Amino acid dipepetide frequency for Phytoplasma australiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.332AlaAla: 2.332 ± 0.171
0.539AlaCys: 0.539 ± 0.048
1.866AlaAsp: 1.866 ± 0.12
2.099AlaGlu: 2.099 ± 0.138
2.693AlaPhe: 2.693 ± 0.145
1.982AlaGly: 1.982 ± 0.143
0.777AlaHis: 0.777 ± 0.07
3.998AlaIle: 3.998 ± 0.154
4.486AlaLys: 4.486 ± 0.189
5.702AlaLeu: 5.702 ± 0.198
0.927AlaMet: 0.927 ± 0.078
2.582AlaAsn: 2.582 ± 0.124
1.122AlaPro: 1.122 ± 0.122
2.226AlaGln: 2.226 ± 0.174
1.494AlaArg: 1.494 ± 0.096
2.737AlaSer: 2.737 ± 0.146
2.671AlaThr: 2.671 ± 0.11
2.232AlaVal: 2.232 ± 0.122
0.233AlaTrp: 0.233 ± 0.038
1.51AlaTyr: 1.51 ± 0.092
0.0AlaXaa: 0.0 ± 0.0
Cys
0.322CysAla: 0.322 ± 0.044
0.178CysCys: 0.178 ± 0.033
0.539CysAsp: 0.539 ± 0.052
0.35CysGlu: 0.35 ± 0.046
0.822CysPhe: 0.822 ± 0.082
0.466CysGly: 0.466 ± 0.051
0.333CysHis: 0.333 ± 0.037
0.594CysIle: 0.594 ± 0.063
0.733CysLys: 0.733 ± 0.07
1.022CysLeu: 1.022 ± 0.073
0.167CysMet: 0.167 ± 0.03
0.544CysAsn: 0.544 ± 0.061
0.289CysPro: 0.289 ± 0.041
0.583CysGln: 0.583 ± 0.062
0.328CysArg: 0.328 ± 0.041
0.511CysSer: 0.511 ± 0.055
0.239CysThr: 0.239 ± 0.036
0.489CysVal: 0.489 ± 0.055
0.067CysTrp: 0.067 ± 0.019
0.35CysTyr: 0.35 ± 0.051
0.0CysXaa: 0.0 ± 0.0
Asp
2.215AspAla: 2.215 ± 0.127
0.439AspCys: 0.439 ± 0.048
2.088AspAsp: 2.088 ± 0.15
2.726AspGlu: 2.726 ± 0.134
3.348AspPhe: 3.348 ± 0.137
2.476AspGly: 2.476 ± 0.165
0.655AspHis: 0.655 ± 0.059
4.109AspIle: 4.109 ± 0.15
4.464AspLys: 4.464 ± 0.189
5.491AspLeu: 5.491 ± 0.176
0.494AspMet: 0.494 ± 0.057
2.687AspAsn: 2.687 ± 0.122
1.782AspPro: 1.782 ± 0.113
1.788AspGln: 1.788 ± 0.088
0.988AspArg: 0.988 ± 0.071
2.449AspSer: 2.449 ± 0.133
1.854AspThr: 1.854 ± 0.104
2.821AspVal: 2.821 ± 0.131
0.383AspTrp: 0.383 ± 0.056
2.143AspTyr: 2.143 ± 0.129
0.0AspXaa: 0.0 ± 0.0
Glu
3.492GluAla: 3.492 ± 0.181
0.444GluCys: 0.444 ± 0.06
2.254GluAsp: 2.254 ± 0.145
4.947GluGlu: 4.947 ± 0.233
2.176GluPhe: 2.176 ± 0.113
2.748GluGly: 2.748 ± 0.119
0.788GluHis: 0.788 ± 0.067
7.14GluIle: 7.14 ± 0.224
8.384GluLys: 8.384 ± 0.32
6.218GluLeu: 6.218 ± 0.255
1.416GluMet: 1.416 ± 0.096
4.719GluAsn: 4.719 ± 0.202
1.371GluPro: 1.371 ± 0.113
2.882GluGln: 2.882 ± 0.199
1.727GluArg: 1.727 ± 0.114
2.682GluSer: 2.682 ± 0.136
3.97GluThr: 3.97 ± 0.167
3.57GluVal: 3.57 ± 0.171
0.372GluTrp: 0.372 ± 0.044
2.043GluTyr: 2.043 ± 0.115
0.0GluXaa: 0.0 ± 0.0
Phe
2.176PheAla: 2.176 ± 0.128
0.872PheCys: 0.872 ± 0.066
2.66PheAsp: 2.66 ± 0.138
3.181PheGlu: 3.181 ± 0.125
4.675PhePhe: 4.675 ± 0.249
2.393PheGly: 2.393 ± 0.123
1.027PheHis: 1.027 ± 0.071
4.842PheIle: 4.842 ± 0.202
4.98PheLys: 4.98 ± 0.17
8.123PheLeu: 8.123 ± 0.347
1.255PheMet: 1.255 ± 0.091
3.664PheAsn: 3.664 ± 0.167
1.743PhePro: 1.743 ± 0.127
2.804PheGln: 2.804 ± 0.173
1.544PheArg: 1.544 ± 0.084
3.942PheSer: 3.942 ± 0.174
1.938PheThr: 1.938 ± 0.126
2.843PheVal: 2.843 ± 0.14
0.472PheTrp: 0.472 ± 0.054
2.554PheTyr: 2.554 ± 0.135
0.0PheXaa: 0.0 ± 0.0
Gly
2.271GlyAla: 2.271 ± 0.127
0.333GlyCys: 0.333 ± 0.037
1.693GlyAsp: 1.693 ± 0.114
2.315GlyGlu: 2.315 ± 0.136
3.242GlyPhe: 3.242 ± 0.131
2.315GlyGly: 2.315 ± 0.15
1.033GlyHis: 1.033 ± 0.088
4.092GlyIle: 4.092 ± 0.163
4.819GlyLys: 4.819 ± 0.185
4.331GlyLeu: 4.331 ± 0.174
0.955GlyMet: 0.955 ± 0.071
2.182GlyAsn: 2.182 ± 0.124
1.077GlyPro: 1.077 ± 0.089
1.521GlyGln: 1.521 ± 0.099
1.588GlyArg: 1.588 ± 0.104
2.726GlySer: 2.726 ± 0.141
2.487GlyThr: 2.487 ± 0.118
2.826GlyVal: 2.826 ± 0.129
0.183GlyTrp: 0.183 ± 0.036
1.677GlyTyr: 1.677 ± 0.127
0.0GlyXaa: 0.0 ± 0.0
His
0.716HisAla: 0.716 ± 0.066
0.133HisCys: 0.133 ± 0.023
0.811HisAsp: 0.811 ± 0.061
0.872HisGlu: 0.872 ± 0.069
1.31HisPhe: 1.31 ± 0.089
0.688HisGly: 0.688 ± 0.07
0.733HisHis: 0.733 ± 0.061
1.36HisIle: 1.36 ± 0.076
1.544HisLys: 1.544 ± 0.093
2.365HisLeu: 2.365 ± 0.128
0.233HisMet: 0.233 ± 0.035
1.205HisAsn: 1.205 ± 0.08
0.961HisPro: 0.961 ± 0.09
1.549HisGln: 1.549 ± 0.102
0.683HisArg: 0.683 ± 0.066
0.961HisSer: 0.961 ± 0.079
0.883HisThr: 0.883 ± 0.089
0.722HisVal: 0.722 ± 0.063
0.15HisTrp: 0.15 ± 0.03
0.922HisTyr: 0.922 ± 0.077
0.0HisXaa: 0.0 ± 0.0
Ile
5.047IleAla: 5.047 ± 0.184
0.805IleCys: 0.805 ± 0.066
4.625IleAsp: 4.625 ± 0.201
5.402IleGlu: 5.402 ± 0.191
5.064IlePhe: 5.064 ± 0.192
3.298IleGly: 3.298 ± 0.153
1.266IleHis: 1.266 ± 0.088
9.078IleIle: 9.078 ± 0.241
10.738IleLys: 10.738 ± 0.296
9.045IleLeu: 9.045 ± 0.327
1.455IleMet: 1.455 ± 0.093
7.173IleAsn: 7.173 ± 0.264
3.22IlePro: 3.22 ± 0.136
4.259IleGln: 4.259 ± 0.193
2.465IleArg: 2.465 ± 0.113
5.996IleSer: 5.996 ± 0.216
5.341IleThr: 5.341 ± 0.167
4.658IleVal: 4.658 ± 0.173
0.511IleTrp: 0.511 ± 0.053
3.154IleTyr: 3.154 ± 0.153
0.0IleXaa: 0.0 ± 0.0
Lys
4.542LysAla: 4.542 ± 0.173
0.544LysCys: 0.544 ± 0.054
5.641LysAsp: 5.641 ± 0.197
9.067LysGlu: 9.067 ± 0.308
3.104LysPhe: 3.104 ± 0.114
4.281LysGly: 4.281 ± 0.175
1.904LysHis: 1.904 ± 0.107
11.976LysIle: 11.976 ± 0.326
13.908LysLys: 13.908 ± 0.36
9.206LysLeu: 9.206 ± 0.244
2.565LysMet: 2.565 ± 0.13
10.011LysAsn: 10.011 ± 0.271
3.148LysPro: 3.148 ± 0.142
5.647LysGln: 5.647 ± 0.281
3.692LysArg: 3.692 ± 0.157
4.569LysSer: 4.569 ± 0.157
8.101LysThr: 8.101 ± 0.26
4.73LysVal: 4.73 ± 0.216
0.6LysTrp: 0.6 ± 0.07
4.203LysTyr: 4.203 ± 0.167
0.0LysXaa: 0.0 ± 0.0
Leu
4.78LeuAla: 4.78 ± 0.186
0.844LeuCys: 0.844 ± 0.064
5.363LeuAsp: 5.363 ± 0.2
7.945LeuGlu: 7.945 ± 0.326
6.257LeuPhe: 6.257 ± 0.239
5.747LeuGly: 5.747 ± 0.191
1.749LeuHis: 1.749 ± 0.094
10.377LeuIle: 10.377 ± 0.284
12.615LeuLys: 12.615 ± 0.307
10.355LeuLeu: 10.355 ± 0.263
1.838LeuMet: 1.838 ± 0.102
7.218LeuAsn: 7.218 ± 0.201
3.076LeuPro: 3.076 ± 0.167
5.219LeuGln: 5.219 ± 0.216
2.61LeuArg: 2.61 ± 0.145
6.94LeuSer: 6.94 ± 0.211
5.691LeuThr: 5.691 ± 0.203
5.069LeuVal: 5.069 ± 0.176
0.639LeuTrp: 0.639 ± 0.057
2.932LeuTyr: 2.932 ± 0.111
0.0LeuXaa: 0.0 ± 0.0
Met
1.055MetAla: 1.055 ± 0.078
0.094MetCys: 0.094 ± 0.023
0.838MetAsp: 0.838 ± 0.066
1.049MetGlu: 1.049 ± 0.078
0.994MetPhe: 0.994 ± 0.079
0.866MetGly: 0.866 ± 0.071
0.35MetHis: 0.35 ± 0.048
1.649MetIle: 1.649 ± 0.1
2.21MetLys: 2.21 ± 0.112
1.749MetLeu: 1.749 ± 0.081
0.411MetMet: 0.411 ± 0.049
1.238MetAsn: 1.238 ± 0.085
0.605MetPro: 0.605 ± 0.06
1.022MetGln: 1.022 ± 0.076
0.428MetArg: 0.428 ± 0.051
1.072MetSer: 1.072 ± 0.073
0.872MetThr: 0.872 ± 0.062
0.838MetVal: 0.838 ± 0.066
0.089MetTrp: 0.089 ± 0.024
0.527MetTyr: 0.527 ± 0.057
0.0MetXaa: 0.0 ± 0.0
Asn
2.487AsnAla: 2.487 ± 0.111
0.655AsnCys: 0.655 ± 0.064
3.009AsnAsp: 3.009 ± 0.128
3.887AsnGlu: 3.887 ± 0.197
4.02AsnPhe: 4.02 ± 0.172
1.977AsnGly: 1.977 ± 0.119
1.932AsnHis: 1.932 ± 0.109
5.858AsnIle: 5.858 ± 0.203
7.99AsnLys: 7.99 ± 0.245
8.295AsnLeu: 8.295 ± 0.289
1.26AsnMet: 1.26 ± 0.083
6.84AsnAsn: 6.84 ± 0.307
3.553AsnPro: 3.553 ± 0.217
4.986AsnGln: 4.986 ± 0.247
2.093AsnArg: 2.093 ± 0.116
3.442AsnSer: 3.442 ± 0.138
3.037AsnThr: 3.037 ± 0.138
2.554AsnVal: 2.554 ± 0.141
0.483AsnTrp: 0.483 ± 0.053
3.57AsnTyr: 3.57 ± 0.149
0.0AsnXaa: 0.0 ± 0.0
Pro
1.016ProAla: 1.016 ± 0.082
0.444ProCys: 0.444 ± 0.052
1.349ProAsp: 1.349 ± 0.099
2.376ProGlu: 2.376 ± 0.112
2.254ProPhe: 2.254 ± 0.102
1.255ProGly: 1.255 ± 0.087
0.838ProHis: 0.838 ± 0.074
2.249ProIle: 2.249 ± 0.118
3.537ProLys: 3.537 ± 0.179
3.387ProLeu: 3.387 ± 0.151
0.328ProMet: 0.328 ± 0.042
2.515ProAsn: 2.515 ± 0.173
1.199ProPro: 1.199 ± 0.108
2.332ProGln: 2.332 ± 0.141
0.855ProArg: 0.855 ± 0.057
2.027ProSer: 2.027 ± 0.102
1.749ProThr: 1.749 ± 0.1
1.31ProVal: 1.31 ± 0.126
0.261ProTrp: 0.261 ± 0.037
1.266ProTyr: 1.266 ± 0.076
0.0ProXaa: 0.0 ± 0.0
Gln
2.487GlnAla: 2.487 ± 0.137
0.228GlnCys: 0.228 ± 0.034
1.754GlnAsp: 1.754 ± 0.099
4.303GlnGlu: 4.303 ± 0.221
1.771GlnPhe: 1.771 ± 0.091
2.043GlnGly: 2.043 ± 0.121
0.65GlnHis: 0.65 ± 0.055
5.574GlnIle: 5.574 ± 0.194
8.661GlnLys: 8.661 ± 0.387
5.003GlnLeu: 5.003 ± 0.239
1.099GlnMet: 1.099 ± 0.073
4.17GlnAsn: 4.17 ± 0.211
1.227GlnPro: 1.227 ± 0.104
2.626GlnGln: 2.626 ± 0.185
1.916GlnArg: 1.916 ± 0.104
2.543GlnSer: 2.543 ± 0.121
3.553GlnThr: 3.553 ± 0.166
1.921GlnVal: 1.921 ± 0.115
0.211GlnTrp: 0.211 ± 0.035
1.249GlnTyr: 1.249 ± 0.085
0.0GlnXaa: 0.0 ± 0.0
Arg
1.238ArgAla: 1.238 ± 0.105
0.339ArgCys: 0.339 ± 0.041
1.421ArgAsp: 1.421 ± 0.097
1.921ArgGlu: 1.921 ± 0.129
1.655ArgPhe: 1.655 ± 0.11
1.316ArgGly: 1.316 ± 0.097
0.622ArgHis: 0.622 ± 0.059
2.665ArgIle: 2.665 ± 0.128
3.259ArgLys: 3.259 ± 0.136
3.037ArgLeu: 3.037 ± 0.131
0.594ArgMet: 0.594 ± 0.058
2.065ArgAsn: 2.065 ± 0.119
1.016ArgPro: 1.016 ± 0.088
1.516ArgGln: 1.516 ± 0.091
1.16ArgArg: 1.16 ± 0.092
1.482ArgSer: 1.482 ± 0.098
1.316ArgThr: 1.316 ± 0.101
1.46ArgVal: 1.46 ± 0.092
0.244ArgTrp: 0.244 ± 0.034
1.21ArgTyr: 1.21 ± 0.094
0.0ArgXaa: 0.0 ± 0.0
Ser
1.699SerAla: 1.699 ± 0.093
0.633SerCys: 0.633 ± 0.061
2.826SerAsp: 2.826 ± 0.129
2.993SerGlu: 2.993 ± 0.12
4.125SerPhe: 4.125 ± 0.172
2.882SerGly: 2.882 ± 0.154
1.266SerHis: 1.266 ± 0.093
4.314SerIle: 4.314 ± 0.156
5.486SerLys: 5.486 ± 0.147
6.707SerLeu: 6.707 ± 0.234
0.727SerMet: 0.727 ± 0.069
3.559SerAsn: 3.559 ± 0.154
1.949SerPro: 1.949 ± 0.11
3.825SerGln: 3.825 ± 0.136
1.86SerArg: 1.86 ± 0.103
3.742SerSer: 3.742 ± 0.167
2.221SerThr: 2.221 ± 0.126
2.454SerVal: 2.454 ± 0.152
0.483SerTrp: 0.483 ± 0.051
2.315SerTyr: 2.315 ± 0.092
0.0SerXaa: 0.0 ± 0.0
Thr
2.071ThrAla: 2.071 ± 0.103
0.366ThrCys: 0.366 ± 0.044
1.899ThrAsp: 1.899 ± 0.105
2.87ThrGlu: 2.87 ± 0.152
3.081ThrPhe: 3.081 ± 0.129
2.415ThrGly: 2.415 ± 0.132
1.088ThrHis: 1.088 ± 0.083
5.141ThrIle: 5.141 ± 0.174
6.318ThrLys: 6.318 ± 0.291
5.719ThrLeu: 5.719 ± 0.186
0.566ThrMet: 0.566 ± 0.057
3.831ThrAsn: 3.831 ± 0.179
2.432ThrPro: 2.432 ± 0.118
2.959ThrGln: 2.959 ± 0.14
1.405ThrArg: 1.405 ± 0.101
3.093ThrSer: 3.093 ± 0.139
3.492ThrThr: 3.492 ± 0.162
2.226ThrVal: 2.226 ± 0.153
0.344ThrTrp: 0.344 ± 0.048
2.038ThrTyr: 2.038 ± 0.115
0.0ThrXaa: 0.0 ± 0.0
Val
2.665ValAla: 2.665 ± 0.143
0.561ValCys: 0.561 ± 0.06
2.415ValAsp: 2.415 ± 0.118
2.782ValGlu: 2.782 ± 0.134
3.753ValPhe: 3.753 ± 0.173
2.615ValGly: 2.615 ± 0.129
0.594ValHis: 0.594 ± 0.063
4.808ValIle: 4.808 ± 0.159
4.048ValLys: 4.048 ± 0.156
5.597ValLeu: 5.597 ± 0.246
0.988ValMet: 0.988 ± 0.078
2.826ValAsn: 2.826 ± 0.139
1.388ValPro: 1.388 ± 0.089
1.549ValGln: 1.549 ± 0.093
1.155ValArg: 1.155 ± 0.09
3.048ValSer: 3.048 ± 0.157
1.988ValThr: 1.988 ± 0.149
3.526ValVal: 3.526 ± 0.174
0.316ValTrp: 0.316 ± 0.044
1.666ValTyr: 1.666 ± 0.113
0.0ValXaa: 0.0 ± 0.0
Trp
0.2TrpAla: 0.2 ± 0.032
0.067TrpCys: 0.067 ± 0.021
0.267TrpAsp: 0.267 ± 0.049
0.455TrpGlu: 0.455 ± 0.055
0.561TrpPhe: 0.561 ± 0.059
0.3TrpGly: 0.3 ± 0.045
0.161TrpHis: 0.161 ± 0.03
0.316TrpIle: 0.316 ± 0.044
0.594TrpLys: 0.594 ± 0.054
0.883TrpLeu: 0.883 ± 0.075
0.189TrpMet: 0.189 ± 0.03
0.344TrpAsn: 0.344 ± 0.051
0.144TrpPro: 0.144 ± 0.034
0.494TrpGln: 0.494 ± 0.057
0.233TrpArg: 0.233 ± 0.036
0.278TrpSer: 0.278 ± 0.04
0.205TrpThr: 0.205 ± 0.038
0.333TrpVal: 0.333 ± 0.042
0.05TrpTrp: 0.05 ± 0.017
0.283TrpTyr: 0.283 ± 0.043
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.394TyrAla: 1.394 ± 0.109
0.405TyrCys: 0.405 ± 0.044
2.082TyrAsp: 2.082 ± 0.114
1.804TyrGlu: 1.804 ± 0.107
2.782TyrPhe: 2.782 ± 0.124
1.605TyrGly: 1.605 ± 0.088
1.033TyrHis: 1.033 ± 0.075
2.465TyrIle: 2.465 ± 0.147
2.665TyrLys: 2.665 ± 0.136
5.03TyrLeu: 5.03 ± 0.18
0.483TyrMet: 0.483 ± 0.045
2.554TyrAsn: 2.554 ± 0.155
1.244TyrPro: 1.244 ± 0.09
3.204TyrGln: 3.204 ± 0.149
1.316TyrArg: 1.316 ± 0.089
1.827TyrSer: 1.827 ± 0.112
1.749TyrThr: 1.749 ± 0.125
1.705TyrVal: 1.705 ± 0.126
0.267TyrTrp: 0.267 ± 0.042
2.032TyrTyr: 2.032 ± 0.133
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 633 proteins (180110 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski