209TyrPro: 1.209 ± 0.034	0.886TyrGln: 0.886 ± 0.028	2.069TyrArg: 2.069 ± 0.047	1.245TyrSer: 1.245 ± 0.034	1.24TyrThr: 1.24 ± 0.04	1.803TyrVal: 1.803 ± 0.043	0.405TyrTrp: 0.405 ± 0.017	0.693TyrTyr: 0.693 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3582 proteins (1194724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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