Amino acid dipepetide frequency for Staphylococcus virus Twort

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.051AlaAla: 0.051 ± 0.032
0.357AlaCys: 0.357 ± 0.111
1.937AlaAsp: 1.937 ± 0.265
2.065AlaGlu: 2.065 ± 0.325
1.504AlaPhe: 1.504 ± 0.219
1.657AlaGly: 1.657 ± 0.331
0.561AlaHis: 0.561 ± 0.118
2.88AlaIle: 2.88 ± 0.347
3.925AlaLys: 3.925 ± 0.389
3.671AlaLeu: 3.671 ± 0.366
1.071AlaMet: 1.071 ± 0.217
1.402AlaAsn: 1.402 ± 0.233
1.122AlaPro: 1.122 ± 0.196
1.402AlaGln: 1.402 ± 0.221
1.631AlaArg: 1.631 ± 0.23
2.702AlaSer: 2.702 ± 0.374
2.753AlaThr: 2.753 ± 0.346
2.574AlaVal: 2.574 ± 0.304
0.357AlaTrp: 0.357 ± 0.101
2.014AlaTyr: 2.014 ± 0.214
0.0AlaXaa: 0.0 ± 0.0
Cys
0.229CysAla: 0.229 ± 0.068
0.102CysCys: 0.102 ± 0.06
0.306CysAsp: 0.306 ± 0.086
0.306CysGlu: 0.306 ± 0.103
0.178CysPhe: 0.178 ± 0.064
0.765CysGly: 0.765 ± 0.152
0.127CysHis: 0.127 ± 0.056
0.586CysIle: 0.586 ± 0.146
0.612CysLys: 0.612 ± 0.133
0.561CysLeu: 0.561 ± 0.142
0.178CysMet: 0.178 ± 0.08
0.586CysAsn: 0.586 ± 0.15
0.28CysPro: 0.28 ± 0.101
0.153CysGln: 0.153 ± 0.072
0.28CysArg: 0.28 ± 0.101
0.459CysSer: 0.459 ± 0.112
0.357CysThr: 0.357 ± 0.094
0.331CysVal: 0.331 ± 0.095
0.127CysTrp: 0.127 ± 0.055
0.612CysTyr: 0.612 ± 0.14
0.0CysXaa: 0.0 ± 0.0
Asp
2.651AspAla: 2.651 ± 0.369
0.357AspCys: 0.357 ± 0.092
2.906AspAsp: 2.906 ± 0.266
4.41AspGlu: 4.41 ± 0.393
3.008AspPhe: 3.008 ± 0.267
3.161AspGly: 3.161 ± 0.343
0.484AspHis: 0.484 ± 0.137
6.423AspIle: 6.423 ± 0.465
6.729AspLys: 6.729 ± 0.48
5.302AspLeu: 5.302 ± 0.351
1.376AspMet: 1.376 ± 0.178
5.2AspAsn: 5.2 ± 0.441
1.606AspPro: 1.606 ± 0.213
0.79AspGln: 0.79 ± 0.162
2.422AspArg: 2.422 ± 0.246
4.257AspSer: 4.257 ± 0.34
4.129AspThr: 4.129 ± 0.329
4.308AspVal: 4.308 ± 0.297
0.586AspTrp: 0.586 ± 0.105
3.951AspTyr: 3.951 ± 0.333
0.0AspXaa: 0.0 ± 0.0
Glu
2.498GluAla: 2.498 ± 0.295
0.51GluCys: 0.51 ± 0.104
5.863GluAsp: 5.863 ± 0.462
8.361GluGlu: 8.361 ± 0.728
3.008GluPhe: 3.008 ± 0.277
4.18GluGly: 4.18 ± 0.287
1.173GluHis: 1.173 ± 0.188
4.971GluIle: 4.971 ± 0.333
7.112GluLys: 7.112 ± 0.511
7.8GluLeu: 7.8 ± 0.484
2.32GluMet: 2.32 ± 0.224
4.588GluAsn: 4.588 ± 0.366
2.192GluPro: 2.192 ± 0.399
3.951GluGln: 3.951 ± 0.419
2.625GluArg: 2.625 ± 0.266
4.945GluSer: 4.945 ± 0.377
3.722GluThr: 3.722 ± 0.298
5.735GluVal: 5.735 ± 0.444
0.663GluTrp: 0.663 ± 0.189
4.767GluTyr: 4.767 ± 0.423
0.0GluXaa: 0.0 ± 0.0
Phe
1.071PheAla: 1.071 ± 0.195
0.357PheCys: 0.357 ± 0.104
2.778PheAsp: 2.778 ± 0.281
3.161PheGlu: 3.161 ± 0.289
1.351PhePhe: 1.351 ± 0.163
1.861PheGly: 1.861 ± 0.24
0.612PheHis: 0.612 ± 0.147
3.492PheIle: 3.492 ± 0.33
4.257PheLys: 4.257 ± 0.331
2.855PheLeu: 2.855 ± 0.301
0.943PheMet: 0.943 ± 0.185
3.594PheAsn: 3.594 ± 0.303
0.841PhePro: 0.841 ± 0.153
1.147PheGln: 1.147 ± 0.169
0.994PheArg: 0.994 ± 0.168
2.676PheSer: 2.676 ± 0.243
3.11PheThr: 3.11 ± 0.28
2.396PheVal: 2.396 ± 0.25
0.229PheTrp: 0.229 ± 0.08
2.498PheTyr: 2.498 ± 0.328
0.0PheXaa: 0.0 ± 0.0
Gly
2.32GlyAla: 2.32 ± 0.372
0.459GlyCys: 0.459 ± 0.104
2.727GlyAsp: 2.727 ± 0.307
3.518GlyGlu: 3.518 ± 0.344
2.524GlyPhe: 2.524 ± 0.236
3.186GlyGly: 3.186 ± 0.638
0.994GlyHis: 0.994 ± 0.141
4.231GlyIle: 4.231 ± 0.435
5.735GlyLys: 5.735 ± 0.551
4.767GlyLeu: 4.767 ± 0.429
1.122GlyMet: 1.122 ± 0.175
4.053GlyAsn: 4.053 ± 0.362
0.051GlyPro: 0.051 ± 0.032
1.886GlyGln: 1.886 ± 0.267
2.141GlyArg: 2.141 ± 0.267
4.027GlySer: 4.027 ± 0.561
3.773GlyThr: 3.773 ± 0.444
3.645GlyVal: 3.645 ± 0.291
0.586GlyTrp: 0.586 ± 0.135
3.314GlyTyr: 3.314 ± 0.279
0.0GlyXaa: 0.0 ± 0.0
His
0.459HisAla: 0.459 ± 0.108
0.229HisCys: 0.229 ± 0.076
0.943HisAsp: 0.943 ± 0.15
1.02HisGlu: 1.02 ± 0.177
0.816HisPhe: 0.816 ± 0.141
1.02HisGly: 1.02 ± 0.163
0.331HisHis: 0.331 ± 0.087
1.325HisIle: 1.325 ± 0.195
1.682HisLys: 1.682 ± 0.192
1.3HisLeu: 1.3 ± 0.276
0.433HisMet: 0.433 ± 0.112
0.969HisAsn: 0.969 ± 0.171
0.51HisPro: 0.51 ± 0.117
0.586HisGln: 0.586 ± 0.15
0.586HisArg: 0.586 ± 0.13
0.816HisSer: 0.816 ± 0.14
0.841HisThr: 0.841 ± 0.13
1.173HisVal: 1.173 ± 0.189
0.178HisTrp: 0.178 ± 0.078
0.714HisTyr: 0.714 ± 0.139
0.0HisXaa: 0.0 ± 0.0
Ile
2.6IleAla: 2.6 ± 0.238
0.459IleCys: 0.459 ± 0.119
5.506IleAsp: 5.506 ± 0.409
6.169IleGlu: 6.169 ± 0.472
2.804IlePhe: 2.804 ± 0.299
3.467IleGly: 3.467 ± 0.326
1.096IleHis: 1.096 ± 0.176
5.837IleIle: 5.837 ± 0.556
7.494IleLys: 7.494 ± 0.53
5.965IleLeu: 5.965 ± 0.44
1.58IleMet: 1.58 ± 0.2
5.225IleAsn: 5.225 ± 0.313
2.065IlePro: 2.065 ± 0.24
2.625IleGln: 2.625 ± 0.321
2.422IleArg: 2.422 ± 0.233
4.92IleSer: 4.92 ± 0.414
4.92IleThr: 4.92 ± 0.437
4.257IleVal: 4.257 ± 0.349
0.51IleTrp: 0.51 ± 0.122
3.288IleTyr: 3.288 ± 0.323
0.0IleXaa: 0.0 ± 0.0
Lys
3.798LysAla: 3.798 ± 0.535
0.714LysCys: 0.714 ± 0.172
7.545LysAsp: 7.545 ± 0.49
10.782LysGlu: 10.782 ± 0.711
3.467LysPhe: 3.467 ± 0.251
5.914LysGly: 5.914 ± 0.687
1.708LysHis: 1.708 ± 0.241
5.098LysIle: 5.098 ± 0.338
9.023LysLys: 9.023 ± 0.655
7.749LysLeu: 7.749 ± 0.501
1.657LysMet: 1.657 ± 0.193
6.067LysAsn: 6.067 ± 0.345
2.753LysPro: 2.753 ± 0.269
4.078LysGln: 4.078 ± 0.323
3.441LysArg: 3.441 ± 0.356
5.149LysSer: 5.149 ± 0.366
5.174LysThr: 5.174 ± 0.45
7.163LysVal: 7.163 ± 0.43
0.739LysTrp: 0.739 ± 0.118
5.225LysTyr: 5.225 ± 0.437
0.0LysXaa: 0.0 ± 0.0
Leu
3.161LeuAla: 3.161 ± 0.3
0.382LeuCys: 0.382 ± 0.094
6.143LeuAsp: 6.143 ± 0.446
8.029LeuGlu: 8.029 ± 0.533
3.263LeuPhe: 3.263 ± 0.315
4.69LeuGly: 4.69 ± 0.496
1.453LeuHis: 1.453 ± 0.221
5.251LeuIle: 5.251 ± 0.487
7.418LeuLys: 7.418 ± 0.47
7.214LeuLeu: 7.214 ± 0.622
2.09LeuMet: 2.09 ± 0.258
5.786LeuAsn: 5.786 ± 0.379
2.574LeuPro: 2.574 ± 0.263
3.518LeuGln: 3.518 ± 0.32
3.161LeuArg: 3.161 ± 0.294
6.322LeuSer: 6.322 ± 0.384
5.251LeuThr: 5.251 ± 0.383
5.2LeuVal: 5.2 ± 0.39
0.433LeuTrp: 0.433 ± 0.098
3.416LeuTyr: 3.416 ± 0.312
0.0LeuXaa: 0.0 ± 0.0
Met
1.096MetAla: 1.096 ± 0.202
0.102MetCys: 0.102 ± 0.051
1.249MetAsp: 1.249 ± 0.196
2.039MetGlu: 2.039 ± 0.224
0.918MetPhe: 0.918 ± 0.17
1.122MetGly: 1.122 ± 0.232
0.229MetHis: 0.229 ± 0.093
1.376MetIle: 1.376 ± 0.187
2.09MetLys: 2.09 ± 0.249
1.657MetLeu: 1.657 ± 0.213
0.306MetMet: 0.306 ± 0.09
1.504MetAsn: 1.504 ± 0.229
0.637MetPro: 0.637 ± 0.137
0.612MetGln: 0.612 ± 0.114
1.224MetArg: 1.224 ± 0.229
1.657MetSer: 1.657 ± 0.196
1.147MetThr: 1.147 ± 0.167
1.478MetVal: 1.478 ± 0.208
0.229MetTrp: 0.229 ± 0.071
1.427MetTyr: 1.427 ± 0.163
0.0MetXaa: 0.0 ± 0.0
Asn
2.371AsnAla: 2.371 ± 0.236
0.637AsnCys: 0.637 ± 0.141
3.671AsnAsp: 3.671 ± 0.369
4.792AsnGlu: 4.792 ± 0.336
2.625AsnPhe: 2.625 ± 0.299
4.282AsnGly: 4.282 ± 0.367
0.994AsnHis: 0.994 ± 0.159
5.48AsnIle: 5.48 ± 0.494
7.953AsnLys: 7.953 ± 0.44
5.531AsnLeu: 5.531 ± 0.361
1.325AsnMet: 1.325 ± 0.173
6.22AsnAsn: 6.22 ± 0.493
2.549AsnPro: 2.549 ± 0.298
1.784AsnGln: 1.784 ± 0.209
2.371AsnArg: 2.371 ± 0.212
4.333AsnSer: 4.333 ± 0.385
5.022AsnThr: 5.022 ± 0.354
3.976AsnVal: 3.976 ± 0.351
0.612AsnTrp: 0.612 ± 0.113
3.62AsnTyr: 3.62 ± 0.368
0.0AsnXaa: 0.0 ± 0.0
Pro
0.637ProAla: 0.637 ± 0.123
0.178ProCys: 0.178 ± 0.083
1.529ProAsp: 1.529 ± 0.235
2.167ProGlu: 2.167 ± 0.239
1.173ProPhe: 1.173 ± 0.217
0.918ProGly: 0.918 ± 0.168
0.535ProHis: 0.535 ± 0.111
1.81ProIle: 1.81 ± 0.205
2.702ProLys: 2.702 ± 0.3
2.014ProLeu: 2.014 ± 0.239
0.561ProMet: 0.561 ± 0.114
2.116ProAsn: 2.116 ± 0.27
0.612ProPro: 0.612 ± 0.236
1.249ProGln: 1.249 ± 0.206
1.096ProArg: 1.096 ± 0.154
2.116ProSer: 2.116 ± 0.281
2.141ProThr: 2.141 ± 0.28
1.784ProVal: 1.784 ± 0.245
0.127ProTrp: 0.127 ± 0.059
1.631ProTyr: 1.631 ± 0.219
0.0ProXaa: 0.0 ± 0.0
Gln
1.759GlnAla: 1.759 ± 0.293
0.204GlnCys: 0.204 ± 0.076
2.294GlnAsp: 2.294 ± 0.222
3.263GlnGlu: 3.263 ± 0.295
1.224GlnPhe: 1.224 ± 0.198
2.192GlnGly: 2.192 ± 0.237
0.535GlnHis: 0.535 ± 0.116
2.09GlnIle: 2.09 ± 0.259
2.982GlnLys: 2.982 ± 0.289
3.314GlnLeu: 3.314 ± 0.368
0.586GlnMet: 0.586 ± 0.124
1.886GlnAsn: 1.886 ± 0.212
1.173GlnPro: 1.173 ± 0.286
1.988GlnGln: 1.988 ± 0.338
1.224GlnArg: 1.224 ± 0.176
2.447GlnSer: 2.447 ± 0.251
1.504GlnThr: 1.504 ± 0.177
2.396GlnVal: 2.396 ± 0.267
0.408GlnTrp: 0.408 ± 0.101
1.784GlnTyr: 1.784 ± 0.24
0.0GlnXaa: 0.0 ± 0.0
Arg
1.453ArgAla: 1.453 ± 0.206
0.28ArgCys: 0.28 ± 0.103
2.192ArgAsp: 2.192 ± 0.228
2.167ArgGlu: 2.167 ± 0.226
1.529ArgPhe: 1.529 ± 0.235
2.014ArgGly: 2.014 ± 0.241
0.637ArgHis: 0.637 ± 0.117
2.804ArgIle: 2.804 ± 0.36
3.237ArgLys: 3.237 ± 0.326
3.671ArgLeu: 3.671 ± 0.299
1.147ArgMet: 1.147 ± 0.213
2.498ArgAsn: 2.498 ± 0.244
0.969ArgPro: 0.969 ± 0.163
1.325ArgGln: 1.325 ± 0.148
1.453ArgArg: 1.453 ± 0.215
1.81ArgSer: 1.81 ± 0.201
2.039ArgThr: 2.039 ± 0.206
2.192ArgVal: 2.192 ± 0.231
0.331ArgTrp: 0.331 ± 0.09
1.886ArgTyr: 1.886 ± 0.235
0.0ArgXaa: 0.0 ± 0.0
Ser
2.778SerAla: 2.778 ± 0.275
0.433SerCys: 0.433 ± 0.116
4.104SerAsp: 4.104 ± 0.382
4.461SerGlu: 4.461 ± 0.388
3.212SerPhe: 3.212 ± 0.286
4.155SerGly: 4.155 ± 0.483
0.892SerHis: 0.892 ± 0.127
5.073SerIle: 5.073 ± 0.408
6.627SerLys: 6.627 ± 0.425
5.353SerLeu: 5.353 ± 0.333
1.402SerMet: 1.402 ± 0.202
4.971SerAsn: 4.971 ± 0.471
1.529SerPro: 1.529 ± 0.205
1.708SerGln: 1.708 ± 0.221
2.269SerArg: 2.269 ± 0.247
5.2SerSer: 5.2 ± 0.615
3.849SerThr: 3.849 ± 0.416
4.053SerVal: 4.053 ± 0.343
0.688SerTrp: 0.688 ± 0.145
3.365SerTyr: 3.365 ± 0.335
0.0SerXaa: 0.0 ± 0.0
Thr
2.065ThrAla: 2.065 ± 0.305
0.306ThrCys: 0.306 ± 0.085
4.078ThrAsp: 4.078 ± 0.344
3.722ThrGlu: 3.722 ± 0.333
2.982ThrPhe: 2.982 ± 0.371
3.543ThrGly: 3.543 ± 0.391
1.376ThrHis: 1.376 ± 0.217
5.047ThrIle: 5.047 ± 0.379
6.092ThrLys: 6.092 ± 0.378
5.378ThrLeu: 5.378 ± 0.421
1.045ThrMet: 1.045 ± 0.171
4.359ThrAsn: 4.359 ± 0.347
2.422ThrPro: 2.422 ± 0.297
2.625ThrGln: 2.625 ± 0.236
2.167ThrArg: 2.167 ± 0.269
3.62ThrSer: 3.62 ± 0.48
4.104ThrThr: 4.104 ± 0.465
4.333ThrVal: 4.333 ± 0.342
0.535ThrTrp: 0.535 ± 0.108
2.931ThrTyr: 2.931 ± 0.285
0.0ThrXaa: 0.0 ± 0.0
Val
2.473ValAla: 2.473 ± 0.336
0.637ValCys: 0.637 ± 0.136
4.512ValAsp: 4.512 ± 0.38
6.041ValGlu: 6.041 ± 0.459
2.651ValPhe: 2.651 ± 0.253
3.671ValGly: 3.671 ± 0.343
1.122ValHis: 1.122 ± 0.174
4.461ValIle: 4.461 ± 0.348
5.531ValLys: 5.531 ± 0.372
5.327ValLeu: 5.327 ± 0.317
1.3ValMet: 1.3 ± 0.168
4.384ValAsn: 4.384 ± 0.352
1.657ValPro: 1.657 ± 0.255
1.963ValGln: 1.963 ± 0.215
2.065ValArg: 2.065 ± 0.251
4.869ValSer: 4.869 ± 0.414
4.588ValThr: 4.588 ± 0.365
4.384ValVal: 4.384 ± 0.403
0.484ValTrp: 0.484 ± 0.129
2.957ValTyr: 2.957 ± 0.262
0.0ValXaa: 0.0 ± 0.0
Trp
0.255TrpAla: 0.255 ± 0.09
0.051TrpCys: 0.051 ± 0.039
0.561TrpAsp: 0.561 ± 0.125
0.714TrpGlu: 0.714 ± 0.117
0.28TrpPhe: 0.28 ± 0.089
0.663TrpGly: 0.663 ± 0.17
0.127TrpHis: 0.127 ± 0.053
0.688TrpIle: 0.688 ± 0.128
0.714TrpLys: 0.714 ± 0.139
0.79TrpLeu: 0.79 ± 0.146
0.255TrpMet: 0.255 ± 0.073
0.612TrpAsn: 0.612 ± 0.129
0.0TrpPro: 0.0 ± 0.0
0.204TrpGln: 0.204 ± 0.07
0.306TrpArg: 0.306 ± 0.095
0.433TrpSer: 0.433 ± 0.148
0.433TrpThr: 0.433 ± 0.096
0.688TrpVal: 0.688 ± 0.127
0.102TrpTrp: 0.102 ± 0.061
0.51TrpTyr: 0.51 ± 0.119
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.912TyrAla: 1.912 ± 0.231
0.382TyrCys: 0.382 ± 0.083
3.212TyrAsp: 3.212 ± 0.31
3.798TyrGlu: 3.798 ± 0.335
1.708TyrPhe: 1.708 ± 0.217
2.6TyrGly: 2.6 ± 0.277
0.969TyrHis: 0.969 ± 0.153
4.282TyrIle: 4.282 ± 0.353
5.327TyrLys: 5.327 ± 0.399
4.537TyrLeu: 4.537 ± 0.35
1.376TyrMet: 1.376 ± 0.182
4.129TyrAsn: 4.129 ± 0.351
1.555TyrPro: 1.555 ± 0.232
1.657TyrGln: 1.657 ± 0.194
1.759TyrArg: 1.759 ± 0.215
3.365TyrSer: 3.365 ± 0.478
3.874TyrThr: 3.874 ± 0.486
3.008TyrVal: 3.008 ± 0.276
0.459TyrTrp: 0.459 ± 0.098
3.314TyrTyr: 3.314 ± 0.361
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 188 proteins (39232 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski