Amino acid dipepetide frequency for Alteromonas phage P24

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.585AlaAla: 8.585 ± 1.121
0.692AlaCys: 0.692 ± 0.224
4.5AlaAsp: 4.5 ± 0.437
6.3AlaGlu: 6.3 ± 0.6
3.669AlaPhe: 3.669 ± 0.507
5.123AlaGly: 5.123 ± 0.772
1.177AlaHis: 1.177 ± 0.335
6.3AlaIle: 6.3 ± 0.6
5.746AlaLys: 5.746 ± 0.576
7.408AlaLeu: 7.408 ± 0.795
3.877AlaMet: 3.877 ± 0.572
4.846AlaAsn: 4.846 ± 0.584
2.077AlaPro: 2.077 ± 0.382
4.846AlaGln: 4.846 ± 0.842
5.054AlaArg: 5.054 ± 0.589
6.577AlaSer: 6.577 ± 0.89
5.885AlaThr: 5.885 ± 1.021
5.608AlaVal: 5.608 ± 0.78
0.692AlaTrp: 0.692 ± 0.202
2.423AlaTyr: 2.423 ± 0.392
0.0AlaXaa: 0.0 ± 0.0
Cys
0.485CysAla: 0.485 ± 0.189
0.415CysCys: 0.415 ± 0.185
0.346CysAsp: 0.346 ± 0.141
0.692CysGlu: 0.692 ± 0.223
0.346CysPhe: 0.346 ± 0.149
0.346CysGly: 0.346 ± 0.162
0.208CysHis: 0.208 ± 0.123
0.831CysIle: 0.831 ± 0.259
0.623CysLys: 0.623 ± 0.219
0.277CysLeu: 0.277 ± 0.156
0.277CysMet: 0.277 ± 0.137
0.831CysAsn: 0.831 ± 0.252
0.623CysPro: 0.623 ± 0.264
0.277CysGln: 0.277 ± 0.137
0.623CysArg: 0.623 ± 0.25
0.485CysSer: 0.485 ± 0.152
0.623CysThr: 0.623 ± 0.243
0.069CysVal: 0.069 ± 0.074
0.208CysTrp: 0.208 ± 0.13
0.346CysTyr: 0.346 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
5.885AspAla: 5.885 ± 0.619
0.692AspCys: 0.692 ± 0.26
3.808AspAsp: 3.808 ± 0.58
3.669AspGlu: 3.669 ± 0.482
2.977AspPhe: 2.977 ± 0.402
3.462AspGly: 3.462 ± 0.393
1.038AspHis: 1.038 ± 0.263
4.431AspIle: 4.431 ± 0.53
3.462AspLys: 3.462 ± 0.455
5.123AspLeu: 5.123 ± 0.419
0.969AspMet: 0.969 ± 0.387
2.908AspAsn: 2.908 ± 0.531
2.008AspPro: 2.008 ± 0.431
1.454AspGln: 1.454 ± 0.382
0.969AspArg: 0.969 ± 0.297
4.223AspSer: 4.223 ± 0.582
2.215AspThr: 2.215 ± 0.42
3.946AspVal: 3.946 ± 0.481
0.554AspTrp: 0.554 ± 0.182
2.077AspTyr: 2.077 ± 0.35
0.0AspXaa: 0.0 ± 0.0
Glu
7.685GluAla: 7.685 ± 0.676
0.831GluCys: 0.831 ± 0.281
2.631GluAsp: 2.631 ± 0.377
3.946GluGlu: 3.946 ± 0.595
2.077GluPhe: 2.077 ± 0.378
4.223GluGly: 4.223 ± 0.607
1.592GluHis: 1.592 ± 0.306
3.6GluIle: 3.6 ± 0.578
3.669GluLys: 3.669 ± 0.595
6.646GluLeu: 6.646 ± 0.646
1.454GluMet: 1.454 ± 0.38
3.115GluAsn: 3.115 ± 0.505
1.939GluPro: 1.939 ± 0.306
4.154GluGln: 4.154 ± 0.579
3.185GluArg: 3.185 ± 0.494
5.262GluSer: 5.262 ± 0.635
3.6GluThr: 3.6 ± 0.427
4.846GluVal: 4.846 ± 0.62
1.315GluTrp: 1.315 ± 0.403
1.939GluTyr: 1.939 ± 0.312
0.0GluXaa: 0.0 ± 0.0
Phe
2.977PheAla: 2.977 ± 0.385
0.208PheCys: 0.208 ± 0.133
3.6PheAsp: 3.6 ± 0.497
2.7PheGlu: 2.7 ± 0.405
1.108PhePhe: 1.108 ± 0.259
2.354PheGly: 2.354 ± 0.38
0.623PheHis: 0.623 ± 0.199
2.423PheIle: 2.423 ± 0.327
3.046PheLys: 3.046 ± 0.503
2.631PheLeu: 2.631 ± 0.344
1.177PheMet: 1.177 ± 0.31
2.354PheAsn: 2.354 ± 0.421
1.177PhePro: 1.177 ± 0.301
0.9PheGln: 0.9 ± 0.22
1.315PheArg: 1.315 ± 0.291
2.215PheSer: 2.215 ± 0.375
2.562PheThr: 2.562 ± 0.348
1.939PheVal: 1.939 ± 0.36
0.762PheTrp: 0.762 ± 0.211
1.246PheTyr: 1.246 ± 0.258
0.0PheXaa: 0.0 ± 0.0
Gly
5.746GlyAla: 5.746 ± 0.64
0.762GlyCys: 0.762 ± 0.282
3.185GlyAsp: 3.185 ± 0.602
3.669GlyGlu: 3.669 ± 0.521
2.423GlyPhe: 2.423 ± 0.432
4.431GlyGly: 4.431 ± 0.463
1.246GlyHis: 1.246 ± 0.271
3.115GlyIle: 3.115 ± 0.492
5.054GlyLys: 5.054 ± 0.607
5.331GlyLeu: 5.331 ± 0.518
1.731GlyMet: 1.731 ± 0.348
3.323GlyAsn: 3.323 ± 0.52
1.108GlyPro: 1.108 ± 0.269
2.977GlyGln: 2.977 ± 0.495
3.046GlyArg: 3.046 ± 0.581
5.816GlySer: 5.816 ± 0.591
3.877GlyThr: 3.877 ± 0.691
4.985GlyVal: 4.985 ± 0.516
1.038GlyTrp: 1.038 ± 0.337
2.492GlyTyr: 2.492 ± 0.384
0.0GlyXaa: 0.0 ± 0.0
His
1.246HisAla: 1.246 ± 0.271
0.277HisCys: 0.277 ± 0.16
1.108HisAsp: 1.108 ± 0.257
1.454HisGlu: 1.454 ± 0.417
1.177HisPhe: 1.177 ± 0.249
1.177HisGly: 1.177 ± 0.319
0.415HisHis: 0.415 ± 0.192
1.315HisIle: 1.315 ± 0.32
1.592HisLys: 1.592 ± 0.323
2.077HisLeu: 2.077 ± 0.393
0.0HisMet: 0.0 ± 0.0
0.554HisAsn: 0.554 ± 0.193
0.554HisPro: 0.554 ± 0.196
1.038HisGln: 1.038 ± 0.227
1.385HisArg: 1.385 ± 0.378
1.108HisSer: 1.108 ± 0.218
0.415HisThr: 0.415 ± 0.191
1.592HisVal: 1.592 ± 0.456
0.346HisTrp: 0.346 ± 0.153
0.554HisTyr: 0.554 ± 0.187
0.0HisXaa: 0.0 ± 0.0
Ile
5.054IleAla: 5.054 ± 0.483
0.623IleCys: 0.623 ± 0.21
4.569IleAsp: 4.569 ± 0.509
5.539IleGlu: 5.539 ± 0.74
1.662IlePhe: 1.662 ± 0.408
4.016IleGly: 4.016 ± 0.563
0.762IleHis: 0.762 ± 0.236
3.185IleIle: 3.185 ± 0.45
4.916IleLys: 4.916 ± 0.673
3.946IleLeu: 3.946 ± 0.596
0.692IleMet: 0.692 ± 0.209
4.223IleAsn: 4.223 ± 0.513
2.077IlePro: 2.077 ± 0.286
2.492IleGln: 2.492 ± 0.355
2.492IleArg: 2.492 ± 0.386
5.4IleSer: 5.4 ± 0.735
5.054IleThr: 5.054 ± 0.695
3.046IleVal: 3.046 ± 0.462
0.969IleTrp: 0.969 ± 0.27
2.354IleTyr: 2.354 ± 0.425
0.0IleXaa: 0.0 ± 0.0
Lys
6.369LysAla: 6.369 ± 0.595
0.346LysCys: 0.346 ± 0.163
3.531LysAsp: 3.531 ± 0.585
5.4LysGlu: 5.4 ± 0.803
2.423LysPhe: 2.423 ± 0.366
4.569LysGly: 4.569 ± 0.571
1.108LysHis: 1.108 ± 0.301
3.392LysIle: 3.392 ± 0.531
4.154LysLys: 4.154 ± 0.703
5.539LysLeu: 5.539 ± 0.621
1.454LysMet: 1.454 ± 0.374
3.046LysAsn: 3.046 ± 0.512
3.185LysPro: 3.185 ± 0.506
3.531LysGln: 3.531 ± 0.536
4.223LysArg: 4.223 ± 0.587
4.016LysSer: 4.016 ± 0.789
3.115LysThr: 3.115 ± 0.413
4.292LysVal: 4.292 ± 0.556
0.831LysTrp: 0.831 ± 0.218
1.454LysTyr: 1.454 ± 0.36
0.0LysXaa: 0.0 ± 0.0
Leu
8.516LeuAla: 8.516 ± 1.016
0.277LeuCys: 0.277 ± 0.117
4.154LeuAsp: 4.154 ± 0.534
5.469LeuGlu: 5.469 ± 0.626
3.392LeuPhe: 3.392 ± 0.591
5.192LeuGly: 5.192 ± 0.527
1.315LeuHis: 1.315 ± 0.29
5.192LeuIle: 5.192 ± 0.665
5.262LeuLys: 5.262 ± 0.631
4.985LeuLeu: 4.985 ± 0.574
1.454LeuMet: 1.454 ± 0.3
4.5LeuAsn: 4.5 ± 0.556
2.562LeuPro: 2.562 ± 0.431
3.115LeuGln: 3.115 ± 0.402
4.292LeuArg: 4.292 ± 0.52
8.1LeuSer: 8.1 ± 0.763
5.192LeuThr: 5.192 ± 0.934
4.362LeuVal: 4.362 ± 0.651
0.9LeuTrp: 0.9 ± 0.343
1.731LeuTyr: 1.731 ± 0.437
0.0LeuXaa: 0.0 ± 0.0
Met
2.977MetAla: 2.977 ± 0.455
0.346MetCys: 0.346 ± 0.148
0.9MetAsp: 0.9 ± 0.295
1.177MetGlu: 1.177 ± 0.274
0.9MetPhe: 0.9 ± 0.235
1.8MetGly: 1.8 ± 0.414
0.762MetHis: 0.762 ± 0.215
0.9MetIle: 0.9 ± 0.257
1.523MetLys: 1.523 ± 0.355
2.423MetLeu: 2.423 ± 0.53
0.623MetMet: 0.623 ± 0.268
1.385MetAsn: 1.385 ± 0.388
0.831MetPro: 0.831 ± 0.248
1.523MetGln: 1.523 ± 0.321
0.9MetArg: 0.9 ± 0.286
1.662MetSer: 1.662 ± 0.322
1.315MetThr: 1.315 ± 0.332
1.108MetVal: 1.108 ± 0.295
0.069MetTrp: 0.069 ± 0.069
0.277MetTyr: 0.277 ± 0.128
0.0MetXaa: 0.0 ± 0.0
Asn
4.431AsnAla: 4.431 ± 0.769
0.415AsnCys: 0.415 ± 0.165
3.323AsnAsp: 3.323 ± 0.425
3.185AsnGlu: 3.185 ± 0.421
2.146AsnPhe: 2.146 ± 0.354
5.469AsnGly: 5.469 ± 0.716
1.108AsnHis: 1.108 ± 0.335
2.7AsnIle: 2.7 ± 0.435
3.323AsnLys: 3.323 ± 0.443
3.115AsnLeu: 3.115 ± 0.425
1.177AsnMet: 1.177 ± 0.295
2.562AsnAsn: 2.562 ± 0.463
2.354AsnPro: 2.354 ± 0.417
2.354AsnGln: 2.354 ± 0.4
2.077AsnArg: 2.077 ± 0.393
3.946AsnSer: 3.946 ± 0.473
2.423AsnThr: 2.423 ± 0.377
2.354AsnVal: 2.354 ± 0.367
1.177AsnTrp: 1.177 ± 0.245
2.354AsnTyr: 2.354 ± 0.347
0.0AsnXaa: 0.0 ± 0.0
Pro
2.077ProAla: 2.077 ± 0.292
0.277ProCys: 0.277 ± 0.183
2.008ProAsp: 2.008 ± 0.305
2.839ProGlu: 2.839 ± 0.36
1.454ProPhe: 1.454 ± 0.28
1.592ProGly: 1.592 ± 0.326
0.831ProHis: 0.831 ± 0.242
2.562ProIle: 2.562 ± 0.544
1.939ProLys: 1.939 ± 0.357
2.562ProLeu: 2.562 ± 0.375
0.969ProMet: 0.969 ± 0.319
2.423ProAsn: 2.423 ± 0.383
1.246ProPro: 1.246 ± 0.312
1.177ProGln: 1.177 ± 0.408
1.662ProArg: 1.662 ± 0.376
3.6ProSer: 3.6 ± 0.543
1.939ProThr: 1.939 ± 0.313
2.146ProVal: 2.146 ± 0.428
0.346ProTrp: 0.346 ± 0.158
0.692ProTyr: 0.692 ± 0.183
0.0ProXaa: 0.0 ± 0.0
Gln
3.808GlnAla: 3.808 ± 0.71
0.208GlnCys: 0.208 ± 0.122
1.731GlnAsp: 1.731 ± 0.336
2.492GlnGlu: 2.492 ± 0.41
1.454GlnPhe: 1.454 ± 0.384
2.354GlnGly: 2.354 ± 0.438
1.108GlnHis: 1.108 ± 0.299
2.769GlnIle: 2.769 ± 0.437
2.423GlnLys: 2.423 ± 0.406
4.431GlnLeu: 4.431 ± 0.602
1.315GlnMet: 1.315 ± 0.26
1.869GlnAsn: 1.869 ± 0.328
2.146GlnPro: 2.146 ± 0.311
2.769GlnGln: 2.769 ± 0.469
2.908GlnArg: 2.908 ± 0.411
2.769GlnSer: 2.769 ± 0.468
2.908GlnThr: 2.908 ± 0.556
3.046GlnVal: 3.046 ± 0.525
0.346GlnTrp: 0.346 ± 0.134
1.662GlnTyr: 1.662 ± 0.4
0.0GlnXaa: 0.0 ± 0.0
Arg
3.946ArgAla: 3.946 ± 0.514
0.554ArgCys: 0.554 ± 0.196
3.185ArgAsp: 3.185 ± 0.408
3.185ArgGlu: 3.185 ± 0.481
1.869ArgPhe: 1.869 ± 0.311
2.631ArgGly: 2.631 ± 0.416
1.177ArgHis: 1.177 ± 0.288
3.115ArgIle: 3.115 ± 0.517
4.016ArgLys: 4.016 ± 0.721
4.5ArgLeu: 4.5 ± 0.521
1.177ArgMet: 1.177 ± 0.281
2.354ArgAsn: 2.354 ± 0.322
1.8ArgPro: 1.8 ± 0.463
2.146ArgGln: 2.146 ± 0.411
2.562ArgArg: 2.562 ± 0.452
2.285ArgSer: 2.285 ± 0.314
2.631ArgThr: 2.631 ± 0.469
3.6ArgVal: 3.6 ± 0.431
0.415ArgTrp: 0.415 ± 0.172
1.731ArgTyr: 1.731 ± 0.427
0.0ArgXaa: 0.0 ± 0.0
Ser
7.546SerAla: 7.546 ± 0.863
0.415SerCys: 0.415 ± 0.176
3.669SerAsp: 3.669 ± 0.433
4.916SerGlu: 4.916 ± 0.478
2.562SerPhe: 2.562 ± 0.514
5.262SerGly: 5.262 ± 0.845
1.592SerHis: 1.592 ± 0.374
6.023SerIle: 6.023 ± 0.741
5.123SerLys: 5.123 ± 0.705
6.162SerLeu: 6.162 ± 0.542
1.385SerMet: 1.385 ± 0.348
3.185SerAsn: 3.185 ± 0.473
2.146SerPro: 2.146 ± 0.316
3.115SerGln: 3.115 ± 0.465
2.977SerArg: 2.977 ± 0.417
5.885SerSer: 5.885 ± 0.579
3.462SerThr: 3.462 ± 0.462
6.577SerVal: 6.577 ± 0.7
0.623SerTrp: 0.623 ± 0.209
2.631SerTyr: 2.631 ± 0.449
0.0SerXaa: 0.0 ± 0.0
Thr
6.092ThrAla: 6.092 ± 0.855
0.277ThrCys: 0.277 ± 0.123
3.046ThrAsp: 3.046 ± 0.384
3.323ThrGlu: 3.323 ± 0.531
2.354ThrPhe: 2.354 ± 0.314
5.054ThrGly: 5.054 ± 0.62
1.385ThrHis: 1.385 ± 0.264
4.016ThrIle: 4.016 ± 0.632
3.323ThrLys: 3.323 ± 0.621
5.262ThrLeu: 5.262 ± 0.583
0.554ThrMet: 0.554 ± 0.208
2.769ThrAsn: 2.769 ± 0.507
3.254ThrPro: 3.254 ± 0.632
2.008ThrGln: 2.008 ± 0.494
2.562ThrArg: 2.562 ± 0.488
2.908ThrSer: 2.908 ± 0.512
4.639ThrThr: 4.639 ± 0.633
4.154ThrVal: 4.154 ± 0.582
0.554ThrTrp: 0.554 ± 0.206
1.8ThrTyr: 1.8 ± 0.426
0.0ThrXaa: 0.0 ± 0.0
Val
4.431ValAla: 4.431 ± 0.547
0.692ValCys: 0.692 ± 0.269
3.6ValAsp: 3.6 ± 0.509
5.539ValGlu: 5.539 ± 0.579
2.146ValPhe: 2.146 ± 0.341
3.531ValGly: 3.531 ± 0.522
0.831ValHis: 0.831 ± 0.282
4.016ValIle: 4.016 ± 0.503
4.5ValLys: 4.5 ± 0.643
3.115ValLeu: 3.115 ± 0.439
2.008ValMet: 2.008 ± 0.324
3.392ValAsn: 3.392 ± 0.468
1.939ValPro: 1.939 ± 0.353
2.631ValGln: 2.631 ± 0.442
3.531ValArg: 3.531 ± 0.58
5.885ValSer: 5.885 ± 0.845
5.331ValThr: 5.331 ± 0.723
3.739ValVal: 3.739 ± 0.579
0.762ValTrp: 0.762 ± 0.199
2.077ValTyr: 2.077 ± 0.328
0.0ValXaa: 0.0 ± 0.0
Trp
1.523TrpAla: 1.523 ± 0.318
0.346TrpCys: 0.346 ± 0.157
0.692TrpAsp: 0.692 ± 0.236
0.415TrpGlu: 0.415 ± 0.205
0.415TrpPhe: 0.415 ± 0.203
0.9TrpGly: 0.9 ± 0.228
0.415TrpHis: 0.415 ± 0.181
0.831TrpIle: 0.831 ± 0.239
0.346TrpLys: 0.346 ± 0.135
1.454TrpLeu: 1.454 ± 0.29
0.138TrpMet: 0.138 ± 0.1
0.554TrpAsn: 0.554 ± 0.196
0.277TrpPro: 0.277 ± 0.134
0.692TrpGln: 0.692 ± 0.236
1.038TrpArg: 1.038 ± 0.261
0.762TrpSer: 0.762 ± 0.243
0.485TrpThr: 0.485 ± 0.172
0.831TrpVal: 0.831 ± 0.228
0.0TrpTrp: 0.0 ± 0.0
0.485TrpTyr: 0.485 ± 0.204
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.008TyrAla: 2.008 ± 0.319
0.277TyrCys: 0.277 ± 0.152
2.285TyrAsp: 2.285 ± 0.354
1.8TyrGlu: 1.8 ± 0.345
0.762TyrPhe: 0.762 ± 0.197
1.869TyrGly: 1.869 ± 0.305
0.692TyrHis: 0.692 ± 0.255
2.354TyrIle: 2.354 ± 0.381
2.008TyrLys: 2.008 ± 0.382
2.977TyrLeu: 2.977 ± 0.378
0.9TyrMet: 0.9 ± 0.203
1.8TyrAsn: 1.8 ± 0.293
1.038TyrPro: 1.038 ± 0.262
1.315TyrGln: 1.315 ± 0.316
2.077TyrArg: 2.077 ± 0.397
2.354TyrSer: 2.354 ± 0.379
1.662TyrThr: 1.662 ± 0.348
1.454TyrVal: 1.454 ± 0.309
0.692TyrTrp: 0.692 ± 0.226
0.692TyrTyr: 0.692 ± 0.217
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 74 proteins (14445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski