Amino acid dipepetide frequency for Nitrincola lacisaponensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.335AlaAla: 10.335 ± 0.138	1.178AlaCys: 1.178 ± 0.034	5.709AlaAsp: 5.709 ± 0.079	7.03AlaGlu: 7.03 ± 0.093	3.561AlaPhe: 3.561 ± 0.062	7.533AlaGly: 7.533 ± 0.106	1.966AlaHis: 1.966 ± 0.045	5.377AlaIle: 5.377 ± 0.076	2.632AlaLys: 2.632 ± 0.061	12.193AlaLeu: 12.193 ± 0.13	2.695AlaMet: 2.695 ± 0.054	2.576AlaAsn: 2.576 ± 0.055	3.317AlaPro: 3.317 ± 0.076	4.615AlaGln: 4.615 ± 0.082	5.732AlaArg: 5.732 ± 0.09	5.593AlaSer: 5.593 ± 0.087	4.419AlaThr: 4.419 ± 0.072	6.868AlaVal: 6.868 ± 0.094	1.195AlaTrp: 1.195 ± 0.034	2.367AlaTyr: 2.367 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.864CysAla: 0.864 ± 0.032	0.157CysCys: 0.157 ± 0.013	0.595CysAsp: 0.595 ± 0.023	0.557CysGlu: 0.557 ± 0.025	0.428CysPhe: 0.428 ± 0.021	0.846CysGly: 0.846 ± 0.03	0.337CysHis: 0.337 ± 0.021	0.558CysIle: 0.558 ± 0.023	0.303CysLys: 0.303 ± 0.018	1.146CysLeu: 1.146 ± 0.036	0.234CysMet: 0.234 ± 0.014	0.296CysAsn: 0.296 ± 0.019	0.471CysPro: 0.471 ± 0.021	0.581CysGln: 0.581 ± 0.028	0.657CysArg: 0.657 ± 0.03	0.607CysSer: 0.607 ± 0.026	0.464CysThr: 0.464 ± 0.02	0.724CysVal: 0.724 ± 0.023	0.134CysTrp: 0.134 ± 0.012	0.343CysTyr: 0.343 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.371AspAla: 5.371 ± 0.078	0.511AspCys: 0.511 ± 0.021	2.81AspAsp: 2.81 ± 0.063	3.647AspGlu: 3.647 ± 0.058	2.168AspPhe: 2.168 ± 0.055	3.458AspGly: 3.458 ± 0.081	1.186AspHis: 1.186 ± 0.035	3.117AspIle: 3.117 ± 0.059	1.847AspLys: 1.847 ± 0.04	6.242AspLeu: 6.242 ± 0.084	1.373AspMet: 1.373 ± 0.035	1.669AspAsn: 1.669 ± 0.046	2.855AspPro: 2.855 ± 0.055	2.97AspGln: 2.97 ± 0.056	3.121AspArg: 3.121 ± 0.063	3.024AspSer: 3.024 ± 0.052	2.829AspThr: 2.829 ± 0.058	3.444AspVal: 3.444 ± 0.056	1.007AspTrp: 1.007 ± 0.033	1.771AspTyr: 1.771 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.435GluAla: 6.435 ± 0.084	0.452GluCys: 0.452 ± 0.022	2.657GluAsp: 2.657 ± 0.054	3.284GluGlu: 3.284 ± 0.068	2.063GluPhe: 2.063 ± 0.046	3.894GluGly: 3.894 ± 0.057	1.568GluHis: 1.568 ± 0.036	3.484GluIle: 3.484 ± 0.062	2.392GluLys: 2.392 ± 0.059	7.122GluLeu: 7.122 ± 0.091	1.683GluMet: 1.683 ± 0.04	1.832GluAsn: 1.832 ± 0.045	2.41GluPro: 2.41 ± 0.066	4.354GluGln: 4.354 ± 0.083	4.331GluArg: 4.331 ± 0.079	3.406GluSer: 3.406 ± 0.056	3.282GluThr: 3.282 ± 0.063	4.24GluVal: 4.24 ± 0.073	0.778GluTrp: 0.778 ± 0.026	1.471GluTyr: 1.471 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.483PheAla: 3.483 ± 0.067	0.486PheCys: 0.486 ± 0.022	2.447PheAsp: 2.447 ± 0.049	2.244PheGlu: 2.244 ± 0.041	1.593PhePhe: 1.593 ± 0.043	2.886PheGly: 2.886 ± 0.06	0.764PheHis: 0.764 ± 0.03	2.337PheIle: 2.337 ± 0.055	1.247PheLys: 1.247 ± 0.037	3.361PheLeu: 3.361 ± 0.072	1.074PheMet: 1.074 ± 0.035	1.57PheAsn: 1.57 ± 0.041	1.551PhePro: 1.551 ± 0.039	1.46PheGln: 1.46 ± 0.036	2.069PheArg: 2.069 ± 0.047	2.967PheSer: 2.967 ± 0.059	2.011PheThr: 2.011 ± 0.047	2.461PheVal: 2.461 ± 0.053	0.54PheTrp: 0.54 ± 0.028	1.185PheTyr: 1.185 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.742GlyAla: 5.742 ± 0.089	0.9GlyCys: 0.9 ± 0.032	3.76GlyAsp: 3.76 ± 0.071	4.175GlyGlu: 4.175 ± 0.076	3.342GlyPhe: 3.342 ± 0.056	5.036GlyGly: 5.036 ± 0.12	1.731GlyHis: 1.731 ± 0.047	4.549GlyIle: 4.549 ± 0.073	2.84GlyLys: 2.84 ± 0.065	8.054GlyLeu: 8.054 ± 0.099	2.263GlyMet: 2.263 ± 0.054	2.17GlyAsn: 2.17 ± 0.062	2.041GlyPro: 2.041 ± 0.047	3.558GlyGln: 3.558 ± 0.064	4.288GlyArg: 4.288 ± 0.072	4.17GlySer: 4.17 ± 0.078	3.367GlyThr: 3.367 ± 0.07	5.561GlyVal: 5.561 ± 0.081	1.15GlyTrp: 1.15 ± 0.038	2.518GlyTyr: 2.518 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.123HisAla: 2.123 ± 0.042	0.333HisCys: 0.333 ± 0.019	1.073HisAsp: 1.073 ± 0.039	1.235HisGlu: 1.235 ± 0.039	1.046HisPhe: 1.046 ± 0.034	1.474HisGly: 1.474 ± 0.042	0.718HisHis: 0.718 ± 0.027	1.184HisIle: 1.184 ± 0.034	0.711HisLys: 0.711 ± 0.027	2.839HisLeu: 2.839 ± 0.056	0.514HisMet: 0.514 ± 0.023	0.748HisAsn: 0.748 ± 0.027	1.51HisPro: 1.51 ± 0.039	1.537HisGln: 1.537 ± 0.041	1.353HisArg: 1.353 ± 0.037	1.28HisSer: 1.28 ± 0.038	1.194HisThr: 1.194 ± 0.034	1.159HisVal: 1.159 ± 0.038	0.508HisTrp: 0.508 ± 0.025	0.886HisTyr: 0.886 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.664IleAla: 5.664 ± 0.087	0.636IleCys: 0.636 ± 0.025	3.571IleAsp: 3.571 ± 0.056	4.021IleGlu: 4.021 ± 0.071	1.83IlePhe: 1.83 ± 0.045	4.188IleGly: 4.188 ± 0.067	1.293IleHis: 1.293 ± 0.037	2.876IleIle: 2.876 ± 0.063	1.83IleLys: 1.83 ± 0.054	5.391IleLeu: 5.391 ± 0.082	1.16IleMet: 1.16 ± 0.036	2.275IleAsn: 2.275 ± 0.051	2.601IlePro: 2.601 ± 0.046	2.522IleGln: 2.522 ± 0.045	3.708IleArg: 3.708 ± 0.063	3.845IleSer: 3.845 ± 0.059	3.29IleThr: 3.29 ± 0.059	3.258IleVal: 3.258 ± 0.075	0.646IleTrp: 0.646 ± 0.024	1.461IleTyr: 1.461 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	3.38LysAla: 3.38 ± 0.072	0.2LysCys: 0.2 ± 0.015	1.683LysAsp: 1.683 ± 0.049	1.74LysGlu: 1.74 ± 0.054	0.811LysPhe: 0.811 ± 0.031	2.405LysGly: 2.405 ± 0.049	0.823LysHis: 0.823 ± 0.035	1.821LysIle: 1.821 ± 0.052	1.437LysLys: 1.437 ± 0.052	3.437LysLeu: 3.437 ± 0.062	0.834LysMet: 0.834 ± 0.028	1.039LysAsn: 1.039 ± 0.036	1.785LysPro: 1.785 ± 0.038	1.871LysGln: 1.871 ± 0.051	2.284LysArg: 2.284 ± 0.052	1.878LysSer: 1.878 ± 0.048	1.947LysThr: 1.947 ± 0.047	2.411LysVal: 2.411 ± 0.047	0.312LysTrp: 0.312 ± 0.019	0.711LysTyr: 0.711 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.74LeuAla: 11.74 ± 0.115	1.221LeuCys: 1.221 ± 0.041	6.337LeuAsp: 6.337 ± 0.089	6.838LeuGlu: 6.838 ± 0.09	4.229LeuPhe: 4.229 ± 0.078	7.787LeuGly: 7.787 ± 0.101	2.52LeuHis: 2.52 ± 0.051	6.739LeuIle: 6.739 ± 0.103	4.504LeuLys: 4.504 ± 0.078	14.416LeuLeu: 14.416 ± 0.203	3.152LeuMet: 3.152 ± 0.065	4.323LeuAsn: 4.323 ± 0.059	6.1LeuPro: 6.1 ± 0.084	6.018LeuGln: 6.018 ± 0.096	6.65LeuArg: 6.65 ± 0.085	8.214LeuSer: 8.214 ± 0.109	6.251LeuThr: 6.251 ± 0.085	7.56LeuVal: 7.56 ± 0.111	1.274LeuTrp: 1.274 ± 0.04	2.638LeuTyr: 2.638 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.717MetAla: 2.717 ± 0.059	0.183MetCys: 0.183 ± 0.014	1.303MetAsp: 1.303 ± 0.035	1.285MetGlu: 1.285 ± 0.032	0.798MetPhe: 0.798 ± 0.031	1.81MetGly: 1.81 ± 0.052	0.545MetHis: 0.545 ± 0.023	1.503MetIle: 1.503 ± 0.041	1.071MetLys: 1.071 ± 0.034	3.119MetLeu: 3.119 ± 0.064	0.706MetMet: 0.706 ± 0.026	0.923MetAsn: 0.923 ± 0.033	1.336MetPro: 1.336 ± 0.035	1.415MetGln: 1.415 ± 0.038	1.55MetArg: 1.55 ± 0.034	1.803MetSer: 1.803 ± 0.042	1.712MetThr: 1.712 ± 0.039	1.692MetVal: 1.692 ± 0.042	0.152MetTrp: 0.152 ± 0.012	0.4MetTyr: 0.4 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.985AsnAla: 2.985 ± 0.06	0.299AsnCys: 0.299 ± 0.017	1.603AsnAsp: 1.603 ± 0.046	1.653AsnGlu: 1.653 ± 0.043	1.161AsnPhe: 1.161 ± 0.036	2.08AsnGly: 2.08 ± 0.05	0.752AsnHis: 0.752 ± 0.024	1.887AsnIle: 1.887 ± 0.051	1.0AsnLys: 1.0 ± 0.036	3.625AsnLeu: 3.625 ± 0.062	0.764AsnMet: 0.764 ± 0.029	1.05AsnAsn: 1.05 ± 0.035	2.158AsnPro: 2.158 ± 0.054	1.66AsnGln: 1.66 ± 0.047	2.172AsnArg: 2.172 ± 0.053	1.724AsnSer: 1.724 ± 0.037	1.849AsnThr: 1.849 ± 0.047	1.761AsnVal: 1.761 ± 0.048	0.449AsnTrp: 0.449 ± 0.023	0.836AsnTyr: 0.836 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.53ProAla: 4.53 ± 0.067	0.363ProCys: 0.363 ± 0.018	3.292ProAsp: 3.292 ± 0.055	4.018ProGlu: 4.018 ± 0.072	1.689ProPhe: 1.689 ± 0.036	3.611ProGly: 3.611 ± 0.058	0.948ProHis: 0.948 ± 0.03	2.023ProIle: 2.023 ± 0.051	1.273ProLys: 1.273 ± 0.038	5.122ProLeu: 5.122 ± 0.08	1.122ProMet: 1.122 ± 0.031	1.241ProAsn: 1.241 ± 0.036	1.626ProPro: 1.626 ± 0.05	1.87ProGln: 1.87 ± 0.051	2.041ProArg: 2.041 ± 0.054	2.378ProSer: 2.378 ± 0.049	1.832ProThr: 1.832 ± 0.051	4.196ProVal: 4.196 ± 0.068	0.675ProTrp: 0.675 ± 0.023	1.108ProTyr: 1.108 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.7GlnAla: 5.7 ± 0.091	0.428GlnCys: 0.428 ± 0.021	2.288GlnAsp: 2.288 ± 0.045	2.347GlnGlu: 2.347 ± 0.055	1.528GlnPhe: 1.528 ± 0.037	3.979GlnGly: 3.979 ± 0.062	1.5GlnHis: 1.5 ± 0.041	2.658GlnIle: 2.658 ± 0.048	1.388GlnLys: 1.388 ± 0.036	6.845GlnLeu: 6.845 ± 0.099	1.251GlnMet: 1.251 ± 0.036	1.221GlnAsn: 1.221 ± 0.036	2.584GlnPro: 2.584 ± 0.058	4.531GlnGln: 4.531 ± 0.111	3.904GlnArg: 3.904 ± 0.068	2.886GlnSer: 2.886 ± 0.059	2.479GlnThr: 2.479 ± 0.049	4.037GlnVal: 4.037 ± 0.07	0.695GlnTrp: 0.695 ± 0.025	1.083GlnTyr: 1.083 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.79ArgAla: 4.79 ± 0.076	0.606ArgCys: 0.606 ± 0.028	3.247ArgAsp: 3.247 ± 0.057	3.92ArgGlu: 3.92 ± 0.058	2.856ArgPhe: 2.856 ± 0.049	3.38ArgGly: 3.38 ± 0.066	1.651ArgHis: 1.651 ± 0.044	3.936ArgIle: 3.936 ± 0.07	2.112ArgLys: 2.112 ± 0.058	7.825ArgLeu: 7.825 ± 0.094	1.725ArgMet: 1.725 ± 0.04	1.961ArgAsn: 1.961 ± 0.044	2.401ArgPro: 2.401 ± 0.05	3.805ArgGln: 3.805 ± 0.074	3.817ArgArg: 3.817 ± 0.077	3.422ArgSer: 3.422 ± 0.061	2.563ArgThr: 2.563 ± 0.051	4.376ArgVal: 4.376 ± 0.073	0.969ArgTrp: 0.969 ± 0.03	2.131ArgTyr: 2.131 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.915SerAla: 5.915 ± 0.091	0.593SerCys: 0.593 ± 0.025	3.281SerAsp: 3.281 ± 0.067	3.489SerGlu: 3.489 ± 0.069	2.394SerPhe: 2.394 ± 0.05	5.336SerGly: 5.336 ± 0.084	1.446SerHis: 1.446 ± 0.039	3.356SerIle: 3.356 ± 0.057	1.656SerLys: 1.656 ± 0.053	7.335SerLeu: 7.335 ± 0.086	1.638SerMet: 1.638 ± 0.036	1.716SerAsn: 1.716 ± 0.046	2.598SerPro: 2.598 ± 0.057	2.778SerGln: 2.778 ± 0.059	3.797SerArg: 3.797 ± 0.067	3.625SerSer: 3.625 ± 0.066	2.806SerThr: 2.806 ± 0.055	4.461SerVal: 4.461 ± 0.074	0.868SerTrp: 0.868 ± 0.03	1.594SerTyr: 1.594 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.04ThrAla: 5.04 ± 0.067	0.469ThrCys: 0.469 ± 0.022	2.998ThrAsp: 2.998 ± 0.057	3.27ThrGlu: 3.27 ± 0.058	1.751ThrPhe: 1.751 ± 0.049	4.549ThrGly: 4.549 ± 0.09	1.233ThrHis: 1.233 ± 0.035	2.127ThrIle: 2.127 ± 0.052	0.964ThrLys: 0.964 ± 0.034	7.481ThrLeu: 7.481 ± 0.09	0.788ThrMet: 0.788 ± 0.029	1.245ThrAsn: 1.245 ± 0.039	2.943ThrPro: 2.943 ± 0.058	2.443ThrGln: 2.443 ± 0.065	3.205ThrArg: 3.205 ± 0.056	2.719ThrSer: 2.719 ± 0.054	2.532ThrThr: 2.532 ± 0.058	3.107ThrVal: 3.107 ± 0.058	0.594ThrTrp: 0.594 ± 0.029	1.162ThrTyr: 1.162 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.784ValAla: 6.784 ± 0.083	0.82ValCys: 0.82 ± 0.029	3.802ValAsp: 3.802 ± 0.061	4.404ValGlu: 4.404 ± 0.077	2.785ValPhe: 2.785 ± 0.06	4.321ValGly: 4.321 ± 0.081	1.362ValHis: 1.362 ± 0.039	4.384ValIle: 4.384 ± 0.067	2.369ValLys: 2.369 ± 0.06	7.638ValLeu: 7.638 ± 0.094	2.069ValMet: 2.069 ± 0.057	2.38ValAsn: 2.38 ± 0.049	2.734ValPro: 2.734 ± 0.053	2.686ValGln: 2.686 ± 0.056	3.983ValArg: 3.983 ± 0.063	4.805ValSer: 4.805 ± 0.07	3.849ValThr: 3.849 ± 0.071	5.056ValVal: 5.056 ± 0.092	0.845ValTrp: 0.845 ± 0.032	1.774ValTyr: 1.774 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.835TrpAla: 0.835 ± 0.026	0.168TrpCys: 0.168 ± 0.013	0.533TrpAsp: 0.533 ± 0.025	0.544TrpGlu: 0.544 ± 0.023	0.562TrpPhe: 0.562 ± 0.023	0.778TrpGly: 0.778 ± 0.031	0.387TrpHis: 0.387 ± 0.019	0.827TrpIle: 0.827 ± 0.032	0.459TrpLys: 0.459 ± 0.02	2.12TrpLeu: 2.12 ± 0.055	0.424TrpMet: 0.424 ± 0.022	0.391TrpAsn: 0.391 ± 0.02	0.589TrpPro: 0.589 ± 0.024	1.07TrpGln: 1.07 ± 0.039	0.84TrpArg: 0.84 ± 0.026	0.817TrpSer: 0.817 ± 0.03	0.558TrpThr: 0.558 ± 0.023	0.944TrpVal: 0.944 ± 0.03	0.207TrpTrp: 0.207 ± 0.016	0.35TrpTyr: 0.35 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.459TyrAla: 2.459 ± 0.056	0.3TyrCys: 0.3 ± 0.016	1.431TyrAsp: 1.431 ± 0.038	1.438TyrGlu: 1.438 ± 0.039	1.141TyrPhe: 1.141 ± 0.035	1.865TyrGly: 1.865 ± 0.045	0.69TyrHis: 0.69 ± 0.024	1.323TyrIle: 1.323 ± 0.041	0.775TyrLys: 0.775 ± 0.03	3.197TyrLeu: 3.197 ± 0.064	0.554TyrMet: 0.554 ± 0.021	0.842TyrAsn: 0.842 ± 0.033	1.348TyrPro: 1.348 ± 0.04	1.587TyrGln: 1.587 ± 0.043	1.989TyrArg: 1.989 ± 0.045	1.522TyrSer: 1.522 ± 0.041	1.386TyrThr: 1.386 ± 0.04	1.535TyrVal: 1.535 ± 0.043	0.407TyrTrp: 0.407 ± 0.023	0.864TyrTyr: 0.864 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3092 proteins (1040077 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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