Amino acid dipepetide frequency for Clostridium sp. CAG:452

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.65AlaAla: 2.65 ± 0.121
0.545AlaCys: 0.545 ± 0.045
2.683AlaAsp: 2.683 ± 0.083
4.27AlaGlu: 4.27 ± 0.144
2.03AlaPhe: 2.03 ± 0.086
3.77AlaGly: 3.77 ± 0.111
0.744AlaHis: 0.744 ± 0.046
6.176AlaIle: 6.176 ± 0.148
6.002AlaLys: 6.002 ± 0.14
4.489AlaLeu: 4.489 ± 0.115
1.297AlaMet: 1.297 ± 0.067
3.15AlaAsn: 3.15 ± 0.112
1.2AlaPro: 1.2 ± 0.063
1.538AlaGln: 1.538 ± 0.075
2.088AlaArg: 2.088 ± 0.083
2.865AlaSer: 2.865 ± 0.084
3.208AlaThr: 3.208 ± 0.093
3.687AlaVal: 3.687 ± 0.127
0.34AlaTrp: 0.34 ± 0.037
2.049AlaTyr: 2.049 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.564CysAla: 0.564 ± 0.038
0.177CysCys: 0.177 ± 0.025
0.57CysAsp: 0.57 ± 0.037
0.7CysGlu: 0.7 ± 0.044
0.473CysPhe: 0.473 ± 0.033
0.957CysGly: 0.957 ± 0.062
0.136CysHis: 0.136 ± 0.021
1.17CysIle: 1.17 ± 0.055
1.198CysLys: 1.198 ± 0.064
0.846CysLeu: 0.846 ± 0.049
0.254CysMet: 0.254 ± 0.026
0.791CysAsn: 0.791 ± 0.048
0.407CysPro: 0.407 ± 0.039
0.216CysGln: 0.216 ± 0.022
0.368CysArg: 0.368 ± 0.033
0.683CysSer: 0.683 ± 0.044
0.6CysThr: 0.6 ± 0.043
0.628CysVal: 0.628 ± 0.043
0.072CysTrp: 0.072 ± 0.015
0.49CysTyr: 0.49 ± 0.039
0.0CysXaa: 0.0 ± 0.0
Asp
2.29AspAla: 2.29 ± 0.081
0.567AspCys: 0.567 ± 0.046
2.478AspAsp: 2.478 ± 0.118
4.931AspGlu: 4.931 ± 0.144
2.434AspPhe: 2.434 ± 0.09
3.167AspGly: 3.167 ± 0.112
0.49AspHis: 0.49 ± 0.035
5.885AspIle: 5.885 ± 0.13
5.249AspLys: 5.249 ± 0.13
4.826AspLeu: 4.826 ± 0.123
1.377AspMet: 1.377 ± 0.061
3.358AspAsn: 3.358 ± 0.095
1.225AspPro: 1.225 ± 0.068
0.921AspGln: 0.921 ± 0.054
1.693AspArg: 1.693 ± 0.079
3.04AspSer: 3.04 ± 0.105
2.777AspThr: 2.777 ± 0.092
3.418AspVal: 3.418 ± 0.098
0.376AspTrp: 0.376 ± 0.031
2.688AspTyr: 2.688 ± 0.105
0.0AspXaa: 0.0 ± 0.0
Glu
4.597GluAla: 4.597 ± 0.121
0.791GluCys: 0.791 ± 0.044
4.525GluAsp: 4.525 ± 0.137
9.072GluGlu: 9.072 ± 0.236
3.103GluPhe: 3.103 ± 0.109
3.902GluGly: 3.902 ± 0.111
0.979GluHis: 0.979 ± 0.055
8.72GluIle: 8.72 ± 0.168
9.943GluLys: 9.943 ± 0.207
7.34GluLeu: 7.34 ± 0.173
1.969GluMet: 1.969 ± 0.081
6.361GluAsn: 6.361 ± 0.149
1.765GluPro: 1.765 ± 0.081
2.829GluGln: 2.829 ± 0.093
2.702GluArg: 2.702 ± 0.1
3.319GluSer: 3.319 ± 0.106
3.916GluThr: 3.916 ± 0.107
4.721GluVal: 4.721 ± 0.133
0.443GluTrp: 0.443 ± 0.035
