Amino acid dipepetide frequency for Candidatus Doolittlea endobia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.302AlaAla: 7.302 ± 0.201
1.119AlaCys: 1.119 ± 0.085
4.357AlaAsp: 4.357 ± 0.19
4.89AlaGlu: 4.89 ± 0.192
2.837AlaPhe: 2.837 ± 0.137
5.907AlaGly: 5.907 ± 0.184
1.49AlaHis: 1.49 ± 0.089
5.77AlaIle: 5.77 ± 0.22
4.399AlaLys: 4.399 ± 0.175
10.665AlaLeu: 10.665 ± 0.296
2.442AlaMet: 2.442 ± 0.117
3.076AlaAsn: 3.076 ± 0.159
2.855AlaPro: 2.855 ± 0.163
3.657AlaGln: 3.657 ± 0.133
5.434AlaArg: 5.434 ± 0.194
4.884AlaSer: 4.884 ± 0.182
3.914AlaThr: 3.914 ± 0.152
6.051AlaVal: 6.051 ± 0.19
0.922AlaTrp: 0.922 ± 0.073
2.262AlaTyr: 2.262 ± 0.119
0.0AlaXaa: 0.0 ± 0.0
Cys
0.982CysAla: 0.982 ± 0.065
0.227CysCys: 0.227 ± 0.037
0.814CysAsp: 0.814 ± 0.071
0.527CysGlu: 0.527 ± 0.052
0.509CysPhe: 0.509 ± 0.055
1.059CysGly: 1.059 ± 0.079
0.455CysHis: 0.455 ± 0.058
0.844CysIle: 0.844 ± 0.081
0.539CysLys: 0.539 ± 0.061
1.191CysLeu: 1.191 ± 0.084
0.299CysMet: 0.299 ± 0.043
0.527CysAsn: 0.527 ± 0.056
0.557CysPro: 0.557 ± 0.055
0.628CysGln: 0.628 ± 0.068
0.766CysArg: 0.766 ± 0.062
0.778CysSer: 0.778 ± 0.071
0.652CysThr: 0.652 ± 0.064
0.802CysVal: 0.802 ± 0.074
0.203CysTrp: 0.203 ± 0.043
0.473CysTyr: 0.473 ± 0.049
0.0CysXaa: 0.0 ± 0.0
Asp
4.429AspAla: 4.429 ± 0.195
0.497AspCys: 0.497 ± 0.06
2.747AspAsp: 2.747 ± 0.164
2.963AspGlu: 2.963 ± 0.132
2.4AspPhe: 2.4 ± 0.142
3.477AspGly: 3.477 ± 0.158
1.006AspHis: 1.006 ± 0.074
3.926AspIle: 3.926 ± 0.14
2.957AspLys: 2.957 ± 0.135
4.992AspLeu: 4.992 ± 0.177
1.484AspMet: 1.484 ± 0.102
2.448AspAsn: 2.448 ± 0.117
1.831AspPro: 1.831 ± 0.104
1.586AspGln: 1.586 ± 0.098
3.178AspArg: 3.178 ± 0.171
2.957AspSer: 2.957 ± 0.119
2.592AspThr: 2.592 ± 0.156
3.765AspVal: 3.765 ± 0.189
0.7AspTrp: 0.7 ± 0.064
1.808AspTyr: 1.808 ± 0.112
0.0AspXaa: 0.0 ± 0.0
Glu
5.045GluAla: 5.045 ± 0.193
0.616GluCys: 0.616 ± 0.065
2.526GluAsp: 2.526 ± 0.147
3.13GluGlu: 3.13 ± 0.171
1.772GluPhe: 1.772 ± 0.118
3.274GluGly: 3.274 ± 0.142
1.514GluHis: 1.514 ± 0.09
4.088GluIle: 4.088 ± 0.158
3.406GluLys: 3.406 ± 0.163
5.476GluLeu: 5.476 ± 0.205
1.592GluMet: 1.592 ± 0.116
2.346GluAsn: 2.346 ± 0.141
1.664GluPro: 1.664 ± 0.098
2.843GluGln: 2.843 ± 0.135
4.022GluArg: 4.022 ± 0.177
2.604GluSer: 2.604 ± 0.133
2.915GluThr: 2.915 ± 0.123
3.95GluVal: 3.95 ± 0.178
