Amino acid dipepetide frequency for Plasmodiophora brassicae (Clubroot disease)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.528AlaAla: 11.528 ± 0.084	1.933AlaCys: 1.933 ± 0.023	6.183AlaAsp: 6.183 ± 0.045	4.744AlaGlu: 4.744 ± 0.041	4.011AlaPhe: 4.011 ± 0.036	6.257AlaGly: 6.257 ± 0.047	2.193AlaHis: 2.193 ± 0.023	5.037AlaIle: 5.037 ± 0.038	3.631AlaLys: 3.631 ± 0.038	10.601AlaLeu: 10.601 ± 0.075	2.735AlaMet: 2.735 ± 0.023	2.995AlaAsn: 2.995 ± 0.026	5.289AlaPro: 5.289 ± 0.053	3.504AlaGln: 3.504 ± 0.033	6.775AlaArg: 6.775 ± 0.049	8.239AlaSer: 8.239 ± 0.051	5.735AlaThr: 5.735 ± 0.04	8.28AlaVal: 8.28 ± 0.051	1.138AlaTrp: 1.138 ± 0.02	2.162AlaTyr: 2.162 ± 0.025	0.003AlaXaa: 0.003 ± 0.001
Cys	1.691CysAla: 1.691 ± 0.023	0.427CysCys: 0.427 ± 0.011	1.139CysAsp: 1.139 ± 0.016	0.748CysGlu: 0.748 ± 0.013	0.608CysPhe: 0.608 ± 0.013	1.308CysGly: 1.308 ± 0.023	0.495CysHis: 0.495 ± 0.013	0.918CysIle: 0.918 ± 0.015	0.593CysLys: 0.593 ± 0.013	1.826CysLeu: 1.826 ± 0.022	0.399CysMet: 0.399 ± 0.01	0.638CysAsn: 0.638 ± 0.013	1.136CysPro: 1.136 ± 0.046	0.727CysGln: 0.727 ± 0.014	1.549CysArg: 1.549 ± 0.024	1.401CysSer: 1.401 ± 0.024	1.09CysThr: 1.09 ± 0.019	1.326CysVal: 1.326 ± 0.02	0.229CysTrp: 0.229 ± 0.007	0.339CysTyr: 0.339 ± 0.009	0.001CysXaa: 0.001 ± 0.0
Asp	7.045AspAla: 7.045 ± 0.048	0.93AspCys: 0.93 ± 0.016	6.183AspAsp: 6.183 ± 0.068	3.985AspGlu: 3.985 ± 0.038	1.874AspPhe: 1.874 ± 0.023	4.444AspGly: 4.444 ± 0.037	1.462AspHis: 1.462 ± 0.022	2.884AspIle: 2.884 ± 0.025	1.853AspLys: 1.853 ± 0.022	6.23AspLeu: 6.23 ± 0.048	1.363AspMet: 1.363 ± 0.018	1.827AspAsn: 1.827 ± 0.022	3.264AspPro: 3.264 ± 0.028	2.037AspGln: 2.037 ± 0.024	4.318AspArg: 4.318 ± 0.036	3.487AspSer: 3.487 ± 0.034	2.744AspThr: 2.744 ± 0.022	5.584AspVal: 5.584 ± 0.043	0.73AspTrp: 0.73 ± 0.015	1.22AspTyr: 1.22 ± 0.019	0.001AspXaa: 0.001 ± 0.0
Glu	4.732GluAla: 4.732 ± 0.039	0.871GluCys: 0.871 ± 0.014	2.681GluAsp: 2.681 ± 0.029	2.949GluGlu: 2.949 ± 0.04	2.131GluPhe: 2.131 ± 0.026	2.343GluGly: 2.343 ± 0.025	1.383GluHis: 1.383 ± 0.019	2.42GluIle: 2.42 ± 0.027	2.005GluLys: 2.005 ± 0.033	4.758GluLeu: 4.758 ± 0.042	1.261GluMet: 1.261 ± 0.017	1.389GluAsn: 1.389 ± 0.021	2.273GluPro: 2.273 ± 0.026	2.357GluGln: 2.357 ± 0.029	4.511GluArg: 4.511 ± 0.046	3.606GluSer: 3.606 ± 0.031	2.642GluThr: 2.642 ± 0.024	3.027GluVal: 3.027 ± 0.025	0.607GluTrp: 0.607 ± 0.011	1.246GluTyr: 1.246 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.702PheAla: 3.702 ± 0.034	0.708PheCys: 0.708 ± 0.013	2.676PheAsp: 2.676 ± 0.029	1.942PheGlu: 1.942 ± 0.022	1.292PhePhe: 1.292 ± 0.02	2.567PheGly: 2.567 ± 0.028	0.901PheHis: 0.901 ± 0.016	1.642PheIle: 1.642 ± 0.02	1.233PheLys: 1.233 ± 0.019	3.446PheLeu: 3.446 ± 0.032	0.833PheMet: 0.833 ± 0.012	1.222PheAsn: 1.222 ± 0.019	1.618PhePro: 1.618 ± 0.021	1.403PheGln: 1.403 ± 0.018	2.367PheArg: 2.367 ± 0.026	2.535PheSer: 2.535 ± 0.027	1.922PheThr: 1.922 ± 0.022	3.185PheVal: 3.185 ± 0.032	0.505PheTrp: 0.505 ± 0.012	0.903PheTyr: 0.903 ± 0.015	0.001PheXaa: 0.001 ± 0.0
Gly	6.079GlyAla: 6.079 ± 0.053	1.02GlyCys: 1.02 ± 0.017	4.06GlyAsp: 4.06 ± 0.037	2.68GlyGlu: 2.68 ± 0.025	2.157GlyPhe: 2.157 ± 0.023	4.193GlyGly: 4.193 ± 0.047	1.807GlyHis: 1.807 ± 0.024	2.952GlyIle: 2.952 ± 0.031	2.351GlyLys: 2.351 ± 0.025	5.097GlyLeu: 5.097 ± 0.043	1.367GlyMet: 1.367 ± 0.018	2.149GlyAsn: 2.149 ± 0.024	2.851GlyPro: 2.851 ± 0.029	2.334GlyGln: 2.334 ± 0.025	4.703GlyArg: 4.703 ± 0.035	4.839GlySer: 4.839 ± 0.044	3.687GlyThr: 3.687 ± 0.036	4.592GlyVal: 4.592 ± 0.039	0.743GlyTrp: 0.743 ± 0.013	1.462GlyTyr: 1.462 ± 0.022	0.002GlyXaa: 0.002 ± 0.001
His	2.416HisAla: 2.416 ± 0.024	0.579HisCys: 0.579 ± 0.013	1.676HisAsp: 1.676 ± 0.021	1.278HisGlu: 1.278 ± 0.019	0.803HisPhe: 0.803 ± 0.014	1.67HisGly: 1.67 ± 0.021	0.768HisHis: 0.768 ± 0.015	1.105HisIle: 1.105 ± 0.016	0.719HisLys: 0.719 ± 0.013	2.56HisLeu: 2.56 ± 0.033	0.557HisMet: 0.557 ± 0.011	0.694HisAsn: 0.694 ± 0.012	1.437HisPro: 1.437 ± 0.022	0.92HisGln: 0.92 ± 0.016	2.119HisArg: 2.119 ± 0.022	1.6HisSer: 1.6 ± 0.022	1.072HisThr: 1.072 ± 0.016	2.204HisVal: 2.204 ± 0.021	0.389HisTrp: 0.389 ± 0.01	0.6HisTyr: 0.6 ± 0.011	0.001HisXaa: 0.001 ± 0.0
Ile	5.236IleAla: 5.236 ± 0.039	0.926IleCys: 0.926 ± 0.014	3.298IleAsp: 3.298 ± 0.031	2.605IleGlu: 2.605 ± 0.028	1.302IlePhe: 1.302 ± 0.019	3.121IleGly: 3.121 ± 0.03	0.981IleHis: 0.981 ± 0.013	1.968IleIle: 1.968 ± 0.024	1.519IleLys: 1.519 ± 0.022	3.83IleLeu: 3.83 ± 0.032	1.025IleMet: 1.025 ± 0.014	1.315IleAsn: 1.315 ± 0.017	2.232IlePro: 2.232 ± 0.024	1.648IleGln: 1.648 ± 0.022	3.376IleArg: 3.376 ± 0.033	3.034IleSer: 3.034 ± 0.03	2.318IleThr: 2.318 ± 0.026	4.523IleVal: 4.523 ± 0.037	0.569IleTrp: 0.569 ± 0.012	0.908IleTyr: 0.908 ± 0.016	0.001IleXaa: 0.001 ± 0.0
Lys	3.657LysAla: 3.657 ± 0.035	0.579LysCys: 0.579 ± 0.013	1.86LysAsp: 1.86 ± 0.02	1.889LysGlu: 1.889 ± 0.032	1.3LysPhe: 1.3 ± 0.018	1.914LysGly: 1.914 ± 0.025	0.907LysHis: 0.907 ± 0.015	1.436LysIle: 1.436 ± 0.02	1.966LysLys: 1.966 ± 0.034	3.17LysLeu: 3.17 ± 0.032	0.853LysMet: 0.853 ± 0.015	1.036LysAsn: 1.036 ± 0.018	1.845LysPro: 1.845 ± 0.028	1.655LysGln: 1.655 ± 0.023	3.088LysArg: 3.088 ± 0.032	2.643LysSer: 2.643 ± 0.029	2.03LysThr: 2.03 ± 0.023	2.429LysVal: 2.429 ± 0.026	0.453LysTrp: 0.453 ± 0.01	0.933LysTyr: 0.933 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	9.424LeuAla: 9.424 ± 0.057	1.851LeuCys: 1.851 ± 0.026	5.773LeuAsp: 5.773 ± 0.039	4.766LeuGlu: 4.766 ± 0.044	3.7LeuPhe: 3.7 ± 0.035	5.191LeuGly: 5.191 ± 0.039	2.823LeuHis: 2.823 ± 0.032	3.848LeuIle: 3.848 ± 0.038	3.475LeuLys: 3.475 ± 0.038	10.019LeuLeu: 10.019 ± 0.077	2.068LeuMet: 2.068 ± 0.024	2.816LeuAsn: 2.816 ± 0.026	5.011LeuPro: 5.011 ± 0.04	4.343LeuGln: 4.343 ± 0.036	6.968LeuArg: 6.968 ± 0.053	7.934LeuSer: 7.934 ± 0.059	5.048LeuThr: 5.048 ± 0.038	7.035LeuVal: 7.035 ± 0.043	1.085LeuTrp: 1.085 ± 0.016	2.263LeuTyr: 2.263 ± 0.029	0.001LeuXaa: 0.001 ± 0.0
Met	2.57MetAla: 2.57 ± 0.022	0.364MetCys: 0.364 ± 0.008	1.231MetAsp: 1.231 ± 0.016	1.124MetGlu: 1.124 ± 0.02	1.023MetPhe: 1.023 ± 0.016	1.275MetGly: 1.275 ± 0.019	0.611MetHis: 0.611 ± 0.011	1.005MetIle: 1.005 ± 0.017	0.932MetLys: 0.932 ± 0.016	2.335MetLeu: 2.335 ± 0.026	0.681MetMet: 0.681 ± 0.013	0.697MetAsn: 0.697 ± 0.013	1.27MetPro: 1.27 ± 0.016	1.031MetGln: 1.031 ± 0.018	1.622MetArg: 1.622 ± 0.019	2.076MetSer: 2.076 ± 0.019	1.542MetThr: 1.542 ± 0.019	1.575MetVal: 1.575 ± 0.02	0.252MetTrp: 0.252 ± 0.007	0.532MetTyr: 0.532 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.602AsnAla: 3.602 ± 0.034	0.5AsnCys: 0.5 ± 0.013	2.149AsnAsp: 2.149 ± 0.024	1.698AsnGlu: 1.698 ± 0.02	0.904AsnPhe: 0.904 ± 0.017	2.302AsnGly: 2.302 ± 0.028	0.612AsnHis: 0.612 ± 0.012	1.326AsnIle: 1.326 ± 0.02	0.96AsnLys: 0.96 ± 0.016	2.79AsnLeu: 2.79 ± 0.028	0.665AsnMet: 0.665 ± 0.013	0.956AsnAsn: 0.956 ± 0.017	1.685AsnPro: 1.685 ± 0.02	0.998AsnGln: 0.998 ± 0.018	2.109AsnArg: 2.109 ± 0.024	1.726AsnSer: 1.726 ± 0.023	1.355AsnThr: 1.355 ± 0.02	2.923AsnVal: 2.923 ± 0.03	0.382AsnTrp: 0.382 ± 0.01	0.599AsnTyr: 0.599 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.773ProAla: 5.773 ± 0.055	0.827ProCys: 0.827 ± 0.023	3.682ProAsp: 3.682 ± 0.035	2.622ProGlu: 2.622 ± 0.028	1.903ProPhe: 1.903 ± 0.022	3.751ProGly: 3.751 ± 0.041	1.115ProHis: 1.115 ± 0.016	2.253ProIle: 2.253 ± 0.024	1.687ProLys: 1.687 ± 0.023	4.155ProLeu: 4.155 ± 0.032	1.182ProMet: 1.182 ± 0.017	1.611ProAsn: 1.611 ± 0.02	3.713ProPro: 3.713 ± 0.051	1.53ProGln: 1.53 ± 0.02	3.047ProArg: 3.047 ± 0.029	5.006ProSer: 5.006 ± 0.045	3.115ProThr: 3.115 ± 0.032	4.561ProVal: 4.561 ± 0.039	0.56ProTrp: 0.56 ± 0.012	1.096ProTyr: 1.096 ± 0.017	0.001ProXaa: 0.001 ± 0.001
Gln	4.021GlnAla: 4.021 ± 0.033	0.842GlnCys: 0.842 ± 0.017	1.785GlnAsp: 1.785 ± 0.022	1.898GlnGlu: 1.898 ± 0.026	1.541GlnPhe: 1.541 ± 0.019	2.011GlnGly: 2.011 ± 0.024	1.108GlnHis: 1.108 ± 0.017	1.825GlnIle: 1.825 ± 0.021	1.354GlnLys: 1.354 ± 0.021	3.733GlnLeu: 3.733 ± 0.038	1.07GlnMet: 1.07 ± 0.016	0.967GlnAsn: 0.967 ± 0.015	1.809GlnPro: 1.809 ± 0.02	2.293GlnGln: 2.293 ± 0.044	3.373GlnArg: 3.373 ± 0.037	2.731GlnSer: 2.731 ± 0.027	2.153GlnThr: 2.153 ± 0.024	2.728GlnVal: 2.728 ± 0.029	0.611GlnTrp: 0.611 ± 0.014	0.997GlnTyr: 0.997 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	6.659ArgAla: 6.659 ± 0.048	1.486ArgCys: 1.486 ± 0.023	4.183ArgAsp: 4.183 ± 0.035	3.234ArgGlu: 3.234 ± 0.034	2.786ArgPhe: 2.786 ± 0.029	3.429ArgGly: 3.429 ± 0.032	2.31ArgHis: 2.31 ± 0.024	3.6ArgIle: 3.6 ± 0.03	2.688ArgLys: 2.688 ± 0.031	7.63ArgLeu: 7.63 ± 0.051	1.681ArgMet: 1.681 ± 0.02	2.174ArgAsn: 2.174 ± 0.023	4.001ArgPro: 4.001 ± 0.038	3.463ArgGln: 3.463 ± 0.032	7.133ArgArg: 7.133 ± 0.066	5.744ArgSer: 5.744 ± 0.041	3.678ArgThr: 3.678 ± 0.031	5.154ArgVal: 5.154 ± 0.036	0.995ArgTrp: 0.995 ± 0.018	1.751ArgTyr: 1.751 ± 0.02	0.002ArgXaa: 0.002 ± 0.001
Ser	7.819SerAla: 7.819 ± 0.056	1.458SerCys: 1.458 ± 0.023	4.327SerAsp: 4.327 ± 0.035	3.22SerGlu: 3.22 ± 0.031	2.648SerPhe: 2.648 ± 0.028	5.145SerGly: 5.145 ± 0.043	1.612SerHis: 1.612 ± 0.02	3.577SerIle: 3.577 ± 0.034	2.771SerLys: 2.771 ± 0.031	7.246SerLeu: 7.246 ± 0.05	1.93SerMet: 1.93 ± 0.023	2.382SerAsn: 2.382 ± 0.026	4.473SerPro: 4.473 ± 0.047	2.576SerGln: 2.576 ± 0.029	5.195SerArg: 5.195 ± 0.041	8.116SerSer: 8.116 ± 0.074	4.741SerThr: 4.741 ± 0.043	5.727SerVal: 5.727 ± 0.042	1.03SerTrp: 1.03 ± 0.016	1.558SerTyr: 1.558 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.325ThrAla: 5.325 ± 0.04	1.107ThrCys: 1.107 ± 0.019	2.795ThrAsp: 2.795 ± 0.027	2.186ThrGlu: 2.186 ± 0.025	2.243ThrPhe: 2.243 ± 0.026	3.681ThrGly: 3.681 ± 0.038	1.079ThrHis: 1.079 ± 0.015	2.818ThrIle: 2.818 ± 0.031	1.894ThrLys: 1.894 ± 0.028	5.264ThrLeu: 5.264 ± 0.042	1.535ThrMet: 1.535 ± 0.02	1.621ThrAsn: 1.621 ± 0.022	3.265ThrPro: 3.265 ± 0.037	1.594ThrGln: 1.594 ± 0.018	3.452ThrArg: 3.452 ± 0.03	4.673ThrSer: 4.673 ± 0.038	3.713ThrThr: 3.713 ± 0.038	4.341ThrVal: 4.341 ± 0.036	0.769ThrTrp: 0.769 ± 0.013	1.229ThrTyr: 1.229 ± 0.021	0.001ThrXaa: 0.001 ± 0.0
Val	8.275ValAla: 8.275 ± 0.055	1.457ValCys: 1.457 ± 0.023	5.582ValAsp: 5.582 ± 0.038	3.973ValGlu: 3.973 ± 0.032	2.999ValPhe: 2.999 ± 0.031	4.466ValGly: 4.466 ± 0.034	2.103ValHis: 2.103 ± 0.023	3.523ValIle: 3.523 ± 0.031	2.678ValLys: 2.678 ± 0.028	7.41ValLeu: 7.41 ± 0.043	1.646ValMet: 1.646 ± 0.023	2.462ValAsn: 2.462 ± 0.03	4.424ValPro: 4.424 ± 0.036	3.107ValGln: 3.107 ± 0.025	5.296ValArg: 5.296 ± 0.041	5.654ValSer: 5.654 ± 0.045	4.016ValThr: 4.016 ± 0.041	7.355ValVal: 7.355 ± 0.057	0.92ValTrp: 0.92 ± 0.015	1.778ValTyr: 1.778 ± 0.021	0.001ValXaa: 0.001 ± 0.0
Trp	1.275TrpAla: 1.275 ± 0.021	0.231TrpCys: 0.231 ± 0.008	0.703TrpAsp: 0.703 ± 0.017	0.485TrpGlu: 0.485 ± 0.011	0.488TrpPhe: 0.488 ± 0.01	0.586TrpGly: 0.586 ± 0.013	0.338TrpHis: 0.338 ± 0.009	0.647TrpIle: 0.647 ± 0.011	0.533TrpLys: 0.533 ± 0.012	1.099TrpLeu: 1.099 ± 0.018	0.37TrpMet: 0.37 ± 0.01	0.482TrpAsn: 0.482 ± 0.01	0.548TrpPro: 0.548 ± 0.013	0.517TrpGln: 0.517 ± 0.011	1.026TrpArg: 1.026 ± 0.021	1.007TrpSer: 1.007 ± 0.015	0.825TrpThr: 0.825 ± 0.015	0.833TrpVal: 0.833 ± 0.014	0.172TrpTrp: 0.172 ± 0.007	0.288TrpTyr: 0.288 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.139TyrAla: 2.139 ± 0.022	0.496TyrCys: 0.496 ± 0.018	1.502TyrAsp: 1.502 ± 0.019	1.165TyrGlu: 1.165 ± 0.016	0.889TyrPhe: 0.889 ± 0.014	1.47TyrGly: 1.47 ± 0.02	0.559TyrHis: 0.559 ± 0.013	0.948TyrIle: 0.948 ± 0.016	0.8TyrLys: 0.8 ± 0.014	2.241TyrLeu: 2.241 ± 0.026	0.527TyrMet: 0.527 ± 0.01	0.805TyrAsn: 0.805 ± 0.015	1.045TyrPro: 1.045 ± 0.014	0.812TyrGln: 0.812 ± 0.015	1.753TyrArg: 1.753 ± 0.021	1.499TyrSer: 1.499 ± 0.021	1.158TyrThr: 1.158 ± 0.017	1.744TyrVal: 1.744 ± 0.021	0.313TyrTrp: 0.313 ± 0.008	0.626TyrTyr: 0.626 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.058XaaXaa: 0.058 ± 0.011

Statistics based on 9720 proteins (4369470 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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