3.842GluTyr: 3.842 ± 0.093
0.0GluXaa: 0.0 ± 0.0
Phe
2.442PheAla: 2.442 ± 0.087
0.567PheCys: 0.567 ± 0.037
2.329PheAsp: 2.329 ± 0.095
2.998PheGlu: 2.998 ± 0.098
1.505PhePhe: 1.505 ± 0.087
2.492PheGly: 2.492 ± 0.1
0.307PheHis: 0.307 ± 0.03
3.571PheIle: 3.571 ± 0.135
3.587PheLys: 3.587 ± 0.115
3.424PheLeu: 3.424 ± 0.099
0.938PheMet: 0.938 ± 0.042
2.544PheAsn: 2.544 ± 0.086
1.051PhePro: 1.051 ± 0.059
0.644PheGln: 0.644 ± 0.042
1.236PheArg: 1.236 ± 0.059
2.497PheSer: 2.497 ± 0.099
2.143PheThr: 2.143 ± 0.08
2.423PheVal: 2.423 ± 0.099
0.277PheTrp: 0.277 ± 0.031
1.565PheTyr: 1.565 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
3.371GlyAla: 3.371 ± 0.12
0.678GlyCys: 0.678 ± 0.053
2.907GlyAsp: 2.907 ± 0.095
4.306GlyGlu: 4.306 ± 0.123
2.522GlyPhe: 2.522 ± 0.089
3.512GlyGly: 3.512 ± 0.11
0.924GlyHis: 0.924 ± 0.058
6.4GlyIle: 6.4 ± 0.135
5.841GlyLys: 5.841 ± 0.147
4.834GlyLeu: 4.834 ± 0.124
1.554GlyMet: 1.554 ± 0.059
3.308GlyAsn: 3.308 ± 0.103
1.073GlyPro: 1.073 ± 0.061
1.399GlyGln: 1.399 ± 0.054
2.152GlyArg: 2.152 ± 0.084
2.887GlySer: 2.887 ± 0.088
3.792GlyThr: 3.792 ± 0.121
3.75GlyVal: 3.75 ± 0.121
0.434GlyTrp: 0.434 ± 0.038
2.76GlyTyr: 2.76 ± 0.108
0.0GlyXaa: 0.0 ± 0.0
His
0.575HisAla: 0.575 ± 0.039
0.188HisCys: 0.188 ± 0.023
0.57HisAsp: 0.57 ± 0.042
0.694HisGlu: 0.694 ± 0.05
0.484HisPhe: 0.484 ± 0.039
0.819HisGly: 0.819 ± 0.052
0.224HisHis: 0.224 ± 0.025
1.222HisIle: 1.222 ± 0.059
0.962HisLys: 0.962 ± 0.05
0.971HisLeu: 0.971 ± 0.06
0.235HisMet: 0.235 ± 0.026
0.758HisAsn: 0.758 ± 0.049
0.564HisPro: 0.564 ± 0.042
0.301HisGln: 0.301 ± 0.028
0.456HisArg: 0.456 ± 0.04
0.741HisSer: 0.741 ± 0.05
0.689HisThr: 0.689 ± 0.049
0.658HisVal: 0.658 ± 0.037
0.072HisTrp: 0.072 ± 0.013
0.387HisTyr: 0.387 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.3IleAla: 6.3 ± 0.123
1.314IleCys: 1.314 ± 0.057
5.755IleAsp: 5.755 ± 0.137
8.521IleGlu: 8.521 ± 0.188
3.936IlePhe: 3.936 ± 0.132
5.706IleGly: 5.706 ± 0.136
1.068IleHis: 1.068 ± 0.061
9.965IleIle: 9.965 ± 0.265
9.799IleLys: 9.799 ± 0.206
8.936IleLeu: 8.936 ± 0.219
2.149IleMet: 2.149 ± 0.092
6.693IleAsn: 6.693 ± 0.183
3.233IlePro: 3.233 ± 0.087
2.475IleGln: 2.475 ± 0.081
3.106IleArg: 3.106 ± 0.095
6.596IleSer: 6.596 ± 0.161
5.755IleThr: 5.755 ± 0.123
6.284IleVal: 6.284 ± 0.128
0.55IleTrp: 0.55 ± 0.042
4.185IleTyr: 4.185 ± 0.121
0.0IleXaa: 0.0 ± 0.0
Lys
5.285LysAla: 5.285 ± 0.138
0.976LysCys: 0.976 ± 0.061
5.811LysAsp: 5.811 ± 0.136
11.126LysGlu: 11.126 ± 0.208
3.194LysPhe: 3.194 ± 0.082
4.857LysGly: 4.857 ± 0.126
1.009LysHis: 1.009 ± 0.048
10.452LysIle: 10.452 ± 0.198
10.139LysLys: 10.139 ± 0.229
8.3LysLeu: 8.3 ± 0.15
2.677LysMet: 2.677 ± 0.083
7.335LysAsn: 7.335 ± 0.179
2.398LysPro: 2.398 ± 0.08
3.435LysGln: 3.435 ± 0.116
3.537LysArg: 3.537 ± 0.118
4.71LysSer: 4.71 ± 0.119
6.082LysThr: 6.082 ± 0.127
5.567LysVal: 5.567 ± 0.132
0.539LysTrp: 0.539 ± 0.039
4.948LysTyr: 4.948 ± 0.137
0.0LysXaa: 0.0 ± 0.0
Leu
5.0LeuAla: 5.0 ± 0.109
0.927LeuCys: 0.927 ± 0.053
4.92LeuAsp: 4.92 ± 0.128
7.346LeuGlu: 7.346 ± 0.15
3.117LeuPhe: 3.117 ± 0.123
5.1LeuGly: 5.1 ± 0.112
1.009LeuHis: 1.009 ± 0.054
7.833LeuIle: 7.833 ± 0.186
8.687LeuLys: 8.687 ± 0.186
6.986LeuLeu: 6.986 ± 0.179
1.82LeuMet: 1.82 ± 0.066
5.473LeuAsn: 5.473 ± 0.149
2.603LeuPro: 2.603 ± 0.091
2.177LeuGln: 2.177 ± 0.071
2.708LeuArg: 2.708 ± 0.095
5.28LeuSer: 5.28 ± 0.124
4.326LeuThr: 4.326 ± 0.114
5.011LeuVal: 5.011 ± 0.135
0.509LeuTrp: 0.509 ± 0.038
3.211LeuTyr: 3.211 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.524MetAla: 1.524 ± 0.069
0.324MetCys: 0.324 ± 0.03
1.231MetAsp: 1.231 ± 0.054
1.878MetGlu: 1.878 ± 0.073
1.026MetPhe: 1.026 ± 0.067
1.416MetGly: 1.416 ± 0.066
0.299MetHis: 0.299 ± 0.027
1.74MetIle: 1.74 ± 0.068
2.478MetLys: 2.478 ± 0.086
2.296MetLeu: 2.296 ± 0.076
0.495MetMet: 0.495 ± 0.036
1.518MetAsn: 1.518 ± 0.066
0.935MetPro: 0.935 ± 0.056
0.882MetGln: 0.882 ± 0.052
0.644MetArg: 0.644 ± 0.042
1.458MetSer: 1.458 ± 0.062
1.045MetThr: 1.045 ± 0.05
1.247MetVal: 1.247 ± 0.055
0.16MetTrp: 0.16 ± 0.02
1.007MetTyr: 1.007 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
3.164AsnAla: 3.164 ± 0.098
0.824AsnCys: 0.824 ± 0.05
3.087AsnAsp: 3.087 ± 0.101
4.895AsnGlu: 4.895 ± 0.122
2.373AsnPhe: 2.373 ± 0.09
4.03AsnGly: 4.03 ± 0.12
0.664AsnHis: 0.664 ± 0.046
7.509AsnIle: 7.509 ± 0.201
7.443AsnLys: 7.443 ± 0.163
5.556AsnLeu: 5.556 ± 0.124
1.712AsnMet: 1.712 ± 0.072
5.269AsnAsn: 5.269 ± 0.164
2.166AsnPro: 2.166 ± 0.084
1.668AsnGln: 1.668 ± 0.07
1.986AsnArg: 1.986 ± 0.087
4.068AsnSer: 4.068 ± 0.128
3.543AsnThr: 3.543 ± 0.114
3.933AsnVal: 3.933 ± 0.107
0.459AsnTrp: 0.459 ± 0.04
2.843AsnTyr: 2.843 ± 0.1
0.0AsnXaa: 0.0 ± 0.0
Pro
1.366ProAla: 1.366 ± 0.069
0.307ProCys: 0.307 ± 0.027
1.488ProAsp: 1.488 ± 0.066
2.686ProGlu: 2.686 ± 0.097
1.173ProPhe: 1.173 ± 0.062
1.543ProGly: 1.543 ± 0.078
0.346ProHis: 0.346 ± 0.034
2.752ProIle: 2.752 ± 0.087
2.517ProLys: 2.517 ± 0.091
2.044ProLeu: 2.044 ± 0.077
0.567ProMet: 0.567 ± 0.041
1.823ProAsn: 1.823 ± 0.072
0.539ProPro: 0.539 ± 0.044
0.827ProGln: 0.827 ± 0.049
0.788ProArg: 0.788 ± 0.048
1.383ProSer: 1.383 ± 0.063
1.626ProThr: 1.626 ± 0.072
1.85ProVal: 1.85 ± 0.074
0.16ProTrp: 0.16 ± 0.02
1.214ProTyr: 1.214 ± 0.069
0.0ProXaa: 0.0 ± 0.0
Gln
1.635GlnAla: 1.635 ± 0.071
0.218GlnCys: 0.218 ± 0.028
1.46GlnAsp: 1.46 ± 0.064
2.752GlnGlu: 2.752 ± 0.089
0.763GlnPhe: 0.763 ± 0.049
1.438GlnGly: 1.438 ± 0.067
0.232GlnHis: 0.232 ± 0.025
3.001GlnIle: 3.001 ± 0.096
2.984GlnLys: 2.984 ± 0.102
1.792GlnLeu: 1.792 ± 0.076
0.805GlnMet: 0.805 ± 0.048
2.03GlnAsn: 2.03 ± 0.085
0.492GlnPro: 0.492 ± 0.039
0.633GlnGln: 0.633 ± 0.053
0.929GlnArg: 0.929 ± 0.055
1.283GlnSer: 1.283 ± 0.057
1.599GlnThr: 1.599 ± 0.072
1.516GlnVal: 1.516 ± 0.062
0.141GlnTrp: 0.141 ± 0.019
1.009GlnTyr: 1.009 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
1.767ArgAla: 1.767 ± 0.078
0.42ArgCys: 0.42 ± 0.035
1.765ArgAsp: 1.765 ± 0.077
2.705ArgGlu: 2.705 ± 0.09
1.311ArgPhe: 1.311 ± 0.059
1.842ArgGly: 1.842 ± 0.086
0.437ArgHis: 0.437 ± 0.039
3.299ArgIle: 3.299 ± 0.101
3.449ArgLys: 3.449 ± 0.105
2.68ArgLeu: 2.68 ± 0.09
0.974ArgMet: 0.974 ± 0.054
2.135ArgAsn: 2.135 ± 0.073
1.023ArgPro: 1.023 ± 0.064
0.943ArgGln: 0.943 ± 0.049
1.496ArgArg: 1.496 ± 0.078
1.394ArgSer: 1.394 ± 0.067
1.883ArgThr: 1.883 ± 0.084
2.0ArgVal: 2.0 ± 0.073
0.213ArgTrp: 0.213 ± 0.024
1.361ArgTyr: 1.361 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
2.755SerAla: 2.755 ± 0.098
0.55SerCys: 0.55 ± 0.042
2.768SerAsp: 2.768 ± 0.094
3.778SerGlu: 3.778 ± 0.114
2.503SerPhe: 2.503 ± 0.09
3.526SerGly: 3.526 ± 0.116
0.7SerHis: 0.7 ± 0.045
5.833SerIle: 5.833 ± 0.141
6.026SerLys: 6.026 ± 0.139
4.384SerLeu: 4.384 ± 0.145
1.211SerMet: 1.211 ± 0.051
4.013SerAsn: 4.013 ± 0.109
1.339SerPro: 1.339 ± 0.067
1.61SerGln: 1.61 ± 0.074
1.886SerArg: 1.886 ± 0.078
3.64SerSer: 3.64 ± 0.128
3.23SerThr: 3.23 ± 0.107
3.33SerVal: 3.33 ± 0.092
0.34SerTrp: 0.34 ± 0.03
2.257SerTyr: 2.257 ± 0.082
0.0SerXaa: 0.0 ± 0.0
Thr
3.319ThrAla: 3.319 ± 0.112
0.575ThrCys: 0.575 ± 0.045
3.015ThrAsp: 3.015 ± 0.082
3.803ThrGlu: 3.803 ± 0.108
2.074ThrPhe: 2.074 ± 0.07
3.933ThrGly: 3.933 ± 0.121
0.691ThrHis: 0.691 ± 0.045
5.811ThrIle: 5.811 ± 0.123
5.15ThrLys: 5.15 ± 0.137
4.597ThrLeu: 4.597 ± 0.122
1.112ThrMet: 1.112 ± 0.058
3.413ThrAsn: 3.413 ± 0.105
1.825ThrPro: 1.825 ± 0.088
1.452ThrGln: 1.452 ± 0.07
1.845ThrArg: 1.845 ± 0.073
3.181ThrSer: 3.181 ± 0.104
3.203ThrThr: 3.203 ± 0.105
3.781ThrVal: 3.781 ± 0.113
0.34ThrTrp: 0.34 ± 0.034
2.365ThrTyr: 2.365 ± 0.1
0.0ThrXaa: 0.0 ± 0.0
Val
3.831ValAla: 3.831 ± 0.106
0.783ValCys: 0.783 ± 0.044
3.203ValAsp: 3.203 ± 0.11
4.815ValGlu: 4.815 ± 0.124
2.356ValPhe: 2.356 ± 0.079
3.537ValGly: 3.537 ± 0.104
0.725ValHis: 0.725 ± 0.043
6.082ValIle: 6.082 ± 0.151
5.91ValLys: 5.91 ± 0.131
5.518ValLeu: 5.518 ± 0.132
1.314ValMet: 1.314 ± 0.063
3.548ValAsn: 3.548 ± 0.098
1.859ValPro: 1.859 ± 0.063
1.463ValGln: 1.463 ± 0.058
1.883ValArg: 1.883 ± 0.082
3.642ValSer: 3.642 ± 0.107
3.427ValThr: 3.427 ± 0.102
4.099ValVal: 4.099 ± 0.13
0.376ValTrp: 0.376 ± 0.036
2.475ValTyr: 2.475 ± 0.084
0.0ValXaa: 0.0 ± 0.0
Trp
0.282TrpAla: 0.282 ± 0.025
0.102TrpCys: 0.102 ± 0.017
0.332TrpAsp: 0.332 ± 0.028
0.431TrpGlu: 0.431 ± 0.034
0.307TrpPhe: 0.307 ± 0.028
0.398TrpGly: 0.398 ± 0.033
0.108TrpHis: 0.108 ± 0.017
0.52TrpIle: 0.52 ± 0.04
0.584TrpLys: 0.584 ± 0.039
0.542TrpLeu: 0.542 ± 0.041
0.171TrpMet: 0.171 ± 0.024
0.404TrpAsn: 0.404 ± 0.035
0.108TrpPro: 0.108 ± 0.017
0.263TrpGln: 0.263 ± 0.024
0.213TrpArg: 0.213 ± 0.026
0.346TrpSer: 0.346 ± 0.031
0.288TrpThr: 0.288 ± 0.029
0.346TrpVal: 0.346 ± 0.03
0.077TrpTrp: 0.077 ± 0.015
0.332TrpTyr: 0.332 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.063TyrAla: 2.063 ± 0.074
0.465TyrCys: 0.465 ± 0.034
2.296TyrAsp: 2.296 ± 0.095
3.134TyrGlu: 3.134 ± 0.089
1.856TyrPhe: 1.856 ± 0.085
2.461TyrGly: 2.461 ± 0.089
0.481TyrHis: 0.481 ± 0.039
4.386TyrIle: 4.386 ± 0.112
4.431TyrLys: 4.431 ± 0.118
3.681TyrLeu: 3.681 ± 0.106
0.968TyrMet: 0.968 ± 0.06
3.266TyrAsn: 3.266 ± 0.1
1.195TyrPro: 1.195 ± 0.064
1.037TyrGln: 1.037 ± 0.056
1.38TyrArg: 1.38 ± 0.07
2.666TyrSer: 2.666 ± 0.083
2.351TyrThr: 2.351 ± 0.096
2.597TyrVal: 2.597 ± 0.087
0.274TyrTrp: 0.274 ± 0.028
1.875TyrTyr: 1.875 ± 0.092
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1317 proteins (361571 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski