Amino acid dipepetide frequency for Klebsiella virus KpS8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.054AlaAla: 6.054 ± 0.561
0.947AlaCys: 0.947 ± 0.154
4.829AlaAsp: 4.829 ± 0.331
4.922AlaGlu: 4.922 ± 0.372
2.819AlaPhe: 2.819 ± 0.258
5.407AlaGly: 5.407 ± 0.416
1.017AlaHis: 1.017 ± 0.156
4.251AlaIle: 4.251 ± 0.259
5.083AlaLys: 5.083 ± 0.367
6.192AlaLeu: 6.192 ± 0.439
2.495AlaMet: 2.495 ± 0.253
3.142AlaAsn: 3.142 ± 0.305
2.241AlaPro: 2.241 ± 0.223
2.611AlaGln: 2.611 ± 0.286
3.535AlaArg: 3.535 ± 0.344
3.974AlaSer: 3.974 ± 0.337
4.228AlaThr: 4.228 ± 0.347
4.714AlaVal: 4.714 ± 0.279
1.271AlaTrp: 1.271 ± 0.163
2.726AlaTyr: 2.726 ± 0.264
0.0AlaXaa: 0.0 ± 0.0
Cys
0.739CysAla: 0.739 ± 0.134
0.231CysCys: 0.231 ± 0.07
0.901CysAsp: 0.901 ± 0.155
0.693CysGlu: 0.693 ± 0.131
0.67CysPhe: 0.67 ± 0.125
1.178CysGly: 1.178 ± 0.165
0.393CysHis: 0.393 ± 0.089
0.67CysIle: 0.67 ± 0.115
0.878CysLys: 0.878 ± 0.151
1.109CysLeu: 1.109 ± 0.175
0.277CysMet: 0.277 ± 0.081
0.508CysAsn: 0.508 ± 0.098
0.462CysPro: 0.462 ± 0.116
0.462CysGln: 0.462 ± 0.101
0.578CysArg: 0.578 ± 0.141
0.716CysSer: 0.716 ± 0.135
0.601CysThr: 0.601 ± 0.132
0.762CysVal: 0.762 ± 0.133
0.254CysTrp: 0.254 ± 0.077
0.508CysTyr: 0.508 ± 0.111
0.0CysXaa: 0.0 ± 0.0
Asp
4.044AspAla: 4.044 ± 0.328
0.832AspCys: 0.832 ± 0.13
3.905AspAsp: 3.905 ± 0.374
4.852AspGlu: 4.852 ± 0.371
2.888AspPhe: 2.888 ± 0.3
4.875AspGly: 4.875 ± 0.403
1.409AspHis: 1.409 ± 0.192
3.905AspIle: 3.905 ± 0.33
4.182AspLys: 4.182 ± 0.279
6.169AspLeu: 6.169 ± 0.387
1.825AspMet: 1.825 ± 0.203
3.119AspAsn: 3.119 ± 0.268
2.911AspPro: 2.911 ± 0.262
1.779AspGln: 1.779 ± 0.195
2.842AspArg: 2.842 ± 0.276
3.258AspSer: 3.258 ± 0.279
3.42AspThr: 3.42 ± 0.292
4.621AspVal: 4.621 ± 0.355
1.34AspTrp: 1.34 ± 0.201
2.588AspTyr: 2.588 ± 0.248
0.0AspXaa: 0.0 ± 0.0
Glu
5.892GluAla: 5.892 ± 0.402
0.67GluCys: 0.67 ± 0.136
4.182GluAsp: 4.182 ± 0.29
5.361GluGlu: 5.361 ± 0.403
2.75GluPhe: 2.75 ± 0.245
3.512GluGly: 3.512 ± 0.298
1.202GluHis: 1.202 ± 0.196
4.69GluIle: 4.69 ± 0.285
5.776GluLys: 5.776 ± 0.382
5.545GluLeu: 5.545 ± 0.363
2.172GluMet: 2.172 ± 0.202
3.304GluAsn: 3.304 ± 0.255
1.617GluPro: 1.617 ± 0.184
2.08GluGln: 2.08 ± 0.199
3.397GluArg: 3.397 ± 0.359
3.812GluSer: 3.812 ± 0.291
3.119GluThr: 3.119 ± 0.289
4.714GluVal: 4.714 ± 0.359
1.294GluTrp: 1.294 ± 0.163
2.842GluTyr: 2.842 ± 0.28
0.0GluXaa: 0.0 ± 0.0
Phe
2.703PheAla: 2.703 ± 0.257
0.762PheCys: 0.762 ± 0.129
3.119PheAsp: 3.119 ± 0.313
2.726PheGlu: 2.726 ± 0.276
1.848PhePhe: 1.848 ± 0.244
3.628PheGly: 3.628 ± 0.257
0.693PheHis: 0.693 ± 0.115
2.426PheIle: 2.426 ± 0.232
2.126PheLys: 2.126 ± 0.203
2.981PheLeu: 2.981 ± 0.283
1.109PheMet: 1.109 ± 0.142
2.38PheAsn: 2.38 ± 0.211
1.363PhePro: 1.363 ± 0.158
1.433PheGln: 1.433 ± 0.202
2.056PheArg: 2.056 ± 0.205
2.981PheSer: 2.981 ± 0.295
2.519PheThr: 2.519 ± 0.291
2.819PheVal: 2.819 ± 0.271
0.716PheTrp: 0.716 ± 0.136
1.594PheTyr: 1.594 ± 0.187
0.0PheXaa: 0.0 ± 0.0
Gly
4.321GlyAla: 4.321 ± 0.352
0.901GlyCys: 0.901 ± 0.15
4.529GlyAsp: 4.529 ± 0.315
4.552GlyGlu: 4.552 ± 0.331
3.327GlyPhe: 3.327 ± 0.286
4.968GlyGly: 4.968 ± 0.389
1.271GlyHis: 1.271 ± 0.178
3.928GlyIle: 3.928 ± 0.3
5.684GlyLys: 5.684 ± 0.356
5.222GlyLeu: 5.222 ± 0.332
2.241GlyMet: 2.241 ± 0.207
3.189GlyAsn: 3.189 ± 0.263
1.456GlyPro: 1.456 ± 0.186
2.126GlyGln: 2.126 ± 0.245
3.166GlyArg: 3.166 ± 0.295
4.228GlySer: 4.228 ± 0.435
4.044GlyThr: 4.044 ± 0.48
5.407GlyVal: 5.407 ± 0.339
1.687GlyTrp: 1.687 ± 0.206
3.42GlyTyr: 3.42 ± 0.274
0.0GlyXaa: 0.0 ± 0.0
His
0.878HisAla: 0.878 ± 0.126
0.254HisCys: 0.254 ± 0.076
1.248HisAsp: 1.248 ± 0.161
1.525HisGlu: 1.525 ± 0.195
1.178HisPhe: 1.178 ± 0.144
1.386HisGly: 1.386 ± 0.201
0.462HisHis: 0.462 ± 0.102
1.363HisIle: 1.363 ± 0.164
1.178HisLys: 1.178 ± 0.16
1.409HisLeu: 1.409 ± 0.191
0.555HisMet: 0.555 ± 0.106
0.855HisAsn: 0.855 ± 0.139
0.786HisPro: 0.786 ± 0.128
0.485HisGln: 0.485 ± 0.116
0.994HisArg: 0.994 ± 0.17
1.34HisSer: 1.34 ± 0.168
1.086HisThr: 1.086 ± 0.167
0.97HisVal: 0.97 ± 0.159
0.231HisTrp: 0.231 ± 0.077
0.878HisTyr: 0.878 ± 0.189
0.0HisXaa: 0.0 ± 0.0
Ile
4.575IleAla: 4.575 ± 0.31
0.994IleCys: 0.994 ± 0.172
3.928IleAsp: 3.928 ± 0.292
4.067IleGlu: 4.067 ± 0.295
2.311IlePhe: 2.311 ± 0.222
3.674IleGly: 3.674 ± 0.262
1.456IleHis: 1.456 ± 0.171
3.743IleIle: 3.743 ± 0.301
4.09IleLys: 4.09 ± 0.293
4.275IleLeu: 4.275 ± 0.319
1.872IleMet: 1.872 ± 0.22
2.449IleAsn: 2.449 ± 0.215
2.68IlePro: 2.68 ± 0.246
1.479IleGln: 1.479 ± 0.207
3.581IleArg: 3.581 ± 0.273
4.321IleSer: 4.321 ± 0.324
3.397IleThr: 3.397 ± 0.266
4.321IleVal: 4.321 ± 0.35
0.67IleTrp: 0.67 ± 0.134
2.472IleTyr: 2.472 ± 0.243
0.0IleXaa: 0.0 ± 0.0
Lys
5.8LysAla: 5.8 ± 0.423
0.624LysCys: 0.624 ± 0.128
4.598LysAsp: 4.598 ± 0.379
5.314LysGlu: 5.314 ± 0.451
2.842LysPhe: 2.842 ± 0.279
4.575LysGly: 4.575 ± 0.286
1.409LysHis: 1.409 ± 0.188
4.367LysIle: 4.367 ± 0.301
5.199LysLys: 5.199 ± 0.456
5.268LysLeu: 5.268 ± 0.34
2.172LysMet: 2.172 ± 0.222
3.212LysAsn: 3.212 ± 0.279
2.01LysPro: 2.01 ± 0.222
2.703LysGln: 2.703 ± 0.237
3.397LysArg: 3.397 ± 0.288
3.466LysSer: 3.466 ± 0.256
4.251LysThr: 4.251 ± 0.295
5.384LysVal: 5.384 ± 0.358
1.225LysTrp: 1.225 ± 0.181
2.842LysTyr: 2.842 ± 0.222
0.0LysXaa: 0.0 ± 0.0
Leu
6.354LeuAla: 6.354 ± 0.411
1.017LeuCys: 1.017 ± 0.156
5.499LeuAsp: 5.499 ± 0.345
5.892LeuGlu: 5.892 ± 0.422
2.588LeuPhe: 2.588 ± 0.236
4.644LeuGly: 4.644 ± 0.364
1.617LeuHis: 1.617 ± 0.191
4.344LeuIle: 4.344 ± 0.322
5.337LeuLys: 5.337 ± 0.338
5.8LeuLeu: 5.8 ± 0.373
2.195LeuMet: 2.195 ± 0.188
3.836LeuAsn: 3.836 ± 0.331
3.42LeuPro: 3.42 ± 0.291
2.426LeuGln: 2.426 ± 0.23
4.621LeuArg: 4.621 ± 0.324
5.753LeuSer: 5.753 ± 0.37
4.783LeuThr: 4.783 ± 0.352
4.922LeuVal: 4.922 ± 0.373
1.225LeuTrp: 1.225 ± 0.174
3.189LeuTyr: 3.189 ± 0.282
0.0LeuXaa: 0.0 ± 0.0
Met
2.472MetAla: 2.472 ± 0.235
0.393MetCys: 0.393 ± 0.096
1.202MetAsp: 1.202 ± 0.213
1.872MetGlu: 1.872 ± 0.221
1.502MetPhe: 1.502 ± 0.169
1.71MetGly: 1.71 ± 0.195
0.416MetHis: 0.416 ± 0.11
2.08MetIle: 2.08 ± 0.235
3.119MetLys: 3.119 ± 0.271
2.08MetLeu: 2.08 ± 0.205
1.04MetMet: 1.04 ± 0.163
1.617MetAsn: 1.617 ± 0.185
1.086MetPro: 1.086 ± 0.163
0.739MetGln: 0.739 ± 0.143
1.409MetArg: 1.409 ± 0.205
2.241MetSer: 2.241 ± 0.244
1.872MetThr: 1.872 ± 0.223
1.733MetVal: 1.733 ± 0.176
0.231MetTrp: 0.231 ± 0.07
0.901MetTyr: 0.901 ± 0.12
0.0MetXaa: 0.0 ± 0.0
Asn
3.235AsnAla: 3.235 ± 0.31
0.693AsnCys: 0.693 ± 0.115
2.611AsnAsp: 2.611 ± 0.218
2.056AsnGlu: 2.056 ± 0.254
2.056AsnPhe: 2.056 ± 0.222
3.951AsnGly: 3.951 ± 0.329
0.878AsnHis: 0.878 ± 0.132
3.004AsnIle: 3.004 ± 0.244
3.35AsnLys: 3.35 ± 0.269
3.789AsnLeu: 3.789 ± 0.286
1.594AsnMet: 1.594 ± 0.201
2.449AsnAsn: 2.449 ± 0.271
2.103AsnPro: 2.103 ± 0.218
1.71AsnGln: 1.71 ± 0.185
2.426AsnArg: 2.426 ± 0.246
2.842AsnSer: 2.842 ± 0.262
3.235AsnThr: 3.235 ± 0.347
2.911AsnVal: 2.911 ± 0.331
0.67AsnTrp: 0.67 ± 0.128
1.733AsnTyr: 1.733 ± 0.233
0.0AsnXaa: 0.0 ± 0.0
Pro
2.311ProAla: 2.311 ± 0.232
0.254ProCys: 0.254 ± 0.088
2.796ProAsp: 2.796 ± 0.285
3.373ProGlu: 3.373 ± 0.269
1.525ProPhe: 1.525 ± 0.17
2.75ProGly: 2.75 ± 0.249
0.67ProHis: 0.67 ± 0.127
1.409ProIle: 1.409 ± 0.163
2.033ProLys: 2.033 ± 0.208
2.611ProLeu: 2.611 ± 0.289
0.901ProMet: 0.901 ± 0.12
1.664ProAsn: 1.664 ± 0.163
0.924ProPro: 0.924 ± 0.182
1.456ProGln: 1.456 ± 0.158
1.386ProArg: 1.386 ± 0.19
1.964ProSer: 1.964 ± 0.221
2.241ProThr: 2.241 ± 0.242
3.05ProVal: 3.05 ± 0.265
0.508ProTrp: 0.508 ± 0.099
1.479ProTyr: 1.479 ± 0.193
0.0ProXaa: 0.0 ± 0.0
Gln
2.357GlnAla: 2.357 ± 0.214
0.416GlnCys: 0.416 ± 0.089
1.733GlnAsp: 1.733 ± 0.208
2.334GlnGlu: 2.334 ± 0.214
1.317GlnPhe: 1.317 ± 0.162
2.172GlnGly: 2.172 ± 0.175
0.37GlnHis: 0.37 ± 0.091
2.357GlnIle: 2.357 ± 0.223
2.172GlnLys: 2.172 ± 0.26
2.726GlnLeu: 2.726 ± 0.267
0.809GlnMet: 0.809 ± 0.133
1.872GlnAsn: 1.872 ± 0.191
0.947GlnPro: 0.947 ± 0.154
1.687GlnGln: 1.687 ± 0.203
1.433GlnArg: 1.433 ± 0.164
1.664GlnSer: 1.664 ± 0.18
1.964GlnThr: 1.964 ± 0.232
2.357GlnVal: 2.357 ± 0.236
0.485GlnTrp: 0.485 ± 0.111
1.202GlnTyr: 1.202 ± 0.168
0.0GlnXaa: 0.0 ± 0.0
Arg
3.212ArgAla: 3.212 ± 0.265
0.739ArgCys: 0.739 ± 0.129
3.605ArgAsp: 3.605 ± 0.281
3.073ArgGlu: 3.073 ± 0.26
1.733ArgPhe: 1.733 ± 0.213
3.512ArgGly: 3.512 ± 0.277
1.017ArgHis: 1.017 ± 0.161
2.934ArgIle: 2.934 ± 0.261
3.743ArgLys: 3.743 ± 0.267
4.228ArgLeu: 4.228 ± 0.345
1.409ArgMet: 1.409 ± 0.172
2.611ArgAsn: 2.611 ± 0.267
1.848ArgPro: 1.848 ± 0.224
1.802ArgGln: 1.802 ± 0.208
2.819ArgArg: 2.819 ± 0.299
2.842ArgSer: 2.842 ± 0.256
2.657ArgThr: 2.657 ± 0.284
3.073ArgVal: 3.073 ± 0.29
0.693ArgTrp: 0.693 ± 0.134
1.941ArgTyr: 1.941 ± 0.173
0.0ArgXaa: 0.0 ± 0.0
Ser
4.529SerAla: 4.529 ± 0.355
0.786SerCys: 0.786 ± 0.134
3.743SerAsp: 3.743 ± 0.276
3.512SerGlu: 3.512 ± 0.259
2.519SerPhe: 2.519 ± 0.184
4.783SerGly: 4.783 ± 0.347
0.947SerHis: 0.947 ± 0.151
3.674SerIle: 3.674 ± 0.322
4.067SerLys: 4.067 ± 0.293
4.875SerLeu: 4.875 ± 0.417
1.571SerMet: 1.571 ± 0.191
3.004SerAsn: 3.004 ± 0.261
2.241SerPro: 2.241 ± 0.2
1.848SerGln: 1.848 ± 0.196
3.212SerArg: 3.212 ± 0.309
3.581SerSer: 3.581 ± 0.377
3.674SerThr: 3.674 ± 0.304
4.113SerVal: 4.113 ± 0.303
0.947SerTrp: 0.947 ± 0.127
2.126SerTyr: 2.126 ± 0.2
0.0SerXaa: 0.0 ± 0.0
Thr
4.298ThrAla: 4.298 ± 0.326
0.578ThrCys: 0.578 ± 0.131
3.558ThrAsp: 3.558 ± 0.333
3.489ThrGlu: 3.489 ± 0.274
2.519ThrPhe: 2.519 ± 0.239
5.153ThrGly: 5.153 ± 0.501
1.34ThrHis: 1.34 ± 0.179
3.512ThrIle: 3.512 ± 0.334
4.113ThrLys: 4.113 ± 0.284
4.852ThrLeu: 4.852 ± 0.402
1.409ThrMet: 1.409 ± 0.175
2.172ThrAsn: 2.172 ± 0.229
3.073ThrPro: 3.073 ± 0.236
1.617ThrGln: 1.617 ± 0.167
2.357ThrArg: 2.357 ± 0.206
3.096ThrSer: 3.096 ± 0.249
3.743ThrThr: 3.743 ± 0.425
4.898ThrVal: 4.898 ± 0.397
1.294ThrTrp: 1.294 ± 0.189
2.357ThrTyr: 2.357 ± 0.236
0.0ThrXaa: 0.0 ± 0.0
Val
4.783ValAla: 4.783 ± 0.388
0.878ValCys: 0.878 ± 0.179
4.644ValAsp: 4.644 ± 0.332
4.829ValGlu: 4.829 ± 0.366
3.281ValPhe: 3.281 ± 0.312
4.367ValGly: 4.367 ± 0.339
1.086ValHis: 1.086 ± 0.16
4.552ValIle: 4.552 ± 0.333
4.991ValLys: 4.991 ± 0.331
5.361ValLeu: 5.361 ± 0.286
1.779ValMet: 1.779 ± 0.19
2.958ValAsn: 2.958 ± 0.302
2.103ValPro: 2.103 ± 0.238
1.964ValGln: 1.964 ± 0.267
3.397ValArg: 3.397 ± 0.298
4.436ValSer: 4.436 ± 0.349
5.06ValThr: 5.06 ± 0.418
6.077ValVal: 6.077 ± 0.449
1.109ValTrp: 1.109 ± 0.152
2.703ValTyr: 2.703 ± 0.271
0.0ValXaa: 0.0 ± 0.0
Trp
1.109TrpAla: 1.109 ± 0.155
0.139TrpCys: 0.139 ± 0.068
1.109TrpAsp: 1.109 ± 0.19
1.386TrpGlu: 1.386 ± 0.199
0.693TrpPhe: 0.693 ± 0.122
0.832TrpGly: 0.832 ± 0.147
0.37TrpHis: 0.37 ± 0.092
1.04TrpIle: 1.04 ± 0.173
1.04TrpLys: 1.04 ± 0.165
1.571TrpLeu: 1.571 ± 0.195
0.97TrpMet: 0.97 ± 0.149
0.924TrpAsn: 0.924 ± 0.17
0.37TrpPro: 0.37 ± 0.098
0.531TrpGln: 0.531 ± 0.113
0.716TrpArg: 0.716 ± 0.163
0.994TrpSer: 0.994 ± 0.123
0.855TrpThr: 0.855 ± 0.153
0.878TrpVal: 0.878 ± 0.129
0.462TrpTrp: 0.462 ± 0.1
0.97TrpTyr: 0.97 ± 0.139
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.796TyrAla: 2.796 ± 0.267
0.485TyrCys: 0.485 ± 0.1
3.027TyrAsp: 3.027 ± 0.293
2.103TyrGlu: 2.103 ± 0.192
1.617TyrPhe: 1.617 ± 0.178
2.611TyrGly: 2.611 ± 0.252
1.04TyrHis: 1.04 ± 0.172
2.103TyrIle: 2.103 ± 0.25
2.495TyrLys: 2.495 ± 0.276
3.397TyrLeu: 3.397 ± 0.278
1.294TyrMet: 1.294 ± 0.178
2.033TyrAsn: 2.033 ± 0.207
1.664TyrPro: 1.664 ± 0.188
1.433TyrGln: 1.433 ± 0.166
2.172TyrArg: 2.172 ± 0.228
2.241TyrSer: 2.241 ± 0.24
2.68TyrThr: 2.68 ± 0.254
2.634TyrVal: 2.634 ± 0.206
0.647TyrTrp: 0.647 ± 0.109
1.918TyrTyr: 1.918 ± 0.229
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 261 proteins (43280 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski