Amino acid dipepetide frequency for Bdellovibrio bacteriovorus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.723AlaAla: 7.723 ± 0.118	0.852AlaCys: 0.852 ± 0.029	4.212AlaAsp: 4.212 ± 0.064	5.318AlaGlu: 5.318 ± 0.088	3.526AlaPhe: 3.526 ± 0.061	5.95AlaGly: 5.95 ± 0.083	1.65AlaHis: 1.65 ± 0.039	4.635AlaIle: 4.635 ± 0.067	5.658AlaLys: 5.658 ± 0.091	8.721AlaLeu: 8.721 ± 0.098	2.101AlaMet: 2.101 ± 0.046	3.19AlaAsn: 3.19 ± 0.061	3.191AlaPro: 3.191 ± 0.065	3.913AlaGln: 3.913 ± 0.065	3.726AlaArg: 3.726 ± 0.055	5.731AlaSer: 5.731 ± 0.086	4.297AlaThr: 4.297 ± 0.079	5.341AlaVal: 5.341 ± 0.071	0.936AlaTrp: 0.936 ± 0.031	2.282AlaTyr: 2.282 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.755CysAla: 0.755 ± 0.027	0.078CysCys: 0.078 ± 0.008	0.505CysAsp: 0.505 ± 0.021	0.601CysGlu: 0.601 ± 0.024	0.405CysPhe: 0.405 ± 0.018	0.72CysGly: 0.72 ± 0.024	0.235CysHis: 0.235 ± 0.016	0.43CysIle: 0.43 ± 0.02	0.452CysLys: 0.452 ± 0.022	0.862CysLeu: 0.862 ± 0.029	0.19CysMet: 0.19 ± 0.014	0.324CysAsn: 0.324 ± 0.02	0.445CysPro: 0.445 ± 0.021	0.386CysGln: 0.386 ± 0.019	0.435CysArg: 0.435 ± 0.023	0.669CysSer: 0.669 ± 0.026	0.513CysThr: 0.513 ± 0.019	0.643CysVal: 0.643 ± 0.021	0.084CysTrp: 0.084 ± 0.008	0.261CysTyr: 0.261 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.669AspAla: 3.669 ± 0.062	0.427AspCys: 0.427 ± 0.022	2.405AspAsp: 2.405 ± 0.05	3.244AspGlu: 3.244 ± 0.057	2.971AspPhe: 2.971 ± 0.057	3.537AspGly: 3.537 ± 0.068	1.021AspHis: 1.021 ± 0.034	3.38AspIle: 3.38 ± 0.061	3.088AspLys: 3.088 ± 0.053	5.864AspLeu: 5.864 ± 0.079	1.234AspMet: 1.234 ± 0.032	1.735AspAsn: 1.735 ± 0.036	2.385AspPro: 2.385 ± 0.042	2.079AspGln: 2.079 ± 0.045	2.545AspArg: 2.545 ± 0.05	3.208AspSer: 3.208 ± 0.052	2.233AspThr: 2.233 ± 0.044	3.682AspVal: 3.682 ± 0.061	0.678AspTrp: 0.678 ± 0.026	1.756AspTyr: 1.756 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.466GluAla: 5.466 ± 0.074	0.438GluCys: 0.438 ± 0.021	3.065GluAsp: 3.065 ± 0.058	4.266GluGlu: 4.266 ± 0.077	2.796GluPhe: 2.796 ± 0.048	3.962GluGly: 3.962 ± 0.062	1.122GluHis: 1.122 ± 0.032	4.66GluIle: 4.66 ± 0.071	5.486GluLys: 5.486 ± 0.086	5.968GluLeu: 5.968 ± 0.091	1.838GluMet: 1.838 ± 0.04	3.042GluAsn: 3.042 ± 0.051	1.775GluPro: 1.775 ± 0.041	2.305GluGln: 2.305 ± 0.045	3.095GluArg: 3.095 ± 0.061	3.93GluSer: 3.93 ± 0.06	3.202GluThr: 3.202 ± 0.057	4.598GluVal: 4.598 ± 0.068	0.683GluTrp: 0.683 ± 0.024	1.756GluTyr: 1.756 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.874PheAla: 3.874 ± 0.061	0.519PheCys: 0.519 ± 0.019	2.583PheAsp: 2.583 ± 0.044	2.963PheGlu: 2.963 ± 0.061	2.429PhePhe: 2.429 ± 0.051	3.156PheGly: 3.156 ± 0.06	0.903PheHis: 0.903 ± 0.025	2.729PheIle: 2.729 ± 0.052	3.015PheLys: 3.015 ± 0.051	4.651PheLeu: 4.651 ± 0.073	1.174PheMet: 1.174 ± 0.033	1.98PheAsn: 1.98 ± 0.041	1.697PhePro: 1.697 ± 0.042	1.684PheGln: 1.684 ± 0.034	1.921PheArg: 1.921 ± 0.037	3.662PheSer: 3.662 ± 0.054	2.311PheThr: 2.311 ± 0.041	3.224PheVal: 3.224 ± 0.048	0.604PheTrp: 0.604 ± 0.028	1.566PheTyr: 1.566 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.65GlyAla: 5.65 ± 0.086	0.714GlyCys: 0.714 ± 0.028	3.442GlyAsp: 3.442 ± 0.048	3.896GlyGlu: 3.896 ± 0.07	3.582GlyPhe: 3.582 ± 0.069	5.49GlyGly: 5.49 ± 0.106	1.441GlyHis: 1.441 ± 0.036	4.235GlyIle: 4.235 ± 0.06	4.481GlyLys: 4.481 ± 0.06	6.799GlyLeu: 6.799 ± 0.086	1.794GlyMet: 1.794 ± 0.061	2.595GlyAsn: 2.595 ± 0.052	2.34GlyPro: 2.34 ± 0.046	2.595GlyGln: 2.595 ± 0.05	3.218GlyArg: 3.218 ± 0.046	5.074GlySer: 5.074 ± 0.076	4.439GlyThr: 4.439 ± 0.117	5.028GlyVal: 5.028 ± 0.065	0.857GlyTrp: 0.857 ± 0.03	2.384GlyTyr: 2.384 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.317HisAla: 1.317 ± 0.036	0.232HisCys: 0.232 ± 0.015	0.921HisAsp: 0.921 ± 0.028	1.219HisGlu: 1.219 ± 0.03	1.093HisPhe: 1.093 ± 0.029	1.381HisGly: 1.381 ± 0.033	0.52HisHis: 0.52 ± 0.028	1.098HisIle: 1.098 ± 0.031	0.982HisLys: 0.982 ± 0.035	2.097HisLeu: 2.097 ± 0.043	0.497HisMet: 0.497 ± 0.022	0.636HisAsn: 0.636 ± 0.02	1.152HisPro: 1.152 ± 0.03	0.735HisGln: 0.735 ± 0.024	1.025HisArg: 1.025 ± 0.032	1.222HisSer: 1.222 ± 0.035	0.839HisThr: 0.839 ± 0.024	1.189HisVal: 1.189 ± 0.03	0.285HisTrp: 0.285 ± 0.016	0.652HisTyr: 0.652 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.097IleAla: 5.097 ± 0.069	0.618IleCys: 0.618 ± 0.024	3.196IleAsp: 3.196 ± 0.064	4.093IleGlu: 4.093 ± 0.067	2.836IlePhe: 2.836 ± 0.052	3.896IleGly: 3.896 ± 0.078	1.186IleHis: 1.186 ± 0.032	3.052IleIle: 3.052 ± 0.064	3.697IleLys: 3.697 ± 0.057	6.137IleLeu: 6.137 ± 0.093	1.199IleMet: 1.199 ± 0.031	2.452IleAsn: 2.452 ± 0.044	2.827IlePro: 2.827 ± 0.046	2.413IleGln: 2.413 ± 0.043	3.006IleArg: 3.006 ± 0.054	4.682IleSer: 4.682 ± 0.063	3.234IleThr: 3.234 ± 0.063	3.829IleVal: 3.829 ± 0.062	0.571IleTrp: 0.571 ± 0.023	1.818IleTyr: 1.818 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.699LysAla: 5.699 ± 0.08	0.381LysCys: 0.381 ± 0.018	3.989LysAsp: 3.989 ± 0.067	4.792LysGlu: 4.792 ± 0.073	2.575LysPhe: 2.575 ± 0.048	4.024LysGly: 4.024 ± 0.071	1.044LysHis: 1.044 ± 0.032	4.746LysIle: 4.746 ± 0.06	6.048LysLys: 6.048 ± 0.093	5.479LysLeu: 5.479 ± 0.083	2.142LysMet: 2.142 ± 0.046	3.826LysAsn: 3.826 ± 0.057	2.507LysPro: 2.507 ± 0.045	2.012LysGln: 2.012 ± 0.048	2.685LysArg: 2.685 ± 0.051	4.647LysSer: 4.647 ± 0.067	4.115LysThr: 4.115 ± 0.068	4.681LysVal: 4.681 ± 0.066	0.727LysTrp: 0.727 ± 0.027	2.016LysTyr: 2.016 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	8.135LeuAla: 8.135 ± 0.095	0.841LeuCys: 0.841 ± 0.027	4.776LeuAsp: 4.776 ± 0.068	6.221LeuGlu: 6.221 ± 0.076	4.256LeuPhe: 4.256 ± 0.074	6.904LeuGly: 6.904 ± 0.105	1.786LeuHis: 1.786 ± 0.032	5.751LeuIle: 5.751 ± 0.076	7.685LeuLys: 7.685 ± 0.097	8.806LeuLeu: 8.806 ± 0.11	2.633LeuMet: 2.633 ± 0.05	4.583LeuAsn: 4.583 ± 0.07	4.111LeuPro: 4.111 ± 0.06	3.706LeuGln: 3.706 ± 0.058	5.053LeuArg: 5.053 ± 0.075	7.607LeuSer: 7.607 ± 0.084	5.334LeuThr: 5.334 ± 0.071	6.315LeuVal: 6.315 ± 0.074	1.028LeuTrp: 1.028 ± 0.031	2.493LeuTyr: 2.493 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.483MetAla: 2.483 ± 0.049	0.181MetCys: 0.181 ± 0.014	1.379MetAsp: 1.379 ± 0.034	1.425MetGlu: 1.425 ± 0.033	0.807MetPhe: 0.807 ± 0.029	1.934MetGly: 1.934 ± 0.048	0.417MetHis: 0.417 ± 0.02	1.606MetIle: 1.606 ± 0.04	2.465MetLys: 2.465 ± 0.052	1.936MetLeu: 1.936 ± 0.043	0.801MetMet: 0.801 ± 0.028	1.268MetAsn: 1.268 ± 0.032	1.047MetPro: 1.047 ± 0.033	0.981MetGln: 0.981 ± 0.03	1.222MetArg: 1.222 ± 0.034	1.921MetSer: 1.921 ± 0.041	1.69MetThr: 1.69 ± 0.034	1.568MetVal: 1.568 ± 0.04	0.219MetTrp: 0.219 ± 0.015	0.554MetTyr: 0.554 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.172AsnAla: 3.172 ± 0.062	0.447AsnCys: 0.447 ± 0.02	1.984AsnAsp: 1.984 ± 0.038	2.431AsnGlu: 2.431 ± 0.044	2.12AsnPhe: 2.12 ± 0.043	2.946AsnGly: 2.946 ± 0.065	0.765AsnHis: 0.765 ± 0.025	2.685AsnIle: 2.685 ± 0.046	2.531AsnLys: 2.531 ± 0.045	4.271AsnLeu: 4.271 ± 0.058	1.021AsnMet: 1.021 ± 0.029	1.693AsnAsn: 1.693 ± 0.045	2.403AsnPro: 2.403 ± 0.051	1.753AsnGln: 1.753 ± 0.041	1.873AsnArg: 1.873 ± 0.041	3.04AsnSer: 3.04 ± 0.06	2.166AsnThr: 2.166 ± 0.053	2.681AsnVal: 2.681 ± 0.053	0.596AsnTrp: 0.596 ± 0.024	1.463AsnTyr: 1.463 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.452ProAla: 3.452 ± 0.059	0.273ProCys: 0.273 ± 0.017	2.207ProAsp: 2.207 ± 0.043	3.291ProGlu: 3.291 ± 0.057	1.867ProPhe: 1.867 ± 0.04	2.841ProGly: 2.841 ± 0.049	0.912ProHis: 0.912 ± 0.027	2.022ProIle: 2.022 ± 0.043	2.466ProLys: 2.466 ± 0.052	3.868ProLeu: 3.868 ± 0.06	0.983ProMet: 0.983 ± 0.027	1.598ProAsn: 1.598 ± 0.036	1.607ProPro: 1.607 ± 0.048	1.874ProGln: 1.874 ± 0.04	1.71ProArg: 1.71 ± 0.036	2.84ProSer: 2.84 ± 0.055	2.361ProThr: 2.361 ± 0.048	2.925ProVal: 2.925 ± 0.054	0.566ProTrp: 0.566 ± 0.024	1.269ProTyr: 1.269 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.404GlnAla: 3.404 ± 0.068	0.267GlnCys: 0.267 ± 0.016	2.112GlnAsp: 2.112 ± 0.042	2.602GlnGlu: 2.602 ± 0.055	1.691GlnPhe: 1.691 ± 0.04	2.805GlnGly: 2.805 ± 0.05	0.607GlnHis: 0.607 ± 0.019	2.597GlnIle: 2.597 ± 0.047	3.162GlnLys: 3.162 ± 0.058	3.269GlnLeu: 3.269 ± 0.054	1.216GlnMet: 1.216 ± 0.036	1.923GlnAsn: 1.923 ± 0.038	1.191GlnPro: 1.191 ± 0.038	1.426GlnGln: 1.426 ± 0.041	1.848GlnArg: 1.848 ± 0.048	2.641GlnSer: 2.641 ± 0.049	2.061GlnThr: 2.061 ± 0.04	2.877GlnVal: 2.877 ± 0.053	0.554GlnTrp: 0.554 ± 0.021	1.102GlnTyr: 1.102 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.691ArgAla: 3.691 ± 0.056	0.352ArgCys: 0.352 ± 0.018	2.477ArgAsp: 2.477 ± 0.05	3.073ArgGlu: 3.073 ± 0.048	2.244ArgPhe: 2.244 ± 0.047	2.988ArgGly: 2.988 ± 0.05	0.982ArgHis: 0.982 ± 0.031	3.005ArgIle: 3.005 ± 0.051	2.934ArgLys: 2.934 ± 0.061	4.767ArgLeu: 4.767 ± 0.063	1.418ArgMet: 1.418 ± 0.037	1.925ArgAsn: 1.925 ± 0.037	1.899ArgPro: 1.899 ± 0.042	1.874ArgGln: 1.874 ± 0.043	2.496ArgArg: 2.496 ± 0.052	3.05ArgSer: 3.05 ± 0.052	2.344ArgThr: 2.344 ± 0.05	3.229ArgVal: 3.229 ± 0.057	0.659ArgTrp: 0.659 ± 0.026	1.527ArgTyr: 1.527 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.909SerAla: 5.909 ± 0.087	0.769SerCys: 0.769 ± 0.028	3.312SerAsp: 3.312 ± 0.056	4.295SerGlu: 4.295 ± 0.065	3.793SerPhe: 3.793 ± 0.067	5.584SerGly: 5.584 ± 0.121	1.38SerHis: 1.38 ± 0.042	3.866SerIle: 3.866 ± 0.058	4.068SerLys: 4.068 ± 0.061	7.722SerLeu: 7.722 ± 0.095	1.72SerMet: 1.72 ± 0.038	2.502SerAsn: 2.502 ± 0.051	3.061SerPro: 3.061 ± 0.048	2.958SerGln: 2.958 ± 0.051	3.155SerArg: 3.155 ± 0.054	5.767SerSer: 5.767 ± 0.106	3.689SerThr: 3.689 ± 0.073	4.887SerVal: 4.887 ± 0.063	1.037SerTrp: 1.037 ± 0.034	2.359SerTyr: 2.359 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.76ThrAla: 4.76 ± 0.08	0.525ThrCys: 0.525 ± 0.024	2.67ThrAsp: 2.67 ± 0.05	3.123ThrGlu: 3.123 ± 0.05	2.32ThrPhe: 2.32 ± 0.044	4.097ThrGly: 4.097 ± 0.096	1.046ThrHis: 1.046 ± 0.031	2.815ThrIle: 2.815 ± 0.06	3.095ThrLys: 3.095 ± 0.047	5.518ThrLeu: 5.518 ± 0.077	1.223ThrMet: 1.223 ± 0.034	2.121ThrAsn: 2.121 ± 0.053	2.937ThrPro: 2.937 ± 0.051	2.157ThrGln: 2.157 ± 0.041	2.306ThrArg: 2.306 ± 0.049	4.057ThrSer: 4.057 ± 0.087	3.323ThrThr: 3.323 ± 0.095	3.734ThrVal: 3.734 ± 0.063	0.707ThrTrp: 0.707 ± 0.031	1.681ThrTyr: 1.681 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.559ValAla: 5.559 ± 0.065	0.645ValCys: 0.645 ± 0.024	3.653ValAsp: 3.653 ± 0.058	4.143ValGlu: 4.143 ± 0.062	3.143ValPhe: 3.143 ± 0.057	4.855ValGly: 4.855 ± 0.08	1.23ValHis: 1.23 ± 0.03	4.224ValIle: 4.224 ± 0.067	4.231ValLys: 4.231 ± 0.072	7.02ValLeu: 7.02 ± 0.087	1.664ValMet: 1.664 ± 0.035	2.734ValAsn: 2.734 ± 0.053	2.737ValPro: 2.737 ± 0.048	2.665ValGln: 2.665 ± 0.054	3.333ValArg: 3.333 ± 0.065	4.94ValSer: 4.94 ± 0.065	3.923ValThr: 3.923 ± 0.077	4.889ValVal: 4.889 ± 0.067	0.706ValTrp: 0.706 ± 0.025	1.851ValTyr: 1.851 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.99TrpAla: 0.99 ± 0.027	0.104TrpCys: 0.104 ± 0.009	0.644TrpAsp: 0.644 ± 0.025	0.607TrpGlu: 0.607 ± 0.023	0.47TrpPhe: 0.47 ± 0.02	0.889TrpGly: 0.889 ± 0.033	0.247TrpHis: 0.247 ± 0.015	0.778TrpIle: 0.778 ± 0.025	0.799TrpLys: 0.799 ± 0.029	1.108TrpLeu: 1.108 ± 0.032	0.376TrpMet: 0.376 ± 0.017	0.654TrpAsn: 0.654 ± 0.024	0.429TrpPro: 0.429 ± 0.02	0.493TrpGln: 0.493 ± 0.02	0.59TrpArg: 0.59 ± 0.024	0.876TrpSer: 0.876 ± 0.031	0.71TrpThr: 0.71 ± 0.032	0.88TrpVal: 0.88 ± 0.03	0.162TrpTrp: 0.162 ± 0.011	0.3TrpTyr: 0.3 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.145TyrAla: 2.145 ± 0.042	0.327TyrCys: 0.327 ± 0.016	1.611TyrAsp: 1.611 ± 0.043	1.854TyrGlu: 1.854 ± 0.042	1.721TyrPhe: 1.721 ± 0.039	2.099TyrGly: 2.099 ± 0.043	0.598TyrHis: 0.598 ± 0.021	1.525TyrIle: 1.525 ± 0.041	1.789TyrLys: 1.789 ± 0.04	3.161TyrLeu: 3.161 ± 0.054	0.677TyrMet: 0.677 ± 0.027	1.259TyrAsn: 1.259 ± 0.035	1.193TyrPro: 1.193 ± 0.035	1.346TyrGln: 1.346 ± 0.036	1.693TyrArg: 1.693 ± 0.04	2.27TyrSer: 2.27 ± 0.042	1.432TyrThr: 1.432 ± 0.036	1.943TyrVal: 1.943 ± 0.039	0.447TyrTrp: 0.447 ± 0.019	1.121TyrTyr: 1.121 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3712 proteins (1191860 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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