Amino acid dipepetide frequency for Streptococcus criceti HS-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.909AlaAla: 6.909 ± 0.191
0.505AlaCys: 0.505 ± 0.03
5.26AlaAsp: 5.26 ± 0.098
4.819AlaGlu: 4.819 ± 0.11
3.358AlaPhe: 3.358 ± 0.07
5.927AlaGly: 5.927 ± 0.125
1.386AlaHis: 1.386 ± 0.048
6.071AlaIle: 6.071 ± 0.101
5.721AlaLys: 5.721 ± 0.119
7.879AlaLeu: 7.879 ± 0.143
1.984AlaMet: 1.984 ± 0.058
3.365AlaAsn: 3.365 ± 0.084
2.506AlaPro: 2.506 ± 0.078
3.934AlaGln: 3.934 ± 0.096
2.954AlaArg: 2.954 ± 0.068
4.989AlaSer: 4.989 ± 0.105
4.199AlaThr: 4.199 ± 0.148
5.783AlaVal: 5.783 ± 0.109
0.655AlaTrp: 0.655 ± 0.034
3.087AlaTyr: 3.087 ± 0.097
0.0AlaXaa: 0.0 ± 0.0
Cys
0.313CysAla: 0.313 ± 0.025
0.05CysCys: 0.05 ± 0.009
0.272CysAsp: 0.272 ± 0.022
0.183CysGlu: 0.183 ± 0.018
0.251CysPhe: 0.251 ± 0.021
0.493CysGly: 0.493 ± 0.027
0.179CysHis: 0.179 ± 0.019
0.262CysIle: 0.262 ± 0.022
0.191CysLys: 0.191 ± 0.016
0.636CysLeu: 0.636 ± 0.036
0.11CysMet: 0.11 ± 0.013
0.169CysAsn: 0.169 ± 0.016
0.271CysPro: 0.271 ± 0.02
0.368CysGln: 0.368 ± 0.023
0.25CysArg: 0.25 ± 0.021
0.306CysSer: 0.306 ± 0.022
0.236CysThr: 0.236 ± 0.019
0.275CysVal: 0.275 ± 0.022
0.044CysTrp: 0.044 ± 0.009
0.227CysTyr: 0.227 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.81AspAla: 3.81 ± 0.085
0.35AspCys: 0.35 ± 0.024
3.468AspAsp: 3.468 ± 0.101
3.719AspGlu: 3.719 ± 0.084
3.459AspPhe: 3.459 ± 0.074
4.421AspGly: 4.421 ± 0.183
1.096AspHis: 1.096 ± 0.04
4.317AspIle: 4.317 ± 0.079
4.579AspLys: 4.579 ± 0.097
6.204AspLeu: 6.204 ± 0.113
1.562AspMet: 1.562 ± 0.051
2.76AspAsn: 2.76 ± 0.076
1.82AspPro: 1.82 ± 0.064
2.79AspGln: 2.79 ± 0.08
2.326AspArg: 2.326 ± 0.07
3.663AspSer: 3.663 ± 0.084
2.917AspThr: 2.917 ± 0.071
3.751AspVal: 3.751 ± 0.084
0.802AspTrp: 0.802 ± 0.04
3.271AspTyr: 3.271 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
5.412GluAla: 5.412 ± 0.104
0.191GluCys: 0.191 ± 0.016
3.622GluAsp: 3.622 ± 0.092
5.03GluGlu: 5.03 ± 0.118
2.298GluPhe: 2.298 ± 0.063
3.43GluGly: 3.43 ± 0.082
1.167GluHis: 1.167 ± 0.043
4.424GluIle: 4.424 ± 0.099
4.83GluLys: 4.83 ± 0.102
6.128GluLeu: 6.128 ± 0.116
1.63GluMet: 1.63 ± 0.056
3.314GluAsn: 3.314 ± 0.067
1.693GluPro: 1.693 ± 0.074
2.701GluGln: 2.701 ± 0.079
2.984GluArg: 2.984 ± 0.068
3.078GluSer: 3.078 ± 0.071
3.538GluThr: 3.538 ± 0.078
4.288GluVal: 4.288 ± 0.093
0.536GluTrp: 0.536 ± 0.031
1.674GluTyr: 1.674 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.509PheAla: 3.509 ± 0.084
0.236PheCys: 0.236 ± 0.018
3.058PheAsp: 3.058 ± 0.081
2.687PheGlu: 2.687 ± 0.071
2.044PhePhe: 2.044 ± 0.07
3.096PheGly: 3.096 ± 0.081
0.749PheHis: 0.749 ± 0.034
3.035PheIle: 3.035 ± 0.084
2.601PheLys: 2.601 ± 0.066
4.405PheLeu: 4.405 ± 0.098
1.027PheMet: 1.027 ± 0.043
1.976PheAsn: 1.976 ± 0.056
1.527PhePro: 1.527 ± 0.05
1.578PheGln: 1.578 ± 0.053
1.487PheArg: 1.487 ± 0.046
3.099PheSer: 3.099 ± 0.074
2.459PheThr: 2.459 ± 0.06
2.928PheVal: 2.928 ± 0.069
0.508PheTrp: 0.508 ± 0.028
1.852PheTyr: 1.852 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.945GlyAla: 4.945 ± 0.107
0.402GlyCys: 0.402 ± 0.025
3.771GlyAsp: 3.771 ± 0.089
3.235GlyGlu: 3.235 ± 0.073
3.29GlyPhe: 3.29 ± 0.074
4.317GlyGly: 4.317 ± 0.099
1.554GlyHis: 1.554 ± 0.045
5.099GlyIle: 5.099 ± 0.102
4.726GlyLys: 4.726 ± 0.117
7.095GlyLeu: 7.095 ± 0.112
1.775GlyMet: 1.775 ± 0.057
2.705GlyAsn: 2.705 ± 0.078
1.522GlyPro: 1.522 ± 0.048
3.674GlyGln: 3.674 ± 0.091
2.925GlyArg: 2.925 ± 0.073
4.101GlySer: 4.101 ± 0.099
3.848GlyThr: 3.848 ± 0.096
4.642GlyVal: 4.642 ± 0.101
0.775GlyTrp: 0.775 ± 0.033
2.804GlyTyr: 2.804 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.253HisAla: 1.253 ± 0.043
0.123HisCys: 0.123 ± 0.013
1.056HisAsp: 1.056 ± 0.042
0.985HisGlu: 0.985 ± 0.037
1.08HisPhe: 1.08 ± 0.051
1.282HisGly: 1.282 ± 0.046
0.56HisHis: 0.56 ± 0.029
1.283HisIle: 1.283 ± 0.043
1.092HisLys: 1.092 ± 0.048
2.173HisLeu: 2.173 ± 0.065
0.406HisMet: 0.406 ± 0.025
0.772HisAsn: 0.772 ± 0.035
0.888HisPro: 0.888 ± 0.041
0.95HisGln: 0.95 ± 0.036
0.847HisArg: 0.847 ± 0.036
0.999HisSer: 0.999 ± 0.037
0.94HisThr: 0.94 ± 0.04
1.094HisVal: 1.094 ± 0.046
0.256HisTrp: 0.256 ± 0.02
1.059HisTyr: 1.059 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.82IleAla: 5.82 ± 0.112
0.522IleCys: 0.522 ± 0.027
4.231IleAsp: 4.231 ± 0.081
4.291IleGlu: 4.291 ± 0.09
3.397IlePhe: 3.397 ± 0.093
4.772IleGly: 4.772 ± 0.093
1.2IleHis: 1.2 ± 0.041
4.862IleIle: 4.862 ± 0.112
4.499IleLys: 4.499 ± 0.101
7.022IleLeu: 7.022 ± 0.141
1.631IleMet: 1.631 ± 0.055
3.129IleAsn: 3.129 ± 0.075
2.748IlePro: 2.748 ± 0.072
2.308IleGln: 2.308 ± 0.068
2.702IleArg: 2.702 ± 0.072
4.871IleSer: 4.871 ± 0.094
3.972IleThr: 3.972 ± 0.108
4.565IleVal: 4.565 ± 0.092
0.631IleTrp: 0.631 ± 0.032
2.565IleTyr: 2.565 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
5.579LysAla: 5.579 ± 0.13
0.163LysCys: 0.163 ± 0.017
4.415LysAsp: 4.415 ± 0.102
5.281LysGlu: 5.281 ± 0.101
2.065LysPhe: 2.065 ± 0.058
4.011LysGly: 4.011 ± 0.093
1.129LysHis: 1.129 ± 0.04
4.697LysIle: 4.697 ± 0.097
5.243LysLys: 5.243 ± 0.134
5.751LysLeu: 5.751 ± 0.092
1.817LysMet: 1.817 ± 0.058
3.356LysAsn: 3.356 ± 0.071
2.103LysPro: 2.103 ± 0.059
2.743LysGln: 2.743 ± 0.068
3.066LysArg: 3.066 ± 0.081
3.99LysSer: 3.99 ± 0.078
4.107LysThr: 4.107 ± 0.095
4.435LysVal: 4.435 ± 0.085
0.623LysTrp: 0.623 ± 0.032
2.202LysTyr: 2.202 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
9.625LeuAla: 9.625 ± 0.144
0.477LeuCys: 0.477 ± 0.029
5.933LeuAsp: 5.933 ± 0.118
6.405LeuGlu: 6.405 ± 0.116
4.037LeuPhe: 4.037 ± 0.106
6.741LeuGly: 6.741 ± 0.134
1.604LeuHis: 1.604 ± 0.052
6.817LeuIle: 6.817 ± 0.139
6.319LeuLys: 6.319 ± 0.1
9.726LeuLeu: 9.726 ± 0.177
2.426LeuMet: 2.426 ± 0.073
4.098LeuAsn: 4.098 ± 0.084
4.045LeuPro: 4.045 ± 0.085
3.344LeuGln: 3.344 ± 0.079
3.79LeuArg: 3.79 ± 0.087
7.142LeuSer: 7.142 ± 0.12
6.361LeuThr: 6.361 ± 0.106
6.979LeuVal: 6.979 ± 0.126
0.732LeuTrp: 0.732 ± 0.038
3.02LeuTyr: 3.02 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.27MetAla: 2.27 ± 0.066
0.113MetCys: 0.113 ± 0.014
1.357MetAsp: 1.357 ± 0.053
1.332MetGlu: 1.332 ± 0.045
0.761MetPhe: 0.761 ± 0.037
1.708MetGly: 1.708 ± 0.061
0.321MetHis: 0.321 ± 0.021
1.829MetIle: 1.829 ± 0.053
1.696MetLys: 1.696 ± 0.054
2.127MetLeu: 2.127 ± 0.069
0.669MetMet: 0.669 ± 0.03
1.136MetAsn: 1.136 ± 0.039
0.903MetPro: 0.903 ± 0.036
0.859MetGln: 0.859 ± 0.034
0.902MetArg: 0.902 ± 0.038
1.669MetSer: 1.669 ± 0.052
2.022MetThr: 2.022 ± 0.057
1.672MetVal: 1.672 ± 0.05
0.162MetTrp: 0.162 ± 0.016
0.583MetTyr: 0.583 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.97AsnAla: 2.97 ± 0.084
0.257AsnCys: 0.257 ± 0.02
2.509AsnAsp: 2.509 ± 0.055
2.205AsnGlu: 2.205 ± 0.062
2.047AsnPhe: 2.047 ± 0.063
3.382AsnGly: 3.382 ± 0.095
1.123AsnHis: 1.123 ± 0.038
2.964AsnIle: 2.964 ± 0.075
2.739AsnLys: 2.739 ± 0.072
4.591AsnLeu: 4.591 ± 0.089
1.106AsnMet: 1.106 ± 0.042
2.038AsnAsn: 2.038 ± 0.084
2.295AsnPro: 2.295 ± 0.061
2.572AsnGln: 2.572 ± 0.067
2.068AsnArg: 2.068 ± 0.06
2.659AsnSer: 2.659 ± 0.071
2.114AsnThr: 2.114 ± 0.064
2.43AsnVal: 2.43 ± 0.063
0.537AsnTrp: 0.537 ± 0.029
1.876AsnTyr: 1.876 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.884ProAla: 2.884 ± 0.086
0.145ProCys: 0.145 ± 0.015
2.569ProAsp: 2.569 ± 0.071
2.789ProGlu: 2.789 ± 0.075
1.53ProPhe: 1.53 ± 0.055
1.73ProGly: 1.73 ± 0.054
0.701ProHis: 0.701 ± 0.04
2.386ProIle: 2.386 ± 0.072
2.303ProLys: 2.303 ± 0.062
3.117ProLeu: 3.117 ± 0.074
0.719ProMet: 0.719 ± 0.035
1.792ProAsn: 1.792 ± 0.061
0.708ProPro: 0.708 ± 0.054
1.536ProGln: 1.536 ± 0.053
1.132ProArg: 1.132 ± 0.045
2.329ProSer: 2.329 ± 0.069
2.09ProThr: 2.09 ± 0.08
2.648ProVal: 2.648 ± 0.068
0.297ProTrp: 0.297 ± 0.021
1.327ProTyr: 1.327 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.954GlnAla: 4.954 ± 0.133
0.123GlnCys: 0.123 ± 0.014
2.497GlnAsp: 2.497 ± 0.064
3.518GlnGlu: 3.518 ± 0.085
1.592GlnPhe: 1.592 ± 0.051
2.768GlnGly: 2.768 ± 0.079
0.725GlnHis: 0.725 ± 0.033
2.855GlnIle: 2.855 ± 0.062
3.031GlnLys: 3.031 ± 0.07
4.185GlnLeu: 4.185 ± 0.088
1.038GlnMet: 1.038 ± 0.037
1.835GlnAsn: 1.835 ± 0.053
1.627GlnPro: 1.627 ± 0.079
1.698GlnGln: 1.698 ± 0.063
1.646GlnArg: 1.646 ± 0.057
2.42GlnSer: 2.42 ± 0.072
2.854GlnThr: 2.854 ± 0.07
3.494GlnVal: 3.494 ± 0.069
0.387GlnTrp: 0.387 ± 0.026
1.407GlnTyr: 1.407 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.668ArgAla: 2.668 ± 0.073
0.189ArgCys: 0.189 ± 0.019
2.456ArgAsp: 2.456 ± 0.064
2.73ArgGlu: 2.73 ± 0.067
1.902ArgPhe: 1.902 ± 0.056
2.245ArgGly: 2.245 ± 0.061
0.909ArgHis: 0.909 ± 0.04
2.851ArgIle: 2.851 ± 0.071
2.852ArgLys: 2.852 ± 0.072
4.303ArgLeu: 4.303 ± 0.079
0.994ArgMet: 0.994 ± 0.046
1.708ArgAsn: 1.708 ± 0.054
1.395ArgPro: 1.395 ± 0.05
2.309ArgGln: 2.309 ± 0.066
2.055ArgArg: 2.055 ± 0.064
2.22ArgSer: 2.22 ± 0.063
1.94ArgThr: 1.94 ± 0.055
2.707ArgVal: 2.707 ± 0.075
0.331ArgTrp: 0.331 ± 0.024
1.695ArgTyr: 1.695 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.571SerAla: 4.571 ± 0.125
0.307SerCys: 0.307 ± 0.024
3.868SerAsp: 3.868 ± 0.088
3.324SerGlu: 3.324 ± 0.091
2.943SerPhe: 2.943 ± 0.071
4.745SerGly: 4.745 ± 0.093
1.413SerHis: 1.413 ± 0.052
4.005SerIle: 4.005 ± 0.079
3.865SerLys: 3.865 ± 0.084
6.72SerLeu: 6.72 ± 0.105
1.366SerMet: 1.366 ± 0.041
2.718SerAsn: 2.718 ± 0.071
2.094SerPro: 2.094 ± 0.059
3.769SerGln: 3.769 ± 0.088
2.58SerArg: 2.58 ± 0.062
4.548SerSer: 4.548 ± 0.139
3.169SerThr: 3.169 ± 0.087
4.011SerVal: 4.011 ± 0.083
0.616SerTrp: 0.616 ± 0.034
2.699SerTyr: 2.699 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
4.674ThrAla: 4.674 ± 0.114
0.265ThrCys: 0.265 ± 0.02
3.509ThrAsp: 3.509 ± 0.095
2.96ThrGlu: 2.96 ± 0.078
2.507ThrPhe: 2.507 ± 0.067
4.559ThrGly: 4.559 ± 0.107
0.984ThrHis: 0.984 ± 0.037
4.34ThrIle: 4.34 ± 0.094
3.498ThrLys: 3.498 ± 0.082
5.372ThrLeu: 5.372 ± 0.093
1.209ThrMet: 1.209 ± 0.045
2.489ThrAsn: 2.489 ± 0.074
2.36ThrPro: 2.36 ± 0.075
2.126ThrGln: 2.126 ± 0.061
1.822ThrArg: 1.822 ± 0.052
3.612ThrSer: 3.612 ± 0.083
3.147ThrThr: 3.147 ± 0.093
4.588ThrVal: 4.588 ± 0.125
0.545ThrTrp: 0.545 ± 0.03
2.519ThrTyr: 2.519 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
5.885ValAla: 5.885 ± 0.116
0.384ValCys: 0.384 ± 0.025
4.098ValAsp: 4.098 ± 0.079
3.924ValGlu: 3.924 ± 0.075
2.825ValPhe: 2.825 ± 0.068
4.355ValGly: 4.355 ± 0.086
1.148ValHis: 1.148 ± 0.046
4.763ValIle: 4.763 ± 0.091
4.4ValLys: 4.4 ± 0.084
6.736ValLeu: 6.736 ± 0.122
1.595ValMet: 1.595 ± 0.058
2.969ValAsn: 2.969 ± 0.071
2.595ValPro: 2.595 ± 0.069
2.386ValGln: 2.386 ± 0.065
2.737ValArg: 2.737 ± 0.071
4.644ValSer: 4.644 ± 0.088
4.629ValThr: 4.629 ± 0.119
4.506ValVal: 4.506 ± 0.096
0.567ValTrp: 0.567 ± 0.035
2.32ValTyr: 2.32 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.616TrpAla: 0.616 ± 0.032
0.051TrpCys: 0.051 ± 0.01
0.48TrpAsp: 0.48 ± 0.026
0.513TrpGlu: 0.513 ± 0.026
0.471TrpPhe: 0.471 ± 0.027
0.666TrpGly: 0.666 ± 0.034
0.225TrpHis: 0.225 ± 0.019
0.572TrpIle: 0.572 ± 0.033
0.519TrpLys: 0.519 ± 0.031
1.165TrpLeu: 1.165 ± 0.041
0.239TrpMet: 0.239 ± 0.022
0.504TrpAsn: 0.504 ± 0.027
0.221TrpPro: 0.221 ± 0.017
0.602TrpGln: 0.602 ± 0.035
0.421TrpArg: 0.421 ± 0.027
0.642TrpSer: 0.642 ± 0.034
0.558TrpThr: 0.558 ± 0.027
0.537TrpVal: 0.537 ± 0.03
0.144TrpTrp: 0.144 ± 0.015
0.399TrpTyr: 0.399 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.624TyrAla: 2.624 ± 0.064
0.232TyrCys: 0.232 ± 0.021
2.657TyrAsp: 2.657 ± 0.088
2.038TyrGlu: 2.038 ± 0.068
2.005TyrPhe: 2.005 ± 0.068
2.556TyrGly: 2.556 ± 0.072
0.926TyrHis: 0.926 ± 0.04
2.305TyrIle: 2.305 ± 0.063
2.076TyrLys: 2.076 ± 0.058
4.284TyrLeu: 4.284 ± 0.083
0.788TyrMet: 0.788 ± 0.034
1.649TyrAsn: 1.649 ± 0.055
1.407TyrPro: 1.407 ± 0.045
2.404TyrGln: 2.404 ± 0.071
1.766TyrArg: 1.766 ± 0.058
2.354TyrSer: 2.354 ± 0.065
1.987TyrThr: 1.987 ± 0.062
2.132TyrVal: 2.132 ± 0.057
0.396TyrTrp: 0.396 ± 0.024
1.838TyrTyr: 1.838 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2261 proteins (660879 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski