Amino acid dipepetide frequency for Zancudomyces culisetae (Gut fungus) (Smittium culisetae)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.423AlaAla: 4.423 ± 0.065	0.813AlaCys: 0.813 ± 0.019	2.912AlaAsp: 2.912 ± 0.032	3.829AlaGlu: 3.829 ± 0.041	2.092AlaPhe: 2.092 ± 0.028	3.637AlaGly: 3.637 ± 0.043	1.102AlaHis: 1.102 ± 0.017	3.69AlaIle: 3.69 ± 0.039	4.087AlaLys: 4.087 ± 0.039	4.852AlaLeu: 4.852 ± 0.043	1.316AlaMet: 1.316 ± 0.021	3.329AlaAsn: 3.329 ± 0.037	2.289AlaPro: 2.289 ± 0.039	2.271AlaGln: 2.271 ± 0.039	2.599AlaArg: 2.599 ± 0.034	5.348AlaSer: 5.348 ± 0.055	3.679AlaThr: 3.679 ± 0.044	3.684AlaVal: 3.684 ± 0.043	0.397AlaTrp: 0.397 ± 0.012	1.693AlaTyr: 1.693 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.707CysAla: 0.707 ± 0.016	0.316CysCys: 0.316 ± 0.014	0.718CysAsp: 0.718 ± 0.019	0.741CysGlu: 0.741 ± 0.02	0.58CysPhe: 0.58 ± 0.017	0.983CysGly: 0.983 ± 0.028	0.283CysHis: 0.283 ± 0.011	0.942CysIle: 0.942 ± 0.021	0.867CysLys: 0.867 ± 0.02	1.111CysLeu: 1.111 ± 0.022	0.306CysMet: 0.306 ± 0.011	0.676CysAsn: 0.676 ± 0.016	0.525CysPro: 0.525 ± 0.017	0.398CysGln: 0.398 ± 0.012	0.61CysArg: 0.61 ± 0.018	1.174CysSer: 1.174 ± 0.024	0.829CysThr: 0.829 ± 0.023	0.88CysVal: 0.88 ± 0.02	0.117CysTrp: 0.117 ± 0.006	0.5CysTyr: 0.5 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.904AspAla: 2.904 ± 0.036	0.652AspCys: 0.652 ± 0.018	3.417AspAsp: 3.417 ± 0.059	4.229AspGlu: 4.229 ± 0.048	2.34AspPhe: 2.34 ± 0.032	3.543AspGly: 3.543 ± 0.041	0.955AspHis: 0.955 ± 0.018	3.93AspIle: 3.93 ± 0.037	3.627AspLys: 3.627 ± 0.036	4.501AspLeu: 4.501 ± 0.045	1.27AspMet: 1.27 ± 0.025	3.162AspAsn: 3.162 ± 0.046	2.158AspPro: 2.158 ± 0.035	1.823AspGln: 1.823 ± 0.029	2.366AspArg: 2.366 ± 0.036	5.467AspSer: 5.467 ± 0.051	3.285AspThr: 3.285 ± 0.046	3.35AspVal: 3.35 ± 0.036	0.53AspTrp: 0.53 ± 0.017	2.044AspTyr: 2.044 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	3.614GluAla: 3.614 ± 0.038	0.794GluCys: 0.794 ± 0.018	3.617GluAsp: 3.617 ± 0.045	5.902GluGlu: 5.902 ± 0.105	2.492GluPhe: 2.492 ± 0.03	3.533GluGly: 3.533 ± 0.045	1.337GluHis: 1.337 ± 0.023	4.186GluIle: 4.186 ± 0.042	6.275GluLys: 6.275 ± 0.075	5.971GluLeu: 5.971 ± 0.06	1.766GluMet: 1.766 ± 0.028	4.742GluAsn: 4.742 ± 0.056	1.987GluPro: 1.987 ± 0.034	2.92GluGln: 2.92 ± 0.045	3.371GluArg: 3.371 ± 0.048	5.241GluSer: 5.241 ± 0.059	3.555GluThr: 3.555 ± 0.056	3.339GluVal: 3.339 ± 0.043	0.592GluTrp: 0.592 ± 0.014	2.795GluTyr: 2.795 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	2.186PheAla: 2.186 ± 0.031	0.643PheCys: 0.643 ± 0.017	2.447PheAsp: 2.447 ± 0.032	2.521PheGlu: 2.521 ± 0.029	1.536PhePhe: 1.536 ± 0.028	2.896PheGly: 2.896 ± 0.033	0.657PheHis: 0.657 ± 0.018	2.182PheIle: 2.182 ± 0.028	2.274PheLys: 2.274 ± 0.03	3.109PheLeu: 3.109 ± 0.037	0.888PheMet: 0.888 ± 0.018	2.141PheAsn: 2.141 ± 0.026	1.455PhePro: 1.455 ± 0.026	1.066PheGln: 1.066 ± 0.017	1.524PheArg: 1.524 ± 0.026	3.771PheSer: 3.771 ± 0.034	2.18PheThr: 2.18 ± 0.031	2.486PheVal: 2.486 ± 0.032	0.362PheTrp: 0.362 ± 0.012	1.364PheTyr: 1.364 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	3.618GlyAla: 3.618 ± 0.042	0.84GlyCys: 0.84 ± 0.023	3.359GlyAsp: 3.359 ± 0.037	3.826GlyGlu: 3.826 ± 0.042	2.457GlyPhe: 2.457 ± 0.031	5.479GlyGly: 5.479 ± 0.075	1.176GlyHis: 1.176 ± 0.02	3.957GlyIle: 3.957 ± 0.039	4.352GlyLys: 4.352 ± 0.051	4.752GlyLeu: 4.752 ± 0.05	1.529GlyMet: 1.529 ± 0.028	3.884GlyAsn: 3.884 ± 0.057	1.68GlyPro: 1.68 ± 0.028	1.831GlyGln: 1.831 ± 0.035	2.916GlyArg: 2.916 ± 0.04	5.75GlySer: 5.75 ± 0.063	3.461GlyThr: 3.461 ± 0.04	4.156GlyVal: 4.156 ± 0.042	0.58GlyTrp: 0.58 ± 0.014	2.526GlyTyr: 2.526 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	0.99HisAla: 0.99 ± 0.019	0.31HisCys: 0.31 ± 0.011	0.914HisAsp: 0.914 ± 0.019	1.13HisGlu: 1.13 ± 0.024	0.773HisPhe: 0.773 ± 0.018	1.137HisGly: 1.137 ± 0.022	0.617HisHis: 0.617 ± 0.021	1.163HisIle: 1.163 ± 0.02	1.248HisLys: 1.248 ± 0.021	1.672HisLeu: 1.672 ± 0.023	0.421HisMet: 0.421 ± 0.012	1.194HisAsn: 1.194 ± 0.022	1.165HisPro: 1.165 ± 0.026	0.875HisGln: 0.875 ± 0.022	1.007HisArg: 1.007 ± 0.02	1.928HisSer: 1.928 ± 0.03	1.176HisThr: 1.176 ± 0.021	1.126HisVal: 1.126 ± 0.02	0.157HisTrp: 0.157 ± 0.007	0.721HisTyr: 0.721 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	3.398IleAla: 3.398 ± 0.035	0.893IleCys: 0.893 ± 0.017	3.826IleAsp: 3.826 ± 0.039	4.258IleGlu: 4.258 ± 0.042	2.273IlePhe: 2.273 ± 0.03	3.481IleGly: 3.481 ± 0.044	1.215IleHis: 1.215 ± 0.019	3.226IleIle: 3.226 ± 0.041	4.373IleLys: 4.373 ± 0.045	5.022IleLeu: 5.022 ± 0.051	1.187IleMet: 1.187 ± 0.02	3.835IleAsn: 3.835 ± 0.051	2.942IlePro: 2.942 ± 0.038	2.28IleGln: 2.28 ± 0.029	2.713IleArg: 2.713 ± 0.037	5.791IleSer: 5.791 ± 0.054	3.493IleThr: 3.493 ± 0.061	3.478IleVal: 3.478 ± 0.041	0.464IleTrp: 0.464 ± 0.013	1.979IleTyr: 1.979 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.983LysAla: 3.983 ± 0.043	0.851LysCys: 0.851 ± 0.02	3.808LysAsp: 3.808 ± 0.042	5.111LysGlu: 5.111 ± 0.077	2.221LysPhe: 2.221 ± 0.028	3.523LysGly: 3.523 ± 0.044	1.485LysHis: 1.485 ± 0.026	4.265LysIle: 4.265 ± 0.042	6.519LysLys: 6.519 ± 0.08	6.059LysLeu: 6.059 ± 0.051	1.625LysMet: 1.625 ± 0.024	4.846LysAsn: 4.846 ± 0.055	2.814LysPro: 2.814 ± 0.044	2.806LysGln: 2.806 ± 0.038	4.082LysArg: 4.082 ± 0.048	6.125LysSer: 6.125 ± 0.053	4.05LysThr: 4.05 ± 0.048	4.041LysVal: 4.041 ± 0.043	0.578LysTrp: 0.578 ± 0.014	2.838LysTyr: 2.838 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	5.258LeuAla: 5.258 ± 0.052	1.194LeuCys: 1.194 ± 0.023	4.934LeuAsp: 4.934 ± 0.054	5.941LeuGlu: 5.941 ± 0.059	3.414LeuPhe: 3.414 ± 0.042	5.01LeuGly: 5.01 ± 0.043	1.593LeuHis: 1.593 ± 0.026	4.336LeuIle: 4.336 ± 0.048	5.83LeuLys: 5.83 ± 0.056	8.002LeuLeu: 8.002 ± 0.089	1.8LeuMet: 1.8 ± 0.025	4.682LeuAsn: 4.682 ± 0.048	3.715LeuPro: 3.715 ± 0.042	3.12LeuGln: 3.12 ± 0.037	3.714LeuArg: 3.714 ± 0.038	7.655LeuSer: 7.655 ± 0.063	4.174LeuThr: 4.174 ± 0.056	5.557LeuVal: 5.557 ± 0.059	0.671LeuTrp: 0.671 ± 0.016	2.838LeuTyr: 2.838 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	1.465MetAla: 1.465 ± 0.027	0.283MetCys: 0.283 ± 0.01	1.451MetAsp: 1.451 ± 0.022	1.628MetGlu: 1.628 ± 0.025	0.937MetPhe: 0.937 ± 0.019	1.424MetGly: 1.424 ± 0.024	0.397MetHis: 0.397 ± 0.014	1.19MetIle: 1.19 ± 0.021	1.298MetLys: 1.298 ± 0.024	2.015MetLeu: 2.015 ± 0.027	0.578MetMet: 0.578 ± 0.013	1.261MetAsn: 1.261 ± 0.024	0.758MetPro: 0.758 ± 0.018	0.801MetGln: 0.801 ± 0.018	0.966MetArg: 0.966 ± 0.021	1.714MetSer: 1.714 ± 0.023	1.032MetThr: 1.032 ± 0.018	1.554MetVal: 1.554 ± 0.028	0.176MetTrp: 0.176 ± 0.008	0.823MetTyr: 0.823 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.347AsnAla: 3.347 ± 0.034	0.767AsnCys: 0.767 ± 0.019	3.366AsnAsp: 3.366 ± 0.037	3.997AsnGlu: 3.997 ± 0.044	1.94AsnPhe: 1.94 ± 0.029	3.913AsnGly: 3.913 ± 0.05	1.127AsnHis: 1.127 ± 0.02	4.077AsnIle: 4.077 ± 0.042	4.554AsnLys: 4.554 ± 0.051	4.412AsnLeu: 4.412 ± 0.043	1.317AsnMet: 1.317 ± 0.023	5.355AsnAsn: 5.355 ± 0.1	2.947AsnPro: 2.947 ± 0.043	2.273AsnGln: 2.273 ± 0.034	2.758AsnArg: 2.758 ± 0.035	6.453AsnSer: 6.453 ± 0.075	4.695AsnThr: 4.695 ± 0.06	3.439AsnVal: 3.439 ± 0.035	0.452AsnTrp: 0.452 ± 0.013	1.984AsnTyr: 1.984 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	2.498ProAla: 2.498 ± 0.04	0.415ProCys: 0.415 ± 0.016	1.949ProAsp: 1.949 ± 0.03	2.75ProGlu: 2.75 ± 0.035	1.589ProPhe: 1.589 ± 0.026	2.249ProGly: 2.249 ± 0.034	0.89ProHis: 0.89 ± 0.025	2.577ProIle: 2.577 ± 0.033	2.79ProLys: 2.79 ± 0.036	3.251ProLeu: 3.251 ± 0.038	0.756ProMet: 0.756 ± 0.019	2.555ProAsn: 2.555 ± 0.037	2.547ProPro: 2.547 ± 0.066	1.771ProGln: 1.771 ± 0.035	1.662ProArg: 1.662 ± 0.029	4.189ProSer: 4.189 ± 0.058	3.275ProThr: 3.275 ± 0.055	2.669ProVal: 2.669 ± 0.037	0.285ProTrp: 0.285 ± 0.009	1.228ProTyr: 1.228 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	2.063GlnAla: 2.063 ± 0.034	0.382GlnCys: 0.382 ± 0.012	1.801GlnAsp: 1.801 ± 0.026	2.641GlnGlu: 2.641 ± 0.041	1.246GlnPhe: 1.246 ± 0.023	1.832GlnGly: 1.832 ± 0.032	0.915GlnHis: 0.915 ± 0.022	2.063GlnIle: 2.063 ± 0.027	2.796GlnLys: 2.796 ± 0.039	3.498GlnLeu: 3.498 ± 0.039	0.838GlnMet: 0.838 ± 0.018	2.475GlnAsn: 2.475 ± 0.034	1.847GlnPro: 1.847 ± 0.049	3.369GlnGln: 3.369 ± 0.12	1.901GlnArg: 1.901 ± 0.027	3.048GlnSer: 3.048 ± 0.034	2.16GlnThr: 2.16 ± 0.043	2.09GlnVal: 2.09 ± 0.028	0.26GlnTrp: 0.26 ± 0.01	1.258GlnTyr: 1.258 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	2.707ArgAla: 2.707 ± 0.034	0.575ArgCys: 0.575 ± 0.016	2.511ArgAsp: 2.511 ± 0.036	3.079ArgGlu: 3.079 ± 0.049	1.857ArgPhe: 1.857 ± 0.022	2.776ArgGly: 2.776 ± 0.042	0.95ArgHis: 0.95 ± 0.02	3.006ArgIle: 3.006 ± 0.032	3.516ArgLys: 3.516 ± 0.044	4.081ArgLeu: 4.081 ± 0.042	1.086ArgMet: 1.086 ± 0.022	2.794ArgAsn: 2.794 ± 0.034	1.757ArgPro: 1.757 ± 0.034	1.765ArgGln: 1.765 ± 0.031	2.818ArgArg: 2.818 ± 0.04	3.571ArgSer: 3.571 ± 0.045	2.39ArgThr: 2.39 ± 0.034	2.82ArgVal: 2.82 ± 0.03	0.387ArgTrp: 0.387 ± 0.012	1.738ArgTyr: 1.738 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	5.52SerAla: 5.52 ± 0.058	1.139SerCys: 1.139 ± 0.023	5.054SerAsp: 5.054 ± 0.056	5.526SerGlu: 5.526 ± 0.057	3.351SerPhe: 3.351 ± 0.038	6.222SerGly: 6.222 ± 0.059	1.8SerHis: 1.8 ± 0.03	5.617SerIle: 5.617 ± 0.051	6.37SerLys: 6.37 ± 0.06	7.209SerLeu: 7.209 ± 0.066	1.825SerMet: 1.825 ± 0.029	6.045SerAsn: 6.045 ± 0.079	3.794SerPro: 3.794 ± 0.053	3.24SerGln: 3.24 ± 0.04	4.142SerArg: 4.142 ± 0.051	11.484SerSer: 11.484 ± 0.138	7.249SerThr: 7.249 ± 0.107	5.331SerVal: 5.331 ± 0.055	0.68SerTrp: 0.68 ± 0.014	2.595SerTyr: 2.595 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	3.547ThrAla: 3.547 ± 0.048	0.759ThrCys: 0.759 ± 0.018	3.126ThrAsp: 3.126 ± 0.051	3.788ThrGlu: 3.788 ± 0.074	2.2ThrPhe: 2.2 ± 0.031	3.736ThrGly: 3.736 ± 0.043	1.216ThrHis: 1.216 ± 0.022	3.724ThrIle: 3.724 ± 0.07	4.039ThrLys: 4.039 ± 0.05	4.76ThrLeu: 4.76 ± 0.045	1.04ThrMet: 1.04 ± 0.018	4.148ThrAsn: 4.148 ± 0.06	3.2ThrPro: 3.2 ± 0.048	2.372ThrGln: 2.372 ± 0.04	2.641ThrArg: 2.641 ± 0.038	6.451ThrSer: 6.451 ± 0.108	5.352ThrThr: 5.352 ± 0.148	3.611ThrVal: 3.611 ± 0.069	0.415ThrTrp: 0.415 ± 0.013	1.58ThrTyr: 1.58 ± 0.028	0.001ThrXaa: 0.001 ± 0.001
Val	3.668ValAla: 3.668 ± 0.039	0.96ValCys: 0.96 ± 0.021	3.916ValAsp: 3.916 ± 0.037	4.537ValGlu: 4.537 ± 0.05	2.508ValPhe: 2.508 ± 0.034	4.013ValGly: 4.013 ± 0.051	1.133ValHis: 1.133 ± 0.019	3.366ValIle: 3.366 ± 0.036	3.913ValLys: 3.913 ± 0.042	5.299ValLeu: 5.299 ± 0.044	1.254ValMet: 1.254 ± 0.021	3.258ValAsn: 3.258 ± 0.04	2.556ValPro: 2.556 ± 0.039	2.044ValGln: 2.044 ± 0.026	2.395ValArg: 2.395 ± 0.031	5.183ValSer: 5.183 ± 0.05	3.245ValThr: 3.245 ± 0.067	4.444ValVal: 4.444 ± 0.058	0.527ValTrp: 0.527 ± 0.015	2.155ValTyr: 2.155 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.485TrpAla: 0.485 ± 0.014	0.145TrpCys: 0.145 ± 0.007	0.535TrpAsp: 0.535 ± 0.016	0.508TrpGlu: 0.508 ± 0.014	0.359TrpPhe: 0.359 ± 0.011	0.466TrpGly: 0.466 ± 0.014	0.141TrpHis: 0.141 ± 0.006	0.565TrpIle: 0.565 ± 0.016	0.568TrpLys: 0.568 ± 0.016	0.746TrpLeu: 0.746 ± 0.018	0.203TrpMet: 0.203 ± 0.007	0.494TrpAsn: 0.494 ± 0.015	0.246TrpPro: 0.246 ± 0.009	0.233TrpGln: 0.233 ± 0.01	0.415TrpArg: 0.415 ± 0.013	0.612TrpSer: 0.612 ± 0.015	0.398TrpThr: 0.398 ± 0.012	0.497TrpVal: 0.497 ± 0.013	0.131TrpTrp: 0.131 ± 0.006	0.315TrpTyr: 0.315 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.66TyrAla: 1.66 ± 0.024	0.531TyrCys: 0.531 ± 0.017	1.893TyrAsp: 1.893 ± 0.025	2.086TyrGlu: 2.086 ± 0.029	1.521TyrPhe: 1.521 ± 0.023	2.277TyrGly: 2.277 ± 0.034	0.736TyrHis: 0.736 ± 0.018	2.063TyrIle: 2.063 ± 0.032	2.334TyrLys: 2.334 ± 0.031	3.115TyrLeu: 3.115 ± 0.037	0.747TyrMet: 0.747 ± 0.015	2.297TyrAsn: 2.297 ± 0.028	1.512TyrPro: 1.512 ± 0.031	1.227TyrGln: 1.227 ± 0.026	1.584TyrArg: 1.584 ± 0.025	3.236TyrSer: 3.236 ± 0.042	2.027TyrThr: 2.027 ± 0.032	1.823TyrVal: 1.823 ± 0.025	0.302TyrTrp: 0.302 ± 0.011	1.507TyrTyr: 1.507 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.083XaaXaa: 0.083 ± 0.038

Statistics based on 7387 proteins (2891333 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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