Amino acid dipepetide frequency for Human papillomavirus 133

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.394AlaAla: 5.394 ± 2.221
0.415AlaCys: 0.415 ± 0.514
2.905AlaAsp: 2.905 ± 0.729
2.905AlaGlu: 2.905 ± 0.725
4.564AlaPhe: 4.564 ± 1.203
3.32AlaGly: 3.32 ± 1.07
0.83AlaHis: 0.83 ± 0.466
3.734AlaIle: 3.734 ± 0.88
3.32AlaLys: 3.32 ± 0.963
3.734AlaLeu: 3.734 ± 0.951
0.415AlaMet: 0.415 ± 0.358
2.075AlaAsn: 2.075 ± 1.124
2.49AlaPro: 2.49 ± 1.432
0.83AlaGln: 0.83 ± 0.628
4.149AlaArg: 4.149 ± 0.823
4.149AlaSer: 4.149 ± 0.662
5.394AlaThr: 5.394 ± 1.847
2.075AlaVal: 2.075 ± 1.008
0.83AlaTrp: 0.83 ± 0.481
2.49AlaTyr: 2.49 ± 0.942
0.0AlaXaa: 0.0 ± 0.0
Cys
2.49CysAla: 2.49 ± 1.206
0.83CysCys: 0.83 ± 0.599
0.83CysAsp: 0.83 ± 0.599
0.415CysGlu: 0.415 ± 0.361
0.415CysPhe: 0.415 ± 0.482
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
2.075CysIle: 2.075 ± 1.559
2.49CysLys: 2.49 ± 1.053
2.075CysLeu: 2.075 ± 1.42
0.415CysMet: 0.415 ± 0.514
1.66CysAsn: 1.66 ± 0.936
0.83CysPro: 0.83 ± 0.466
0.0CysGln: 0.0 ± 0.0
2.075CysArg: 2.075 ± 1.465
0.83CysSer: 0.83 ± 0.722
0.83CysThr: 0.83 ± 0.591
0.415CysVal: 0.415 ± 0.514
0.83CysTrp: 0.83 ± 0.481
0.83CysTyr: 0.83 ± 0.628
0.0CysXaa: 0.0 ± 0.0
Asp
2.49AspAla: 2.49 ± 1.164
2.49AspCys: 2.49 ± 1.215
3.734AspAsp: 3.734 ± 0.739
3.734AspGlu: 3.734 ± 1.627
4.149AspPhe: 4.149 ± 1.101
2.49AspGly: 2.49 ± 0.503
1.245AspHis: 1.245 ± 0.669
4.149AspIle: 4.149 ± 1.272
1.66AspLys: 1.66 ± 0.559
8.714AspLeu: 8.714 ± 1.239
0.83AspMet: 0.83 ± 0.397
2.905AspAsn: 2.905 ± 0.565
4.564AspPro: 4.564 ± 1.402
2.075AspGln: 2.075 ± 0.889
2.075AspArg: 2.075 ± 0.943
4.979AspSer: 4.979 ± 1.359
2.49AspThr: 2.49 ± 0.985
6.224AspVal: 6.224 ± 2.37
1.245AspTrp: 1.245 ± 0.669
0.83AspTyr: 0.83 ± 0.509
0.0AspXaa: 0.0 ± 0.0
Glu
3.32GluAla: 3.32 ± 0.502
0.83GluCys: 0.83 ± 0.722
7.054GluAsp: 7.054 ± 1.727
8.714GluGlu: 8.714 ± 2.714
1.66GluPhe: 1.66 ± 0.862
2.49GluGly: 2.49 ± 1.294
2.075GluHis: 2.075 ± 1.088
2.075GluIle: 2.075 ± 0.896
2.075GluLys: 2.075 ± 1.498
6.224GluLeu: 6.224 ± 1.606
1.66GluMet: 1.66 ± 1.445
3.32GluAsn: 3.32 ± 1.241
5.809GluPro: 5.809 ± 1.728
2.49GluGln: 2.49 ± 0.519
1.66GluArg: 1.66 ± 0.638
5.809GluSer: 5.809 ± 1.553
2.49GluThr: 2.49 ± 1.128
2.905GluVal: 2.905 ± 1.229
0.83GluTrp: 0.83 ± 0.481
2.49GluTyr: 2.49 ± 0.783
0.0GluXaa: 0.0 ± 0.0
Phe
1.66PheAla: 1.66 ± 0.662
1.245PheCys: 1.245 ± 1.541
3.32PheAsp: 3.32 ± 0.75
3.734PheGlu: 3.734 ± 1.717
1.66PhePhe: 1.66 ± 0.615
2.905PheGly: 2.905 ± 0.93
0.415PheHis: 0.415 ± 0.358
4.149PheIle: 4.149 ± 1.1
4.564PheLys: 4.564 ± 1.535
3.32PheLeu: 3.32 ± 0.75
0.83PheMet: 0.83 ± 0.722
2.075PheAsn: 2.075 ± 0.883
0.415PhePro: 0.415 ± 0.482
1.245PheGln: 1.245 ± 0.925
0.83PheArg: 0.83 ± 0.73
3.32PheSer: 3.32 ± 1.253
0.83PheThr: 0.83 ± 0.544
3.734PheVal: 3.734 ± 0.634
0.83PheTrp: 0.83 ± 0.397
2.075PheTyr: 2.075 ± 0.948
0.0PheXaa: 0.0 ± 0.0
Gly
3.32GlyAla: 3.32 ± 1.024
0.83GlyCys: 0.83 ± 0.397
4.564GlyAsp: 4.564 ± 1.309
4.564GlyGlu: 4.564 ± 1.636
1.245GlyPhe: 1.245 ± 1.089
3.32GlyGly: 3.32 ± 1.127
1.245GlyHis: 1.245 ± 0.745
2.905GlyIle: 2.905 ± 0.929
2.905GlyLys: 2.905 ± 1.232
4.979GlyLeu: 4.979 ± 1.445
0.0GlyMet: 0.0 ± 0.0
4.979GlyAsn: 4.979 ± 0.988
3.734GlyPro: 3.734 ± 1.678
1.66GlyGln: 1.66 ± 0.717
3.734GlyArg: 3.734 ± 1.456
4.149GlySer: 4.149 ± 1.145
6.224GlyThr: 6.224 ± 1.303
2.49GlyVal: 2.49 ± 0.953
0.415GlyTrp: 0.415 ± 0.482
0.83GlyTyr: 0.83 ± 0.521
0.0GlyXaa: 0.0 ± 0.0
His
0.415HisAla: 0.415 ± 0.358
0.83HisCys: 0.83 ± 0.431
0.0HisAsp: 0.0 ± 0.0
0.83HisGlu: 0.83 ± 0.63
1.245HisPhe: 1.245 ± 0.759
0.0HisGly: 0.0 ± 0.0
0.415HisHis: 0.415 ± 0.482
2.49HisIle: 2.49 ± 1.004
1.66HisLys: 1.66 ± 0.962
0.415HisLeu: 0.415 ± 0.514
0.415HisMet: 0.415 ± 0.361
1.245HisAsn: 1.245 ± 0.669
2.075HisPro: 2.075 ± 0.84
1.245HisGln: 1.245 ± 0.848
1.245HisArg: 1.245 ± 0.648
1.66HisSer: 1.66 ± 0.265
0.83HisThr: 0.83 ± 0.466
0.83HisVal: 0.83 ± 0.466
0.0HisTrp: 0.0 ± 0.0
0.415HisTyr: 0.415 ± 0.358
0.0HisXaa: 0.0 ± 0.0
Ile
1.245IleAla: 1.245 ± 0.408
0.83IleCys: 0.83 ± 0.696
4.564IleAsp: 4.564 ± 1.881
5.809IleGlu: 5.809 ± 1.623
1.245IlePhe: 1.245 ± 0.408
2.49IleGly: 2.49 ± 0.736
0.415IleHis: 0.415 ± 0.367
1.66IleIle: 1.66 ± 1.077
1.66IleLys: 1.66 ± 0.962
4.149IleLeu: 4.149 ± 0.57
0.415IleMet: 0.415 ± 0.361
0.83IleAsn: 0.83 ± 0.397
4.564IlePro: 4.564 ± 1.633
2.075IleGln: 2.075 ± 0.769
2.49IleArg: 2.49 ± 0.917
4.564IleSer: 4.564 ± 2.041
2.49IleThr: 2.49 ± 1.07
3.734IleVal: 3.734 ± 1.707
0.415IleTrp: 0.415 ± 0.361
2.49IleTyr: 2.49 ± 0.585
0.0IleXaa: 0.0 ± 0.0
Lys
4.149LysAla: 4.149 ± 1.266
1.245LysCys: 1.245 ± 0.693
2.49LysAsp: 2.49 ± 1.443
2.49LysGlu: 2.49 ± 1.094
1.66LysPhe: 1.66 ± 0.789
2.49LysGly: 2.49 ± 0.688
1.245LysHis: 1.245 ± 0.669
0.83LysIle: 0.83 ± 0.722
2.49LysLys: 2.49 ± 1.391
5.809LysLeu: 5.809 ± 1.524
0.83LysMet: 0.83 ± 0.481
3.734LysAsn: 3.734 ± 2.032
1.66LysPro: 1.66 ± 0.763
1.245LysGln: 1.245 ± 0.623
6.639LysArg: 6.639 ± 1.333
2.075LysSer: 2.075 ± 0.63
4.979LysThr: 4.979 ± 2.387
4.149LysVal: 4.149 ± 0.621
1.245LysTrp: 1.245 ± 0.676
3.734LysTyr: 3.734 ± 1.629
0.0LysXaa: 0.0 ± 0.0
Leu
7.469LeuAla: 7.469 ± 0.864
1.66LeuCys: 1.66 ± 1.07
3.734LeuAsp: 3.734 ± 0.473
5.809LeuGlu: 5.809 ± 1.247
7.054LeuPhe: 7.054 ± 1.952
7.884LeuGly: 7.884 ± 3.054
1.66LeuHis: 1.66 ± 0.798
4.149LeuIle: 4.149 ± 1.645
3.734LeuLys: 3.734 ± 0.99
12.448LeuLeu: 12.448 ± 3.111
1.66LeuMet: 1.66 ± 0.872
4.564LeuAsn: 4.564 ± 1.18
4.149LeuPro: 4.149 ± 1.296
7.054LeuGln: 7.054 ± 0.964
3.734LeuArg: 3.734 ± 1.577
6.224LeuSer: 6.224 ± 1.302
4.979LeuThr: 4.979 ± 0.707
4.564LeuVal: 4.564 ± 1.521
1.66LeuTrp: 1.66 ± 0.911
5.394LeuTyr: 5.394 ± 2.402
0.0LeuXaa: 0.0 ± 0.0
Met
0.83MetAla: 0.83 ± 0.466
1.245MetCys: 1.245 ± 1.084
0.83MetAsp: 0.83 ± 0.431
0.83MetGlu: 0.83 ± 0.719
0.83MetPhe: 0.83 ± 0.397
1.66MetGly: 1.66 ± 0.991
0.0MetHis: 0.0 ± 0.0
0.415MetIle: 0.415 ± 0.507
0.415MetLys: 0.415 ± 0.361
0.415MetLeu: 0.415 ± 0.361
0.0MetMet: 0.0 ± 0.0
0.83MetAsn: 0.83 ± 0.397
1.66MetPro: 1.66 ± 0.755
1.245MetGln: 1.245 ± 0.669
1.66MetArg: 1.66 ± 1.198
0.83MetSer: 0.83 ± 0.722
1.66MetThr: 1.66 ± 0.265
1.245MetVal: 1.245 ± 1.084
0.415MetTrp: 0.415 ± 0.361
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.32AsnAla: 3.32 ± 1.066
1.66AsnCys: 1.66 ± 0.58
2.075AsnAsp: 2.075 ± 1.146
2.075AsnGlu: 2.075 ± 0.9
3.32AsnPhe: 3.32 ± 1.422
2.905AsnGly: 2.905 ± 1.35
0.83AsnHis: 0.83 ± 0.722
3.734AsnIle: 3.734 ± 1.678
2.905AsnLys: 2.905 ± 0.65
4.149AsnLeu: 4.149 ± 0.824
0.0AsnMet: 0.0 ± 0.0
2.075AsnAsn: 2.075 ± 1.035
4.149AsnPro: 4.149 ± 2.38
2.49AsnGln: 2.49 ± 0.932
0.83AsnArg: 0.83 ± 0.466
4.979AsnSer: 4.979 ± 2.022
3.32AsnThr: 3.32 ± 1.504
0.83AsnVal: 0.83 ± 0.431
0.415AsnTrp: 0.415 ± 0.514
0.83AsnTyr: 0.83 ± 0.722
0.0AsnXaa: 0.0 ± 0.0
Pro
3.32ProAla: 3.32 ± 1.74
1.66ProCys: 1.66 ± 0.737
6.224ProAsp: 6.224 ± 1.862
3.734ProGlu: 3.734 ± 1.269
2.49ProPhe: 2.49 ± 0.956
3.32ProGly: 3.32 ± 1.71
0.415ProHis: 0.415 ± 0.556
2.075ProIle: 2.075 ± 0.997
3.734ProLys: 3.734 ± 0.608
7.054ProLeu: 7.054 ± 2.37
0.415ProMet: 0.415 ± 0.514
1.245ProAsn: 1.245 ± 1.075
5.394ProPro: 5.394 ± 2.55
4.149ProGln: 4.149 ± 2.259
1.66ProArg: 1.66 ± 0.717
6.639ProSer: 6.639 ± 2.091
2.905ProThr: 2.905 ± 2.17
2.905ProVal: 2.905 ± 0.951
0.415ProTrp: 0.415 ± 0.482
2.49ProTyr: 2.49 ± 1.442
0.0ProXaa: 0.0 ± 0.0
Gln
1.245GlnAla: 1.245 ± 0.701
0.415GlnCys: 0.415 ± 0.514
3.32GlnAsp: 3.32 ± 0.875
2.49GlnGlu: 2.49 ± 1.245
3.32GlnPhe: 3.32 ± 0.982
3.32GlnGly: 3.32 ± 1.409
0.415GlnHis: 0.415 ± 0.361
0.83GlnIle: 0.83 ± 0.521
2.075GlnLys: 2.075 ± 1.035
4.979GlnLeu: 4.979 ± 1.658
0.83GlnMet: 0.83 ± 0.529
2.075GlnAsn: 2.075 ± 1.234
1.66GlnPro: 1.66 ± 0.636
3.32GlnGln: 3.32 ± 1.009
2.49GlnArg: 2.49 ± 1.352
2.075GlnSer: 2.075 ± 0.685
4.149GlnThr: 4.149 ± 1.696
4.149GlnVal: 4.149 ± 1.056
0.83GlnTrp: 0.83 ± 0.431
1.66GlnTyr: 1.66 ± 0.559
0.0GlnXaa: 0.0 ± 0.0
Arg
2.905ArgAla: 2.905 ± 1.361
1.66ArgCys: 1.66 ± 0.737
2.905ArgAsp: 2.905 ± 0.731
2.905ArgGlu: 2.905 ± 1.364
2.075ArgPhe: 2.075 ± 1.088
3.32ArgGly: 3.32 ± 1.319
1.66ArgHis: 1.66 ± 0.583
2.49ArgIle: 2.49 ± 0.575
3.32ArgLys: 3.32 ± 1.21
7.469ArgLeu: 7.469 ± 1.374
0.83ArgMet: 0.83 ± 0.466
3.32ArgAsn: 3.32 ± 1.323
2.905ArgPro: 2.905 ± 1.383
3.32ArgGln: 3.32 ± 1.825
5.809ArgArg: 5.809 ± 1.28
4.979ArgSer: 4.979 ± 1.507
1.66ArgThr: 1.66 ± 0.648
2.49ArgVal: 2.49 ± 1.122
0.415ArgTrp: 0.415 ± 0.358
1.66ArgTyr: 1.66 ± 1.385
0.0ArgXaa: 0.0 ± 0.0
Ser
3.734SerAla: 3.734 ± 1.016
0.83SerCys: 0.83 ± 0.599
4.564SerAsp: 4.564 ± 1.368
4.564SerGlu: 4.564 ± 1.341
1.66SerPhe: 1.66 ± 1.052
5.809SerGly: 5.809 ± 1.723
1.66SerHis: 1.66 ± 0.657
3.32SerIle: 3.32 ± 1.141
4.564SerLys: 4.564 ± 2.57
7.884SerLeu: 7.884 ± 2.053
1.66SerMet: 1.66 ± 0.636
3.32SerAsn: 3.32 ± 1.354
3.734SerPro: 3.734 ± 2.173
2.905SerGln: 2.905 ± 1.226
5.394SerArg: 5.394 ± 1.812
7.884SerSer: 7.884 ± 2.337
4.564SerThr: 4.564 ± 1.534
4.979SerVal: 4.979 ± 1.771
0.0SerTrp: 0.0 ± 0.0
2.075SerTyr: 2.075 ± 0.694
0.0SerXaa: 0.0 ± 0.0
Thr
2.075ThrAla: 2.075 ± 0.842
0.415ThrCys: 0.415 ± 0.358
2.49ThrAsp: 2.49 ± 1.768
4.979ThrGlu: 4.979 ± 0.892
0.415ThrPhe: 0.415 ± 0.358
4.564ThrGly: 4.564 ± 0.939
1.245ThrHis: 1.245 ± 0.759
3.32ThrIle: 3.32 ± 1.35
2.905ThrLys: 2.905 ± 0.695
4.564ThrLeu: 4.564 ± 2.056
2.075ThrMet: 2.075 ± 0.922
2.075ThrAsn: 2.075 ± 0.883
7.469ThrPro: 7.469 ± 1.124
3.32ThrGln: 3.32 ± 1.61
3.32ThrArg: 3.32 ± 2.219
4.979ThrSer: 4.979 ± 1.3
2.905ThrThr: 2.905 ± 1.436
5.394ThrVal: 5.394 ± 0.885
0.83ThrTrp: 0.83 ± 0.481
0.415ThrTyr: 0.415 ± 0.361
0.0ThrXaa: 0.0 ± 0.0
Val
2.905ValAla: 2.905 ± 0.736
0.83ValCys: 0.83 ± 0.598
4.564ValAsp: 4.564 ± 1.213
3.734ValGlu: 3.734 ± 0.964
1.245ValPhe: 1.245 ± 0.502
3.32ValGly: 3.32 ± 1.173
1.66ValHis: 1.66 ± 0.668
2.49ValIle: 2.49 ± 1.808
4.149ValLys: 4.149 ± 1.153
4.564ValLeu: 4.564 ± 1.167
0.83ValMet: 0.83 ± 0.696
2.075ValAsn: 2.075 ± 0.491
3.734ValPro: 3.734 ± 1.394
4.149ValGln: 4.149 ± 1.542
4.564ValArg: 4.564 ± 1.303
3.32ValSer: 3.32 ± 1.506
4.979ValThr: 4.979 ± 0.8
3.32ValVal: 3.32 ± 1.141
0.415ValTrp: 0.415 ± 0.358
2.075ValTyr: 2.075 ± 0.857
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.245TrpAsp: 1.245 ± 0.925
0.415TrpGlu: 0.415 ± 0.482
0.0TrpPhe: 0.0 ± 0.0
0.83TrpGly: 0.83 ± 0.636
0.83TrpHis: 0.83 ± 0.965
0.83TrpIle: 0.83 ± 0.397
1.66TrpLys: 1.66 ± 0.839
1.66TrpLeu: 1.66 ± 0.615
0.83TrpMet: 0.83 ± 0.397
0.83TrpAsn: 0.83 ± 0.397
0.415TrpPro: 0.415 ± 0.358
0.0TrpGln: 0.0 ± 0.0
1.66TrpArg: 1.66 ± 0.638
0.415TrpSer: 0.415 ± 0.482
0.0TrpThr: 0.0 ± 0.0
0.83TrpVal: 0.83 ± 0.481
0.0TrpTrp: 0.0 ± 0.0
0.415TrpTyr: 0.415 ± 0.361
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.734TyrAla: 3.734 ± 0.725
0.415TyrCys: 0.415 ± 0.514
1.66TyrAsp: 1.66 ± 1.393
1.245TyrGlu: 1.245 ± 0.673
2.905TyrPhe: 2.905 ± 0.954
1.66TyrGly: 1.66 ± 1.019
0.0TyrHis: 0.0 ± 0.0
0.415TyrIle: 0.415 ± 0.482
2.905TyrLys: 2.905 ± 1.425
4.979TyrLeu: 4.979 ± 1.418
1.66TyrMet: 1.66 ± 1.137
1.66TyrAsn: 1.66 ± 0.676
0.83TyrPro: 0.83 ± 0.466
0.83TyrGln: 0.83 ± 0.397
2.075TyrArg: 2.075 ± 1.18
1.245TyrSer: 1.245 ± 0.701
2.075TyrThr: 2.075 ± 1.264
2.075TyrVal: 2.075 ± 0.91
0.83TyrTrp: 0.83 ± 0.509
2.49TyrTyr: 2.49 ± 2.339
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2411 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski