Amino acid dipepetide frequency for Pseudogymnoascus sp. VKM F-4281 (FW-2241)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.02AlaAla: 10.02 ± 0.088	0.992AlaCys: 0.992 ± 0.015	4.515AlaAsp: 4.515 ± 0.043	5.582AlaGlu: 5.582 ± 0.052	3.066AlaPhe: 3.066 ± 0.03	6.177AlaGly: 6.177 ± 0.05	1.722AlaHis: 1.722 ± 0.023	4.518AlaIle: 4.518 ± 0.045	4.484AlaLys: 4.484 ± 0.046	7.802AlaLeu: 7.802 ± 0.044	2.02AlaMet: 2.02 ± 0.025	3.161AlaAsn: 3.161 ± 0.034	5.179AlaPro: 5.179 ± 0.055	3.476AlaGln: 3.476 ± 0.043	4.935AlaArg: 4.935 ± 0.044	7.225AlaSer: 7.225 ± 0.046	5.653AlaThr: 5.653 ± 0.042	5.598AlaVal: 5.598 ± 0.04	1.099AlaTrp: 1.099 ± 0.019	2.192AlaTyr: 2.192 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.922CysAla: 0.922 ± 0.016	0.226CysCys: 0.226 ± 0.009	0.629CysAsp: 0.629 ± 0.015	0.595CysGlu: 0.595 ± 0.013	0.48CysPhe: 0.48 ± 0.011	0.954CysGly: 0.954 ± 0.019	0.303CysHis: 0.303 ± 0.009	0.685CysIle: 0.685 ± 0.014	0.496CysLys: 0.496 ± 0.011	1.138CysLeu: 1.138 ± 0.017	0.259CysMet: 0.259 ± 0.008	0.414CysAsn: 0.414 ± 0.009	0.6CysPro: 0.6 ± 0.014	0.408CysGln: 0.408 ± 0.01	0.663CysArg: 0.663 ± 0.013	0.827CysSer: 0.827 ± 0.016	0.643CysThr: 0.643 ± 0.012	0.708CysVal: 0.708 ± 0.014	0.178CysTrp: 0.178 ± 0.007	0.339CysTyr: 0.339 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.96AspAla: 4.96 ± 0.047	0.596AspCys: 0.596 ± 0.013	4.335AspAsp: 4.335 ± 0.056	4.699AspGlu: 4.699 ± 0.046	2.17AspPhe: 2.17 ± 0.024	4.278AspGly: 4.278 ± 0.041	1.113AspHis: 1.113 ± 0.017	3.165AspIle: 3.165 ± 0.029	2.483AspLys: 2.483 ± 0.027	4.868AspLeu: 4.868 ± 0.036	1.274AspMet: 1.274 ± 0.02	2.015AspAsn: 2.015 ± 0.023	3.046AspPro: 3.046 ± 0.027	1.731AspGln: 1.731 ± 0.02	2.915AspArg: 2.915 ± 0.031	4.201AspSer: 4.201 ± 0.038	3.05AspThr: 3.05 ± 0.031	3.806AspVal: 3.806 ± 0.034	0.839AspTrp: 0.839 ± 0.014	1.607AspTyr: 1.607 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.857GluAla: 5.857 ± 0.045	0.614GluCys: 0.614 ± 0.013	4.351GluAsp: 4.351 ± 0.041	5.907GluGlu: 5.907 ± 0.055	1.968GluPhe: 1.968 ± 0.021	4.384GluGly: 4.384 ± 0.037	1.296GluHis: 1.296 ± 0.018	3.154GluIle: 3.154 ± 0.028	3.876GluLys: 3.876 ± 0.034	5.318GluLeu: 5.318 ± 0.053	1.555GluMet: 1.555 ± 0.019	2.303GluAsn: 2.303 ± 0.025	2.781GluPro: 2.781 ± 0.036	2.371GluGln: 2.371 ± 0.033	4.074GluArg: 4.074 ± 0.039	4.416GluSer: 4.416 ± 0.035	3.528GluThr: 3.528 ± 0.034	3.939GluVal: 3.939 ± 0.037	0.879GluTrp: 0.879 ± 0.014	1.725GluTyr: 1.725 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.004PheAla: 3.004 ± 0.029	0.505PheCys: 0.505 ± 0.011	2.18PheAsp: 2.18 ± 0.026	2.143PheGlu: 2.143 ± 0.023	1.488PhePhe: 1.488 ± 0.023	2.871PheGly: 2.871 ± 0.032	0.803PheHis: 0.803 ± 0.016	1.781PheIle: 1.781 ± 0.021	1.595PheLys: 1.595 ± 0.021	3.197PheLeu: 3.197 ± 0.03	0.787PheMet: 0.787 ± 0.015	1.407PheAsn: 1.407 ± 0.019	1.842PhePro: 1.842 ± 0.021	1.331PheGln: 1.331 ± 0.022	1.778PheArg: 1.778 ± 0.02	2.828PheSer: 2.828 ± 0.029	2.079PheThr: 2.079 ± 0.026	2.309PheVal: 2.309 ± 0.025	0.593PheTrp: 0.593 ± 0.012	1.049PheTyr: 1.049 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.906GlyAla: 5.906 ± 0.054	0.869GlyCys: 0.869 ± 0.016	3.923GlyAsp: 3.923 ± 0.036	4.215GlyGlu: 4.215 ± 0.039	2.773GlyPhe: 2.773 ± 0.029	6.708GlyGly: 6.708 ± 0.068	1.675GlyHis: 1.675 ± 0.025	3.621GlyIle: 3.621 ± 0.031	3.854GlyLys: 3.854 ± 0.034	6.061GlyLeu: 6.061 ± 0.048	1.701GlyMet: 1.701 ± 0.023	2.758GlyAsn: 2.758 ± 0.031	3.304GlyPro: 3.304 ± 0.034	2.579GlyGln: 2.579 ± 0.03	4.277GlyArg: 4.277 ± 0.038	5.799GlySer: 5.799 ± 0.045	4.085GlyThr: 4.085 ± 0.035	4.637GlyVal: 4.637 ± 0.044	1.157GlyTrp: 1.157 ± 0.018	2.093GlyTyr: 2.093 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.734HisAla: 1.734 ± 0.02	0.298HisCys: 0.298 ± 0.009	1.226HisAsp: 1.226 ± 0.018	1.255HisGlu: 1.255 ± 0.02	0.872HisPhe: 0.872 ± 0.014	1.669HisGly: 1.669 ± 0.023	0.73HisHis: 0.73 ± 0.015	1.207HisIle: 1.207 ± 0.019	0.923HisLys: 0.923 ± 0.015	2.056HisLeu: 2.056 ± 0.018	0.459HisMet: 0.459 ± 0.011	0.86HisAsn: 0.86 ± 0.014	1.526HisPro: 1.526 ± 0.02	0.924HisGln: 0.924 ± 0.016	1.376HisArg: 1.376 ± 0.02	1.687HisSer: 1.687 ± 0.023	1.273HisThr: 1.273 ± 0.017	1.337HisVal: 1.337 ± 0.019	0.307HisTrp: 0.307 ± 0.009	0.662HisTyr: 0.662 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.395IleAla: 4.395 ± 0.036	0.718IleCys: 0.718 ± 0.015	2.964IleAsp: 2.964 ± 0.025	3.074IleGlu: 3.074 ± 0.03	1.98IlePhe: 1.98 ± 0.026	3.285IleGly: 3.285 ± 0.035	1.122IleHis: 1.122 ± 0.017	2.652IleIle: 2.652 ± 0.029	2.359IleLys: 2.359 ± 0.026	4.492IleLeu: 4.492 ± 0.036	1.064IleMet: 1.064 ± 0.017	1.889IleAsn: 1.889 ± 0.018	3.063IlePro: 3.063 ± 0.025	1.851IleGln: 1.851 ± 0.023	2.745IleArg: 2.745 ± 0.027	4.005IleSer: 4.005 ± 0.034	3.042IleThr: 3.042 ± 0.029	3.221IleVal: 3.221 ± 0.03	0.688IleTrp: 0.688 ± 0.013	1.438IleTyr: 1.438 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.691LysAla: 4.691 ± 0.043	0.507LysCys: 0.507 ± 0.013	2.876LysAsp: 2.876 ± 0.03	3.666LysGlu: 3.666 ± 0.039	1.528LysPhe: 1.528 ± 0.019	3.325LysGly: 3.325 ± 0.029	1.109LysHis: 1.109 ± 0.015	2.416LysIle: 2.416 ± 0.024	3.572LysLys: 3.572 ± 0.053	4.296LysLeu: 4.296 ± 0.037	1.067LysMet: 1.067 ± 0.015	1.849LysAsn: 1.849 ± 0.022	2.786LysPro: 2.786 ± 0.029	1.824LysGln: 1.824 ± 0.02	3.443LysArg: 3.443 ± 0.038	3.76LysSer: 3.76 ± 0.027	2.978LysThr: 2.978 ± 0.028	3.012LysVal: 3.012 ± 0.029	0.687LysTrp: 0.687 ± 0.013	1.437LysTyr: 1.437 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.855LeuAla: 7.855 ± 0.05	1.101LeuCys: 1.101 ± 0.017	5.031LeuAsp: 5.031 ± 0.037	5.547LeuGlu: 5.547 ± 0.049	3.09LeuPhe: 3.09 ± 0.032	5.882LeuGly: 5.882 ± 0.042	2.038LeuHis: 2.038 ± 0.025	3.941LeuIle: 3.941 ± 0.035	4.359LeuLys: 4.359 ± 0.036	8.136LeuLeu: 8.136 ± 0.057	1.71LeuMet: 1.71 ± 0.023	3.076LeuAsn: 3.076 ± 0.029	5.344LeuPro: 5.344 ± 0.043	3.651LeuGln: 3.651 ± 0.036	5.442LeuArg: 5.442 ± 0.042	7.142LeuSer: 7.142 ± 0.043	4.697LeuThr: 4.697 ± 0.031	5.188LeuVal: 5.188 ± 0.042	1.142LeuTrp: 1.142 ± 0.02	2.275LeuTyr: 2.275 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.247MetAla: 2.247 ± 0.025	0.224MetCys: 0.224 ± 0.007	1.302MetAsp: 1.302 ± 0.015	1.36MetGlu: 1.36 ± 0.019	0.742MetPhe: 0.742 ± 0.012	1.591MetGly: 1.591 ± 0.023	0.477MetHis: 0.477 ± 0.01	0.978MetIle: 0.978 ± 0.017	1.055MetLys: 1.055 ± 0.018	1.812MetLeu: 1.812 ± 0.022	0.584MetMet: 0.584 ± 0.012	0.785MetAsn: 0.785 ± 0.014	1.214MetPro: 1.214 ± 0.015	0.825MetGln: 0.825 ± 0.014	1.288MetArg: 1.288 ± 0.017	1.884MetSer: 1.884 ± 0.023	1.222MetThr: 1.222 ± 0.019	1.332MetVal: 1.332 ± 0.018	0.244MetTrp: 0.244 ± 0.008	0.523MetTyr: 0.523 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.218AsnAla: 3.218 ± 0.033	0.442AsnCys: 0.442 ± 0.012	2.032AsnAsp: 2.032 ± 0.026	2.118AsnGlu: 2.118 ± 0.022	1.381AsnPhe: 1.381 ± 0.019	3.173AsnGly: 3.173 ± 0.043	0.823AsnHis: 0.823 ± 0.015	2.148AsnIle: 2.148 ± 0.022	1.641AsnLys: 1.641 ± 0.021	3.194AsnLeu: 3.194 ± 0.029	0.863AsnMet: 0.863 ± 0.015	1.586AsnAsn: 1.586 ± 0.023	2.422AsnPro: 2.422 ± 0.023	1.314AsnGln: 1.314 ± 0.018	1.944AsnArg: 1.944 ± 0.023	2.915AsnSer: 2.915 ± 0.03	2.224AsnThr: 2.224 ± 0.023	2.311AsnVal: 2.311 ± 0.023	0.546AsnTrp: 0.546 ± 0.011	1.077AsnTyr: 1.077 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.335ProAla: 5.335 ± 0.048	0.463ProCys: 0.463 ± 0.012	2.977ProAsp: 2.977 ± 0.027	3.706ProGlu: 3.706 ± 0.035	1.907ProPhe: 1.907 ± 0.025	3.84ProGly: 3.84 ± 0.038	1.277ProHis: 1.277 ± 0.018	2.623ProIle: 2.623 ± 0.03	2.832ProLys: 2.832 ± 0.028	4.659ProLeu: 4.659 ± 0.037	1.055ProMet: 1.055 ± 0.02	2.167ProAsn: 2.167 ± 0.024	5.038ProPro: 5.038 ± 0.073	2.47ProGln: 2.47 ± 0.034	3.348ProArg: 3.348 ± 0.033	5.755ProSer: 5.755 ± 0.047	4.233ProThr: 4.233 ± 0.038	3.496ProVal: 3.496 ± 0.027	0.673ProTrp: 0.673 ± 0.013	1.442ProTyr: 1.442 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.377GlnAla: 3.377 ± 0.046	0.408GlnCys: 0.408 ± 0.009	1.959GlnAsp: 1.959 ± 0.024	2.314GlnGlu: 2.314 ± 0.027	1.23GlnPhe: 1.23 ± 0.018	2.517GlnGly: 2.517 ± 0.03	0.998GlnHis: 0.998 ± 0.019	1.858GlnIle: 1.858 ± 0.021	1.969GlnLys: 1.969 ± 0.024	3.342GlnLeu: 3.342 ± 0.031	0.844GlnMet: 0.844 ± 0.019	1.526GlnAsn: 1.526 ± 0.02	2.425GlnPro: 2.425 ± 0.032	2.521GlnGln: 2.521 ± 0.054	2.572GlnArg: 2.572 ± 0.027	2.987GlnSer: 2.987 ± 0.034	2.251GlnThr: 2.251 ± 0.025	2.046GlnVal: 2.046 ± 0.021	0.523GlnTrp: 0.523 ± 0.012	1.161GlnTyr: 1.161 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.811ArgAla: 4.811 ± 0.04	0.662ArgCys: 0.662 ± 0.013	3.324ArgAsp: 3.324 ± 0.034	3.96ArgGlu: 3.96 ± 0.041	1.948ArgPhe: 1.948 ± 0.019	3.986ArgGly: 3.986 ± 0.035	1.48ArgHis: 1.48 ± 0.023	2.853ArgIle: 2.853 ± 0.025	3.46ArgLys: 3.46 ± 0.029	5.125ArgLeu: 5.125 ± 0.038	1.258ArgMet: 1.258 ± 0.018	2.274ArgAsn: 2.274 ± 0.025	3.295ArgPro: 3.295 ± 0.037	2.522ArgGln: 2.522 ± 0.03	4.985ArgArg: 4.985 ± 0.054	4.531ArgSer: 4.531 ± 0.047	3.208ArgThr: 3.208 ± 0.032	3.329ArgVal: 3.329 ± 0.032	0.837ArgTrp: 0.837 ± 0.015	1.518ArgTyr: 1.518 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.729SerAla: 6.729 ± 0.041	0.825SerCys: 0.825 ± 0.016	4.288SerAsp: 4.288 ± 0.035	4.238SerGlu: 4.238 ± 0.041	2.881SerPhe: 2.881 ± 0.027	5.752SerGly: 5.752 ± 0.043	1.863SerHis: 1.863 ± 0.024	4.126SerIle: 4.126 ± 0.036	3.951SerLys: 3.951 ± 0.038	6.892SerLeu: 6.892 ± 0.052	1.69SerMet: 1.69 ± 0.024	3.093SerAsn: 3.093 ± 0.032	5.43SerPro: 5.43 ± 0.051	3.185SerGln: 3.185 ± 0.032	4.802SerArg: 4.802 ± 0.046	8.208SerSer: 8.208 ± 0.075	5.561SerThr: 5.561 ± 0.045	4.493SerVal: 4.493 ± 0.037	1.039SerTrp: 1.039 ± 0.017	2.044SerTyr: 2.044 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.419ThrAla: 5.419 ± 0.037	0.695ThrCys: 0.695 ± 0.015	2.891ThrAsp: 2.891 ± 0.023	3.293ThrGlu: 3.293 ± 0.03	2.153ThrPhe: 2.153 ± 0.026	4.282ThrGly: 4.282 ± 0.04	1.248ThrHis: 1.248 ± 0.019	3.184ThrIle: 3.184 ± 0.026	2.866ThrLys: 2.866 ± 0.025	5.137ThrLeu: 5.137 ± 0.044	1.239ThrMet: 1.239 ± 0.017	2.187ThrAsn: 2.187 ± 0.024	4.483ThrPro: 4.483 ± 0.042	2.047ThrGln: 2.047 ± 0.024	3.088ThrArg: 3.088 ± 0.034	5.364ThrSer: 5.364 ± 0.041	4.521ThrThr: 4.521 ± 0.044	3.715ThrVal: 3.715 ± 0.03	0.808ThrTrp: 0.808 ± 0.014	1.592ThrTyr: 1.592 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.642ValAla: 5.642 ± 0.046	0.759ValCys: 0.759 ± 0.014	3.854ValAsp: 3.854 ± 0.033	4.204ValGlu: 4.204 ± 0.037	2.275ValPhe: 2.275 ± 0.029	4.274ValGly: 4.274 ± 0.039	1.298ValHis: 1.298 ± 0.017	3.006ValIle: 3.006 ± 0.031	3.098ValLys: 3.098 ± 0.032	5.407ValLeu: 5.407 ± 0.044	1.33ValMet: 1.33 ± 0.016	2.24ValAsn: 2.24 ± 0.026	3.514ValPro: 3.514 ± 0.03	2.233ValGln: 2.233 ± 0.025	3.314ValArg: 3.314 ± 0.031	4.479ValSer: 4.479 ± 0.037	3.506ValThr: 3.506 ± 0.034	4.52ValVal: 4.52 ± 0.037	0.829ValTrp: 0.829 ± 0.015	1.67ValTyr: 1.67 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.144TrpAla: 1.144 ± 0.017	0.178TrpCys: 0.178 ± 0.006	0.852TrpAsp: 0.852 ± 0.016	0.846TrpGlu: 0.846 ± 0.014	0.501TrpPhe: 0.501 ± 0.012	0.96TrpGly: 0.96 ± 0.017	0.318TrpHis: 0.318 ± 0.008	0.691TrpIle: 0.691 ± 0.014	0.773TrpLys: 0.773 ± 0.015	1.225TrpLeu: 1.225 ± 0.017	0.343TrpMet: 0.343 ± 0.008	0.581TrpAsn: 0.581 ± 0.014	0.579TrpPro: 0.579 ± 0.011	0.495TrpGln: 0.495 ± 0.012	0.873TrpArg: 0.873 ± 0.015	0.982TrpSer: 0.982 ± 0.015	0.851TrpThr: 0.851 ± 0.014	0.883TrpVal: 0.883 ± 0.015	0.255TrpTrp: 0.255 ± 0.009	0.387TrpTyr: 0.387 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.15TyrAla: 2.15 ± 0.021	0.385TyrCys: 0.385 ± 0.009	1.644TyrAsp: 1.644 ± 0.022	1.577TyrGlu: 1.577 ± 0.017	1.138TyrPhe: 1.138 ± 0.018	2.09TyrGly: 2.09 ± 0.026	0.688TyrHis: 0.688 ± 0.013	1.437TyrIle: 1.437 ± 0.019	1.184TyrLys: 1.184 ± 0.018	2.49TyrLeu: 2.49 ± 0.026	0.587TyrMet: 0.587 ± 0.012	1.198TyrAsn: 1.198 ± 0.018	1.426TyrPro: 1.426 ± 0.022	1.069TyrGln: 1.069 ± 0.018	1.506TyrArg: 1.506 ± 0.019	2.093TyrSer: 2.093 ± 0.026	1.607TyrThr: 1.607 ± 0.021	1.57TyrVal: 1.57 ± 0.022	0.395TyrTrp: 0.395 ± 0.009	0.94TyrTyr: 0.94 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8727 proteins (4351004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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