Amino acid dipepetide frequency for Xylophilus sp. Leaf220

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.834AlaAla: 22.834 ± 0.23	1.309AlaCys: 1.309 ± 0.035	7.683AlaAsp: 7.683 ± 0.078	7.212AlaGlu: 7.212 ± 0.084	4.368AlaPhe: 4.368 ± 0.065	12.772AlaGly: 12.772 ± 0.126	2.814AlaHis: 2.814 ± 0.045	5.008AlaIle: 5.008 ± 0.075	3.437AlaLys: 3.437 ± 0.069	16.109AlaLeu: 16.109 ± 0.142	3.577AlaMet: 3.577 ± 0.055	2.55AlaAsn: 2.55 ± 0.06	7.64AlaPro: 7.64 ± 0.095	5.934AlaGln: 5.934 ± 0.086	10.195AlaArg: 10.195 ± 0.101	6.682AlaSer: 6.682 ± 0.086	6.958AlaThr: 6.958 ± 0.088	10.551AlaVal: 10.551 ± 0.1	2.12AlaTrp: 2.12 ± 0.05	2.495AlaTyr: 2.495 ± 0.044	0.002AlaXaa: 0.002 ± 0.001
Cys	1.15CysAla: 1.15 ± 0.034	0.105CysCys: 0.105 ± 0.01	0.513CysAsp: 0.513 ± 0.023	0.43CysGlu: 0.43 ± 0.019	0.262CysPhe: 0.262 ± 0.015	0.953CysGly: 0.953 ± 0.03	0.224CysHis: 0.224 ± 0.014	0.391CysIle: 0.391 ± 0.018	0.179CysLys: 0.179 ± 0.012	0.793CysLeu: 0.793 ± 0.024	0.213CysMet: 0.213 ± 0.013	0.217CysAsn: 0.217 ± 0.012	0.427CysPro: 0.427 ± 0.02	0.192CysGln: 0.192 ± 0.013	0.55CysArg: 0.55 ± 0.022	0.401CysSer: 0.401 ± 0.02	0.521CysThr: 0.521 ± 0.025	0.649CysVal: 0.649 ± 0.023	0.119CysTrp: 0.119 ± 0.01	0.168CysTyr: 0.168 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.357AspAla: 8.357 ± 0.098	0.432AspCys: 0.432 ± 0.019	2.863AspAsp: 2.863 ± 0.061	2.852AspGlu: 2.852 ± 0.054	2.082AspPhe: 2.082 ± 0.04	5.082AspGly: 5.082 ± 0.072	1.087AspHis: 1.087 ± 0.031	2.374AspIle: 2.374 ± 0.044	1.502AspLys: 1.502 ± 0.041	5.344AspLeu: 5.344 ± 0.074	1.223AspMet: 1.223 ± 0.034	1.104AspAsn: 1.104 ± 0.031	3.096AspPro: 3.096 ± 0.055	1.504AspGln: 1.504 ± 0.039	3.826AspArg: 3.826 ± 0.054	2.091AspSer: 2.091 ± 0.043	2.948AspThr: 2.948 ± 0.046	3.993AspVal: 3.993 ± 0.057	0.932AspTrp: 0.932 ± 0.027	1.328AspTyr: 1.328 ± 0.032	0.001AspXaa: 0.001 ± 0.001
Glu	6.768GluAla: 6.768 ± 0.082	0.333GluCys: 0.333 ± 0.016	2.186GluAsp: 2.186 ± 0.05	2.342GluGlu: 2.342 ± 0.054	1.572GluPhe: 1.572 ± 0.042	3.714GluGly: 3.714 ± 0.067	1.094GluHis: 1.094 ± 0.031	2.5GluIle: 2.5 ± 0.05	1.691GluLys: 1.691 ± 0.043	5.035GluLeu: 5.035 ± 0.082	1.182GluMet: 1.182 ± 0.032	1.118GluAsn: 1.118 ± 0.028	2.342GluPro: 2.342 ± 0.045	2.355GluGln: 2.355 ± 0.049	4.33GluArg: 4.33 ± 0.068	2.406GluSer: 2.406 ± 0.051	2.467GluThr: 2.467 ± 0.044	3.733GluVal: 3.733 ± 0.053	0.639GluTrp: 0.639 ± 0.026	0.902GluTyr: 0.902 ± 0.027	0.001GluXaa: 0.001 ± 0.001
Phe	4.444PheAla: 4.444 ± 0.065	0.395PheCys: 0.395 ± 0.02	2.636PheAsp: 2.636 ± 0.047	1.767PheGlu: 1.767 ± 0.037	1.339PhePhe: 1.339 ± 0.035	3.463PheGly: 3.463 ± 0.054	0.704PheHis: 0.704 ± 0.025	1.187PheIle: 1.187 ± 0.032	1.021PheLys: 1.021 ± 0.032	2.911PheLeu: 2.911 ± 0.047	0.718PheMet: 0.718 ± 0.026	0.962PheAsn: 0.962 ± 0.029	1.522PhePro: 1.522 ± 0.035	1.09PheGln: 1.09 ± 0.027	1.903PheArg: 1.903 ± 0.039	2.018PheSer: 2.018 ± 0.043	1.824PheThr: 1.824 ± 0.036	2.8PheVal: 2.8 ± 0.052	0.523PheTrp: 0.523 ± 0.022	0.808PheTyr: 0.808 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.729GlyAla: 10.729 ± 0.106	0.888GlyCys: 0.888 ± 0.027	4.239GlyAsp: 4.239 ± 0.057	4.089GlyGlu: 4.089 ± 0.059	3.437GlyPhe: 3.437 ± 0.049	7.813GlyGly: 7.813 ± 0.132	1.916GlyHis: 1.916 ± 0.039	4.115GlyIle: 4.115 ± 0.061	2.885GlyLys: 2.885 ± 0.065	9.158GlyLeu: 9.158 ± 0.106	2.359GlyMet: 2.359 ± 0.043	2.149GlyAsn: 2.149 ± 0.054	3.467GlyPro: 3.467 ± 0.052	3.246GlyGln: 3.246 ± 0.055	6.297GlyArg: 6.297 ± 0.079	4.67GlySer: 4.67 ± 0.069	5.468GlyThr: 5.468 ± 0.085	6.582GlyVal: 6.582 ± 0.078	1.514GlyTrp: 1.514 ± 0.043	2.355GlyTyr: 2.355 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	3.114HisAla: 3.114 ± 0.058	0.246HisCys: 0.246 ± 0.013	1.294HisAsp: 1.294 ± 0.032	0.916HisGlu: 0.916 ± 0.026	0.832HisPhe: 0.832 ± 0.026	2.209HisGly: 2.209 ± 0.052	0.576HisHis: 0.576 ± 0.021	0.809HisIle: 0.809 ± 0.025	0.484HisLys: 0.484 ± 0.019	2.176HisLeu: 2.176 ± 0.04	0.428HisMet: 0.428 ± 0.02	0.452HisAsn: 0.452 ± 0.021	1.469HisPro: 1.469 ± 0.034	0.654HisGln: 0.654 ± 0.025	1.621HisArg: 1.621 ± 0.038	0.834HisSer: 0.834 ± 0.025	1.049HisThr: 1.049 ± 0.029	1.394HisVal: 1.394 ± 0.031	0.407HisTrp: 0.407 ± 0.019	0.593HisTyr: 0.593 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.29IleAla: 6.29 ± 0.078	0.355IleCys: 0.355 ± 0.017	2.921IleAsp: 2.921 ± 0.051	2.51IleGlu: 2.51 ± 0.054	1.136IlePhe: 1.136 ± 0.031	4.098IleGly: 4.098 ± 0.06	0.717IleHis: 0.717 ± 0.025	1.036IleIle: 1.036 ± 0.037	1.161IleLys: 1.161 ± 0.035	2.94IleLeu: 2.94 ± 0.055	0.6IleMet: 0.6 ± 0.022	1.05IleAsn: 1.05 ± 0.029	1.837IlePro: 1.837 ± 0.04	1.132IleGln: 1.132 ± 0.034	2.501IleArg: 2.501 ± 0.043	1.847IleSer: 1.847 ± 0.039	2.126IleThr: 2.126 ± 0.046	3.548IleVal: 3.548 ± 0.053	0.384IleTrp: 0.384 ± 0.018	0.78IleTyr: 0.78 ± 0.027	0.001IleXaa: 0.001 ± 0.001
Lys	3.658LysAla: 3.658 ± 0.065	0.122LysCys: 0.122 ± 0.01	1.458LysAsp: 1.458 ± 0.042	1.337LysGlu: 1.337 ± 0.037	0.787LysPhe: 0.787 ± 0.027	2.109LysGly: 2.109 ± 0.044	0.489LysHis: 0.489 ± 0.019	1.264LysIle: 1.264 ± 0.034	1.158LysLys: 1.158 ± 0.038	2.903LysLeu: 2.903 ± 0.055	0.678LysMet: 0.678 ± 0.025	0.788LysAsn: 0.788 ± 0.024	1.817LysPro: 1.817 ± 0.044	1.003LysGln: 1.003 ± 0.03	1.961LysArg: 1.961 ± 0.044	1.531LysSer: 1.531 ± 0.038	1.795LysThr: 1.795 ± 0.044	2.232LysVal: 2.232 ± 0.047	0.28LysTrp: 0.28 ± 0.016	0.535LysTyr: 0.535 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.741LeuAla: 15.741 ± 0.141	0.952LeuCys: 0.952 ± 0.028	5.87LeuAsp: 5.87 ± 0.069	4.884LeuGlu: 4.884 ± 0.081	3.146LeuPhe: 3.146 ± 0.05	8.71LeuGly: 8.71 ± 0.097	2.465LeuHis: 2.465 ± 0.051	3.28LeuIle: 3.28 ± 0.059	2.939LeuLys: 2.939 ± 0.058	11.418LeuLeu: 11.418 ± 0.141	2.203LeuMet: 2.203 ± 0.043	2.255LeuAsn: 2.255 ± 0.044	6.558LeuPro: 6.558 ± 0.073	5.002LeuGln: 5.002 ± 0.065	8.179LeuArg: 8.179 ± 0.097	5.437LeuSer: 5.437 ± 0.068	4.898LeuThr: 4.898 ± 0.065	8.613LeuVal: 8.613 ± 0.091	1.325LeuTrp: 1.325 ± 0.032	1.991LeuTyr: 1.991 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.244MetAla: 3.244 ± 0.054	0.137MetCys: 0.137 ± 0.01	1.051MetAsp: 1.051 ± 0.032	1.039MetGlu: 1.039 ± 0.035	0.674MetPhe: 0.674 ± 0.022	1.858MetGly: 1.858 ± 0.037	0.528MetHis: 0.528 ± 0.023	0.684MetIle: 0.684 ± 0.024	0.802MetLys: 0.802 ± 0.031	2.615MetLeu: 2.615 ± 0.046	0.47MetMet: 0.47 ± 0.02	0.683MetAsn: 0.683 ± 0.023	1.564MetPro: 1.564 ± 0.039	1.108MetGln: 1.108 ± 0.028	1.708MetArg: 1.708 ± 0.036	1.299MetSer: 1.299 ± 0.031	1.38MetThr: 1.38 ± 0.034	1.914MetVal: 1.914 ± 0.044	0.165MetTrp: 0.165 ± 0.013	0.333MetTyr: 0.333 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.125AsnAla: 3.125 ± 0.056	0.215AsnCys: 0.215 ± 0.015	1.152AsnAsp: 1.152 ± 0.031	0.899AsnGlu: 0.899 ± 0.027	0.848AsnPhe: 0.848 ± 0.026	1.973AsnGly: 1.973 ± 0.047	0.428AsnHis: 0.428 ± 0.016	1.076AsnIle: 1.076 ± 0.034	0.641AsnLys: 0.641 ± 0.026	2.486AsnLeu: 2.486 ± 0.046	0.49AsnMet: 0.49 ± 0.022	0.632AsnAsn: 0.632 ± 0.024	1.649AsnPro: 1.649 ± 0.037	0.728AsnGln: 0.728 ± 0.022	1.585AsnArg: 1.585 ± 0.038	0.942AsnSer: 0.942 ± 0.036	1.303AsnThr: 1.303 ± 0.039	1.748AsnVal: 1.748 ± 0.041	0.31AsnTrp: 0.31 ± 0.015	0.605AsnTyr: 0.605 ± 0.023	0.001AsnXaa: 0.001 ± 0.001
Pro	9.061ProAla: 9.061 ± 0.109	0.338ProCys: 0.338 ± 0.02	3.341ProAsp: 3.341 ± 0.052	2.979ProGlu: 2.979 ± 0.051	1.795ProPhe: 1.795 ± 0.033	5.189ProGly: 5.189 ± 0.064	1.22ProHis: 1.22 ± 0.032	1.758ProIle: 1.758 ± 0.042	1.251ProLys: 1.251 ± 0.035	5.499ProLeu: 5.499 ± 0.065	1.236ProMet: 1.236 ± 0.03	1.073ProAsn: 1.073 ± 0.029	3.237ProPro: 3.237 ± 0.082	2.251ProGln: 2.251 ± 0.046	3.291ProArg: 3.291 ± 0.056	2.64ProSer: 2.64 ± 0.047	2.836ProThr: 2.836 ± 0.048	4.805ProVal: 4.805 ± 0.065	0.827ProTrp: 0.827 ± 0.027	1.185ProTyr: 1.185 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.916GlnAla: 5.916 ± 0.073	0.25GlnCys: 0.25 ± 0.016	1.803GlnAsp: 1.803 ± 0.038	1.631GlnGlu: 1.631 ± 0.036	1.144GlnPhe: 1.144 ± 0.029	3.229GlnGly: 3.229 ± 0.058	0.914GlnHis: 0.914 ± 0.029	1.652GlnIle: 1.652 ± 0.034	1.21GlnLys: 1.21 ± 0.032	3.881GlnLeu: 3.881 ± 0.052	0.958GlnMet: 0.958 ± 0.029	0.853GlnAsn: 0.853 ± 0.031	2.294GlnPro: 2.294 ± 0.045	1.98GlnGln: 1.98 ± 0.057	3.359GlnArg: 3.359 ± 0.058	1.921GlnSer: 1.921 ± 0.041	1.896GlnThr: 1.896 ± 0.04	3.238GlnVal: 3.238 ± 0.057	0.606GlnTrp: 0.606 ± 0.022	0.732GlnTyr: 0.732 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.883ArgAla: 8.883 ± 0.082	0.576ArgCys: 0.576 ± 0.023	3.764ArgAsp: 3.764 ± 0.056	3.589ArgGlu: 3.589 ± 0.065	2.847ArgPhe: 2.847 ± 0.055	5.115ArgGly: 5.115 ± 0.076	1.937ArgHis: 1.937 ± 0.047	3.637ArgIle: 3.637 ± 0.049	1.917ArgLys: 1.917 ± 0.041	8.174ArgLeu: 8.174 ± 0.088	2.106ArgMet: 2.106 ± 0.042	1.781ArgAsn: 1.781 ± 0.035	3.674ArgPro: 3.674 ± 0.062	3.018ArgGln: 3.018 ± 0.054	5.649ArgArg: 5.649 ± 0.082	3.642ArgSer: 3.642 ± 0.058	3.849ArgThr: 3.849 ± 0.054	5.033ArgVal: 5.033 ± 0.061	1.254ArgTrp: 1.254 ± 0.035	1.862ArgTyr: 1.862 ± 0.047	0.001ArgXaa: 0.001 ± 0.001
Ser	6.669SerAla: 6.669 ± 0.084	0.373SerCys: 0.373 ± 0.019	2.373SerAsp: 2.373 ± 0.044	2.114SerGlu: 2.114 ± 0.046	1.926SerPhe: 1.926 ± 0.04	4.896SerGly: 4.896 ± 0.079	1.057SerHis: 1.057 ± 0.026	2.109SerIle: 2.109 ± 0.042	1.267SerLys: 1.267 ± 0.032	5.097SerLeu: 5.097 ± 0.064	1.171SerMet: 1.171 ± 0.027	1.145SerAsn: 1.145 ± 0.036	2.873SerPro: 2.873 ± 0.046	1.667SerGln: 1.667 ± 0.042	3.335SerArg: 3.335 ± 0.056	2.71SerSer: 2.71 ± 0.055	2.815SerThr: 2.815 ± 0.055	3.892SerVal: 3.892 ± 0.062	0.648SerTrp: 0.648 ± 0.028	1.183SerTyr: 1.183 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.299ThrAla: 7.299 ± 0.09	0.366ThrCys: 0.366 ± 0.02	2.733ThrAsp: 2.733 ± 0.052	2.277ThrGlu: 2.277 ± 0.045	1.69ThrPhe: 1.69 ± 0.037	5.069ThrGly: 5.069 ± 0.077	1.06ThrHis: 1.06 ± 0.027	1.958ThrIle: 1.958 ± 0.041	1.118ThrLys: 1.118 ± 0.029	6.367ThrLeu: 6.367 ± 0.074	1.028ThrMet: 1.028 ± 0.028	1.138ThrAsn: 1.138 ± 0.037	3.766ThrPro: 3.766 ± 0.056	1.782ThrGln: 1.782 ± 0.044	3.32ThrArg: 3.32 ± 0.056	2.467ThrSer: 2.467 ± 0.047	3.03ThrThr: 3.03 ± 0.065	4.904ThrVal: 4.904 ± 0.063	0.626ThrTrp: 0.626 ± 0.02	1.028ThrTyr: 1.028 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.85ValAla: 10.85 ± 0.118	0.668ValCys: 0.668 ± 0.024	4.217ValAsp: 4.217 ± 0.054	4.25ValGlu: 4.25 ± 0.06	2.783ValPhe: 2.783 ± 0.051	6.115ValGly: 6.115 ± 0.076	1.588ValHis: 1.588 ± 0.04	2.77ValIle: 2.77 ± 0.054	2.178ValLys: 2.178 ± 0.053	8.713ValLeu: 8.713 ± 0.096	1.804ValMet: 1.804 ± 0.042	1.931ValAsn: 1.931 ± 0.045	4.777ValPro: 4.777 ± 0.063	3.256ValGln: 3.256 ± 0.057	5.709ValArg: 5.709 ± 0.073	3.907ValSer: 3.907 ± 0.062	3.945ValThr: 3.945 ± 0.071	7.146ValVal: 7.146 ± 0.079	1.001ValTrp: 1.001 ± 0.031	1.597ValTyr: 1.597 ± 0.035	0.001ValXaa: 0.001 ± 0.001
Trp	1.429TrpAla: 1.429 ± 0.041	0.171TrpCys: 0.171 ± 0.013	0.651TrpAsp: 0.651 ± 0.025	0.525TrpGlu: 0.525 ± 0.021	0.507TrpPhe: 0.507 ± 0.022	0.921TrpGly: 0.921 ± 0.028	0.345TrpHis: 0.345 ± 0.016	0.663TrpIle: 0.663 ± 0.022	0.448TrpLys: 0.448 ± 0.02	1.947TrpLeu: 1.947 ± 0.045	0.452TrpMet: 0.452 ± 0.02	0.436TrpAsn: 0.436 ± 0.022	0.71TrpPro: 0.71 ± 0.023	0.777TrpGln: 0.777 ± 0.023	1.237TrpArg: 1.237 ± 0.035	0.813TrpSer: 0.813 ± 0.026	0.778TrpThr: 0.778 ± 0.024	0.943TrpVal: 0.943 ± 0.029	0.273TrpTrp: 0.273 ± 0.016	0.272TrpTyr: 0.272 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.691TyrAla: 2.691 ± 0.045	0.224TyrCys: 0.224 ± 0.014	1.273TyrAsp: 1.273 ± 0.042	1.066TyrGlu: 1.066 ± 0.027	0.859TyrPhe: 0.859 ± 0.026	2.09TyrGly: 2.09 ± 0.042	0.393TyrHis: 0.393 ± 0.018	0.697TyrIle: 0.697 ± 0.022	0.617TyrLys: 0.617 ± 0.025	2.297TyrLeu: 2.297 ± 0.047	0.358TyrMet: 0.358 ± 0.017	0.519TyrAsn: 0.519 ± 0.02	1.091TyrPro: 1.091 ± 0.027	0.785TyrGln: 0.785 ± 0.026	1.753TyrArg: 1.753 ± 0.045	1.065TyrSer: 1.065 ± 0.031	1.141TyrThr: 1.141 ± 0.033	1.486TyrVal: 1.486 ± 0.036	0.35TyrTrp: 0.35 ± 0.017	0.561TyrTyr: 0.561 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3792 proteins (1269887 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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