Amino acid dipepetide frequency for Bacteroides phage crAss001

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.238AlaAla: 4.238 ± 0.474
0.316AlaCys: 0.316 ± 0.098
3.732AlaAsp: 3.732 ± 0.45
3.701AlaGlu: 3.701 ± 0.436
2.404AlaPhe: 2.404 ± 0.27
3.574AlaGly: 3.574 ± 0.341
0.664AlaHis: 0.664 ± 0.157
4.871AlaIle: 4.871 ± 0.422
4.903AlaLys: 4.903 ± 0.561
5.219AlaLeu: 5.219 ± 0.472
1.835AlaMet: 1.835 ± 0.266
3.764AlaAsn: 3.764 ± 0.399
2.056AlaPro: 2.056 ± 0.338
2.562AlaGln: 2.562 ± 0.364
2.214AlaArg: 2.214 ± 0.261
3.1AlaSer: 3.1 ± 0.323
3.195AlaThr: 3.195 ± 0.389
3.543AlaVal: 3.543 ± 0.349
0.664AlaTrp: 0.664 ± 0.154
2.467AlaTyr: 2.467 ± 0.254
0.0AlaXaa: 0.0 ± 0.0
Cys
0.506CysAla: 0.506 ± 0.171
0.158CysCys: 0.158 ± 0.069
0.474CysAsp: 0.474 ± 0.12
0.569CysGlu: 0.569 ± 0.118
0.285CysPhe: 0.285 ± 0.102
0.917CysGly: 0.917 ± 0.194
0.316CysHis: 0.316 ± 0.104
0.696CysIle: 0.696 ± 0.15
1.012CysLys: 1.012 ± 0.217
0.981CysLeu: 0.981 ± 0.191
0.285CysMet: 0.285 ± 0.105
0.696CysAsn: 0.696 ± 0.177
0.569CysPro: 0.569 ± 0.157
0.253CysGln: 0.253 ± 0.083
0.506CysArg: 0.506 ± 0.146
0.538CysSer: 0.538 ± 0.135
0.474CysThr: 0.474 ± 0.136
0.538CysVal: 0.538 ± 0.129
0.0CysTrp: 0.0 ± 0.0
0.474CysTyr: 0.474 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
3.859AspAla: 3.859 ± 0.446
0.664AspCys: 0.664 ± 0.153
3.163AspAsp: 3.163 ± 0.388
3.827AspGlu: 3.827 ± 0.388
3.163AspPhe: 3.163 ± 0.285
4.333AspGly: 4.333 ± 0.375
0.316AspHis: 0.316 ± 0.087
4.207AspIle: 4.207 ± 0.392
4.839AspLys: 4.839 ± 0.373
4.46AspLeu: 4.46 ± 0.381
1.582AspMet: 1.582 ± 0.269
4.144AspAsn: 4.144 ± 0.379
1.898AspPro: 1.898 ± 0.242
0.949AspGln: 0.949 ± 0.145
3.005AspArg: 3.005 ± 0.315
3.638AspSer: 3.638 ± 0.402
3.954AspThr: 3.954 ± 0.377
3.827AspVal: 3.827 ± 0.364
0.981AspTrp: 0.981 ± 0.159
3.606AspTyr: 3.606 ± 0.338
0.0AspXaa: 0.0 ± 0.0
Glu
4.998GluAla: 4.998 ± 0.484
0.633GluCys: 0.633 ± 0.155
4.681GluAsp: 4.681 ± 0.398
7.338GluGlu: 7.338 ± 0.699
3.732GluPhe: 3.732 ± 0.263
4.998GluGly: 4.998 ± 0.428
1.044GluHis: 1.044 ± 0.2
4.302GluIle: 4.302 ± 0.374
4.713GluLys: 4.713 ± 0.544
6.99GluLeu: 6.99 ± 0.498
2.246GluMet: 2.246 ± 0.273
3.669GluAsn: 3.669 ± 0.411
1.803GluPro: 1.803 ± 0.209
2.625GluGln: 2.625 ± 0.238
3.258GluArg: 3.258 ± 0.332
4.112GluSer: 4.112 ± 0.323
3.543GluThr: 3.543 ± 0.271
4.681GluVal: 4.681 ± 0.417
1.297GluTrp: 1.297 ± 0.197
3.574GluTyr: 3.574 ± 0.352
0.0GluXaa: 0.0 ± 0.0
Phe
1.866PheAla: 1.866 ± 0.211
0.221PheCys: 0.221 ± 0.09
2.878PheAsp: 2.878 ± 0.249
3.068PheGlu: 3.068 ± 0.341
1.835PhePhe: 1.835 ± 0.31
2.404PheGly: 2.404 ± 0.235
0.474PheHis: 0.474 ± 0.103
3.068PheIle: 3.068 ± 0.255
3.827PheLys: 3.827 ± 0.332
3.29PheLeu: 3.29 ± 0.336
1.139PheMet: 1.139 ± 0.169
3.384PheAsn: 3.384 ± 0.322
1.392PhePro: 1.392 ± 0.186
1.518PheGln: 1.518 ± 0.223
1.771PheArg: 1.771 ± 0.211
2.783PheSer: 2.783 ± 0.27
2.436PheThr: 2.436 ± 0.282
2.657PheVal: 2.657 ± 0.291
0.443PheTrp: 0.443 ± 0.123
1.676PheTyr: 1.676 ± 0.164
0.0PheXaa: 0.0 ± 0.0
Gly
3.384GlyAla: 3.384 ± 0.411
0.601GlyCys: 0.601 ± 0.171
3.796GlyAsp: 3.796 ± 0.397
4.713GlyGlu: 4.713 ± 0.366
2.594GlyPhe: 2.594 ± 0.312
4.175GlyGly: 4.175 ± 0.589
0.664GlyHis: 0.664 ± 0.126
4.618GlyIle: 4.618 ± 0.326
5.44GlyLys: 5.44 ± 0.461
4.934GlyLeu: 4.934 ± 0.494
1.518GlyMet: 1.518 ± 0.23
3.891GlyAsn: 3.891 ± 0.426
0.886GlyPro: 0.886 ± 0.164
1.961GlyGln: 1.961 ± 0.276
2.467GlyArg: 2.467 ± 0.304
3.543GlySer: 3.543 ± 0.404
4.238GlyThr: 4.238 ± 0.51
4.238GlyVal: 4.238 ± 0.283
0.791GlyTrp: 0.791 ± 0.129
3.29GlyTyr: 3.29 ± 0.436
0.0GlyXaa: 0.0 ± 0.0
His
0.601HisAla: 0.601 ± 0.156
0.221HisCys: 0.221 ± 0.081
0.411HisAsp: 0.411 ± 0.106
0.728HisGlu: 0.728 ± 0.173
0.696HisPhe: 0.696 ± 0.135
0.506HisGly: 0.506 ± 0.12
0.095HisHis: 0.095 ± 0.048
0.949HisIle: 0.949 ± 0.21
1.202HisLys: 1.202 ± 0.18
0.949HisLeu: 0.949 ± 0.173
0.253HisMet: 0.253 ± 0.087
0.822HisAsn: 0.822 ± 0.167
0.569HisPro: 0.569 ± 0.134
0.221HisGln: 0.221 ± 0.08
0.791HisArg: 0.791 ± 0.171
0.601HisSer: 0.601 ± 0.124
0.728HisThr: 0.728 ± 0.15
0.791HisVal: 0.791 ± 0.15
0.285HisTrp: 0.285 ± 0.092
0.728HisTyr: 0.728 ± 0.168
0.0HisXaa: 0.0 ± 0.0
Ile
3.638IleAla: 3.638 ± 0.349
0.822IleCys: 0.822 ± 0.18
5.314IleAsp: 5.314 ± 0.406
4.586IleGlu: 4.586 ± 0.318
2.309IlePhe: 2.309 ± 0.32
3.859IleGly: 3.859 ± 0.33
1.012IleHis: 1.012 ± 0.196
5.093IleIle: 5.093 ± 0.504
5.44IleLys: 5.44 ± 0.468
4.966IleLeu: 4.966 ± 0.384
1.74IleMet: 1.74 ± 0.216
4.934IleAsn: 4.934 ± 0.348
3.005IlePro: 3.005 ± 0.253
2.625IleGln: 2.625 ± 0.276
2.91IleArg: 2.91 ± 0.335
5.029IleSer: 5.029 ± 0.543
4.839IleThr: 4.839 ± 0.47
4.713IleVal: 4.713 ± 0.486
0.569IleTrp: 0.569 ± 0.142
3.448IleTyr: 3.448 ± 0.424
0.0IleXaa: 0.0 ± 0.0
Lys
4.586LysAla: 4.586 ± 0.436
0.854LysCys: 0.854 ± 0.201
4.808LysAsp: 4.808 ± 0.356
7.528LysGlu: 7.528 ± 0.803
2.689LysPhe: 2.689 ± 0.309
4.808LysGly: 4.808 ± 0.317
0.791LysHis: 0.791 ± 0.181
4.808LysIle: 4.808 ± 0.328
5.82LysLys: 5.82 ± 0.531
5.757LysLeu: 5.757 ± 0.551
1.961LysMet: 1.961 ± 0.241
3.891LysAsn: 3.891 ± 0.29
2.183LysPro: 2.183 ± 0.228
2.847LysGln: 2.847 ± 0.309
3.606LysArg: 3.606 ± 0.387
4.365LysSer: 4.365 ± 0.487
4.365LysThr: 4.365 ± 0.468
5.725LysVal: 5.725 ± 0.375
1.139LysTrp: 1.139 ± 0.201
4.428LysTyr: 4.428 ± 0.458
0.0LysXaa: 0.0 ± 0.0
Leu
5.124LeuAla: 5.124 ± 0.491
1.297LeuCys: 1.297 ± 0.222
4.681LeuAsp: 4.681 ± 0.402
5.788LeuGlu: 5.788 ± 0.479
3.448LeuPhe: 3.448 ± 0.298
4.618LeuGly: 4.618 ± 0.402
1.328LeuHis: 1.328 ± 0.184
5.567LeuIle: 5.567 ± 0.455
5.82LeuLys: 5.82 ± 0.447
5.852LeuLeu: 5.852 ± 0.533
1.645LeuMet: 1.645 ± 0.255
5.852LeuAsn: 5.852 ± 0.611
3.068LeuPro: 3.068 ± 0.284
3.1LeuGln: 3.1 ± 0.348
4.112LeuArg: 4.112 ± 0.359
6.231LeuSer: 6.231 ± 0.403
4.017LeuThr: 4.017 ± 0.305
4.618LeuVal: 4.618 ± 0.383
1.075LeuTrp: 1.075 ± 0.199
3.543LeuTyr: 3.543 ± 0.264
0.0LeuXaa: 0.0 ± 0.0
Met
2.024MetAla: 2.024 ± 0.282
0.253MetCys: 0.253 ± 0.094
1.487MetAsp: 1.487 ± 0.228
1.613MetGlu: 1.613 ± 0.248
1.139MetPhe: 1.139 ± 0.201
1.455MetGly: 1.455 ± 0.195
0.348MetHis: 0.348 ± 0.117
1.55MetIle: 1.55 ± 0.288
2.309MetLys: 2.309 ± 0.33
2.277MetLeu: 2.277 ± 0.286
0.759MetMet: 0.759 ± 0.124
2.024MetAsn: 2.024 ± 0.3
0.633MetPro: 0.633 ± 0.13
0.981MetGln: 0.981 ± 0.174
0.759MetArg: 0.759 ± 0.169
1.676MetSer: 1.676 ± 0.253
1.518MetThr: 1.518 ± 0.226
1.55MetVal: 1.55 ± 0.224
0.316MetTrp: 0.316 ± 0.093
0.917MetTyr: 0.917 ± 0.187
0.0MetXaa: 0.0 ± 0.0
Asn
3.985AsnAla: 3.985 ± 0.408
0.759AsnCys: 0.759 ± 0.236
3.321AsnAsp: 3.321 ± 0.357
3.985AsnGlu: 3.985 ± 0.328
2.341AsnPhe: 2.341 ± 0.274
4.523AsnGly: 4.523 ± 0.447
0.854AsnHis: 0.854 ± 0.184
5.377AsnIle: 5.377 ± 0.605
4.302AsnLys: 4.302 ± 0.298
5.883AsnLeu: 5.883 ± 0.303
1.803AsnMet: 1.803 ± 0.271
5.662AsnAsn: 5.662 ± 0.509
3.701AsnPro: 3.701 ± 0.307
2.024AsnGln: 2.024 ± 0.267
2.752AsnArg: 2.752 ± 0.271
4.46AsnSer: 4.46 ± 0.531
3.669AsnThr: 3.669 ± 0.406
2.625AsnVal: 2.625 ± 0.272
0.759AsnTrp: 0.759 ± 0.144
3.922AsnTyr: 3.922 ± 0.349
0.0AsnXaa: 0.0 ± 0.0
Pro
2.056ProAla: 2.056 ± 0.223
0.411ProCys: 0.411 ± 0.133
2.119ProAsp: 2.119 ± 0.272
2.878ProGlu: 2.878 ± 0.336
1.708ProPhe: 1.708 ± 0.237
0.601ProGly: 0.601 ± 0.12
0.443ProHis: 0.443 ± 0.126
2.183ProIle: 2.183 ± 0.271
2.467ProLys: 2.467 ± 0.322
2.815ProLeu: 2.815 ± 0.299
0.664ProMet: 0.664 ± 0.157
2.847ProAsn: 2.847 ± 0.261
0.38ProPro: 0.38 ± 0.11
1.487ProGln: 1.487 ± 0.22
0.949ProArg: 0.949 ± 0.164
2.53ProSer: 2.53 ± 0.245
2.088ProThr: 2.088 ± 0.274
2.467ProVal: 2.467 ± 0.296
0.506ProTrp: 0.506 ± 0.107
1.582ProTyr: 1.582 ± 0.221
0.0ProXaa: 0.0 ± 0.0
Gln
3.479GlnAla: 3.479 ± 0.396
0.316GlnCys: 0.316 ± 0.097
1.803GlnAsp: 1.803 ± 0.206
3.005GlnGlu: 3.005 ± 0.411
1.676GlnPhe: 1.676 ± 0.2
2.246GlnGly: 2.246 ± 0.303
0.633GlnHis: 0.633 ± 0.144
2.341GlnIle: 2.341 ± 0.31
2.562GlnLys: 2.562 ± 0.26
2.847GlnLeu: 2.847 ± 0.295
0.664GlnMet: 0.664 ± 0.176
1.708GlnAsn: 1.708 ± 0.236
0.696GlnPro: 0.696 ± 0.125
1.392GlnGln: 1.392 ± 0.284
1.929GlnArg: 1.929 ± 0.25
2.341GlnSer: 2.341 ± 0.236
1.74GlnThr: 1.74 ± 0.217
2.214GlnVal: 2.214 ± 0.244
0.348GlnTrp: 0.348 ± 0.103
1.961GlnTyr: 1.961 ± 0.252
0.0GlnXaa: 0.0 ± 0.0
Arg
2.657ArgAla: 2.657 ± 0.294
0.38ArgCys: 0.38 ± 0.094
2.689ArgAsp: 2.689 ± 0.327
3.543ArgGlu: 3.543 ± 0.477
1.803ArgPhe: 1.803 ± 0.222
2.404ArgGly: 2.404 ± 0.248
0.411ArgHis: 0.411 ± 0.11
2.942ArgIle: 2.942 ± 0.275
3.511ArgLys: 3.511 ± 0.366
4.555ArgLeu: 4.555 ± 0.488
1.17ArgMet: 1.17 ± 0.214
2.657ArgAsn: 2.657 ± 0.228
1.234ArgPro: 1.234 ± 0.242
2.056ArgGln: 2.056 ± 0.218
2.341ArgArg: 2.341 ± 0.304
1.74ArgSer: 1.74 ± 0.253
2.119ArgThr: 2.119 ± 0.255
3.479ArgVal: 3.479 ± 0.31
0.569ArgTrp: 0.569 ± 0.093
2.119ArgTyr: 2.119 ± 0.279
0.0ArgXaa: 0.0 ± 0.0
Ser
3.037SerAla: 3.037 ± 0.336
0.569SerCys: 0.569 ± 0.141
3.669SerAsp: 3.669 ± 0.279
4.934SerGlu: 4.934 ± 0.377
2.815SerPhe: 2.815 ± 0.275
4.049SerGly: 4.049 ± 0.357
0.791SerHis: 0.791 ± 0.158
4.523SerIle: 4.523 ± 0.493
4.523SerLys: 4.523 ± 0.332
5.093SerLeu: 5.093 ± 0.381
1.835SerMet: 1.835 ± 0.256
4.08SerAsn: 4.08 ± 0.517
2.72SerPro: 2.72 ± 0.297
2.372SerGln: 2.372 ± 0.305
2.499SerArg: 2.499 ± 0.258
4.555SerSer: 4.555 ± 0.398
4.175SerThr: 4.175 ± 0.379
3.574SerVal: 3.574 ± 0.32
0.759SerTrp: 0.759 ± 0.167
3.163SerTyr: 3.163 ± 0.406
0.0SerXaa: 0.0 ± 0.0
Thr
3.005ThrAla: 3.005 ± 0.374
0.411ThrCys: 0.411 ± 0.114
3.1ThrAsp: 3.1 ± 0.319
3.985ThrGlu: 3.985 ± 0.366
2.594ThrPhe: 2.594 ± 0.283
4.27ThrGly: 4.27 ± 0.4
0.633ThrHis: 0.633 ± 0.131
4.333ThrIle: 4.333 ± 0.409
4.175ThrLys: 4.175 ± 0.367
4.808ThrLeu: 4.808 ± 0.399
1.265ThrMet: 1.265 ± 0.205
3.574ThrAsn: 3.574 ± 0.412
2.752ThrPro: 2.752 ± 0.305
2.436ThrGln: 2.436 ± 0.309
2.372ThrArg: 2.372 ± 0.241
3.732ThrSer: 3.732 ± 0.386
3.669ThrThr: 3.669 ± 0.465
3.479ThrVal: 3.479 ± 0.33
0.696ThrTrp: 0.696 ± 0.154
2.783ThrTyr: 2.783 ± 0.292
0.0ThrXaa: 0.0 ± 0.0
Val
3.701ValAla: 3.701 ± 0.417
0.538ValCys: 0.538 ± 0.144
4.397ValAsp: 4.397 ± 0.37
4.397ValGlu: 4.397 ± 0.393
1.803ValPhe: 1.803 ± 0.269
4.049ValGly: 4.049 ± 0.417
0.664ValHis: 0.664 ± 0.125
4.618ValIle: 4.618 ± 0.433
4.871ValLys: 4.871 ± 0.499
4.776ValLeu: 4.776 ± 0.355
1.518ValMet: 1.518 ± 0.209
3.732ValAsn: 3.732 ± 0.394
2.277ValPro: 2.277 ± 0.286
2.088ValGln: 2.088 ± 0.277
3.258ValArg: 3.258 ± 0.309
3.954ValSer: 3.954 ± 0.306
3.859ValThr: 3.859 ± 0.395
4.207ValVal: 4.207 ± 0.399
0.664ValTrp: 0.664 ± 0.135
2.689ValTyr: 2.689 ± 0.307
0.0ValXaa: 0.0 ± 0.0
Trp
0.506TrpAla: 0.506 ± 0.119
0.158TrpCys: 0.158 ± 0.064
0.917TrpAsp: 0.917 ± 0.139
1.17TrpGlu: 1.17 ± 0.192
0.791TrpPhe: 0.791 ± 0.151
0.664TrpGly: 0.664 ± 0.163
0.095TrpHis: 0.095 ± 0.054
0.633TrpIle: 0.633 ± 0.135
0.728TrpLys: 0.728 ± 0.153
1.17TrpLeu: 1.17 ± 0.171
0.316TrpMet: 0.316 ± 0.113
1.36TrpAsn: 1.36 ± 0.197
0.0TrpPro: 0.0 ± 0.0
0.538TrpGln: 0.538 ± 0.116
0.791TrpArg: 0.791 ± 0.17
0.759TrpSer: 0.759 ± 0.163
0.728TrpThr: 0.728 ± 0.158
0.633TrpVal: 0.633 ± 0.141
0.032TrpTrp: 0.032 ± 0.033
0.538TrpTyr: 0.538 ± 0.13
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.771TyrAla: 1.771 ± 0.234
0.664TyrCys: 0.664 ± 0.179
2.973TyrAsp: 2.973 ± 0.311
2.878TyrGlu: 2.878 ± 0.259
2.309TyrPhe: 2.309 ± 0.264
3.29TyrGly: 3.29 ± 0.255
0.569TyrHis: 0.569 ± 0.143
4.175TyrIle: 4.175 ± 0.392
4.492TyrLys: 4.492 ± 0.415
3.163TyrLeu: 3.163 ± 0.278
1.392TyrMet: 1.392 ± 0.188
4.017TyrAsn: 4.017 ± 0.345
1.36TyrPro: 1.36 ± 0.217
1.866TyrGln: 1.866 ± 0.201
2.088TyrArg: 2.088 ± 0.319
4.049TyrSer: 4.049 ± 0.385
2.72TyrThr: 2.72 ± 0.329
2.499TyrVal: 2.499 ± 0.336
0.633TyrTrp: 0.633 ± 0.163
2.404TyrTyr: 2.404 ± 0.299
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 104 proteins (31616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski