Amino acid dipepetide frequency for Faecalibacterium phage FP_Lagaffe

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.221AlaAla: 15.221 ± 1.248
1.125AlaCys: 1.125 ± 0.244
7.61AlaAsp: 7.61 ± 0.596
8.669AlaGlu: 8.669 ± 0.75
2.316AlaPhe: 2.316 ± 0.335
7.081AlaGly: 7.081 ± 0.79
1.456AlaHis: 1.456 ± 0.296
5.096AlaIle: 5.096 ± 0.686
6.022AlaLys: 6.022 ± 0.607
7.61AlaLeu: 7.61 ± 0.654
2.184AlaMet: 2.184 ± 0.39
2.846AlaAsn: 2.846 ± 0.498
3.11AlaPro: 3.11 ± 0.634
3.441AlaGln: 3.441 ± 0.452
3.772AlaArg: 3.772 ± 0.519
5.824AlaSer: 5.824 ± 0.838
5.956AlaThr: 5.956 ± 0.619
7.147AlaVal: 7.147 ± 0.643
1.125AlaTrp: 1.125 ± 0.253
3.375AlaTyr: 3.375 ± 0.48
0.0AlaXaa: 0.0 ± 0.0
Cys
0.993CysAla: 0.993 ± 0.212
0.199CysCys: 0.199 ± 0.11
0.331CysAsp: 0.331 ± 0.134
0.662CysGlu: 0.662 ± 0.245
0.463CysPhe: 0.463 ± 0.167
1.522CysGly: 1.522 ± 0.485
0.265CysHis: 0.265 ± 0.149
0.463CysIle: 0.463 ± 0.151
0.794CysLys: 0.794 ± 0.231
0.86CysLeu: 0.86 ± 0.268
0.265CysMet: 0.265 ± 0.16
0.529CysAsn: 0.529 ± 0.195
0.529CysPro: 0.529 ± 0.194
0.265CysGln: 0.265 ± 0.143
0.86CysArg: 0.86 ± 0.269
0.662CysSer: 0.662 ± 0.176
0.662CysThr: 0.662 ± 0.197
0.662CysVal: 0.662 ± 0.199
0.463CysTrp: 0.463 ± 0.174
0.529CysTyr: 0.529 ± 0.178
0.0CysXaa: 0.0 ± 0.0
Asp
5.824AspAla: 5.824 ± 0.66
0.397AspCys: 0.397 ± 0.15
3.309AspAsp: 3.309 ± 0.475
4.765AspGlu: 4.765 ± 0.661
2.051AspPhe: 2.051 ± 0.359
5.096AspGly: 5.096 ± 0.492
0.728AspHis: 0.728 ± 0.205
2.316AspIle: 2.316 ± 0.289
3.11AspLys: 3.11 ± 0.414
3.971AspLeu: 3.971 ± 0.518
1.787AspMet: 1.787 ± 0.386
2.581AspAsn: 2.581 ± 0.386
3.375AspPro: 3.375 ± 0.628
1.985AspGln: 1.985 ± 0.303
3.044AspArg: 3.044 ± 0.492
3.441AspSer: 3.441 ± 0.533
4.699AspThr: 4.699 ± 0.397
4.169AspVal: 4.169 ± 0.596
1.125AspTrp: 1.125 ± 0.224
2.184AspTyr: 2.184 ± 0.304
0.0AspXaa: 0.0 ± 0.0
Glu
8.934GluAla: 8.934 ± 0.813
0.926GluCys: 0.926 ± 0.298
3.375GluAsp: 3.375 ± 0.431
3.176GluGlu: 3.176 ± 0.578
1.721GluPhe: 1.721 ± 0.358
4.897GluGly: 4.897 ± 0.611
0.662GluHis: 0.662 ± 0.177
4.831GluIle: 4.831 ± 0.587
5.691GluLys: 5.691 ± 0.603
7.015GluLeu: 7.015 ± 0.83
2.382GluMet: 2.382 ± 0.501
3.243GluAsn: 3.243 ± 0.381
2.912GluPro: 2.912 ± 0.545
3.176GluGln: 3.176 ± 0.421
3.64GluArg: 3.64 ± 0.514
4.434GluSer: 4.434 ± 0.604
5.162GluThr: 5.162 ± 0.629
4.699GluVal: 4.699 ± 0.51
1.125GluTrp: 1.125 ± 0.296
2.713GluTyr: 2.713 ± 0.394
0.0GluXaa: 0.0 ± 0.0
Phe
2.713PheAla: 2.713 ± 0.392
0.86PheCys: 0.86 ± 0.217
2.581PheAsp: 2.581 ± 0.402
1.985PheGlu: 1.985 ± 0.39
0.728PhePhe: 0.728 ± 0.308
1.919PheGly: 1.919 ± 0.333
0.199PheHis: 0.199 ± 0.101
1.059PheIle: 1.059 ± 0.24
1.257PheLys: 1.257 ± 0.268
1.985PheLeu: 1.985 ± 0.412
0.926PheMet: 0.926 ± 0.239
1.456PheAsn: 1.456 ± 0.295
0.926PhePro: 0.926 ± 0.259
0.993PheGln: 0.993 ± 0.2
1.191PheArg: 1.191 ± 0.244
2.118PheSer: 2.118 ± 0.506
2.581PheThr: 2.581 ± 0.522
1.919PheVal: 1.919 ± 0.417
0.596PheTrp: 0.596 ± 0.205
1.257PheTyr: 1.257 ± 0.314
0.0PheXaa: 0.0 ± 0.0
Gly
5.096GlyAla: 5.096 ± 0.704
1.059GlyCys: 1.059 ± 0.268
4.765GlyAsp: 4.765 ± 0.481
5.757GlyGlu: 5.757 ± 0.604
2.647GlyPhe: 2.647 ± 0.472
6.221GlyGly: 6.221 ± 0.541
1.522GlyHis: 1.522 ± 0.308
4.434GlyIle: 4.434 ± 0.538
4.434GlyLys: 4.434 ± 0.627
4.831GlyLeu: 4.831 ± 0.478
2.118GlyMet: 2.118 ± 0.368
3.243GlyAsn: 3.243 ± 0.438
1.787GlyPro: 1.787 ± 0.352
2.581GlyGln: 2.581 ± 0.495
4.368GlyArg: 4.368 ± 0.618
5.36GlySer: 5.36 ± 0.732
5.559GlyThr: 5.559 ± 0.65
5.36GlyVal: 5.36 ± 0.404
1.059GlyTrp: 1.059 ± 0.229
2.581GlyTyr: 2.581 ± 0.347
0.0GlyXaa: 0.0 ± 0.0
His
0.728HisAla: 0.728 ± 0.282
0.199HisCys: 0.199 ± 0.119
0.926HisAsp: 0.926 ± 0.209
1.324HisGlu: 1.324 ± 0.31
0.794HisPhe: 0.794 ± 0.208
1.191HisGly: 1.191 ± 0.26
0.132HisHis: 0.132 ± 0.078
0.86HisIle: 0.86 ± 0.165
0.463HisLys: 0.463 ± 0.169
0.993HisLeu: 0.993 ± 0.237
0.265HisMet: 0.265 ± 0.129
0.794HisAsn: 0.794 ± 0.2
0.993HisPro: 0.993 ± 0.261
0.397HisGln: 0.397 ± 0.152
1.39HisArg: 1.39 ± 0.324
1.059HisSer: 1.059 ± 0.271
1.059HisThr: 1.059 ± 0.258
0.86HisVal: 0.86 ± 0.244
0.265HisTrp: 0.265 ± 0.127
0.596HisTyr: 0.596 ± 0.219
0.0HisXaa: 0.0 ± 0.0
Ile
5.029IleAla: 5.029 ± 0.507
0.728IleCys: 0.728 ± 0.236
2.846IleAsp: 2.846 ± 0.342
4.566IleGlu: 4.566 ± 0.719
1.39IlePhe: 1.39 ± 0.271
3.574IleGly: 3.574 ± 0.388
0.463IleHis: 0.463 ± 0.171
2.184IleIle: 2.184 ± 0.387
4.103IleLys: 4.103 ± 0.475
3.706IleLeu: 3.706 ± 0.468
1.588IleMet: 1.588 ± 0.309
1.985IleAsn: 1.985 ± 0.393
2.912IlePro: 2.912 ± 0.389
2.25IleGln: 2.25 ± 0.334
3.176IleArg: 3.176 ± 0.462
3.375IleSer: 3.375 ± 0.949
4.632IleThr: 4.632 ± 0.59
3.507IleVal: 3.507 ± 0.506
0.86IleTrp: 0.86 ± 0.262
2.316IleTyr: 2.316 ± 0.385
0.0IleXaa: 0.0 ± 0.0
Lys
6.684LysAla: 6.684 ± 0.657
0.529LysCys: 0.529 ± 0.222
2.846LysAsp: 2.846 ± 0.416
4.302LysGlu: 4.302 ± 0.496
1.853LysPhe: 1.853 ± 0.31
4.434LysGly: 4.434 ± 0.558
1.324LysHis: 1.324 ± 0.285
4.368LysIle: 4.368 ± 0.527
4.302LysLys: 4.302 ± 0.62
5.427LysLeu: 5.427 ± 0.51
1.257LysMet: 1.257 ± 0.261
2.581LysAsn: 2.581 ± 0.361
3.441LysPro: 3.441 ± 0.569
3.375LysGln: 3.375 ± 0.427
4.169LysArg: 4.169 ± 0.708
3.044LysSer: 3.044 ± 0.469
3.772LysThr: 3.772 ± 0.484
3.574LysVal: 3.574 ± 0.717
1.125LysTrp: 1.125 ± 0.303
2.316LysTyr: 2.316 ± 0.372
0.0LysXaa: 0.0 ± 0.0
Leu
8.338LeuAla: 8.338 ± 0.596
0.926LeuCys: 0.926 ± 0.262
3.838LeuAsp: 3.838 ± 0.554
5.89LeuGlu: 5.89 ± 0.643
1.654LeuPhe: 1.654 ± 0.286
4.765LeuGly: 4.765 ± 0.629
1.257LeuHis: 1.257 ± 0.328
3.904LeuIle: 3.904 ± 0.546
4.037LeuLys: 4.037 ± 0.469
5.757LeuLeu: 5.757 ± 0.587
1.39LeuMet: 1.39 ± 0.309
3.706LeuAsn: 3.706 ± 0.435
3.772LeuPro: 3.772 ± 0.618
2.449LeuGln: 2.449 ± 0.378
4.765LeuArg: 4.765 ± 0.505
5.427LeuSer: 5.427 ± 0.781
5.294LeuThr: 5.294 ± 0.555
3.309LeuVal: 3.309 ± 0.469
1.588LeuTrp: 1.588 ± 0.246
2.515LeuTyr: 2.515 ± 0.386
0.0LeuXaa: 0.0 ± 0.0
Met
2.846MetAla: 2.846 ± 0.514
0.199MetCys: 0.199 ± 0.119
2.382MetAsp: 2.382 ± 0.397
1.324MetGlu: 1.324 ± 0.288
0.728MetPhe: 0.728 ± 0.209
1.39MetGly: 1.39 ± 0.271
0.463MetHis: 0.463 ± 0.188
1.787MetIle: 1.787 ± 0.409
1.985MetLys: 1.985 ± 0.378
1.853MetLeu: 1.853 ± 0.261
0.132MetMet: 0.132 ± 0.084
1.257MetAsn: 1.257 ± 0.256
0.728MetPro: 0.728 ± 0.206
0.794MetGln: 0.794 ± 0.247
1.654MetArg: 1.654 ± 0.352
1.787MetSer: 1.787 ± 0.371
1.324MetThr: 1.324 ± 0.285
1.191MetVal: 1.191 ± 0.272
0.199MetTrp: 0.199 ± 0.111
0.529MetTyr: 0.529 ± 0.19
0.0MetXaa: 0.0 ± 0.0
Asn
3.904AsnAla: 3.904 ± 0.5
0.331AsnCys: 0.331 ± 0.14
1.985AsnAsp: 1.985 ± 0.33
3.441AsnGlu: 3.441 ± 0.388
1.39AsnPhe: 1.39 ± 0.258
4.5AsnGly: 4.5 ± 0.456
0.596AsnHis: 0.596 ± 0.203
1.919AsnIle: 1.919 ± 0.388
2.647AsnLys: 2.647 ± 0.429
3.044AsnLeu: 3.044 ± 0.537
1.456AsnMet: 1.456 ± 0.291
1.853AsnAsn: 1.853 ± 0.436
2.382AsnPro: 2.382 ± 0.425
0.926AsnGln: 0.926 ± 0.238
1.919AsnArg: 1.919 ± 0.33
1.985AsnSer: 1.985 ± 0.424
2.912AsnThr: 2.912 ± 0.382
2.779AsnVal: 2.779 ± 0.386
0.662AsnTrp: 0.662 ± 0.178
1.721AsnTyr: 1.721 ± 0.327
0.0AsnXaa: 0.0 ± 0.0
Pro
4.897ProAla: 4.897 ± 0.573
0.265ProCys: 0.265 ± 0.134
3.772ProAsp: 3.772 ± 0.591
4.302ProGlu: 4.302 ± 0.527
1.456ProPhe: 1.456 ± 0.259
3.176ProGly: 3.176 ± 0.552
0.794ProHis: 0.794 ± 0.258
2.25ProIle: 2.25 ± 0.435
2.382ProLys: 2.382 ± 0.451
1.721ProLeu: 1.721 ± 0.344
0.794ProMet: 0.794 ± 0.25
1.787ProAsn: 1.787 ± 0.373
1.721ProPro: 1.721 ± 0.362
1.919ProGln: 1.919 ± 0.28
1.324ProArg: 1.324 ± 0.326
2.713ProSer: 2.713 ± 0.347
1.985ProThr: 1.985 ± 0.243
1.919ProVal: 1.919 ± 0.412
0.662ProTrp: 0.662 ± 0.268
1.522ProTyr: 1.522 ± 0.279
0.0ProXaa: 0.0 ± 0.0
Gln
2.713GlnAla: 2.713 ± 0.454
0.199GlnCys: 0.199 ± 0.115
1.654GlnAsp: 1.654 ± 0.271
2.316GlnGlu: 2.316 ± 0.364
0.993GlnPhe: 0.993 ± 0.216
2.118GlnGly: 2.118 ± 0.414
0.596GlnHis: 0.596 ± 0.208
2.846GlnIle: 2.846 ± 0.452
2.912GlnLys: 2.912 ± 0.417
3.243GlnLeu: 3.243 ± 0.44
0.596GlnMet: 0.596 ± 0.258
2.051GlnAsn: 2.051 ± 0.308
1.456GlnPro: 1.456 ± 0.247
2.316GlnGln: 2.316 ± 0.511
2.051GlnArg: 2.051 ± 0.347
2.647GlnSer: 2.647 ± 0.386
2.647GlnThr: 2.647 ± 0.456
1.787GlnVal: 1.787 ± 0.453
0.926GlnTrp: 0.926 ± 0.205
1.324GlnTyr: 1.324 ± 0.297
0.0GlnXaa: 0.0 ± 0.0
Arg
3.971ArgAla: 3.971 ± 0.417
0.397ArgCys: 0.397 ± 0.165
1.919ArgAsp: 1.919 ± 0.337
4.235ArgGlu: 4.235 ± 0.68
1.39ArgPhe: 1.39 ± 0.336
3.706ArgGly: 3.706 ± 0.458
0.596ArgHis: 0.596 ± 0.223
3.309ArgIle: 3.309 ± 0.497
4.368ArgLys: 4.368 ± 0.736
4.5ArgLeu: 4.5 ± 0.542
1.456ArgMet: 1.456 ± 0.276
2.25ArgAsn: 2.25 ± 0.405
1.853ArgPro: 1.853 ± 0.414
2.184ArgGln: 2.184 ± 0.399
4.037ArgArg: 4.037 ± 0.803
3.309ArgSer: 3.309 ± 0.488
2.647ArgThr: 2.647 ± 0.525
2.713ArgVal: 2.713 ± 0.429
0.662ArgTrp: 0.662 ± 0.182
2.051ArgTyr: 2.051 ± 0.357
0.0ArgXaa: 0.0 ± 0.0
Ser
6.154SerAla: 6.154 ± 1.033
0.794SerCys: 0.794 ± 0.234
3.574SerAsp: 3.574 ± 0.508
4.368SerGlu: 4.368 ± 0.565
1.721SerPhe: 1.721 ± 0.364
5.691SerGly: 5.691 ± 1.044
0.926SerHis: 0.926 ± 0.264
2.713SerIle: 2.713 ± 0.399
4.699SerLys: 4.699 ± 0.517
3.706SerLeu: 3.706 ± 0.652
1.456SerMet: 1.456 ± 0.329
2.316SerAsn: 2.316 ± 0.363
2.184SerPro: 2.184 ± 0.384
1.721SerGln: 1.721 ± 0.351
2.449SerArg: 2.449 ± 0.43
3.64SerSer: 3.64 ± 1.503
5.162SerThr: 5.162 ± 1.106
3.375SerVal: 3.375 ± 0.471
1.324SerTrp: 1.324 ± 0.271
1.919SerTyr: 1.919 ± 0.33
0.0SerXaa: 0.0 ± 0.0
Thr
7.081ThrAla: 7.081 ± 0.862
0.662ThrCys: 0.662 ± 0.246
3.772ThrAsp: 3.772 ± 0.545
5.228ThrGlu: 5.228 ± 0.597
1.985ThrPhe: 1.985 ± 0.408
6.419ThrGly: 6.419 ± 0.673
1.059ThrHis: 1.059 ± 0.219
4.897ThrIle: 4.897 ± 0.639
4.103ThrLys: 4.103 ± 0.651
6.154ThrLeu: 6.154 ± 0.769
1.654ThrMet: 1.654 ± 0.356
3.044ThrAsn: 3.044 ± 0.482
3.11ThrPro: 3.11 ± 0.551
2.051ThrGln: 2.051 ± 0.455
2.449ThrArg: 2.449 ± 0.445
2.779ThrSer: 2.779 ± 0.693
4.699ThrThr: 4.699 ± 0.59
5.096ThrVal: 5.096 ± 0.625
0.728ThrTrp: 0.728 ± 0.198
1.787ThrTyr: 1.787 ± 0.405
0.0ThrXaa: 0.0 ± 0.0
Val
6.022ValAla: 6.022 ± 0.691
1.059ValCys: 1.059 ± 0.255
4.302ValAsp: 4.302 ± 0.535
4.368ValGlu: 4.368 ± 0.457
2.051ValPhe: 2.051 ± 0.393
3.11ValGly: 3.11 ± 0.386
0.926ValHis: 0.926 ± 0.215
2.912ValIle: 2.912 ± 0.418
4.302ValLys: 4.302 ± 0.557
4.302ValLeu: 4.302 ± 0.467
1.654ValMet: 1.654 ± 0.286
2.515ValAsn: 2.515 ± 0.446
2.449ValPro: 2.449 ± 0.37
2.978ValGln: 2.978 ± 0.463
2.382ValArg: 2.382 ± 0.418
3.441ValSer: 3.441 ± 0.617
3.904ValThr: 3.904 ± 0.511
3.838ValVal: 3.838 ± 0.39
1.257ValTrp: 1.257 ± 0.263
2.449ValTyr: 2.449 ± 0.449
0.0ValXaa: 0.0 ± 0.0
Trp
1.324TrpAla: 1.324 ± 0.275
0.397TrpCys: 0.397 ± 0.167
1.522TrpAsp: 1.522 ± 0.36
1.588TrpGlu: 1.588 ± 0.361
0.331TrpPhe: 0.331 ± 0.12
0.794TrpGly: 0.794 ± 0.205
0.86TrpHis: 0.86 ± 0.269
0.794TrpIle: 0.794 ± 0.199
0.86TrpLys: 0.86 ± 0.208
1.721TrpLeu: 1.721 ± 0.275
0.199TrpMet: 0.199 ± 0.094
0.794TrpAsn: 0.794 ± 0.257
0.463TrpPro: 0.463 ± 0.246
0.463TrpGln: 0.463 ± 0.147
0.926TrpArg: 0.926 ± 0.279
0.86TrpSer: 0.86 ± 0.271
0.794TrpThr: 0.794 ± 0.172
0.993TrpVal: 0.993 ± 0.269
0.265TrpTrp: 0.265 ± 0.11
0.529TrpTyr: 0.529 ± 0.182
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.515TyrAla: 2.515 ± 0.426
0.728TyrCys: 0.728 ± 0.223
2.647TyrAsp: 2.647 ± 0.412
2.449TyrGlu: 2.449 ± 0.432
1.588TyrPhe: 1.588 ± 0.277
3.176TyrGly: 3.176 ± 0.499
0.463TyrHis: 0.463 ± 0.167
2.25TyrIle: 2.25 ± 0.372
2.316TyrLys: 2.316 ± 0.378
2.184TyrLeu: 2.184 ± 0.416
0.926TyrMet: 0.926 ± 0.2
1.522TyrAsn: 1.522 ± 0.327
1.257TyrPro: 1.257 ± 0.359
1.125TyrGln: 1.125 ± 0.264
1.985TyrArg: 1.985 ± 0.37
1.985TyrSer: 1.985 ± 0.438
3.309TyrThr: 3.309 ± 0.482
1.324TyrVal: 1.324 ± 0.31
0.463TyrTrp: 0.463 ± 0.154
1.787TyrTyr: 1.787 ± 0.326
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (15112 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski