Amino acid dipepetide frequency for Actinomadura meyerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.931AlaAla: 23.931 ± 0.175	1.111AlaCys: 1.111 ± 0.023	8.46AlaAsp: 8.46 ± 0.066	9.52AlaGlu: 9.52 ± 0.08	3.782AlaPhe: 3.782 ± 0.044	14.594AlaGly: 14.594 ± 0.101	2.646AlaHis: 2.646 ± 0.035	3.945AlaIle: 3.945 ± 0.048	2.774AlaLys: 2.774 ± 0.042	14.579AlaLeu: 14.579 ± 0.102	2.682AlaMet: 2.682 ± 0.035	1.812AlaAsn: 1.812 ± 0.03	7.499AlaPro: 7.499 ± 0.066	3.35AlaGln: 3.35 ± 0.044	11.546AlaArg: 11.546 ± 0.09	5.811AlaSer: 5.811 ± 0.057	6.244AlaThr: 6.244 ± 0.053	12.445AlaVal: 12.445 ± 0.097	1.928AlaTrp: 1.928 ± 0.03	2.623AlaTyr: 2.623 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.021	0.093CysCys: 0.093 ± 0.007	0.509CysAsp: 0.509 ± 0.016	0.424CysGlu: 0.424 ± 0.014	0.197CysPhe: 0.197 ± 0.009	0.992CysGly: 0.992 ± 0.019	0.19CysHis: 0.19 ± 0.008	0.146CysIle: 0.146 ± 0.009	0.127CysLys: 0.127 ± 0.007	0.679CysLeu: 0.679 ± 0.015	0.133CysMet: 0.133 ± 0.007	0.128CysAsn: 0.128 ± 0.007	0.49CysPro: 0.49 ± 0.014	0.159CysGln: 0.159 ± 0.008	0.64CysArg: 0.64 ± 0.018	0.38CysSer: 0.38 ± 0.012	0.438CysThr: 0.438 ± 0.014	0.642CysVal: 0.642 ± 0.018	0.114CysTrp: 0.114 ± 0.007	0.165CysTyr: 0.165 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.194AspAla: 8.194 ± 0.062	0.393AspCys: 0.393 ± 0.013	3.931AspAsp: 3.931 ± 0.047	4.107AspGlu: 4.107 ± 0.046	1.54AspPhe: 1.54 ± 0.022	6.805AspGly: 6.805 ± 0.059	1.32AspHis: 1.32 ± 0.023	1.827AspIle: 1.827 ± 0.031	1.001AspLys: 1.001 ± 0.024	6.593AspLeu: 6.593 ± 0.06	0.939AspMet: 0.939 ± 0.019	0.78AspAsn: 0.78 ± 0.019	4.87AspPro: 4.87 ± 0.05	1.402AspGln: 1.402 ± 0.025	5.451AspArg: 5.451 ± 0.048	1.923AspSer: 1.923 ± 0.027	2.601AspThr: 2.601 ± 0.033	5.062AspVal: 5.062 ± 0.045	0.933AspTrp: 0.933 ± 0.021	1.151AspTyr: 1.151 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.608GluAla: 7.608 ± 0.065	0.378GluCys: 0.378 ± 0.013	2.894GluAsp: 2.894 ± 0.035	3.486GluGlu: 3.486 ± 0.047	1.516GluPhe: 1.516 ± 0.025	4.266GluGly: 4.266 ± 0.05	1.595GluHis: 1.595 ± 0.024	2.465GluIle: 2.465 ± 0.033	1.265GluLys: 1.265 ± 0.025	6.668GluLeu: 6.668 ± 0.061	0.998GluMet: 0.998 ± 0.02	0.932GluAsn: 0.932 ± 0.024	3.878GluPro: 3.878 ± 0.045	2.001GluGln: 2.001 ± 0.033	6.263GluArg: 6.263 ± 0.055	2.422GluSer: 2.422 ± 0.034	2.892GluThr: 2.892 ± 0.035	4.603GluVal: 4.603 ± 0.046	0.797GluTrp: 0.797 ± 0.02	1.137GluTyr: 1.137 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.849PheAla: 3.849 ± 0.042	0.273PheCys: 0.273 ± 0.009	1.941PheAsp: 1.941 ± 0.031	1.449PheGlu: 1.449 ± 0.025	0.829PhePhe: 0.829 ± 0.021	3.145PheGly: 3.145 ± 0.035	0.584PheHis: 0.584 ± 0.017	0.763PheIle: 0.763 ± 0.018	0.494PheLys: 0.494 ± 0.017	2.56PheLeu: 2.56 ± 0.032	0.431PheMet: 0.431 ± 0.014	0.535PheAsn: 0.535 ± 0.015	1.396PhePro: 1.396 ± 0.026	0.659PheGln: 0.659 ± 0.016	1.9PheArg: 1.9 ± 0.032	1.3PheSer: 1.3 ± 0.025	1.962PheThr: 1.962 ± 0.024	2.223PheVal: 2.223 ± 0.033	0.42PheTrp: 0.42 ± 0.014	0.575PheTyr: 0.575 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	12.02GlyAla: 12.02 ± 0.092	0.821GlyCys: 0.821 ± 0.018	5.728GlyAsp: 5.728 ± 0.047	5.517GlyGlu: 5.517 ± 0.048	2.914GlyPhe: 2.914 ± 0.032	9.901GlyGly: 9.901 ± 0.107	2.184GlyHis: 2.184 ± 0.029	3.325GlyIle: 3.325 ± 0.039	2.317GlyLys: 2.317 ± 0.039	9.812GlyLeu: 9.812 ± 0.078	2.157GlyMet: 2.157 ± 0.031	1.588GlyAsn: 1.588 ± 0.027	5.715GlyPro: 5.715 ± 0.057	2.365GlyGln: 2.365 ± 0.036	8.851GlyArg: 8.851 ± 0.063	4.65GlySer: 4.65 ± 0.054	6.228GlyThr: 6.228 ± 0.056	7.705GlyVal: 7.705 ± 0.067	1.744GlyTrp: 1.744 ± 0.025	2.272GlyTyr: 2.272 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.622HisAla: 2.622 ± 0.036	0.2HisCys: 0.2 ± 0.008	1.324HisAsp: 1.324 ± 0.025	1.132HisGlu: 1.132 ± 0.022	0.575HisPhe: 0.575 ± 0.017	2.347HisGly: 2.347 ± 0.032	0.597HisHis: 0.597 ± 0.019	0.668HisIle: 0.668 ± 0.017	0.298HisLys: 0.298 ± 0.011	2.295HisLeu: 2.295 ± 0.03	0.355HisMet: 0.355 ± 0.01	0.331HisAsn: 0.331 ± 0.011	1.682HisPro: 1.682 ± 0.03	0.502HisGln: 0.502 ± 0.015	2.075HisArg: 2.075 ± 0.034	0.829HisSer: 0.829 ± 0.02	1.015HisThr: 1.015 ± 0.021	1.695HisVal: 1.695 ± 0.029	0.345HisTrp: 0.345 ± 0.011	0.473HisTyr: 0.473 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.177IleAla: 5.177 ± 0.051	0.272IleCys: 0.272 ± 0.009	2.342IleAsp: 2.342 ± 0.027	2.233IleGlu: 2.233 ± 0.03	0.725IlePhe: 0.725 ± 0.017	3.674IleGly: 3.674 ± 0.038	0.544IleHis: 0.544 ± 0.015	1.008IleIle: 1.008 ± 0.024	0.727IleLys: 0.727 ± 0.019	2.495IleLeu: 2.495 ± 0.037	0.511IleMet: 0.511 ± 0.015	0.666IleAsn: 0.666 ± 0.017	1.767IlePro: 1.767 ± 0.027	0.663IleGln: 0.663 ± 0.016	2.364IleArg: 2.364 ± 0.033	1.564IleSer: 1.564 ± 0.023	2.153IleThr: 2.153 ± 0.027	3.104IleVal: 3.104 ± 0.038	0.381IleTrp: 0.381 ± 0.014	0.521IleTyr: 0.521 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.756LysAla: 2.756 ± 0.043	0.115LysCys: 0.115 ± 0.007	1.193LysAsp: 1.193 ± 0.025	1.069LysGlu: 1.069 ± 0.024	0.405LysPhe: 0.405 ± 0.016	1.717LysGly: 1.717 ± 0.031	0.388LysHis: 0.388 ± 0.015	0.899LysIle: 0.899 ± 0.021	0.703LysLys: 0.703 ± 0.023	1.746LysLeu: 1.746 ± 0.028	0.378LysMet: 0.378 ± 0.011	0.43LysAsn: 0.43 ± 0.015	1.335LysPro: 1.335 ± 0.033	0.584LysGln: 0.584 ± 0.018	1.513LysArg: 1.513 ± 0.028	1.024LysSer: 1.024 ± 0.024	1.181LysThr: 1.181 ± 0.025	1.847LysVal: 1.847 ± 0.034	0.262LysTrp: 0.262 ± 0.01	0.408LysTyr: 0.408 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.868LeuAla: 15.868 ± 0.109	0.798LeuCys: 0.798 ± 0.019	6.984LeuAsp: 6.984 ± 0.055	4.964LeuGlu: 4.964 ± 0.049	2.596LeuPhe: 2.596 ± 0.035	9.455LeuGly: 9.455 ± 0.068	2.144LeuHis: 2.144 ± 0.031	3.371LeuIle: 3.371 ± 0.044	1.857LeuLys: 1.857 ± 0.031	10.917LeuLeu: 10.917 ± 0.1	1.611LeuMet: 1.611 ± 0.024	1.684LeuAsn: 1.684 ± 0.025	6.433LeuPro: 6.433 ± 0.054	1.971LeuGln: 1.971 ± 0.032	9.236LeuArg: 9.236 ± 0.077	4.934LeuSer: 4.934 ± 0.041	6.198LeuThr: 6.198 ± 0.061	8.613LeuVal: 8.613 ± 0.073	1.275LeuTrp: 1.275 ± 0.025	1.778LeuTyr: 1.778 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.486MetAla: 2.486 ± 0.033	0.136MetCys: 0.136 ± 0.007	0.986MetAsp: 0.986 ± 0.018	0.781MetGlu: 0.781 ± 0.02	0.503MetPhe: 0.503 ± 0.017	1.4MetGly: 1.4 ± 0.024	0.35MetHis: 0.35 ± 0.013	0.734MetIle: 0.734 ± 0.016	0.415MetLys: 0.415 ± 0.013	1.886MetLeu: 1.886 ± 0.025	0.302MetMet: 0.302 ± 0.011	0.416MetAsn: 0.416 ± 0.015	1.209MetPro: 1.209 ± 0.02	0.399MetGln: 0.399 ± 0.013	1.688MetArg: 1.688 ± 0.024	1.294MetSer: 1.294 ± 0.02	1.547MetThr: 1.547 ± 0.025	1.338MetVal: 1.338 ± 0.025	0.214MetTrp: 0.214 ± 0.01	0.315MetTyr: 0.315 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.153AsnAla: 2.153 ± 0.035	0.16AsnCys: 0.16 ± 0.008	0.897AsnAsp: 0.897 ± 0.02	0.772AsnGlu: 0.772 ± 0.019	0.424AsnPhe: 0.424 ± 0.012	1.809AsnGly: 1.809 ± 0.033	0.335AsnHis: 0.335 ± 0.011	0.56AsnIle: 0.56 ± 0.016	0.342AsnLys: 0.342 ± 0.013	1.595AsnLeu: 1.595 ± 0.027	0.285AsnMet: 0.285 ± 0.01	0.329AsnAsn: 0.329 ± 0.013	1.288AsnPro: 1.288 ± 0.023	0.416AsnGln: 0.416 ± 0.014	1.225AsnArg: 1.225 ± 0.024	0.668AsnSer: 0.668 ± 0.017	0.915AsnThr: 0.915 ± 0.022	1.4AsnVal: 1.4 ± 0.024	0.254AsnTrp: 0.254 ± 0.01	0.378AsnTyr: 0.378 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.411ProAla: 9.411 ± 0.076	0.358ProCys: 0.358 ± 0.013	4.828ProAsp: 4.828 ± 0.05	4.524ProGlu: 4.524 ± 0.05	1.569ProPhe: 1.569 ± 0.022	7.47ProGly: 7.47 ± 0.067	1.284ProHis: 1.284 ± 0.025	1.527ProIle: 1.527 ± 0.024	1.203ProLys: 1.203 ± 0.026	5.342ProLeu: 5.342 ± 0.053	1.126ProMet: 1.126 ± 0.021	0.908ProAsn: 0.908 ± 0.019	4.683ProPro: 4.683 ± 0.077	1.504ProGln: 1.504 ± 0.035	4.346ProArg: 4.346 ± 0.048	3.349ProSer: 3.349 ± 0.04	2.684ProThr: 2.684 ± 0.041	5.436ProVal: 5.436 ± 0.049	0.946ProTrp: 0.946 ± 0.021	1.305ProTyr: 1.305 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.381GlnAla: 3.381 ± 0.047	0.167GlnCys: 0.167 ± 0.008	1.207GlnAsp: 1.207 ± 0.023	1.255GlnGlu: 1.255 ± 0.024	0.627GlnPhe: 0.627 ± 0.015	2.1GlnGly: 2.1 ± 0.033	0.503GlnHis: 0.503 ± 0.015	1.085GlnIle: 1.085 ± 0.021	0.512GlnLys: 0.512 ± 0.018	2.365GlnLeu: 2.365 ± 0.032	0.472GlnMet: 0.472 ± 0.014	0.461GlnAsn: 0.461 ± 0.014	1.475GlnPro: 1.475 ± 0.037	0.935GlnGln: 0.935 ± 0.032	2.235GlnArg: 2.235 ± 0.027	1.048GlnSer: 1.048 ± 0.02	1.184GlnThr: 1.184 ± 0.021	2.245GlnVal: 2.245 ± 0.033	0.372GlnTrp: 0.372 ± 0.014	0.523GlnTyr: 0.523 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	11.097ArgAla: 11.097 ± 0.084	0.599ArgCys: 0.599 ± 0.017	5.167ArgAsp: 5.167 ± 0.046	5.162ArgGlu: 5.162 ± 0.051	2.533ArgPhe: 2.533 ± 0.033	6.374ArgGly: 6.374 ± 0.062	2.173ArgHis: 2.173 ± 0.027	3.25ArgIle: 3.25 ± 0.039	1.623ArgLys: 1.623 ± 0.028	9.82ArgLeu: 9.82 ± 0.068	1.939ArgMet: 1.939 ± 0.029	1.338ArgAsn: 1.338 ± 0.024	5.744ArgPro: 5.744 ± 0.053	2.124ArgGln: 2.124 ± 0.033	9.111ArgArg: 9.111 ± 0.078	3.884ArgSer: 3.884 ± 0.044	5.121ArgThr: 5.121 ± 0.053	6.551ArgVal: 6.551 ± 0.053	1.456ArgTrp: 1.456 ± 0.025	1.932ArgTyr: 1.932 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.074SerAla: 6.074 ± 0.052	0.366SerCys: 0.366 ± 0.011	2.454SerAsp: 2.454 ± 0.03	2.223SerGlu: 2.223 ± 0.033	1.424SerPhe: 1.424 ± 0.022	5.724SerGly: 5.724 ± 0.06	0.863SerHis: 0.863 ± 0.019	1.438SerIle: 1.438 ± 0.027	0.91SerLys: 0.91 ± 0.02	4.409SerLeu: 4.409 ± 0.041	1.057SerMet: 1.057 ± 0.02	0.704SerAsn: 0.704 ± 0.017	3.124SerPro: 3.124 ± 0.043	1.028SerGln: 1.028 ± 0.022	3.583SerArg: 3.583 ± 0.038	2.424SerSer: 2.424 ± 0.041	2.468SerThr: 2.468 ± 0.036	3.739SerVal: 3.739 ± 0.042	0.817SerTrp: 0.817 ± 0.02	1.089SerTyr: 1.089 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.147ThrAla: 8.147 ± 0.059	0.43ThrCys: 0.43 ± 0.013	3.014ThrAsp: 3.014 ± 0.036	2.853ThrGlu: 2.853 ± 0.035	1.561ThrPhe: 1.561 ± 0.026	6.609ThrGly: 6.609 ± 0.054	0.992ThrHis: 0.992 ± 0.02	1.813ThrIle: 1.813 ± 0.028	1.004ThrLys: 1.004 ± 0.023	5.283ThrLeu: 5.283 ± 0.054	0.987ThrMet: 0.987 ± 0.019	0.84ThrAsn: 0.84 ± 0.019	3.63ThrPro: 3.63 ± 0.048	1.038ThrGln: 1.038 ± 0.022	3.991ThrArg: 3.991 ± 0.047	2.68ThrSer: 2.68 ± 0.039	3.057ThrThr: 3.057 ± 0.041	5.391ThrVal: 5.391 ± 0.049	0.874ThrTrp: 0.874 ± 0.02	1.132ThrTyr: 1.132 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	11.169ValAla: 11.169 ± 0.087	0.697ValCys: 0.697 ± 0.017	4.756ValAsp: 4.756 ± 0.044	4.654ValGlu: 4.654 ± 0.043	2.48ValPhe: 2.48 ± 0.033	6.153ValGly: 6.153 ± 0.051	1.92ValHis: 1.92 ± 0.028	2.993ValIle: 2.993 ± 0.037	1.659ValLys: 1.659 ± 0.031	9.794ValLeu: 9.794 ± 0.076	1.454ValMet: 1.454 ± 0.025	1.589ValAsn: 1.589 ± 0.027	5.668ValPro: 5.668 ± 0.055	2.045ValGln: 2.045 ± 0.027	7.604ValArg: 7.604 ± 0.066	3.977ValSer: 3.977 ± 0.038	5.259ValThr: 5.259 ± 0.053	7.677ValVal: 7.677 ± 0.073	1.117ValTrp: 1.117 ± 0.027	1.587ValTyr: 1.587 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.669TrpAla: 1.669 ± 0.025	0.141TrpCys: 0.141 ± 0.007	0.863TrpAsp: 0.863 ± 0.02	0.728TrpGlu: 0.728 ± 0.018	0.48TrpPhe: 0.48 ± 0.014	1.063TrpGly: 1.063 ± 0.02	0.363TrpHis: 0.363 ± 0.011	0.534TrpIle: 0.534 ± 0.017	0.331TrpLys: 0.331 ± 0.013	1.743TrpLeu: 1.743 ± 0.027	0.289TrpMet: 0.289 ± 0.011	0.37TrpAsn: 0.37 ± 0.013	0.856TrpPro: 0.856 ± 0.022	0.477TrpGln: 0.477 ± 0.014	1.503TrpArg: 1.503 ± 0.023	0.845TrpSer: 0.845 ± 0.02	1.064TrpThr: 1.064 ± 0.022	0.934TrpVal: 0.934 ± 0.02	0.337TrpTrp: 0.337 ± 0.012	0.337TrpTyr: 0.337 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.622TyrAla: 2.622 ± 0.034	0.184TyrCys: 0.184 ± 0.008	1.344TyrAsp: 1.344 ± 0.027	1.212TyrGlu: 1.212 ± 0.023	0.609TyrPhe: 0.609 ± 0.017	2.218TyrGly: 2.218 ± 0.031	0.384TyrHis: 0.384 ± 0.014	0.541TyrIle: 0.541 ± 0.015	0.394TyrLys: 0.394 ± 0.013	2.105TyrLeu: 2.105 ± 0.028	0.294TyrMet: 0.294 ± 0.011	0.365TyrAsn: 0.365 ± 0.012	1.06TyrPro: 1.06 ± 0.018	0.532TyrGln: 0.532 ± 0.014	1.872TyrArg: 1.872 ± 0.031	0.91TyrSer: 0.91 ± 0.019	1.112TyrThr: 1.112 ± 0.023	1.603TyrVal: 1.603 ± 0.025	0.342TyrTrp: 0.342 ± 0.012	0.461TyrTyr: 0.461 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7828 proteins (2564260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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