Amino acid dipepetide frequency for Lampropedia hyalina DSM 16112

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.655AlaAla: 14.655 ± 0.181
1.118AlaCys: 1.118 ± 0.038
6.265AlaAsp: 6.265 ± 0.099
5.945AlaGlu: 5.945 ± 0.093
3.816AlaPhe: 3.816 ± 0.071
8.898AlaGly: 8.898 ± 0.112
3.058AlaHis: 3.058 ± 0.066
5.678AlaIle: 5.678 ± 0.093
3.08AlaLys: 3.08 ± 0.072
13.838AlaLeu: 13.838 ± 0.167
2.73AlaMet: 2.73 ± 0.057
2.794AlaAsn: 2.794 ± 0.061
5.362AlaPro: 5.362 ± 0.092
7.244AlaGln: 7.244 ± 0.11
7.741AlaArg: 7.741 ± 0.105
7.408AlaSer: 7.408 ± 0.092
6.34AlaThr: 6.34 ± 0.086
8.311AlaVal: 8.311 ± 0.108
1.903AlaTrp: 1.903 ± 0.051
2.413AlaTyr: 2.413 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.965CysAla: 0.965 ± 0.035
0.113CysCys: 0.113 ± 0.012
0.409CysAsp: 0.409 ± 0.022
0.44CysGlu: 0.44 ± 0.022
0.251CysPhe: 0.251 ± 0.015
0.814CysGly: 0.814 ± 0.033
0.316CysHis: 0.316 ± 0.019
0.455CysIle: 0.455 ± 0.024
0.197CysLys: 0.197 ± 0.015
0.843CysLeu: 0.843 ± 0.028
0.194CysMet: 0.194 ± 0.016
0.225CysAsn: 0.225 ± 0.015
0.443CysPro: 0.443 ± 0.025
0.367CysGln: 0.367 ± 0.02
0.446CysArg: 0.446 ± 0.023
0.495CysSer: 0.495 ± 0.021
0.472CysThr: 0.472 ± 0.028
0.589CysVal: 0.589 ± 0.028
0.122CysTrp: 0.122 ± 0.011
0.192CysTyr: 0.192 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.063AspAla: 7.063 ± 0.097
0.472AspCys: 0.472 ± 0.024
2.725AspAsp: 2.725 ± 0.066
2.967AspGlu: 2.967 ± 0.055
2.081AspPhe: 2.081 ± 0.052
4.458AspGly: 4.458 ± 0.096
1.089AspHis: 1.089 ± 0.035
2.672AspIle: 2.672 ± 0.05
1.552AspLys: 1.552 ± 0.042
4.904AspLeu: 4.904 ± 0.079
1.12AspMet: 1.12 ± 0.035
1.326AspAsn: 1.326 ± 0.039
2.435AspPro: 2.435 ± 0.061
1.518AspGln: 1.518 ± 0.04
2.932AspArg: 2.932 ± 0.057
2.656AspSer: 2.656 ± 0.06
2.816AspThr: 2.816 ± 0.087
3.748AspVal: 3.748 ± 0.069
1.069AspTrp: 1.069 ± 0.035
1.48AspTyr: 1.48 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.187GluAla: 6.187 ± 0.095
0.382GluCys: 0.382 ± 0.024
2.204GluAsp: 2.204 ± 0.051
2.628GluGlu: 2.628 ± 0.066
1.742GluPhe: 1.742 ± 0.05
3.635GluGly: 3.635 ± 0.071
1.572GluHis: 1.572 ± 0.041
2.674GluIle: 2.674 ± 0.058
2.137GluLys: 2.137 ± 0.053
5.715GluLeu: 5.715 ± 0.079
1.089GluMet: 1.089 ± 0.036
1.641GluAsn: 1.641 ± 0.043
2.514GluPro: 2.514 ± 0.061
3.386GluGln: 3.386 ± 0.069
4.236GluArg: 4.236 ± 0.08
2.508GluSer: 2.508 ± 0.056
2.648GluThr: 2.648 ± 0.055
3.702GluVal: 3.702 ± 0.061
0.803GluTrp: 0.803 ± 0.03
1.274GluTyr: 1.274 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
4.089PheAla: 4.089 ± 0.07
0.373PheCys: 0.373 ± 0.022
2.305PheAsp: 2.305 ± 0.05
1.817PheGlu: 1.817 ± 0.046
1.348PhePhe: 1.348 ± 0.041
2.995PheGly: 2.995 ± 0.065
0.883PheHis: 0.883 ± 0.032
1.578PheIle: 1.578 ± 0.045
0.991PheLys: 0.991 ± 0.034
3.19PheLeu: 3.19 ± 0.07
0.767PheMet: 0.767 ± 0.033
1.236PheAsn: 1.236 ± 0.037
1.402PhePro: 1.402 ± 0.039
1.354PheGln: 1.354 ± 0.037
1.821PheArg: 1.821 ± 0.044
2.323PheSer: 2.323 ± 0.064
1.926PheThr: 1.926 ± 0.044
2.578PheVal: 2.578 ± 0.06
0.589PheTrp: 0.589 ± 0.026
0.893PheTyr: 0.893 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
7.289GlyAla: 7.289 ± 0.108
0.733GlyCys: 0.733 ± 0.03
3.646GlyAsp: 3.646 ± 0.084
4.038GlyGlu: 4.038 ± 0.065
3.218GlyPhe: 3.218 ± 0.057
5.954GlyGly: 5.954 ± 0.139
2.124GlyHis: 2.124 ± 0.052
4.43GlyIle: 4.43 ± 0.085
3.239GlyLys: 3.239 ± 0.06
8.778GlyLeu: 8.778 ± 0.113
2.218GlyMet: 2.218 ± 0.049
2.55GlyAsn: 2.55 ± 0.097
2.247GlyPro: 2.247 ± 0.048
4.167GlyGln: 4.167 ± 0.072
4.773GlyArg: 4.773 ± 0.065
4.671GlySer: 4.671 ± 0.085
4.445GlyThr: 4.445 ± 0.085
5.75GlyVal: 5.75 ± 0.09
1.541GlyTrp: 1.541 ± 0.046
2.226GlyTyr: 2.226 ± 0.053
0.001GlyXaa: 0.001 ± 0.001
His
3.222HisAla: 3.222 ± 0.061
0.309HisCys: 0.309 ± 0.019
1.419HisAsp: 1.419 ± 0.036
1.357HisGlu: 1.357 ± 0.045
1.035HisPhe: 1.035 ± 0.036
2.298HisGly: 2.298 ± 0.046
0.852HisHis: 0.852 ± 0.032
1.292HisIle: 1.292 ± 0.032
0.607HisLys: 0.607 ± 0.027
2.767HisLeu: 2.767 ± 0.061
0.504HisMet: 0.504 ± 0.023
0.669HisAsn: 0.669 ± 0.027
1.753HisPro: 1.753 ± 0.049
1.187HisGln: 1.187 ± 0.039
1.675HisArg: 1.675 ± 0.045
1.533HisSer: 1.533 ± 0.045
1.597HisThr: 1.597 ± 0.044
1.506HisVal: 1.506 ± 0.047
0.612HisTrp: 0.612 ± 0.025
0.801HisTyr: 0.801 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.041IleAla: 6.041 ± 0.091
0.356IleCys: 0.356 ± 0.017
3.052IleAsp: 3.052 ± 0.06
3.066IleGlu: 3.066 ± 0.064
1.468IlePhe: 1.468 ± 0.049
4.254IleGly: 4.254 ± 0.085
1.29IleHis: 1.29 ± 0.037
1.959IleIle: 1.959 ± 0.053
1.359IleLys: 1.359 ± 0.044
3.998IleLeu: 3.998 ± 0.081
0.81IleMet: 0.81 ± 0.037
1.559IleAsn: 1.559 ± 0.048
2.346IlePro: 2.346 ± 0.055
1.87IleGln: 1.87 ± 0.039
2.783IleArg: 2.783 ± 0.061
2.634IleSer: 2.634 ± 0.056
2.608IleThr: 2.608 ± 0.069
3.481IleVal: 3.481 ± 0.067
0.56IleTrp: 0.56 ± 0.025
1.097IleTyr: 1.097 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
3.652LysAla: 3.652 ± 0.076
0.149LysCys: 0.149 ± 0.013
1.549LysAsp: 1.549 ± 0.052
1.52LysGlu: 1.52 ± 0.048
0.784LysPhe: 0.784 ± 0.031
2.251LysGly: 2.251 ± 0.056
0.609LysHis: 0.609 ± 0.024
1.518LysIle: 1.518 ± 0.045
1.357LysLys: 1.357 ± 0.047
3.131LysLeu: 3.131 ± 0.059
0.626LysMet: 0.626 ± 0.027
1.153LysAsn: 1.153 ± 0.043
1.942LysPro: 1.942 ± 0.058
1.175LysGln: 1.175 ± 0.041
1.883LysArg: 1.883 ± 0.051
1.684LysSer: 1.684 ± 0.048
1.955LysThr: 1.955 ± 0.054
2.27LysVal: 2.27 ± 0.054
0.307LysTrp: 0.307 ± 0.019
0.622LysTyr: 0.622 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
13.838LeuAla: 13.838 ± 0.164
0.984LeuCys: 0.984 ± 0.04
5.796LeuAsp: 5.796 ± 0.077
6.135LeuGlu: 6.135 ± 0.103
3.376LeuPhe: 3.376 ± 0.07
8.539LeuGly: 8.539 ± 0.126
3.327LeuHis: 3.327 ± 0.074
4.133LeuIle: 4.133 ± 0.078
3.283LeuLys: 3.283 ± 0.08
12.604LeuLeu: 12.604 ± 0.18
2.253LeuMet: 2.253 ± 0.047
3.227LeuAsn: 3.227 ± 0.057
6.566LeuPro: 6.566 ± 0.097
5.955LeuGln: 5.955 ± 0.093
7.616LeuArg: 7.616 ± 0.1
5.847LeuSer: 5.847 ± 0.094
5.192LeuThr: 5.192 ± 0.087
7.547LeuVal: 7.547 ± 0.1
1.593LeuTrp: 1.593 ± 0.049
2.264LeuTyr: 2.264 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.719MetAla: 2.719 ± 0.062
0.111MetCys: 0.111 ± 0.01
0.899MetAsp: 0.899 ± 0.034
0.997MetGlu: 0.997 ± 0.034
0.577MetPhe: 0.577 ± 0.024
1.662MetGly: 1.662 ± 0.048
0.417MetHis: 0.417 ± 0.02
0.785MetIle: 0.785 ± 0.034
0.75MetLys: 0.75 ± 0.028
2.523MetLeu: 2.523 ± 0.063
0.462MetMet: 0.462 ± 0.024
0.807MetAsn: 0.807 ± 0.03
1.42MetPro: 1.42 ± 0.037
1.363MetGln: 1.363 ± 0.038
1.428MetArg: 1.428 ± 0.044
1.353MetSer: 1.353 ± 0.039
1.328MetThr: 1.328 ± 0.037
1.544MetVal: 1.544 ± 0.041
0.197MetTrp: 0.197 ± 0.013
0.337MetTyr: 0.337 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.596AsnAla: 3.596 ± 0.067
0.209AsnCys: 0.209 ± 0.015
1.443AsnAsp: 1.443 ± 0.067
1.34AsnGlu: 1.34 ± 0.044
1.001AsnPhe: 1.001 ± 0.032
2.354AsnGly: 2.354 ± 0.067
0.712AsnHis: 0.712 ± 0.03
1.489AsnIle: 1.489 ± 0.038
0.762AsnLys: 0.762 ± 0.032
2.978AsnLeu: 2.978 ± 0.062
0.609AsnMet: 0.609 ± 0.031
0.864AsnAsn: 0.864 ± 0.038
2.118AsnPro: 2.118 ± 0.044
1.211AsnGln: 1.211 ± 0.04
1.871AsnArg: 1.871 ± 0.049
1.326AsnSer: 1.326 ± 0.045
1.733AsnThr: 1.733 ± 0.051
2.022AsnVal: 2.022 ± 0.044
0.473AsnTrp: 0.473 ± 0.021
0.734AsnTyr: 0.734 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
6.721ProAla: 6.721 ± 0.108
0.373ProCys: 0.373 ± 0.018
3.261ProAsp: 3.261 ± 0.07
3.186ProGlu: 3.186 ± 0.061
1.733ProPhe: 1.733 ± 0.042
3.939ProGly: 3.939 ± 0.068
1.402ProHis: 1.402 ± 0.044
1.895ProIle: 1.895 ± 0.043
1.154ProLys: 1.154 ± 0.038
5.564ProLeu: 5.564 ± 0.087
1.145ProMet: 1.145 ± 0.034
1.256ProAsn: 1.256 ± 0.041
2.827ProPro: 2.827 ± 0.074
2.83ProGln: 2.83 ± 0.065
2.757ProArg: 2.757 ± 0.059
3.109ProSer: 3.109 ± 0.071
2.658ProThr: 2.658 ± 0.07
4.242ProVal: 4.242 ± 0.073
0.82ProTrp: 0.82 ± 0.033
1.142ProTyr: 1.142 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
7.369GlnAla: 7.369 ± 0.119
0.369GlnCys: 0.369 ± 0.023
2.07GlnAsp: 2.07 ± 0.047
2.521GlnGlu: 2.521 ± 0.06
1.472GlnPhe: 1.472 ± 0.039
3.948GlnGly: 3.948 ± 0.075
1.617GlnHis: 1.617 ± 0.055
2.283GlnIle: 2.283 ± 0.051
1.536GlnLys: 1.536 ± 0.045
4.962GlnLeu: 4.962 ± 0.084
1.077GlnMet: 1.077 ± 0.035
1.354GlnAsn: 1.354 ± 0.038
3.114GlnPro: 3.114 ± 0.059
3.846GlnGln: 3.846 ± 0.089
4.24GlnArg: 4.24 ± 0.072
2.86GlnSer: 2.86 ± 0.051
2.874GlnThr: 2.874 ± 0.053
3.539GlnVal: 3.539 ± 0.068
1.191GlnTrp: 1.191 ± 0.04
1.145GlnTyr: 1.145 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
5.984ArgAla: 5.984 ± 0.095
0.455ArgCys: 0.455 ± 0.023
3.333ArgAsp: 3.333 ± 0.059
3.814ArgGlu: 3.814 ± 0.075
2.633ArgPhe: 2.633 ± 0.055
3.959ArgGly: 3.959 ± 0.071
2.169ArgHis: 2.169 ± 0.056
3.774ArgIle: 3.774 ± 0.067
2.292ArgLys: 2.292 ± 0.057
7.716ArgLeu: 7.716 ± 0.108
1.595ArgMet: 1.595 ± 0.042
2.184ArgAsn: 2.184 ± 0.05
3.053ArgPro: 3.053 ± 0.059
4.111ArgGln: 4.111 ± 0.076
4.321ArgArg: 4.321 ± 0.085
3.475ArgSer: 3.475 ± 0.06
3.329ArgThr: 3.329 ± 0.062
4.31ArgVal: 4.31 ± 0.072
1.126ArgTrp: 1.126 ± 0.037
1.882ArgTyr: 1.882 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
5.88SerAla: 5.88 ± 0.08
0.417SerCys: 0.417 ± 0.022
2.756SerAsp: 2.756 ± 0.061
2.533SerGlu: 2.533 ± 0.052
2.01SerPhe: 2.01 ± 0.046
5.245SerGly: 5.245 ± 0.085
1.595SerHis: 1.595 ± 0.043
2.855SerIle: 2.855 ± 0.058
1.535SerLys: 1.535 ± 0.043
6.335SerLeu: 6.335 ± 0.092
1.215SerMet: 1.215 ± 0.035
1.606SerAsn: 1.606 ± 0.048
3.078SerPro: 3.078 ± 0.056
2.566SerGln: 2.566 ± 0.05
3.66SerArg: 3.66 ± 0.068
3.554SerSer: 3.554 ± 0.093
3.235SerThr: 3.235 ± 0.067
4.019SerVal: 4.019 ± 0.075
0.763SerTrp: 0.763 ± 0.032
1.443SerTyr: 1.443 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
6.75ThrAla: 6.75 ± 0.1
0.373ThrCys: 0.373 ± 0.02
2.64ThrAsp: 2.64 ± 0.057
2.61ThrGlu: 2.61 ± 0.054
1.637ThrPhe: 1.637 ± 0.042
4.739ThrGly: 4.739 ± 0.094
1.306ThrHis: 1.306 ± 0.039
2.443ThrIle: 2.443 ± 0.083
1.152ThrLys: 1.152 ± 0.039
6.627ThrLeu: 6.627 ± 0.082
0.905ThrMet: 0.905 ± 0.033
1.274ThrAsn: 1.274 ± 0.042
3.816ThrPro: 3.816 ± 0.062
2.412ThrGln: 2.412 ± 0.054
3.339ThrArg: 3.339 ± 0.064
2.812ThrSer: 2.812 ± 0.059
2.934ThrThr: 2.934 ± 0.064
4.289ThrVal: 4.289 ± 0.085
0.657ThrTrp: 0.657 ± 0.028
1.048ThrTyr: 1.048 ± 0.04
0.001ThrXaa: 0.001 ± 0.001
Val
8.663ValAla: 8.663 ± 0.123
0.676ValCys: 0.676 ± 0.033
3.425ValAsp: 3.425 ± 0.067
3.914ValGlu: 3.914 ± 0.076
2.683ValPhe: 2.683 ± 0.059
5.051ValGly: 5.051 ± 0.083
1.64ValHis: 1.64 ± 0.043
3.139ValIle: 3.139 ± 0.064
2.06ValLys: 2.06 ± 0.05
8.532ValLeu: 8.532 ± 0.117
1.506ValMet: 1.506 ± 0.048
1.988ValAsn: 1.988 ± 0.058
3.678ValPro: 3.678 ± 0.072
4.315ValGln: 4.315 ± 0.065
4.886ValArg: 4.886 ± 0.079
3.777ValSer: 3.777 ± 0.071
3.651ValThr: 3.651 ± 0.076
5.787ValVal: 5.787 ± 0.103
1.006ValTrp: 1.006 ± 0.036
1.557ValTyr: 1.557 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.266TrpAla: 1.266 ± 0.041
0.156TrpCys: 0.156 ± 0.012
0.614TrpAsp: 0.614 ± 0.025
0.655TrpGlu: 0.655 ± 0.028
0.591TrpPhe: 0.591 ± 0.028
1.009TrpGly: 1.009 ± 0.035
0.475TrpHis: 0.475 ± 0.025
0.637TrpIle: 0.637 ± 0.028
0.465TrpLys: 0.465 ± 0.023
2.573TrpLeu: 2.573 ± 0.064
0.436TrpMet: 0.436 ± 0.024
0.51TrpAsn: 0.51 ± 0.021
0.755TrpPro: 0.755 ± 0.036
1.368TrpGln: 1.368 ± 0.044
1.247TrpArg: 1.247 ± 0.039
0.862TrpSer: 0.862 ± 0.031
0.657TrpThr: 0.657 ± 0.032
1.12TrpVal: 1.12 ± 0.034
0.321TrpTrp: 0.321 ± 0.019
0.349TrpTyr: 0.349 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.648TyrAla: 2.648 ± 0.048
0.221TyrCys: 0.221 ± 0.016
1.27TyrAsp: 1.27 ± 0.039
1.196TyrGlu: 1.196 ± 0.036
1.003TyrPhe: 1.003 ± 0.036
2.038TyrGly: 2.038 ± 0.05
0.543TyrHis: 0.543 ± 0.021
0.904TyrIle: 0.904 ± 0.03
0.63TyrLys: 0.63 ± 0.026
2.498TyrLeu: 2.498 ± 0.057
0.418TyrMet: 0.418 ± 0.022
0.623TyrAsn: 0.623 ± 0.028
1.146TyrPro: 1.146 ± 0.036
1.138TyrGln: 1.138 ± 0.037
1.861TyrArg: 1.861 ± 0.046
1.411TyrSer: 1.411 ± 0.041
1.365TyrThr: 1.365 ± 0.043
1.578TyrVal: 1.578 ± 0.046
0.408TyrTrp: 0.408 ± 0.022
0.584TyrTyr: 0.584 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.001
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.01XaaXaa: 0.01 ± 0.006
Statistics based on 2717 proteins (941002 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski