Amino acid dipepetide frequency for Acidimicrobiia bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.713AlaAla: 12.713 ± 0.144	0.722AlaCys: 0.722 ± 0.026	6.765AlaAsp: 6.765 ± 0.083	7.147AlaGlu: 7.147 ± 0.1	3.32AlaPhe: 3.32 ± 0.072	9.151AlaGly: 9.151 ± 0.1	1.991AlaHis: 1.991 ± 0.045	5.697AlaIle: 5.697 ± 0.081	2.086AlaLys: 2.086 ± 0.048	10.687AlaLeu: 10.687 ± 0.129	2.573AlaMet: 2.573 ± 0.053	2.32AlaAsn: 2.32 ± 0.044	4.384AlaPro: 4.384 ± 0.081	2.672AlaGln: 2.672 ± 0.054	6.484AlaArg: 6.484 ± 0.09	5.891AlaSer: 5.891 ± 0.086	6.587AlaThr: 6.587 ± 0.08	9.403AlaVal: 9.403 ± 0.103	1.321AlaTrp: 1.321 ± 0.035	2.055AlaTyr: 2.055 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.538CysAla: 0.538 ± 0.023	0.086CysCys: 0.086 ± 0.01	0.471CysAsp: 0.471 ± 0.019	0.393CysGlu: 0.393 ± 0.017	0.209CysPhe: 0.209 ± 0.012	0.834CysGly: 0.834 ± 0.031	0.191CysHis: 0.191 ± 0.013	0.224CysIle: 0.224 ± 0.017	0.072CysLys: 0.072 ± 0.008	0.514CysLeu: 0.514 ± 0.022	0.083CysMet: 0.083 ± 0.008	0.28CysAsn: 0.28 ± 0.019	0.565CysPro: 0.565 ± 0.028	0.165CysGln: 0.165 ± 0.013	0.474CysArg: 0.474 ± 0.023	0.408CysSer: 0.408 ± 0.021	0.336CysThr: 0.336 ± 0.017	0.485CysVal: 0.485 ± 0.02	0.129CysTrp: 0.129 ± 0.018	0.144CysTyr: 0.144 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.28AspAla: 6.28 ± 0.079	0.322AspCys: 0.322 ± 0.018	5.041AspAsp: 5.041 ± 0.088	5.128AspGlu: 5.128 ± 0.073	1.941AspPhe: 1.941 ± 0.04	6.442AspGly: 6.442 ± 0.088	1.775AspHis: 1.775 ± 0.046	3.098AspIle: 3.098 ± 0.055	1.069AspLys: 1.069 ± 0.034	7.256AspLeu: 7.256 ± 0.086	1.19AspMet: 1.19 ± 0.033	1.427AspAsn: 1.427 ± 0.041	4.662AspPro: 4.662 ± 0.074	1.907AspGln: 1.907 ± 0.038	5.077AspArg: 5.077 ± 0.068	3.226AspSer: 3.226 ± 0.051	3.684AspThr: 3.684 ± 0.07	5.583AspVal: 5.583 ± 0.073	1.026AspTrp: 1.026 ± 0.031	1.375AspTyr: 1.375 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.014GluAla: 7.014 ± 0.088	0.298GluCys: 0.298 ± 0.016	3.845GluAsp: 3.845 ± 0.071	5.128GluGlu: 5.128 ± 0.099	1.99GluPhe: 1.99 ± 0.041	5.364GluGly: 5.364 ± 0.071	1.385GluHis: 1.385 ± 0.033	3.865GluIle: 3.865 ± 0.063	1.718GluLys: 1.718 ± 0.047	6.609GluLeu: 6.609 ± 0.09	1.883GluMet: 1.883 ± 0.046	1.653GluAsn: 1.653 ± 0.038	3.553GluPro: 3.553 ± 0.072	1.915GluGln: 1.915 ± 0.04	5.154GluArg: 5.154 ± 0.083	3.868GluSer: 3.868 ± 0.061	4.32GluThr: 4.32 ± 0.075	6.136GluVal: 6.136 ± 0.087	1.018GluTrp: 1.018 ± 0.031	1.254GluTyr: 1.254 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.36PheAla: 3.36 ± 0.066	0.364PheCys: 0.364 ± 0.021	2.577PheAsp: 2.577 ± 0.048	2.227PheGlu: 2.227 ± 0.05	1.151PhePhe: 1.151 ± 0.038	3.512PheGly: 3.512 ± 0.063	0.738PheHis: 0.738 ± 0.027	1.33PheIle: 1.33 ± 0.044	0.525PheLys: 0.525 ± 0.022	3.083PheLeu: 3.083 ± 0.059	0.544PheMet: 0.544 ± 0.026	0.773PheAsn: 0.773 ± 0.027	1.584PhePro: 1.584 ± 0.037	0.834PheGln: 0.834 ± 0.028	1.955PheArg: 1.955 ± 0.044	1.986PheSer: 1.986 ± 0.045	1.981PheThr: 1.981 ± 0.047	2.915PheVal: 2.915 ± 0.055	0.472PheTrp: 0.472 ± 0.023	0.713PheTyr: 0.713 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.592GlyAla: 8.592 ± 0.089	0.847GlyCys: 0.847 ± 0.032	5.785GlyAsp: 5.785 ± 0.086	5.96GlyGlu: 5.96 ± 0.08	3.502GlyPhe: 3.502 ± 0.062	8.187GlyGly: 8.187 ± 0.119	2.053GlyHis: 2.053 ± 0.049	4.893GlyIle: 4.893 ± 0.073	2.089GlyLys: 2.089 ± 0.045	9.181GlyLeu: 9.181 ± 0.097	2.37GlyMet: 2.37 ± 0.045	2.088GlyAsn: 2.088 ± 0.053	4.034GlyPro: 4.034 ± 0.072	2.295GlyGln: 2.295 ± 0.048	6.044GlyArg: 6.044 ± 0.084	6.012GlySer: 6.012 ± 0.084	5.373GlyThr: 5.373 ± 0.087	8.027GlyVal: 8.027 ± 0.091	1.741GlyTrp: 1.741 ± 0.041	2.219GlyTyr: 2.219 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.817HisAla: 1.817 ± 0.037	0.193HisCys: 0.193 ± 0.013	1.437HisAsp: 1.437 ± 0.037	1.225HisGlu: 1.225 ± 0.03	0.707HisPhe: 0.707 ± 0.027	1.957HisGly: 1.957 ± 0.041	0.726HisHis: 0.726 ± 0.029	0.902HisIle: 0.902 ± 0.029	0.359HisLys: 0.359 ± 0.018	2.457HisLeu: 2.457 ± 0.051	0.373HisMet: 0.373 ± 0.018	0.501HisAsn: 0.501 ± 0.021	1.681HisPro: 1.681 ± 0.04	0.716HisGln: 0.716 ± 0.028	1.861HisArg: 1.861 ± 0.045	1.092HisSer: 1.092 ± 0.033	1.137HisThr: 1.137 ± 0.038	1.511HisVal: 1.511 ± 0.04	0.311HisTrp: 0.311 ± 0.017	0.493HisTyr: 0.493 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.893IleAla: 5.893 ± 0.075	0.315IleCys: 0.315 ± 0.019	4.064IleAsp: 4.064 ± 0.059	3.833IleGlu: 3.833 ± 0.066	1.365IlePhe: 1.365 ± 0.04	4.959IleGly: 4.959 ± 0.078	1.092IleHis: 1.092 ± 0.035	2.018IleIle: 2.018 ± 0.052	0.858IleLys: 0.858 ± 0.03	4.332IleLeu: 4.332 ± 0.081	0.756IleMet: 0.756 ± 0.024	1.153IleAsn: 1.153 ± 0.033	2.935IlePro: 2.935 ± 0.056	1.121IleGln: 1.121 ± 0.036	3.261IleArg: 3.261 ± 0.057	3.13IleSer: 3.13 ± 0.051	3.158IleThr: 3.158 ± 0.056	4.256IleVal: 4.256 ± 0.06	0.593IleTrp: 0.593 ± 0.024	0.907IleTyr: 0.907 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.048LysAla: 2.048 ± 0.054	0.092LysCys: 0.092 ± 0.008	1.041LysAsp: 1.041 ± 0.033	1.3LysGlu: 1.3 ± 0.03	0.437LysPhe: 0.437 ± 0.023	1.675LysGly: 1.675 ± 0.046	0.389LysHis: 0.389 ± 0.021	1.026LysIle: 1.026 ± 0.033	0.636LysLys: 0.636 ± 0.024	1.818LysLeu: 1.818 ± 0.043	0.541LysMet: 0.541 ± 0.022	0.44LysAsn: 0.44 ± 0.025	1.091LysPro: 1.091 ± 0.033	0.561LysGln: 0.561 ± 0.025	1.552LysArg: 1.552 ± 0.044	1.154LysSer: 1.154 ± 0.035	1.442LysThr: 1.442 ± 0.036	1.86LysVal: 1.86 ± 0.055	0.28LysTrp: 0.28 ± 0.018	0.415LysTyr: 0.415 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	11.847LeuAla: 11.847 ± 0.13	0.581LeuCys: 0.581 ± 0.024	6.939LeuAsp: 6.939 ± 0.08	6.42LeuGlu: 6.42 ± 0.086	3.053LeuPhe: 3.053 ± 0.069	9.588LeuGly: 9.588 ± 0.119	1.873LeuHis: 1.873 ± 0.046	4.788LeuIle: 4.788 ± 0.07	1.715LeuLys: 1.715 ± 0.043	9.445LeuLeu: 9.445 ± 0.14	1.983LeuMet: 1.983 ± 0.044	1.998LeuAsn: 1.998 ± 0.049	4.846LeuPro: 4.846 ± 0.072	2.238LeuGln: 2.238 ± 0.043	6.407LeuArg: 6.407 ± 0.082	5.934LeuSer: 5.934 ± 0.072	5.898LeuThr: 5.898 ± 0.074	9.279LeuVal: 9.279 ± 0.111	1.185LeuTrp: 1.185 ± 0.033	1.722LeuTyr: 1.722 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.762MetAla: 2.762 ± 0.054	0.136MetCys: 0.136 ± 0.01	1.243MetAsp: 1.243 ± 0.033	1.286MetGlu: 1.286 ± 0.034	0.674MetPhe: 0.674 ± 0.025	2.055MetGly: 2.055 ± 0.049	0.32MetHis: 0.32 ± 0.018	1.145MetIle: 1.145 ± 0.034	0.562MetLys: 0.562 ± 0.024	1.854MetLeu: 1.854 ± 0.041	0.54MetMet: 0.54 ± 0.023	0.555MetAsn: 0.555 ± 0.021	1.084MetPro: 1.084 ± 0.031	0.479MetGln: 0.479 ± 0.021	1.461MetArg: 1.461 ± 0.034	1.602MetSer: 1.602 ± 0.036	1.883MetThr: 1.883 ± 0.038	2.236MetVal: 2.236 ± 0.048	0.285MetTrp: 0.285 ± 0.019	0.321MetTyr: 0.321 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.143AsnAla: 2.143 ± 0.044	0.127AsnCys: 0.127 ± 0.013	1.512AsnAsp: 1.512 ± 0.043	1.385AsnGlu: 1.385 ± 0.038	0.698AsnPhe: 0.698 ± 0.027	2.144AsnGly: 2.144 ± 0.048	0.517AsnHis: 0.517 ± 0.02	1.063AsnIle: 1.063 ± 0.034	0.391AsnLys: 0.391 ± 0.019	2.41AsnLeu: 2.41 ± 0.046	0.415AsnMet: 0.415 ± 0.022	0.557AsnAsn: 0.557 ± 0.028	1.968AsnPro: 1.968 ± 0.044	0.796AsnGln: 0.796 ± 0.029	1.75AsnArg: 1.75 ± 0.043	1.126AsnSer: 1.126 ± 0.031	1.382AsnThr: 1.382 ± 0.038	1.845AsnVal: 1.845 ± 0.046	0.361AsnTrp: 0.361 ± 0.021	0.481AsnTyr: 0.481 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	4.739ProAla: 4.739 ± 0.076	0.251ProCys: 0.251 ± 0.016	4.718ProAsp: 4.718 ± 0.07	4.42ProGlu: 4.42 ± 0.067	1.725ProPhe: 1.725 ± 0.046	4.938ProGly: 4.938 ± 0.074	1.156ProHis: 1.156 ± 0.032	2.478ProIle: 2.478 ± 0.045	1.047ProLys: 1.047 ± 0.03	4.547ProLeu: 4.547 ± 0.062	1.192ProMet: 1.192 ± 0.032	1.415ProAsn: 1.415 ± 0.045	3.317ProPro: 3.317 ± 0.075	1.395ProGln: 1.395 ± 0.036	2.947ProArg: 2.947 ± 0.057	3.36ProSer: 3.36 ± 0.059	3.702ProThr: 3.702 ± 0.07	4.493ProVal: 4.493 ± 0.086	0.798ProTrp: 0.798 ± 0.027	1.109ProTyr: 1.109 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.645GlnAla: 2.645 ± 0.045	0.149GlnCys: 0.149 ± 0.012	1.267GlnAsp: 1.267 ± 0.034	1.489GlnGlu: 1.489 ± 0.04	0.841GlnPhe: 0.841 ± 0.031	2.135GlnGly: 2.135 ± 0.045	0.551GlnHis: 0.551 ± 0.02	1.541GlnIle: 1.541 ± 0.035	0.609GlnLys: 0.609 ± 0.024	2.713GlnLeu: 2.713 ± 0.061	0.762GlnMet: 0.762 ± 0.03	0.619GlnAsn: 0.619 ± 0.022	1.501GlnPro: 1.501 ± 0.037	0.919GlnGln: 0.919 ± 0.032	2.198GlnArg: 2.198 ± 0.051	1.406GlnSer: 1.406 ± 0.034	1.536GlnThr: 1.536 ± 0.035	2.339GlnVal: 2.339 ± 0.043	0.405GlnTrp: 0.405 ± 0.02	0.522GlnTyr: 0.522 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.277ArgAla: 6.277 ± 0.082	0.465ArgCys: 0.465 ± 0.021	3.992ArgAsp: 3.992 ± 0.058	3.997ArgGlu: 3.997 ± 0.073	2.668ArgPhe: 2.668 ± 0.055	5.213ArgGly: 5.213 ± 0.074	1.748ArgHis: 1.748 ± 0.046	3.772ArgIle: 3.772 ± 0.061	1.492ArgLys: 1.492 ± 0.042	7.178ArgLeu: 7.178 ± 0.095	1.654ArgMet: 1.654 ± 0.039	1.635ArgAsn: 1.635 ± 0.044	3.514ArgPro: 3.514 ± 0.06	2.102ArgGln: 2.102 ± 0.048	6.368ArgArg: 6.368 ± 0.088	4.577ArgSer: 4.577 ± 0.075	3.749ArgThr: 3.749 ± 0.064	5.498ArgVal: 5.498 ± 0.074	1.293ArgTrp: 1.293 ± 0.039	1.774ArgTyr: 1.774 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.65SerAla: 5.65 ± 0.072	0.365SerCys: 0.365 ± 0.017	4.065SerAsp: 4.065 ± 0.063	3.916SerGlu: 3.916 ± 0.061	2.025SerPhe: 2.025 ± 0.043	6.148SerGly: 6.148 ± 0.082	1.279SerHis: 1.279 ± 0.03	2.842SerIle: 2.842 ± 0.045	1.118SerLys: 1.118 ± 0.034	5.661SerLeu: 5.661 ± 0.086	1.429SerMet: 1.429 ± 0.037	1.427SerAsn: 1.427 ± 0.042	3.323SerPro: 3.323 ± 0.05	1.664SerGln: 1.664 ± 0.036	3.979SerArg: 3.979 ± 0.063	3.663SerSer: 3.663 ± 0.062	3.629SerThr: 3.629 ± 0.064	5.239SerVal: 5.239 ± 0.074	0.948SerTrp: 0.948 ± 0.033	1.248SerTyr: 1.248 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.343ThrAla: 6.343 ± 0.083	0.374ThrCys: 0.374 ± 0.019	4.152ThrAsp: 4.152 ± 0.069	4.203ThrGlu: 4.203 ± 0.067	1.959ThrPhe: 1.959 ± 0.042	5.702ThrGly: 5.702 ± 0.083	1.28ThrHis: 1.28 ± 0.036	3.214ThrIle: 3.214 ± 0.054	1.202ThrLys: 1.202 ± 0.035	5.616ThrLeu: 5.616 ± 0.066	1.499ThrMet: 1.499 ± 0.036	1.496ThrAsn: 1.496 ± 0.04	3.541ThrPro: 3.541 ± 0.057	1.44ThrGln: 1.44 ± 0.04	3.784ThrArg: 3.784 ± 0.065	3.701ThrSer: 3.701 ± 0.059	5.039ThrThr: 5.039 ± 0.112	5.845ThrVal: 5.845 ± 0.082	0.917ThrTrp: 0.917 ± 0.029	1.194ThrTyr: 1.194 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.129ValAla: 10.129 ± 0.114	0.59ValCys: 0.59 ± 0.026	6.286ValAsp: 6.286 ± 0.086	6.145ValGlu: 6.145 ± 0.094	3.095ValPhe: 3.095 ± 0.056	8.169ValGly: 8.169 ± 0.097	1.606ValHis: 1.606 ± 0.041	4.638ValIle: 4.638 ± 0.07	1.559ValLys: 1.559 ± 0.041	8.36ValLeu: 8.36 ± 0.109	1.976ValMet: 1.976 ± 0.046	1.937ValAsn: 1.937 ± 0.046	4.329ValPro: 4.329 ± 0.064	1.679ValGln: 1.679 ± 0.034	5.322ValArg: 5.322 ± 0.073	5.41ValSer: 5.41 ± 0.074	5.757ValThr: 5.757 ± 0.079	9.512ValVal: 9.512 ± 0.122	1.216ValTrp: 1.216 ± 0.034	1.568ValTyr: 1.568 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.407TrpAla: 1.407 ± 0.036	0.136TrpCys: 0.136 ± 0.012	0.941TrpAsp: 0.941 ± 0.031	0.98TrpGlu: 0.98 ± 0.033	0.526TrpPhe: 0.526 ± 0.021	1.163TrpGly: 1.163 ± 0.04	0.29TrpHis: 0.29 ± 0.016	0.733TrpIle: 0.733 ± 0.027	0.377TrpLys: 0.377 ± 0.018	1.637TrpLeu: 1.637 ± 0.04	0.38TrpMet: 0.38 ± 0.021	0.386TrpAsn: 0.386 ± 0.021	0.665TrpPro: 0.665 ± 0.025	0.47TrpGln: 0.47 ± 0.024	1.123TrpArg: 1.123 ± 0.036	0.975TrpSer: 0.975 ± 0.031	0.863TrpThr: 0.863 ± 0.029	1.266TrpVal: 1.266 ± 0.036	0.354TrpTrp: 0.354 ± 0.018	0.303TrpTyr: 0.303 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.77TyrAla: 1.77 ± 0.041	0.19TyrCys: 0.19 ± 0.015	1.372TyrAsp: 1.372 ± 0.042	1.386TyrGlu: 1.386 ± 0.038	0.738TyrPhe: 0.738 ± 0.026	1.956TyrGly: 1.956 ± 0.047	0.49TyrHis: 0.49 ± 0.025	0.732TyrIle: 0.732 ± 0.029	0.316TyrLys: 0.316 ± 0.021	2.381TyrLeu: 2.381 ± 0.044	0.341TyrMet: 0.341 ± 0.018	0.412TyrAsn: 0.412 ± 0.019	1.17TyrPro: 1.17 ± 0.038	0.779TyrGln: 0.779 ± 0.027	1.765TyrArg: 1.765 ± 0.04	1.097TyrSer: 1.097 ± 0.031	1.048TyrThr: 1.048 ± 0.035	1.551TyrVal: 1.551 ± 0.04	0.323TyrTrp: 0.323 ± 0.017	0.435TyrTyr: 0.435 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3762 proteins (1092149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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