0.491GluTrp: 0.491 ± 0.052
1.245GluTyr: 1.245 ± 0.096
0.0GluXaa: 0.0 ± 0.0
Phe
2.681PheAla: 2.681 ± 0.146
0.67PheCys: 0.67 ± 0.068
2.083PheAsp: 2.083 ± 0.119
1.718PheGlu: 1.718 ± 0.117
1.646PhePhe: 1.646 ± 0.138
2.903PheGly: 2.903 ± 0.128
0.826PheHis: 0.826 ± 0.071
2.873PheIle: 2.873 ± 0.145
1.442PheLys: 1.442 ± 0.092
3.394PheLeu: 3.394 ± 0.186
0.856PheMet: 0.856 ± 0.07
1.951PheAsn: 1.951 ± 0.101
1.556PhePro: 1.556 ± 0.108
1.257PheGln: 1.257 ± 0.078
2.137PheArg: 2.137 ± 0.118
3.19PheSer: 3.19 ± 0.119
2.083PheThr: 2.083 ± 0.126
2.334PheVal: 2.334 ± 0.13
0.407PheTrp: 0.407 ± 0.054
1.257PheTyr: 1.257 ± 0.094
0.0PheXaa: 0.0 ± 0.0
Gly
4.986GlyAla: 4.986 ± 0.195
0.898GlyCys: 0.898 ± 0.079
3.585GlyAsp: 3.585 ± 0.165
3.902GlyGlu: 3.902 ± 0.16
2.771GlyPhe: 2.771 ± 0.157
4.656GlyGly: 4.656 ± 0.206
1.706GlyHis: 1.706 ± 0.105
5.267GlyIle: 5.267 ± 0.176
4.435GlyLys: 4.435 ± 0.165
6.608GlyLeu: 6.608 ± 0.211
1.975GlyMet: 1.975 ± 0.104
2.729GlyAsn: 2.729 ± 0.156
1.784GlyPro: 1.784 ± 0.098
2.981GlyGln: 2.981 ± 0.155
4.399GlyArg: 4.399 ± 0.182
3.92GlySer: 3.92 ± 0.17
3.364GlyThr: 3.364 ± 0.121
5.542GlyVal: 5.542 ± 0.205
0.838GlyTrp: 0.838 ± 0.071
2.119GlyTyr: 2.119 ± 0.111
0.0GlyXaa: 0.0 ± 0.0
His
1.849HisAla: 1.849 ± 0.094
0.443HisCys: 0.443 ± 0.051
1.137HisAsp: 1.137 ± 0.081
1.059HisGlu: 1.059 ± 0.087
1.101HisPhe: 1.101 ± 0.082
1.79HisGly: 1.79 ± 0.099
0.772HisHis: 0.772 ± 0.071
1.724HisIle: 1.724 ± 0.096
0.982HisLys: 0.982 ± 0.072
2.568HisLeu: 2.568 ± 0.114
0.622HisMet: 0.622 ± 0.055
0.88HisAsn: 0.88 ± 0.065
1.239HisPro: 1.239 ± 0.088
1.227HisGln: 1.227 ± 0.091
1.478HisArg: 1.478 ± 0.091
1.239HisSer: 1.239 ± 0.094
1.197HisThr: 1.197 ± 0.08
1.424HisVal: 1.424 ± 0.101
0.311HisTrp: 0.311 ± 0.04
0.958HisTyr: 0.958 ± 0.068
0.0HisXaa: 0.0 ± 0.0
Ile
6.596IleAla: 6.596 ± 0.224
0.892IleCys: 0.892 ± 0.063
4.429IleAsp: 4.429 ± 0.18
4.214IleGlu: 4.214 ± 0.172
2.34IlePhe: 2.34 ± 0.127
5.399IleGly: 5.399 ± 0.204
1.598IleHis: 1.598 ± 0.107
4.914IleIle: 4.914 ± 0.171
3.25IleLys: 3.25 ± 0.145
6.057IleLeu: 6.057 ± 0.195
1.574IleMet: 1.574 ± 0.097
3.202IleAsn: 3.202 ± 0.155
2.819IlePro: 2.819 ± 0.121
2.209IleGln: 2.209 ± 0.122
3.872IleArg: 3.872 ± 0.126
4.525IleSer: 4.525 ± 0.159
4.303IleThr: 4.303 ± 0.203
4.782IleVal: 4.782 ± 0.137
0.64IleTrp: 0.64 ± 0.066
1.808IleTyr: 1.808 ± 0.108
0.0IleXaa: 0.0 ± 0.0
Lys
4.237LysAla: 4.237 ± 0.164
0.497LysCys: 0.497 ± 0.05
2.316LysAsp: 2.316 ± 0.122
2.903LysGlu: 2.903 ± 0.134
1.478LysPhe: 1.478 ± 0.095
3.124LysGly: 3.124 ± 0.15
1.131LysHis: 1.131 ± 0.085
3.555LysIle: 3.555 ± 0.171
3.046LysLys: 3.046 ± 0.159
4.962LysLeu: 4.962 ± 0.154
1.466LysMet: 1.466 ± 0.096
2.268LysAsn: 2.268 ± 0.125
1.933LysPro: 1.933 ± 0.108
2.268LysGln: 2.268 ± 0.115
3.573LysArg: 3.573 ± 0.161
2.945LysSer: 2.945 ± 0.153
2.975LysThr: 2.975 ± 0.116
3.543LysVal: 3.543 ± 0.156
0.461LysTrp: 0.461 ± 0.054
1.227LysTyr: 1.227 ± 0.083
0.0LysXaa: 0.0 ± 0.0
Leu
9.337LeuAla: 9.337 ± 0.26
1.43LeuCys: 1.43 ± 0.086
5.853LeuAsp: 5.853 ± 0.202
5.806LeuGlu: 5.806 ± 0.202
3.854LeuPhe: 3.854 ± 0.2
6.416LeuGly: 6.416 ± 0.203
2.765LeuHis: 2.765 ± 0.123
6.446LeuIle: 6.446 ± 0.199
4.896LeuLys: 4.896 ± 0.178
11.396LeuLeu: 11.396 ± 0.349
3.136LeuMet: 3.136 ± 0.14
4.692LeuAsn: 4.692 ± 0.166
5.028LeuPro: 5.028 ± 0.202
4.447LeuGln: 4.447 ± 0.187
7.062LeuArg: 7.062 ± 0.252
7.457LeuSer: 7.457 ± 0.224
6.536LeuThr: 6.536 ± 0.215
6.901LeuVal: 6.901 ± 0.207
1.245LeuTrp: 1.245 ± 0.112
2.867LeuTyr: 2.867 ± 0.133
0.0LeuXaa: 0.0 ± 0.0
Met
2.4MetAla: 2.4 ± 0.114
0.233MetCys: 0.233 ± 0.042
1.257MetAsp: 1.257 ± 0.083
1.365MetGlu: 1.365 ± 0.089
0.94MetPhe: 0.94 ± 0.08
1.712MetGly: 1.712 ± 0.114
0.616MetHis: 0.616 ± 0.065
1.748MetIle: 1.748 ± 0.103
1.347MetLys: 1.347 ± 0.1
3.334MetLeu: 3.334 ± 0.135
0.844MetMet: 0.844 ± 0.085
1.149MetAsn: 1.149 ± 0.091
1.203MetPro: 1.203 ± 0.087
1.131MetGln: 1.131 ± 0.074
1.927MetArg: 1.927 ± 0.11
1.831MetSer: 1.831 ± 0.103
1.568MetThr: 1.568 ± 0.091
1.909MetVal: 1.909 ± 0.105
0.203MetTrp: 0.203 ± 0.033
0.521MetTyr: 0.521 ± 0.051
0.0MetXaa: 0.0 ± 0.0
Asn
3.447AsnAla: 3.447 ± 0.153
0.455AsnCys: 0.455 ± 0.051
2.179AsnAsp: 2.179 ± 0.13
2.089AsnGlu: 2.089 ± 0.11
1.436AsnPhe: 1.436 ± 0.091
2.987AsnGly: 2.987 ± 0.164
0.91AsnHis: 0.91 ± 0.078
3.028AsnIle: 3.028 ± 0.128
2.209AsnLys: 2.209 ± 0.126
4.214AsnLeu: 4.214 ± 0.16
1.041AsnMet: 1.041 ± 0.068
2.071AsnAsn: 2.071 ± 0.124
1.933AsnPro: 1.933 ± 0.105
1.688AsnGln: 1.688 ± 0.102
2.514AsnArg: 2.514 ± 0.121
2.322AsnSer: 2.322 ± 0.122
2.185AsnThr: 2.185 ± 0.129
2.963AsnVal: 2.963 ± 0.146
0.622AsnTrp: 0.622 ± 0.055
1.424AsnTyr: 1.424 ± 0.102
0.0AsnXaa: 0.0 ± 0.0
Pro
3.28ProAla: 3.28 ± 0.149
0.407ProCys: 0.407 ± 0.041
2.089ProAsp: 2.089 ± 0.106
2.484ProGlu: 2.484 ± 0.138
1.622ProPhe: 1.622 ± 0.095
2.669ProGly: 2.669 ± 0.144
0.85ProHis: 0.85 ± 0.072
2.508ProIle: 2.508 ± 0.122
1.819ProLys: 1.819 ± 0.106
4.417ProLeu: 4.417 ± 0.175
1.041ProMet: 1.041 ± 0.082
1.454ProAsn: 1.454 ± 0.099
1.167ProPro: 1.167 ± 0.088
1.478ProGln: 1.478 ± 0.092
1.849ProArg: 1.849 ± 0.115
2.28ProSer: 2.28 ± 0.118
2.131ProThr: 2.131 ± 0.11
3.148ProVal: 3.148 ± 0.138
0.515ProTrp: 0.515 ± 0.057
1.269ProTyr: 1.269 ± 0.097
0.0ProXaa: 0.0 ± 0.0
Gln
4.028GlnAla: 4.028 ± 0.177
0.485GlnCys: 0.485 ± 0.05
1.825GlnAsp: 1.825 ± 0.102
2.089GlnGlu: 2.089 ± 0.117
1.472GlnPhe: 1.472 ± 0.086
2.717GlnGly: 2.717 ± 0.128
1.113GlnHis: 1.113 ± 0.087
2.885GlnIle: 2.885 ± 0.157
2.203GlnLys: 2.203 ± 0.111
4.794GlnLeu: 4.794 ± 0.185
1.161GlnMet: 1.161 ± 0.079
1.395GlnAsn: 1.395 ± 0.085
1.813GlnPro: 1.813 ± 0.104
2.681GlnGln: 2.681 ± 0.174
2.909GlnArg: 2.909 ± 0.146
2.22GlnSer: 2.22 ± 0.115
1.993GlnThr: 1.993 ± 0.106
3.465GlnVal: 3.465 ± 0.145
0.527GlnTrp: 0.527 ± 0.053
1.293GlnTyr: 1.293 ± 0.084
0.0GlnXaa: 0.0 ± 0.0
Arg
5.063ArgAla: 5.063 ± 0.198
0.772ArgCys: 0.772 ± 0.077
3.202ArgAsp: 3.202 ± 0.118
3.657ArgGlu: 3.657 ± 0.165
2.777ArgPhe: 2.777 ± 0.109
4.04ArgGly: 4.04 ± 0.149
1.706ArgHis: 1.706 ± 0.106
4.573ArgIle: 4.573 ± 0.181
2.963ArgLys: 2.963 ± 0.131
7.098ArgLeu: 7.098 ± 0.242
1.616ArgMet: 1.616 ± 0.09
2.49ArgAsn: 2.49 ± 0.099
2.22ArgPro: 2.22 ± 0.126
3.447ArgGln: 3.447 ± 0.147
4.279ArgArg: 4.279 ± 0.187
3.471ArgSer: 3.471 ± 0.149
2.927ArgThr: 2.927 ± 0.132
4.321ArgVal: 4.321 ± 0.154
0.856ArgTrp: 0.856 ± 0.088
2.292ArgTyr: 2.292 ± 0.126
0.0ArgXaa: 0.0 ± 0.0
Ser
5.225SerAla: 5.225 ± 0.193
0.838SerCys: 0.838 ± 0.087
3.005SerAsp: 3.005 ± 0.123
3.16SerGlu: 3.16 ± 0.152
2.232SerPhe: 2.232 ± 0.131
4.992SerGly: 4.992 ± 0.179
1.43SerHis: 1.43 ± 0.116
3.86SerIle: 3.86 ± 0.14
2.61SerLys: 2.61 ± 0.121
6.56SerLeu: 6.56 ± 0.204
1.634SerMet: 1.634 ± 0.098
2.352SerAsn: 2.352 ± 0.137
2.167SerPro: 2.167 ± 0.099
2.334SerGln: 2.334 ± 0.136
3.711SerArg: 3.711 ± 0.15
3.86SerSer: 3.86 ± 0.154
3.352SerThr: 3.352 ± 0.144
4.237SerVal: 4.237 ± 0.166
0.772SerTrp: 0.772 ± 0.073
1.837SerTyr: 1.837 ± 0.105
0.0SerXaa: 0.0 ± 0.0
Thr
4.537ThrAla: 4.537 ± 0.184
0.712ThrCys: 0.712 ± 0.07
2.801ThrAsp: 2.801 ± 0.124
2.921ThrGlu: 2.921 ± 0.127
2.077ThrPhe: 2.077 ± 0.131
4.1ThrGly: 4.1 ± 0.137
1.221ThrHis: 1.221 ± 0.082
3.573ThrIle: 3.573 ± 0.162
2.017ThrLys: 2.017 ± 0.113
7.146ThrLeu: 7.146 ± 0.235
1.251ThrMet: 1.251 ± 0.082
1.927ThrAsn: 1.927 ± 0.106
2.484ThrPro: 2.484 ± 0.117
2.023ThrGln: 2.023 ± 0.121
3.214ThrArg: 3.214 ± 0.125
2.789ThrSer: 2.789 ± 0.137
3.082ThrThr: 3.082 ± 0.145
3.986ThrVal: 3.986 ± 0.15
0.527ThrTrp: 0.527 ± 0.054
1.377ThrTyr: 1.377 ± 0.095
0.0ThrXaa: 0.0 ± 0.0
Val
5.883ValAla: 5.883 ± 0.24
0.862ValCys: 0.862 ± 0.07
3.723ValAsp: 3.723 ± 0.165
3.992ValGlu: 3.992 ± 0.185
2.286ValPhe: 2.286 ± 0.114
4.632ValGly: 4.632 ± 0.205
1.682ValHis: 1.682 ± 0.107
5.255ValIle: 5.255 ± 0.21
3.771ValLys: 3.771 ± 0.177
7.434ValLeu: 7.434 ± 0.207
2.131ValMet: 2.131 ± 0.118
3.106ValAsn: 3.106 ± 0.146
2.717ValPro: 2.717 ± 0.134
2.562ValGln: 2.562 ± 0.107
4.423ValArg: 4.423 ± 0.174
4.686ValSer: 4.686 ± 0.146
4.231ValThr: 4.231 ± 0.167
5.44ValVal: 5.44 ± 0.194
0.64ValTrp: 0.64 ± 0.068
1.706ValTyr: 1.706 ± 0.09
0.0ValXaa: 0.0 ± 0.0
Trp
0.676TrpAla: 0.676 ± 0.064
0.221TrpCys: 0.221 ± 0.037
0.395TrpAsp: 0.395 ± 0.051
0.449TrpGlu: 0.449 ± 0.053
0.491TrpPhe: 0.491 ± 0.051
0.545TrpGly: 0.545 ± 0.056
0.311TrpHis: 0.311 ± 0.046
0.754TrpIle: 0.754 ± 0.079
0.521TrpLys: 0.521 ± 0.06
1.748TrpLeu: 1.748 ± 0.134
0.359TrpMet: 0.359 ± 0.051
0.425TrpAsn: 0.425 ± 0.053
0.449TrpPro: 0.449 ± 0.059
0.892TrpGln: 0.892 ± 0.071
0.928TrpArg: 0.928 ± 0.081
0.533TrpSer: 0.533 ± 0.059
0.407TrpThr: 0.407 ± 0.052
0.79TrpVal: 0.79 ± 0.077
0.132TrpTrp: 0.132 ± 0.029
0.371TrpTyr: 0.371 ± 0.049
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.25TyrAla: 2.25 ± 0.113
0.557TyrCys: 0.557 ± 0.058
1.418TyrAsp: 1.418 ± 0.077
1.203TyrGlu: 1.203 ± 0.078
1.221TyrPhe: 1.221 ± 0.097
2.065TyrGly: 2.065 ± 0.097
0.898TyrHis: 0.898 ± 0.072
1.831TyrIle: 1.831 ± 0.106
1.101TyrLys: 1.101 ± 0.078
3.519TyrLeu: 3.519 ± 0.142
0.706TyrMet: 0.706 ± 0.07
1.227TyrAsn: 1.227 ± 0.079
1.059TyrPro: 1.059 ± 0.081
1.73TyrGln: 1.73 ± 0.109
2.095TyrArg: 2.095 ± 0.101
1.676TyrSer: 1.676 ± 0.127
1.359TyrThr: 1.359 ± 0.099
1.808TyrVal: 1.808 ± 0.125
0.389TyrTrp: 0.389 ± 0.054
1.167TyrTyr: 1.167 ± 0.084
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 568 proteins (167082 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski