Amino acid dipepetide frequency for Alistipes sp. CAG:268

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.809AlaAla: 11.809 ± 0.178	1.416AlaCys: 1.416 ± 0.049	5.838AlaAsp: 5.838 ± 0.092	6.833AlaGlu: 6.833 ± 0.117	3.454AlaPhe: 3.454 ± 0.069	7.949AlaGly: 7.949 ± 0.109	1.528AlaHis: 1.528 ± 0.056	4.316AlaIle: 4.316 ± 0.078	2.999AlaLys: 2.999 ± 0.072	9.093AlaLeu: 9.093 ± 0.14	2.277AlaMet: 2.277 ± 0.054	2.585AlaAsn: 2.585 ± 0.057	3.581AlaPro: 3.581 ± 0.072	3.021AlaGln: 3.021 ± 0.074	6.53AlaArg: 6.53 ± 0.121	5.305AlaSer: 5.305 ± 0.095	4.591AlaThr: 4.591 ± 0.09	7.406AlaVal: 7.406 ± 0.129	1.197AlaTrp: 1.197 ± 0.044	2.956AlaTyr: 2.956 ± 0.07	0.004AlaXaa: 0.004 ± 0.002
Cys	1.142CysAla: 1.142 ± 0.041	0.302CysCys: 0.302 ± 0.02	0.806CysAsp: 0.806 ± 0.031	0.706CysGlu: 0.706 ± 0.033	0.542CysPhe: 0.542 ± 0.028	1.413CysGly: 1.413 ± 0.044	0.285CysHis: 0.285 ± 0.018	0.726CysIle: 0.726 ± 0.035	0.375CysLys: 0.375 ± 0.023	1.062CysLeu: 1.062 ± 0.038	0.317CysMet: 0.317 ± 0.019	0.474CysAsn: 0.474 ± 0.026	0.724CysPro: 0.724 ± 0.035	0.242CysGln: 0.242 ± 0.018	1.192CysArg: 1.192 ± 0.04	0.917CysSer: 0.917 ± 0.034	0.76CysThr: 0.76 ± 0.034	0.721CysVal: 0.721 ± 0.034	0.168CysTrp: 0.168 ± 0.013	0.526CysTyr: 0.526 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	5.305AspAla: 5.305 ± 0.088	0.673AspCys: 0.673 ± 0.031	3.224AspAsp: 3.224 ± 0.077	3.975AspGlu: 3.975 ± 0.069	2.653AspPhe: 2.653 ± 0.063	4.937AspGly: 4.937 ± 0.08	1.013AspHis: 1.013 ± 0.037	3.163AspIle: 3.163 ± 0.059	2.167AspLys: 2.167 ± 0.069	5.102AspLeu: 5.102 ± 0.103	1.296AspMet: 1.296 ± 0.043	2.03AspAsn: 2.03 ± 0.055	3.007AspPro: 3.007 ± 0.07	1.202AspGln: 1.202 ± 0.041	4.557AspArg: 4.557 ± 0.082	2.825AspSer: 2.825 ± 0.069	2.774AspThr: 2.774 ± 0.06	3.634AspVal: 3.634 ± 0.074	0.827AspTrp: 0.827 ± 0.039	2.627AspTyr: 2.627 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	6.698GluAla: 6.698 ± 0.106	0.697GluCys: 0.697 ± 0.033	2.622GluAsp: 2.622 ± 0.059	4.994GluGlu: 4.994 ± 0.094	2.582GluPhe: 2.582 ± 0.062	5.092GluGly: 5.092 ± 0.09	1.409GluHis: 1.409 ± 0.042	4.095GluIle: 4.095 ± 0.074	3.04GluLys: 3.04 ± 0.075	6.377GluLeu: 6.377 ± 0.105	1.936GluMet: 1.936 ± 0.047	2.554GluAsn: 2.554 ± 0.056	2.467GluPro: 2.467 ± 0.059	2.869GluGln: 2.869 ± 0.06	5.391GluArg: 5.391 ± 0.108	3.05GluSer: 3.05 ± 0.061	3.327GluThr: 3.327 ± 0.068	4.727GluVal: 4.727 ± 0.085	0.875GluTrp: 0.875 ± 0.031	2.415GluTyr: 2.415 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.787PheAla: 3.787 ± 0.069	0.563PheCys: 0.563 ± 0.029	3.104PheAsp: 3.104 ± 0.066	2.512PheGlu: 2.512 ± 0.062	1.816PhePhe: 1.816 ± 0.05	3.659PheGly: 3.659 ± 0.066	0.72PheHis: 0.72 ± 0.033	2.128PheIle: 2.128 ± 0.061	1.31PheLys: 1.31 ± 0.049	3.48PheLeu: 3.48 ± 0.071	0.929PheMet: 0.929 ± 0.036	1.578PheAsn: 1.578 ± 0.056	1.679PhePro: 1.679 ± 0.038	0.899PheGln: 0.899 ± 0.041	3.025PheArg: 3.025 ± 0.062	2.706PheSer: 2.706 ± 0.065	2.615PheThr: 2.615 ± 0.059	2.926PheVal: 2.926 ± 0.07	0.544PheTrp: 0.544 ± 0.029	1.624PheTyr: 1.624 ± 0.048	0.003PheXaa: 0.003 ± 0.002
Gly	6.455GlyAla: 6.455 ± 0.09	1.32GlyCys: 1.32 ± 0.049	4.384GlyAsp: 4.384 ± 0.091	5.202GlyGlu: 5.202 ± 0.083	3.392GlyPhe: 3.392 ± 0.063	6.037GlyGly: 6.037 ± 0.114	1.636GlyHis: 1.636 ± 0.061	5.094GlyIle: 5.094 ± 0.092	3.3GlyLys: 3.3 ± 0.08	6.68GlyLeu: 6.68 ± 0.103	2.232GlyMet: 2.232 ± 0.059	2.841GlyAsn: 2.841 ± 0.07	1.973GlyPro: 1.973 ± 0.066	2.271GlyGln: 2.271 ± 0.059	5.864GlyArg: 5.864 ± 0.129	4.664GlySer: 4.664 ± 0.074	4.572GlyThr: 4.572 ± 0.084	5.805GlyVal: 5.805 ± 0.084	1.188GlyTrp: 1.188 ± 0.048	3.44GlyTyr: 3.44 ± 0.084	0.003GlyXaa: 0.003 ± 0.002
His	1.713HisAla: 1.713 ± 0.053	0.338HisCys: 0.338 ± 0.022	1.068HisAsp: 1.068 ± 0.036	1.095HisGlu: 1.095 ± 0.035	0.881HisPhe: 0.881 ± 0.041	1.425HisGly: 1.425 ± 0.046	0.489HisHis: 0.489 ± 0.031	1.191HisIle: 1.191 ± 0.044	0.694HisLys: 0.694 ± 0.03	1.802HisLeu: 1.802 ± 0.063	0.391HisMet: 0.391 ± 0.023	0.719HisAsn: 0.719 ± 0.028	1.228HisPro: 1.228 ± 0.042	0.431HisGln: 0.431 ± 0.025	1.398HisArg: 1.398 ± 0.06	0.929HisSer: 0.929 ± 0.033	1.111HisThr: 1.111 ± 0.039	1.248HisVal: 1.248 ± 0.05	0.221HisTrp: 0.221 ± 0.016	0.84HisTyr: 0.84 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.566IleAla: 5.566 ± 0.099	0.77IleCys: 0.77 ± 0.032	4.173IleAsp: 4.173 ± 0.076	3.914IleGlu: 3.914 ± 0.07	2.051IlePhe: 2.051 ± 0.059	4.513IleGly: 4.513 ± 0.078	1.079IleHis: 1.079 ± 0.041	2.622IleIle: 2.622 ± 0.077	1.86IleLys: 1.86 ± 0.051	4.8IleLeu: 4.8 ± 0.088	1.049IleMet: 1.049 ± 0.041	1.959IleAsn: 1.959 ± 0.054	2.796IlePro: 2.796 ± 0.057	1.211IleGln: 1.211 ± 0.044	4.319IleArg: 4.319 ± 0.082	3.197IleSer: 3.197 ± 0.075	2.952IleThr: 2.952 ± 0.069	4.163IleVal: 4.163 ± 0.082	0.584IleTrp: 0.584 ± 0.023	1.98IleTyr: 1.98 ± 0.05	0.001IleXaa: 0.001 ± 0.001
Lys	3.374LysAla: 3.374 ± 0.075	0.394LysCys: 0.394 ± 0.023	1.701LysAsp: 1.701 ± 0.048	2.892LysGlu: 2.892 ± 0.075	1.368LysPhe: 1.368 ± 0.044	2.881LysGly: 2.881 ± 0.068	0.687LysHis: 0.687 ± 0.03	2.514LysIle: 2.514 ± 0.068	2.014LysLys: 2.014 ± 0.068	3.259LysLeu: 3.259 ± 0.065	1.302LysMet: 1.302 ± 0.041	1.654LysAsn: 1.654 ± 0.059	1.609LysPro: 1.609 ± 0.047	1.356LysGln: 1.356 ± 0.047	2.618LysArg: 2.618 ± 0.062	2.108LysSer: 2.108 ± 0.058	2.206LysThr: 2.206 ± 0.056	2.736LysVal: 2.736 ± 0.064	0.527LysTrp: 0.527 ± 0.027	1.692LysTyr: 1.692 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	8.794LeuAla: 8.794 ± 0.137	1.499LeuCys: 1.499 ± 0.046	5.273LeuAsp: 5.273 ± 0.096	5.335LeuGlu: 5.335 ± 0.097	4.323LeuPhe: 4.323 ± 0.092	6.809LeuGly: 6.809 ± 0.113	2.017LeuHis: 2.017 ± 0.052	4.387LeuIle: 4.387 ± 0.076	3.665LeuLys: 3.665 ± 0.065	9.874LeuLeu: 9.874 ± 0.162	2.188LeuMet: 2.188 ± 0.062	3.101LeuAsn: 3.101 ± 0.068	4.582LeuPro: 4.582 ± 0.088	2.934LeuGln: 2.934 ± 0.073	7.23LeuArg: 7.23 ± 0.124	6.079LeuSer: 6.079 ± 0.103	5.584LeuThr: 5.584 ± 0.097	5.893LeuVal: 5.893 ± 0.12	1.049LeuTrp: 1.049 ± 0.042	3.228LeuTyr: 3.228 ± 0.069	0.001LeuXaa: 0.001 ± 0.001
Met	2.385MetAla: 2.385 ± 0.063	0.233MetCys: 0.233 ± 0.018	1.187MetAsp: 1.187 ± 0.035	1.632MetGlu: 1.632 ± 0.05	0.845MetPhe: 0.845 ± 0.033	1.723MetGly: 1.723 ± 0.061	0.455MetHis: 0.455 ± 0.023	1.339MetIle: 1.339 ± 0.042	1.713MetLys: 1.713 ± 0.044	2.48MetLeu: 2.48 ± 0.062	0.712MetMet: 0.712 ± 0.029	1.16MetAsn: 1.16 ± 0.041	1.23MetPro: 1.23 ± 0.041	0.934MetGln: 0.934 ± 0.034	1.707MetArg: 1.707 ± 0.048	1.431MetSer: 1.431 ± 0.046	1.56MetThr: 1.56 ± 0.042	1.454MetVal: 1.454 ± 0.045	0.294MetTrp: 0.294 ± 0.022	0.694MetTyr: 0.694 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.991AsnAla: 2.991 ± 0.072	0.379AsnCys: 0.379 ± 0.023	1.94AsnAsp: 1.94 ± 0.052	1.909AsnGlu: 1.909 ± 0.048	1.556AsnPhe: 1.556 ± 0.054	2.981AsnGly: 2.981 ± 0.07	0.651AsnHis: 0.651 ± 0.027	2.291AsnIle: 2.291 ± 0.065	1.365AsnLys: 1.365 ± 0.051	3.315AsnLeu: 3.315 ± 0.068	0.84AsnMet: 0.84 ± 0.031	1.425AsnAsn: 1.425 ± 0.045	2.232AsnPro: 2.232 ± 0.067	0.891AsnGln: 0.891 ± 0.034	2.582AsnArg: 2.582 ± 0.06	1.779AsnSer: 1.779 ± 0.052	1.903AsnThr: 1.903 ± 0.052	2.301AsnVal: 2.301 ± 0.061	0.495AsnTrp: 0.495 ± 0.025	1.637AsnTyr: 1.637 ± 0.059	0.001AsnXaa: 0.001 ± 0.001
Pro	4.646ProAla: 4.646 ± 0.087	0.457ProCys: 0.457 ± 0.025	3.199ProAsp: 3.199 ± 0.06	4.067ProGlu: 4.067 ± 0.075	1.872ProPhe: 1.872 ± 0.05	3.323ProGly: 3.323 ± 0.068	0.857ProHis: 0.857 ± 0.04	1.904ProIle: 1.904 ± 0.052	1.519ProLys: 1.519 ± 0.045	3.788ProLeu: 3.788 ± 0.067	1.021ProMet: 1.021 ± 0.038	1.289ProAsn: 1.289 ± 0.043	1.129ProPro: 1.129 ± 0.048	1.517ProGln: 1.517 ± 0.045	2.442ProArg: 2.442 ± 0.063	2.439ProSer: 2.439 ± 0.06	2.17ProThr: 2.17 ± 0.059	3.521ProVal: 3.521 ± 0.075	0.555ProTrp: 0.555 ± 0.031	1.617ProTyr: 1.617 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	2.693GlnAla: 2.693 ± 0.057	0.298GlnCys: 0.298 ± 0.019	1.14GlnAsp: 1.14 ± 0.036	1.75GlnGlu: 1.75 ± 0.042	1.097GlnPhe: 1.097 ± 0.042	2.055GlnGly: 2.055 ± 0.052	0.642GlnHis: 0.642 ± 0.025	1.931GlnIle: 1.931 ± 0.054	1.296GlnLys: 1.296 ± 0.045	3.009GlnLeu: 3.009 ± 0.066	0.891GlnMet: 0.891 ± 0.037	1.276GlnAsn: 1.276 ± 0.046	1.399GlnPro: 1.399 ± 0.046	1.413GlnGln: 1.413 ± 0.054	2.161GlnArg: 2.161 ± 0.064	1.596GlnSer: 1.596 ± 0.044	1.894GlnThr: 1.894 ± 0.055	1.957GlnVal: 1.957 ± 0.056	0.405GlnTrp: 0.405 ± 0.024	1.172GlnTyr: 1.172 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	5.538ArgAla: 5.538 ± 0.108	0.866ArgCys: 0.866 ± 0.036	3.508ArgAsp: 3.508 ± 0.077	5.202ArgGlu: 5.202 ± 0.11	3.229ArgPhe: 3.229 ± 0.071	4.308ArgGly: 4.308 ± 0.086	1.606ArgHis: 1.606 ± 0.065	5.212ArgIle: 5.212 ± 0.096	2.933ArgLys: 2.933 ± 0.064	7.056ArgLeu: 7.056 ± 0.125	2.339ArgMet: 2.339 ± 0.061	2.754ArgAsn: 2.754 ± 0.055	3.059ArgPro: 3.059 ± 0.081	2.481ArgGln: 2.481 ± 0.071	5.931ArgArg: 5.931 ± 0.149	3.818ArgSer: 3.818 ± 0.071	4.253ArgThr: 4.253 ± 0.083	4.21ArgVal: 4.21 ± 0.081	0.98ArgTrp: 0.98 ± 0.04	2.977ArgTyr: 2.977 ± 0.065	0.004ArgXaa: 0.004 ± 0.002
Ser	4.956SerAla: 4.956 ± 0.077	0.808SerCys: 0.808 ± 0.036	3.341SerAsp: 3.341 ± 0.067	3.6SerGlu: 3.6 ± 0.074	2.617SerPhe: 2.617 ± 0.057	5.04SerGly: 5.04 ± 0.081	1.024SerHis: 1.024 ± 0.038	3.061SerIle: 3.061 ± 0.064	2.078SerLys: 2.078 ± 0.058	5.689SerLeu: 5.689 ± 0.096	1.367SerMet: 1.367 ± 0.038	1.838SerAsn: 1.838 ± 0.057	2.54SerPro: 2.54 ± 0.061	1.541SerGln: 1.541 ± 0.048	3.416SerArg: 3.416 ± 0.062	3.398SerSer: 3.398 ± 0.086	2.777SerThr: 2.777 ± 0.074	4.315SerVal: 4.315 ± 0.081	0.751SerTrp: 0.751 ± 0.036	2.389SerTyr: 2.389 ± 0.075	0.0SerXaa: 0.0 ± 0.0
Thr	5.363ThrAla: 5.363 ± 0.089	0.549ThrCys: 0.549 ± 0.025	3.24ThrAsp: 3.24 ± 0.061	3.442ThrGlu: 3.442 ± 0.077	2.433ThrPhe: 2.433 ± 0.056	4.621ThrGly: 4.621 ± 0.083	0.957ThrHis: 0.957 ± 0.038	3.095ThrIle: 3.095 ± 0.067	1.816ThrLys: 1.816 ± 0.06	5.962ThrLeu: 5.962 ± 0.093	1.175ThrMet: 1.175 ± 0.038	1.622ThrAsn: 1.622 ± 0.052	3.179ThrPro: 3.179 ± 0.062	1.533ThrGln: 1.533 ± 0.044	3.058ThrArg: 3.058 ± 0.065	3.075ThrSer: 3.075 ± 0.071	3.137ThrThr: 3.137 ± 0.075	4.533ThrVal: 4.533 ± 0.083	0.648ThrTrp: 0.648 ± 0.031	1.962ThrTyr: 1.962 ± 0.056	0.001ThrXaa: 0.001 ± 0.001
Val	7.07ValAla: 7.07 ± 0.128	1.086ValCys: 1.086 ± 0.031	3.99ValAsp: 3.99 ± 0.084	5.121ValGlu: 5.121 ± 0.091	2.628ValPhe: 2.628 ± 0.067	5.428ValGly: 5.428 ± 0.106	1.177ValHis: 1.177 ± 0.049	3.68ValIle: 3.68 ± 0.081	2.851ValLys: 2.851 ± 0.072	6.298ValLeu: 6.298 ± 0.108	1.638ValMet: 1.638 ± 0.048	2.349ValAsn: 2.349 ± 0.054	2.878ValPro: 2.878 ± 0.059	1.957ValGln: 1.957 ± 0.044	5.103ValArg: 5.103 ± 0.096	4.29ValSer: 4.29 ± 0.08	4.058ValThr: 4.058 ± 0.087	5.968ValVal: 5.968 ± 0.133	0.94ValTrp: 0.94 ± 0.035	2.27ValTyr: 2.27 ± 0.05	0.004ValXaa: 0.004 ± 0.002
Trp	0.899TrpAla: 0.899 ± 0.034	0.22TrpCys: 0.22 ± 0.017	0.662TrpAsp: 0.662 ± 0.03	0.794TrpGlu: 0.794 ± 0.036	0.599TrpPhe: 0.599 ± 0.032	1.044TrpGly: 1.044 ± 0.045	0.278TrpHis: 0.278 ± 0.017	0.817TrpIle: 0.817 ± 0.034	0.556TrpLys: 0.556 ± 0.024	1.278TrpLeu: 1.278 ± 0.043	0.39TrpMet: 0.39 ± 0.022	0.588TrpAsn: 0.588 ± 0.031	0.334TrpPro: 0.334 ± 0.02	0.517TrpGln: 0.517 ± 0.027	0.88TrpArg: 0.88 ± 0.038	0.826TrpSer: 0.826 ± 0.038	0.725TrpThr: 0.725 ± 0.031	0.794TrpVal: 0.794 ± 0.036	0.233TrpTrp: 0.233 ± 0.019	0.496TrpTyr: 0.496 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.504TyrAla: 3.504 ± 0.075	0.535TyrCys: 0.535 ± 0.026	2.589TyrAsp: 2.589 ± 0.062	2.242TyrGlu: 2.242 ± 0.057	1.666TyrPhe: 1.666 ± 0.049	3.11TyrGly: 3.11 ± 0.077	0.7TyrHis: 0.7 ± 0.028	1.993TyrIle: 1.993 ± 0.055	1.34TyrLys: 1.34 ± 0.042	3.44TyrLeu: 3.44 ± 0.066	0.877TyrMet: 0.877 ± 0.035	1.67TyrAsn: 1.67 ± 0.058	1.701TyrPro: 1.701 ± 0.046	0.857TyrGln: 0.857 ± 0.034	2.855TyrArg: 2.855 ± 0.071	2.114TyrSer: 2.114 ± 0.06	2.43TyrThr: 2.43 ± 0.068	2.47TyrVal: 2.47 ± 0.065	0.449TyrTrp: 0.449 ± 0.027	1.682TyrTyr: 1.682 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.005XaaGly: 0.005 ± 0.003	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.003XaaLeu: 0.003 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.004XaaArg: 0.004 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.024XaaXaa: 0.024 ± 0.008

Statistics based on 2200 proteins (781890 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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