Amino acid dipepetide frequency for Faecalibacterium sp. CAG:74

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.13AlaAla: 11.13 ± 0.163	1.412AlaCys: 1.412 ± 0.041	6.373AlaAsp: 6.373 ± 0.103	6.558AlaGlu: 6.558 ± 0.104	3.594AlaPhe: 3.594 ± 0.073	6.631AlaGly: 6.631 ± 0.095	1.855AlaHis: 1.855 ± 0.056	5.34AlaIle: 5.34 ± 0.09	4.275AlaLys: 4.275 ± 0.08	10.732AlaLeu: 10.732 ± 0.134	3.449AlaMet: 3.449 ± 0.073	2.896AlaAsn: 2.896 ± 0.06	3.714AlaPro: 3.714 ± 0.093	4.128AlaGln: 4.128 ± 0.073	4.795AlaArg: 4.795 ± 0.082	4.703AlaSer: 4.703 ± 0.085	4.612AlaThr: 4.612 ± 0.108	7.369AlaVal: 7.369 ± 0.111	1.121AlaTrp: 1.121 ± 0.039	3.105AlaTyr: 3.105 ± 0.067	0.001AlaXaa: 0.001 ± 0.001
Cys	1.661CysAla: 1.661 ± 0.044	0.333CysCys: 0.333 ± 0.02	0.946CysAsp: 0.946 ± 0.031	0.872CysGlu: 0.872 ± 0.036	0.654CysPhe: 0.654 ± 0.027	1.614CysGly: 1.614 ± 0.047	0.349CysHis: 0.349 ± 0.022	0.9CysIle: 0.9 ± 0.036	0.598CysLys: 0.598 ± 0.027	1.31CysLeu: 1.31 ± 0.045	0.454CysMet: 0.454 ± 0.025	0.431CysAsn: 0.431 ± 0.025	0.786CysPro: 0.786 ± 0.04	0.478CysGln: 0.478 ± 0.027	1.019CysArg: 1.019 ± 0.035	0.767CysSer: 0.767 ± 0.033	0.858CysThr: 0.858 ± 0.035	1.249CysVal: 1.249 ± 0.044	0.222CysTrp: 0.222 ± 0.016	0.56CysTyr: 0.56 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	6.629AspAla: 6.629 ± 0.109	0.927AspCys: 0.927 ± 0.041	3.469AspAsp: 3.469 ± 0.076	4.601AspGlu: 4.601 ± 0.089	2.449AspPhe: 2.449 ± 0.053	5.549AspGly: 5.549 ± 0.102	0.942AspHis: 0.942 ± 0.031	3.204AspIle: 3.204 ± 0.069	2.406AspLys: 2.406 ± 0.053	4.597AspLeu: 4.597 ± 0.076	1.903AspMet: 1.903 ± 0.05	1.753AspAsn: 1.753 ± 0.044	2.189AspPro: 2.189 ± 0.058	1.298AspGln: 1.298 ± 0.037	2.451AspArg: 2.451 ± 0.061	2.766AspSer: 2.766 ± 0.065	3.28AspThr: 3.28 ± 0.077	4.608AspVal: 4.608 ± 0.085	0.887AspTrp: 0.887 ± 0.032	2.268AspTyr: 2.268 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.977GluAla: 5.977 ± 0.102	0.781GluCys: 0.781 ± 0.033	3.414GluAsp: 3.414 ± 0.062	4.612GluGlu: 4.612 ± 0.095	1.68GluPhe: 1.68 ± 0.047	3.981GluGly: 3.981 ± 0.077	1.26GluHis: 1.26 ± 0.045	3.923GluIle: 3.923 ± 0.076	4.322GluLys: 4.322 ± 0.091	5.387GluLeu: 5.387 ± 0.089	2.382GluMet: 2.382 ± 0.058	3.25GluAsn: 3.25 ± 0.071	1.863GluPro: 1.863 ± 0.05	2.799GluGln: 2.799 ± 0.071	3.437GluArg: 3.437 ± 0.074	2.984GluSer: 2.984 ± 0.064	3.952GluThr: 3.952 ± 0.08	3.599GluVal: 3.599 ± 0.079	0.636GluTrp: 0.636 ± 0.032	2.074GluTyr: 2.074 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.735PheAla: 3.735 ± 0.081	0.713PheCys: 0.713 ± 0.032	2.419PheAsp: 2.419 ± 0.053	1.77PheGlu: 1.77 ± 0.039	1.432PhePhe: 1.432 ± 0.046	2.873PheGly: 2.873 ± 0.063	0.798PheHis: 0.798 ± 0.032	1.835PheIle: 1.835 ± 0.048	1.036PheLys: 1.036 ± 0.033	3.541PheLeu: 3.541 ± 0.081	0.886PheMet: 0.886 ± 0.036	1.154PheAsn: 1.154 ± 0.041	1.581PhePro: 1.581 ± 0.04	1.203PheGln: 1.203 ± 0.035	2.183PheArg: 2.183 ± 0.067	2.421PheSer: 2.421 ± 0.058	2.372PheThr: 2.372 ± 0.058	2.577PheVal: 2.577 ± 0.061	0.416PheTrp: 0.416 ± 0.026	1.315PheTyr: 1.315 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	6.477GlyAla: 6.477 ± 0.1	1.313GlyCys: 1.313 ± 0.038	4.152GlyAsp: 4.152 ± 0.08	4.908GlyGlu: 4.908 ± 0.085	2.907GlyPhe: 2.907 ± 0.064	5.367GlyGly: 5.367 ± 0.116	1.535GlyHis: 1.535 ± 0.045	4.62GlyIle: 4.62 ± 0.089	4.218GlyLys: 4.218 ± 0.074	6.392GlyLeu: 6.392 ± 0.097	2.727GlyMet: 2.727 ± 0.061	2.668GlyAsn: 2.668 ± 0.064	1.122GlyPro: 1.122 ± 0.041	2.816GlyGln: 2.816 ± 0.07	3.758GlyArg: 3.758 ± 0.067	3.875GlySer: 3.875 ± 0.088	4.62GlyThr: 4.62 ± 0.096	5.753GlyVal: 5.753 ± 0.089	0.981GlyTrp: 0.981 ± 0.034	3.003GlyTyr: 3.003 ± 0.073	0.001GlyXaa: 0.001 ± 0.001
His	1.696HisAla: 1.696 ± 0.046	0.388HisCys: 0.388 ± 0.023	1.201HisAsp: 1.201 ± 0.035	1.133HisGlu: 1.133 ± 0.038	0.843HisPhe: 0.843 ± 0.037	1.642HisGly: 1.642 ± 0.054	0.626HisHis: 0.626 ± 0.035	1.175HisIle: 1.175 ± 0.042	0.623HisLys: 0.623 ± 0.03	1.935HisLeu: 1.935 ± 0.053	0.537HisMet: 0.537 ± 0.027	0.603HisAsn: 0.603 ± 0.032	1.316HisPro: 1.316 ± 0.046	0.875HisGln: 0.875 ± 0.032	1.243HisArg: 1.243 ± 0.047	0.942HisSer: 0.942 ± 0.036	1.031HisThr: 1.031 ± 0.035	1.545HisVal: 1.545 ± 0.04	0.244HisTrp: 0.244 ± 0.02	0.802HisTyr: 0.802 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.837IleAla: 5.837 ± 0.093	1.018IleCys: 1.018 ± 0.036	3.375IleAsp: 3.375 ± 0.071	2.923IleGlu: 2.923 ± 0.07	1.957IlePhe: 1.957 ± 0.058	4.201IleGly: 4.201 ± 0.081	1.248IleHis: 1.248 ± 0.038	2.934IleIle: 2.934 ± 0.069	1.745IleLys: 1.745 ± 0.051	5.281IleLeu: 5.281 ± 0.081	1.243IleMet: 1.243 ± 0.045	1.845IleAsn: 1.845 ± 0.048	2.966IlePro: 2.966 ± 0.071	1.618IleGln: 1.618 ± 0.041	3.718IleArg: 3.718 ± 0.081	3.571IleSer: 3.571 ± 0.068	3.411IleThr: 3.411 ± 0.081	4.13IleVal: 4.13 ± 0.077	0.564IleTrp: 0.564 ± 0.029	1.642IleTyr: 1.642 ± 0.048	0.001IleXaa: 0.001 ± 0.001
Lys	4.434LysAla: 4.434 ± 0.092	0.572LysCys: 0.572 ± 0.023	2.301LysAsp: 2.301 ± 0.059	3.025LysGlu: 3.025 ± 0.076	1.116LysPhe: 1.116 ± 0.041	2.923LysGly: 2.923 ± 0.066	0.965LysHis: 0.965 ± 0.035	2.356LysIle: 2.356 ± 0.057	3.053LysLys: 3.053 ± 0.08	4.206LysLeu: 4.206 ± 0.088	1.598LysMet: 1.598 ± 0.041	1.855LysAsn: 1.855 ± 0.056	2.145LysPro: 2.145 ± 0.063	1.868LysGln: 1.868 ± 0.055	2.652LysArg: 2.652 ± 0.065	2.107LysSer: 2.107 ± 0.05	2.755LysThr: 2.755 ± 0.059	2.901LysVal: 2.901 ± 0.068	0.544LysTrp: 0.544 ± 0.028	1.53LysTyr: 1.53 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	8.63LeuAla: 8.63 ± 0.125	2.022LeuCys: 2.022 ± 0.051	5.427LeuAsp: 5.427 ± 0.087	4.839LeuGlu: 4.839 ± 0.097	3.398LeuPhe: 3.398 ± 0.083	6.274LeuGly: 6.274 ± 0.1	2.213LeuHis: 2.213 ± 0.063	4.907LeuIle: 4.907 ± 0.093	3.947LeuLys: 3.947 ± 0.08	11.501LeuLeu: 11.501 ± 0.179	3.674LeuMet: 3.674 ± 0.073	3.513LeuAsn: 3.513 ± 0.064	5.471LeuPro: 5.471 ± 0.1	3.02LeuGln: 3.02 ± 0.064	6.233LeuArg: 6.233 ± 0.094	6.515LeuSer: 6.515 ± 0.109	7.291LeuThr: 7.291 ± 0.11	5.982LeuVal: 5.982 ± 0.098	1.021LeuTrp: 1.021 ± 0.04	3.276LeuTyr: 3.276 ± 0.071	0.001LeuXaa: 0.001 ± 0.001
Met	3.33MetAla: 3.33 ± 0.07	0.342MetCys: 0.342 ± 0.02	1.819MetAsp: 1.819 ± 0.05	1.855MetGlu: 1.855 ± 0.052	0.882MetPhe: 0.882 ± 0.032	2.225MetGly: 2.225 ± 0.051	0.561MetHis: 0.561 ± 0.026	1.454MetIle: 1.454 ± 0.05	1.935MetLys: 1.935 ± 0.045	3.669MetLeu: 3.669 ± 0.073	1.247MetMet: 1.247 ± 0.048	1.414MetAsn: 1.414 ± 0.043	1.54MetPro: 1.54 ± 0.047	1.451MetGln: 1.451 ± 0.043	1.952MetArg: 1.952 ± 0.051	1.733MetSer: 1.733 ± 0.046	2.341MetThr: 2.341 ± 0.05	2.114MetVal: 2.114 ± 0.053	0.267MetTrp: 0.267 ± 0.019	0.785MetTyr: 0.785 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.702AsnAla: 3.702 ± 0.059	0.531AsnCys: 0.531 ± 0.028	1.795AsnAsp: 1.795 ± 0.051	1.889AsnGlu: 1.889 ± 0.051	1.319AsnPhe: 1.319 ± 0.043	3.306AsnGly: 3.306 ± 0.076	0.681AsnHis: 0.681 ± 0.026	2.042AsnIle: 2.042 ± 0.042	1.287AsnLys: 1.287 ± 0.044	3.254AsnLeu: 3.254 ± 0.072	1.059AsnMet: 1.059 ± 0.032	1.221AsnAsn: 1.221 ± 0.045	2.075AsnPro: 2.075 ± 0.063	1.338AsnGln: 1.338 ± 0.039	2.102AsnArg: 2.102 ± 0.051	1.596AsnSer: 1.596 ± 0.043	1.923AsnThr: 1.923 ± 0.05	2.555AsnVal: 2.555 ± 0.055	0.497AsnTrp: 0.497 ± 0.027	1.293AsnTyr: 1.293 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	4.096ProAla: 4.096 ± 0.087	0.628ProCys: 0.628 ± 0.031	3.197ProAsp: 3.197 ± 0.076	3.86ProGlu: 3.86 ± 0.088	1.674ProPhe: 1.674 ± 0.055	2.944ProGly: 2.944 ± 0.067	0.766ProHis: 0.766 ± 0.029	2.001ProIle: 2.001 ± 0.047	1.745ProLys: 1.745 ± 0.043	3.897ProLeu: 3.897 ± 0.071	1.428ProMet: 1.428 ± 0.037	1.532ProAsn: 1.532 ± 0.043	1.387ProPro: 1.387 ± 0.053	1.575ProGln: 1.575 ± 0.046	1.623ProArg: 1.623 ± 0.05	2.019ProSer: 2.019 ± 0.058	2.551ProThr: 2.551 ± 0.116	3.415ProVal: 3.415 ± 0.076	0.449ProTrp: 0.449 ± 0.023	1.607ProTyr: 1.607 ± 0.044	0.001ProXaa: 0.001 ± 0.001
Gln	3.527GlnAla: 3.527 ± 0.067	0.458GlnCys: 0.458 ± 0.022	1.668GlnAsp: 1.668 ± 0.044	2.549GlnGlu: 2.549 ± 0.061	1.171GlnPhe: 1.171 ± 0.037	2.318GlnGly: 2.318 ± 0.055	0.811GlnHis: 0.811 ± 0.037	1.945GlnIle: 1.945 ± 0.049	1.974GlnLys: 1.974 ± 0.049	3.585GlnLeu: 3.585 ± 0.08	1.376GlnMet: 1.376 ± 0.047	1.476GlnAsn: 1.476 ± 0.04	1.769GlnPro: 1.769 ± 0.058	1.917GlnGln: 1.917 ± 0.066	2.214GlnArg: 2.214 ± 0.059	1.879GlnSer: 1.879 ± 0.06	2.189GlnThr: 2.189 ± 0.051	2.599GlnVal: 2.599 ± 0.065	0.494GlnTrp: 0.494 ± 0.026	1.349GlnTyr: 1.349 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	4.841ArgAla: 4.841 ± 0.082	0.858ArgCys: 0.858 ± 0.036	2.999ArgAsp: 2.999 ± 0.069	3.838ArgGlu: 3.838 ± 0.088	2.258ArgPhe: 2.258 ± 0.063	3.358ArgGly: 3.358 ± 0.077	1.258ArgHis: 1.258 ± 0.042	3.442ArgIle: 3.442 ± 0.073	2.971ArgLys: 2.971 ± 0.067	5.577ArgLeu: 5.577 ± 0.09	1.983ArgMet: 1.983 ± 0.052	1.951ArgAsn: 1.951 ± 0.046	1.981ArgPro: 1.981 ± 0.069	2.533ArgGln: 2.533 ± 0.067	3.888ArgArg: 3.888 ± 0.095	2.439ArgSer: 2.439 ± 0.056	3.058ArgThr: 3.058 ± 0.063	4.198ArgVal: 4.198 ± 0.088	0.637ArgTrp: 0.637 ± 0.031	2.06ArgTyr: 2.06 ± 0.057	0.001ArgXaa: 0.001 ± 0.001
Ser	5.823SerAla: 5.823 ± 0.094	0.819SerCys: 0.819 ± 0.036	3.1SerAsp: 3.1 ± 0.064	2.864SerGlu: 2.864 ± 0.064	2.178SerPhe: 2.178 ± 0.054	5.144SerGly: 5.144 ± 0.1	0.954SerHis: 0.954 ± 0.036	3.128SerIle: 3.128 ± 0.074	1.898SerLys: 1.898 ± 0.054	5.193SerLeu: 5.193 ± 0.082	1.569SerMet: 1.569 ± 0.04	1.582SerAsn: 1.582 ± 0.042	2.105SerPro: 2.105 ± 0.063	1.653SerGln: 1.653 ± 0.043	2.893SerArg: 2.893 ± 0.059	3.012SerSer: 3.012 ± 0.07	2.845SerThr: 2.845 ± 0.067	4.062SerVal: 4.062 ± 0.072	0.636SerTrp: 0.636 ± 0.032	1.848SerTyr: 1.848 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	6.142ThrAla: 6.142 ± 0.119	0.794ThrCys: 0.794 ± 0.031	3.475ThrAsp: 3.475 ± 0.056	3.381ThrGlu: 3.381 ± 0.069	2.317ThrPhe: 2.317 ± 0.062	4.722ThrGly: 4.722 ± 0.093	1.153ThrHis: 1.153 ± 0.043	3.619ThrIle: 3.619 ± 0.071	2.097ThrLys: 2.097 ± 0.055	6.842ThrLeu: 6.842 ± 0.094	1.815ThrMet: 1.815 ± 0.047	1.903ThrAsn: 1.903 ± 0.057	3.304ThrPro: 3.304 ± 0.097	1.917ThrGln: 1.917 ± 0.053	2.862ThrArg: 2.862 ± 0.071	2.94ThrSer: 2.94 ± 0.067	3.236ThrThr: 3.236 ± 0.091	4.993ThrVal: 4.993 ± 0.098	0.682ThrTrp: 0.682 ± 0.031	2.018ThrTyr: 2.018 ± 0.054	0.001ThrXaa: 0.001 ± 0.001
Val	5.755ValAla: 5.755 ± 0.09	1.34ValCys: 1.34 ± 0.043	4.085ValAsp: 4.085 ± 0.077	4.195ValGlu: 4.195 ± 0.078	2.606ValPhe: 2.606 ± 0.054	4.627ValGly: 4.627 ± 0.078	1.375ValHis: 1.375 ± 0.041	3.996ValIle: 3.996 ± 0.074	3.072ValLys: 3.072 ± 0.066	7.798ValLeu: 7.798 ± 0.117	2.286ValMet: 2.286 ± 0.059	2.543ValAsn: 2.543 ± 0.061	3.22ValPro: 3.22 ± 0.069	2.689ValGln: 2.689 ± 0.063	4.29ValArg: 4.29 ± 0.077	4.613ValSer: 4.613 ± 0.084	4.852ValThr: 4.852 ± 0.098	5.157ValVal: 5.157 ± 0.083	0.803ValTrp: 0.803 ± 0.037	2.627ValTyr: 2.627 ± 0.062	0.001ValXaa: 0.001 ± 0.001
Trp	0.944TrpAla: 0.944 ± 0.043	0.242TrpCys: 0.242 ± 0.017	0.683TrpAsp: 0.683 ± 0.035	0.675TrpGlu: 0.675 ± 0.029	0.433TrpPhe: 0.433 ± 0.025	0.771TrpGly: 0.771 ± 0.034	0.27TrpHis: 0.27 ± 0.018	0.508TrpIle: 0.508 ± 0.028	0.608TrpLys: 0.608 ± 0.029	1.142TrpLeu: 1.142 ± 0.042	0.418TrpMet: 0.418 ± 0.023	0.548TrpAsn: 0.548 ± 0.029	0.273TrpPro: 0.273 ± 0.018	0.658TrpGln: 0.658 ± 0.03	0.719TrpArg: 0.719 ± 0.032	0.648TrpSer: 0.648 ± 0.034	0.721TrpThr: 0.721 ± 0.035	0.763TrpVal: 0.763 ± 0.031	0.205TrpTrp: 0.205 ± 0.016	0.503TrpTyr: 0.503 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.428TyrAla: 3.428 ± 0.068	0.573TyrCys: 0.573 ± 0.027	2.279TyrAsp: 2.279 ± 0.055	1.967TyrGlu: 1.967 ± 0.044	1.39TyrPhe: 1.39 ± 0.037	2.744TyrGly: 2.744 ± 0.061	0.78TyrHis: 0.78 ± 0.034	1.897TyrIle: 1.897 ± 0.055	1.097TyrLys: 1.097 ± 0.038	3.317TyrLeu: 3.317 ± 0.07	0.88TyrMet: 0.88 ± 0.034	1.326TyrAsn: 1.326 ± 0.048	1.585TyrPro: 1.585 ± 0.045	1.436TyrGln: 1.436 ± 0.042	2.092TyrArg: 2.092 ± 0.056	1.775TyrSer: 1.775 ± 0.059	2.315TyrThr: 2.315 ± 0.068	2.358TyrVal: 2.358 ± 0.055	0.425TyrTrp: 0.425 ± 0.024	1.451TyrTyr: 1.451 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.004XaaArg: 0.004 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.012XaaXaa: 0.012 ± 0.005

Statistics based on 2464 proteins (819612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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