Amino acid dipepetide frequency for Clostridium sp. CAG:1000

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.999AlaAla: 1.999 ± 0.1
0.642AlaCys: 0.642 ± 0.05
1.982AlaAsp: 1.982 ± 0.083
1.97AlaGlu: 1.97 ± 0.089
2.055AlaPhe: 2.055 ± 0.086
2.224AlaGly: 2.224 ± 0.098
0.572AlaHis: 0.572 ± 0.049
4.36AlaIle: 4.36 ± 0.126
3.896AlaLys: 3.896 ± 0.136
4.378AlaLeu: 4.378 ± 0.114
0.922AlaMet: 0.922 ± 0.066
2.288AlaAsn: 2.288 ± 0.091
0.963AlaPro: 0.963 ± 0.065
0.916AlaGln: 0.916 ± 0.064
1.436AlaArg: 1.436 ± 0.081
3.12AlaSer: 3.12 ± 0.104
2.306AlaThr: 2.306 ± 0.091
2.717AlaVal: 2.717 ± 0.105
0.231AlaTrp: 0.231 ± 0.028
1.926AlaTyr: 1.926 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.546CysAla: 0.546 ± 0.04
0.128CysCys: 0.128 ± 0.021
0.841CysAsp: 0.841 ± 0.051
0.881CysGlu: 0.881 ± 0.045
0.534CysPhe: 0.534 ± 0.041
0.975CysGly: 0.975 ± 0.06
0.169CysHis: 0.169 ± 0.023
1.1CysIle: 1.1 ± 0.062
1.106CysLys: 1.106 ± 0.058
0.94CysLeu: 0.94 ± 0.051
0.219CysMet: 0.219 ± 0.025
0.87CysAsn: 0.87 ± 0.06
0.388CysPro: 0.388 ± 0.039
0.19CysGln: 0.19 ± 0.026
0.298CysArg: 0.298 ± 0.03
0.8CysSer: 0.8 ± 0.049
0.616CysThr: 0.616 ± 0.046
0.712CysVal: 0.712 ± 0.043
0.061CysTrp: 0.061 ± 0.014
0.578CysTyr: 0.578 ± 0.041
0.0CysXaa: 0.0 ± 0.0
Asp
2.559AspAla: 2.559 ± 0.09
0.555AspCys: 0.555 ± 0.047
3.587AspAsp: 3.587 ± 0.118
5.195AspGlu: 5.195 ± 0.132
2.843AspPhe: 2.843 ± 0.095
3.21AspGly: 3.21 ± 0.107
0.59AspHis: 0.59 ± 0.044
6.645AspIle: 6.645 ± 0.141
6.555AspLys: 6.555 ± 0.137
5.148AspLeu: 5.148 ± 0.131
1.468AspMet: 1.468 ± 0.068
4.664AspAsn: 4.664 ± 0.128
1.164AspPro: 1.164 ± 0.068
0.695AspGln: 0.695 ± 0.046
1.757AspArg: 1.757 ± 0.08
3.952AspSer: 3.952 ± 0.11
3.248AspThr: 3.248 ± 0.101
3.45AspVal: 3.45 ± 0.107
0.268AspTrp: 0.268 ± 0.03
3.905AspTyr: 3.905 ± 0.111
0.0AspXaa: 0.0 ± 0.0
Glu
2.895GluAla: 2.895 ± 0.104
0.782GluCys: 0.782 ± 0.049
3.82GluAsp: 3.82 ± 0.12
5.857GluGlu: 5.857 ± 0.153
3.009GluPhe: 3.009 ± 0.106
2.881GluGly: 2.881 ± 0.095
0.841GluHis: 0.841 ± 0.056
6.637GluIle: 6.637 ± 0.146
7.413GluLys: 7.413 ± 0.163
6.96GluLeu: 6.96 ± 0.164
1.894GluMet: 1.894 ± 0.084
5.247GluAsn: 5.247 ± 0.128
1.229GluPro: 1.229 ± 0.067
1.547GluGln: 1.547 ± 0.076
2.291GluArg: 2.291 ± 0.091
4.068GluSer: 4.068 ± 0.121
3.228GluThr: 3.228 ± 0.119
4.664GluVal: 4.664 ± 0.133
0.397GluTrp: 0.397 ± 0.035
4.165GluTyr: 4.165 ± 0.124
0.0GluXaa: 0.0 ± 0.0
Phe
1.847PheAla: 1.847 ± 0.081
0.417PheCys: 0.417 ± 0.039
3.228PheAsp: 3.228 ± 0.099
2.74PheGlu: 2.74 ± 0.099
1.824PhePhe: 1.824 ± 0.086
2.317PheGly: 2.317 ± 0.091
0.417PheHis: 0.417 ± 0.034
4.74PheIle: 4.74 ± 0.141
4.34PheLys: 4.34 ± 0.131
3.774PheLeu: 3.774 ± 0.114
1.115PheMet: 1.115 ± 0.058
3.566PheAsn: 3.566 ± 0.114
1.059PhePro: 1.059 ± 0.055
0.625PheGln: 0.625 ± 0.037
1.217PheArg: 1.217 ± 0.06
2.904PheSer: 2.904 ± 0.102
2.425PheThr: 2.425 ± 0.09
2.6PheVal: 2.6 ± 0.082
0.178PheTrp: 0.178 ± 0.022
2.195PheTyr: 2.195 ± 0.088
0.0PheXaa: 0.0 ± 0.0
Gly
2.265GlyAla: 2.265 ± 0.091
0.835GlyCys: 0.835 ± 0.058
2.866GlyAsp: 2.866 ± 0.104
2.913GlyGlu: 2.913 ± 0.099
2.416GlyPhe: 2.416 ± 0.087
2.962GlyGly: 2.962 ± 0.113
0.957GlyHis: 0.957 ± 0.056
5.23GlyIle: 5.23 ± 0.138
5.367GlyLys: 5.367 ± 0.135
4.357GlyLeu: 4.357 ± 0.122
1.348GlyMet: 1.348 ± 0.067
3.301GlyAsn: 3.301 ± 0.115
0.849GlyPro: 0.849 ± 0.055
1.042GlyGln: 1.042 ± 0.06
1.634GlyArg: 1.634 ± 0.081
3.66GlySer: 3.66 ± 0.132
3.067GlyThr: 3.067 ± 0.113
3.581GlyVal: 3.581 ± 0.116
0.327GlyTrp: 0.327 ± 0.036
3.137GlyTyr: 3.137 ± 0.104
0.0GlyXaa: 0.0 ± 0.0
His
0.584HisAla: 0.584 ± 0.038
0.178HisCys: 0.178 ± 0.025
0.721HisAsp: 0.721 ± 0.042
0.814HisGlu: 0.814 ± 0.051
0.555HisPhe: 0.555 ± 0.04
0.782HisGly: 0.782 ± 0.046
0.239HisHis: 0.239 ± 0.026
1.191HisIle: 1.191 ± 0.06
1.007HisLys: 1.007 ± 0.052
1.054HisLeu: 1.054 ± 0.06
0.315HisMet: 0.315 ± 0.03
0.87HisAsn: 0.87 ± 0.053
0.505HisPro: 0.505 ± 0.041
0.233HisGln: 0.233 ± 0.028
0.449HisArg: 0.449 ± 0.041
0.776HisSer: 0.776 ± 0.049
0.645HisThr: 0.645 ± 0.038
0.61HisVal: 0.61 ± 0.045
0.047HisTrp: 0.047 ± 0.013
0.581HisTyr: 0.581 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
4.13IleAla: 4.13 ± 0.132
1.305IleCys: 1.305 ± 0.069
6.996IleAsp: 6.996 ± 0.147
6.812IleGlu: 6.812 ± 0.177
4.34IlePhe: 4.34 ± 0.16
5.014IleGly: 5.014 ± 0.147
1.007IleHis: 1.007 ± 0.057
10.711IleIle: 10.711 ± 0.243
10.594IleLys: 10.594 ± 0.195
8.998IleLeu: 8.998 ± 0.215
2.221IleMet: 2.221 ± 0.087
8.531IleAsn: 8.531 ± 0.193
2.831IlePro: 2.831 ± 0.08
1.5IleGln: 1.5 ± 0.067
2.843IleArg: 2.843 ± 0.102
7.206IleSer: 7.206 ± 0.152
5.279IleThr: 5.279 ± 0.141
6.324IleVal: 6.324 ± 0.16
0.435IleTrp: 0.435 ± 0.041
4.579IleTyr: 4.579 ± 0.128
0.0IleXaa: 0.0 ± 0.0
Lys
3.359LysAla: 3.359 ± 0.103
1.091LysCys: 1.091 ± 0.065
6.759LysAsp: 6.759 ± 0.15
9.616LysGlu: 9.616 ± 0.21
3.286LysPhe: 3.286 ± 0.094
4.544LysGly: 4.544 ± 0.11
1.144LysHis: 1.144 ± 0.07
10.06LysIle: 10.06 ± 0.174
11.143LysLys: 11.143 ± 0.192
8.51LysLeu: 8.51 ± 0.154
2.793LysMet: 2.793 ± 0.077
8.566LysAsn: 8.566 ± 0.168
1.926LysPro: 1.926 ± 0.08
1.976LysGln: 1.976 ± 0.092
3.269LysArg: 3.269 ± 0.103
6.088LysSer: 6.088 ± 0.144
5.624LysThr: 5.624 ± 0.131
6.21LysVal: 6.21 ± 0.162
0.552LysTrp: 0.552 ± 0.045
6.917LysTyr: 6.917 ± 0.149
0.0LysXaa: 0.0 ± 0.0
Leu
3.476LeuAla: 3.476 ± 0.098
1.089LeuCys: 1.089 ± 0.055
5.434LeuAsp: 5.434 ± 0.146
5.808LeuGlu: 5.808 ± 0.136
4.077LeuPhe: 4.077 ± 0.119
4.891LeuGly: 4.891 ± 0.141
1.004LeuHis: 1.004 ± 0.058
8.808LeuIle: 8.808 ± 0.202
9.047LeuLys: 9.047 ± 0.191
8.493LeuLeu: 8.493 ± 0.211
2.031LeuMet: 2.031 ± 0.08
6.925LeuAsn: 6.925 ± 0.151
2.329LeuPro: 2.329 ± 0.087
1.477LeuGln: 1.477 ± 0.066
2.574LeuArg: 2.574 ± 0.091
7.098LeuSer: 7.098 ± 0.165
4.923LeuThr: 4.923 ± 0.121
5.031LeuVal: 5.031 ± 0.129
0.458LeuTrp: 0.458 ± 0.045
3.917LeuTyr: 3.917 ± 0.104
0.0LeuXaa: 0.0 ± 0.0
Met
1.194MetAla: 1.194 ± 0.062
0.266MetCys: 0.266 ± 0.025
1.316MetAsp: 1.316 ± 0.061
1.442MetGlu: 1.442 ± 0.076
1.162MetPhe: 1.162 ± 0.065
1.22MetGly: 1.22 ± 0.063
0.315MetHis: 0.315 ± 0.035
2.335MetIle: 2.335 ± 0.08
2.685MetLys: 2.685 ± 0.083
1.976MetLeu: 1.976 ± 0.087
0.578MetMet: 0.578 ± 0.046
2.078MetAsn: 2.078 ± 0.071
0.715MetPro: 0.715 ± 0.053
0.528MetGln: 0.528 ± 0.038
0.689MetArg: 0.689 ± 0.04
1.731MetSer: 1.731 ± 0.065
1.249MetThr: 1.249 ± 0.06
1.179MetVal: 1.179 ± 0.057
0.149MetTrp: 0.149 ± 0.023
1.103MetTyr: 1.103 ± 0.064
0.0MetXaa: 0.0 ± 0.0
Asn
2.936AsnAla: 2.936 ± 0.095
0.709AsnCys: 0.709 ± 0.054
5.131AsnAsp: 5.131 ± 0.133
5.638AsnGlu: 5.638 ± 0.145
2.711AsnPhe: 2.711 ± 0.095
3.94AsnGly: 3.94 ± 0.123
0.794AsnHis: 0.794 ± 0.049
8.653AsnIle: 8.653 ± 0.2
9.473AsnLys: 9.473 ± 0.189
5.7AsnLeu: 5.7 ± 0.159
1.897AsnMet: 1.897 ± 0.075
7.311AsnAsn: 7.311 ± 0.218
1.798AsnPro: 1.798 ± 0.068
1.334AsnGln: 1.334 ± 0.074
2.04AsnArg: 2.04 ± 0.086
4.725AsnSer: 4.725 ± 0.141
3.858AsnThr: 3.858 ± 0.127
4.194AsnVal: 4.194 ± 0.114
0.341AsnTrp: 0.341 ± 0.032
4.389AsnTyr: 4.389 ± 0.125
0.0AsnXaa: 0.0 ± 0.0
Pro
1.042ProAla: 1.042 ± 0.059
0.286ProCys: 0.286 ± 0.032
1.345ProAsp: 1.345 ± 0.064
1.614ProGlu: 1.614 ± 0.072
1.302ProPhe: 1.302 ± 0.068
1.235ProGly: 1.235 ± 0.062
0.362ProHis: 0.362 ± 0.036
2.116ProIle: 2.116 ± 0.076
2.221ProLys: 2.221 ± 0.087
1.976ProLeu: 1.976 ± 0.08
0.522ProMet: 0.522 ± 0.035
1.628ProAsn: 1.628 ± 0.072
0.435ProPro: 0.435 ± 0.04
0.537ProGln: 0.537 ± 0.041
0.654ProArg: 0.654 ± 0.039
1.626ProSer: 1.626 ± 0.084
1.407ProThr: 1.407 ± 0.068
1.719ProVal: 1.719 ± 0.093
0.125ProTrp: 0.125 ± 0.02
1.275ProTyr: 1.275 ± 0.068
0.0ProXaa: 0.0 ± 0.0
Gln
1.001GlnAla: 1.001 ± 0.06
0.172GlnCys: 0.172 ± 0.029
0.969GlnAsp: 0.969 ± 0.061
1.459GlnGlu: 1.459 ± 0.073
0.674GlnPhe: 0.674 ± 0.038
0.855GlnGly: 0.855 ± 0.053
0.161GlnHis: 0.161 ± 0.024
2.037GlnIle: 2.037 ± 0.081
1.804GlnLys: 1.804 ± 0.083
1.497GlnLeu: 1.497 ± 0.073
0.546GlnMet: 0.546 ± 0.046
1.299GlnAsn: 1.299 ± 0.065
0.414GlnPro: 0.414 ± 0.046
0.406GlnGln: 0.406 ± 0.037
0.773GlnArg: 0.773 ± 0.048
1.001GlnSer: 1.001 ± 0.053
1.22GlnThr: 1.22 ± 0.065
1.162GlnVal: 1.162 ± 0.058
0.125GlnTrp: 0.125 ± 0.02
0.849GlnTyr: 0.849 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
1.17ArgAla: 1.17 ± 0.059
0.403ArgCys: 0.403 ± 0.033
1.661ArgAsp: 1.661 ± 0.081
2.189ArgGlu: 2.189 ± 0.104
1.319ArgPhe: 1.319 ± 0.073
1.523ArgGly: 1.523 ± 0.072
0.455ArgHis: 0.455 ± 0.041
2.93ArgIle: 2.93 ± 0.108
3.193ArgLys: 3.193 ± 0.104
2.627ArgLeu: 2.627 ± 0.086
0.803ArgMet: 0.803 ± 0.051
2.148ArgAsn: 2.148 ± 0.089
0.662ArgPro: 0.662 ± 0.047
0.768ArgGln: 0.768 ± 0.054
1.199ArgArg: 1.199 ± 0.067
1.596ArgSer: 1.596 ± 0.068
1.623ArgThr: 1.623 ± 0.079
1.947ArgVal: 1.947 ± 0.086
0.178ArgTrp: 0.178 ± 0.023
1.497ArgTyr: 1.497 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
2.65SerAla: 2.65 ± 0.088
0.803SerCys: 0.803 ± 0.055
4.203SerAsp: 4.203 ± 0.123
4.354SerGlu: 4.354 ± 0.117
3.42SerPhe: 3.42 ± 0.109
3.922SerGly: 3.922 ± 0.141
0.87SerHis: 0.87 ± 0.052
6.888SerIle: 6.888 ± 0.15
6.893SerLys: 6.893 ± 0.147
6.409SerLeu: 6.409 ± 0.156
1.503SerMet: 1.503 ± 0.065
5.259SerAsn: 5.259 ± 0.153
1.401SerPro: 1.401 ± 0.072
1.415SerGln: 1.415 ± 0.082
1.83SerArg: 1.83 ± 0.082
5.329SerSer: 5.329 ± 0.19
3.473SerThr: 3.473 ± 0.116
3.873SerVal: 3.873 ± 0.123
0.391SerTrp: 0.391 ± 0.037
3.493SerTyr: 3.493 ± 0.114
0.0SerXaa: 0.0 ± 0.0
Thr
2.209ThrAla: 2.209 ± 0.097
0.68ThrCys: 0.68 ± 0.048
2.834ThrAsp: 2.834 ± 0.102
2.959ThrGlu: 2.959 ± 0.093
2.589ThrPhe: 2.589 ± 0.088
3.21ThrGly: 3.21 ± 0.109
0.75ThrHis: 0.75 ± 0.052
5.729ThrIle: 5.729 ± 0.161
5.037ThrLys: 5.037 ± 0.127
5.046ThrLeu: 5.046 ± 0.127
1.071ThrMet: 1.071 ± 0.059
3.806ThrAsn: 3.806 ± 0.118
1.69ThrPro: 1.69 ± 0.076
1.019ThrGln: 1.019 ± 0.054
1.558ThrArg: 1.558 ± 0.067
4.007ThrSer: 4.007 ± 0.129
3.073ThrThr: 3.073 ± 0.128
3.213ThrVal: 3.213 ± 0.112
0.312ThrTrp: 0.312 ± 0.031
2.755ThrTyr: 2.755 ± 0.122
0.0ThrXaa: 0.0 ± 0.0
Val
2.717ValAla: 2.717 ± 0.097
0.881ValCys: 0.881 ± 0.048
3.674ValAsp: 3.674 ± 0.116
3.633ValGlu: 3.633 ± 0.119
2.738ValPhe: 2.738 ± 0.084
3.301ValGly: 3.301 ± 0.112
0.788ValHis: 0.788 ± 0.051
5.939ValIle: 5.939 ± 0.14
5.554ValLys: 5.554 ± 0.13
5.802ValLeu: 5.802 ± 0.129
1.372ValMet: 1.372 ± 0.069
4.15ValAsn: 4.15 ± 0.133
1.669ValPro: 1.669 ± 0.079
1.03ValGln: 1.03 ± 0.061
1.678ValArg: 1.678 ± 0.076
4.71ValSer: 4.71 ± 0.127
3.394ValThr: 3.394 ± 0.11
4.036ValVal: 4.036 ± 0.119
0.304ValTrp: 0.304 ± 0.031
2.723ValTyr: 2.723 ± 0.085
0.0ValXaa: 0.0 ± 0.0
Trp
0.251TrpAla: 0.251 ± 0.029
0.079TrpCys: 0.079 ± 0.017
0.359TrpAsp: 0.359 ± 0.034
0.298TrpGlu: 0.298 ± 0.034
0.295TrpPhe: 0.295 ± 0.031
0.271TrpGly: 0.271 ± 0.03
0.064TrpHis: 0.064 ± 0.014
0.423TrpIle: 0.423 ± 0.036
0.403TrpLys: 0.403 ± 0.033
0.438TrpLeu: 0.438 ± 0.038
0.146TrpMet: 0.146 ± 0.022
0.403TrpAsn: 0.403 ± 0.035
0.114TrpPro: 0.114 ± 0.019
0.14TrpGln: 0.14 ± 0.024
0.131TrpArg: 0.131 ± 0.022
0.356TrpSer: 0.356 ± 0.035
0.286TrpThr: 0.286 ± 0.03
0.277TrpVal: 0.277 ± 0.028
0.073TrpTrp: 0.073 ± 0.019
0.414TrpTyr: 0.414 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.072TyrAla: 2.072 ± 0.082
0.651TyrCys: 0.651 ± 0.047
3.733TyrAsp: 3.733 ± 0.127
3.631TyrGlu: 3.631 ± 0.111
2.381TyrPhe: 2.381 ± 0.084
2.837TyrGly: 2.837 ± 0.095
0.657TyrHis: 0.657 ± 0.047
5.122TyrIle: 5.122 ± 0.128
5.706TyrLys: 5.706 ± 0.148
4.81TyrLeu: 4.81 ± 0.123
1.141TyrMet: 1.141 ± 0.064
4.664TyrAsn: 4.664 ± 0.133
1.284TyrPro: 1.284 ± 0.061
1.048TyrGln: 1.048 ± 0.051
1.57TyrArg: 1.57 ± 0.071
3.628TyrSer: 3.628 ± 0.1
2.603TyrThr: 2.603 ± 0.113
2.594TyrVal: 2.594 ± 0.101
0.268TyrTrp: 0.268 ± 0.028
3.231TyrTyr: 3.231 ± 0.135
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1142 proteins (342649 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski