Amino acid dipepetide frequency for Piscirickettsia litoralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.063AlaAla: 7.063 ± 0.144	0.987AlaCys: 0.987 ± 0.036	3.827AlaAsp: 3.827 ± 0.069	4.923AlaGlu: 4.923 ± 0.095	2.999AlaPhe: 2.999 ± 0.067	5.59AlaGly: 5.59 ± 0.106	1.613AlaHis: 1.613 ± 0.044	5.667AlaIle: 5.667 ± 0.1	5.108AlaLys: 5.108 ± 0.083	8.995AlaLeu: 8.995 ± 0.142	2.166AlaMet: 2.166 ± 0.055	3.475AlaAsn: 3.475 ± 0.078	2.496AlaPro: 2.496 ± 0.06	3.37AlaGln: 3.37 ± 0.069	3.203AlaArg: 3.203 ± 0.069	5.211AlaSer: 5.211 ± 0.088	4.233AlaThr: 4.233 ± 0.088	5.51AlaVal: 5.51 ± 0.092	0.829AlaTrp: 0.829 ± 0.033	2.528AlaTyr: 2.528 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.862CysAla: 0.862 ± 0.032	0.183CysCys: 0.183 ± 0.015	0.644CysAsp: 0.644 ± 0.031	0.659CysGlu: 0.659 ± 0.033	0.631CysPhe: 0.631 ± 0.027	0.845CysGly: 0.845 ± 0.033	0.35CysHis: 0.35 ± 0.02	0.791CysIle: 0.791 ± 0.031	0.628CysLys: 0.628 ± 0.028	1.234CysLeu: 1.234 ± 0.041	0.287CysMet: 0.287 ± 0.02	0.477CysAsn: 0.477 ± 0.025	0.449CysPro: 0.449 ± 0.024	0.599CysGln: 0.599 ± 0.029	0.467CysArg: 0.467 ± 0.023	0.851CysSer: 0.851 ± 0.032	0.48CysThr: 0.48 ± 0.028	0.607CysVal: 0.607 ± 0.031	0.146CysTrp: 0.146 ± 0.013	0.501CysTyr: 0.501 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.694AspAla: 3.694 ± 0.075	0.63AspCys: 0.63 ± 0.028	2.791AspAsp: 2.791 ± 0.078	3.366AspGlu: 3.366 ± 0.08	2.391AspPhe: 2.391 ± 0.058	2.957AspGly: 2.957 ± 0.074	1.341AspHis: 1.341 ± 0.044	3.937AspIle: 3.937 ± 0.081	3.325AspLys: 3.325 ± 0.075	5.135AspLeu: 5.135 ± 0.083	1.03AspMet: 1.03 ± 0.032	2.397AspAsn: 2.397 ± 0.061	1.826AspPro: 1.826 ± 0.054	2.601AspGln: 2.601 ± 0.069	2.058AspArg: 2.058 ± 0.061	3.231AspSer: 3.231 ± 0.071	2.285AspThr: 2.285 ± 0.064	3.24AspVal: 3.24 ± 0.071	0.638AspTrp: 0.638 ± 0.031	2.251AspTyr: 2.251 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.355GluAla: 4.355 ± 0.091	0.622GluCys: 0.622 ± 0.028	2.57GluAsp: 2.57 ± 0.071	3.653GluGlu: 3.653 ± 0.086	2.264GluPhe: 2.264 ± 0.057	3.177GluGly: 3.177 ± 0.081	1.576GluHis: 1.576 ± 0.046	4.078GluIle: 4.078 ± 0.076	4.801GluLys: 4.801 ± 0.082	6.296GluLeu: 6.296 ± 0.099	1.327GluMet: 1.327 ± 0.044	3.047GluAsn: 3.047 ± 0.059	1.641GluPro: 1.641 ± 0.045	3.247GluGln: 3.247 ± 0.074	3.066GluArg: 3.066 ± 0.072	3.874GluSer: 3.874 ± 0.071	2.708GluThr: 2.708 ± 0.065	3.954GluVal: 3.954 ± 0.075	0.532GluTrp: 0.532 ± 0.026	1.824GluTyr: 1.824 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.2PheAla: 3.2 ± 0.068	0.552PheCys: 0.552 ± 0.027	2.56PheAsp: 2.56 ± 0.065	2.249PheGlu: 2.249 ± 0.054	1.926PhePhe: 1.926 ± 0.054	2.616PheGly: 2.616 ± 0.066	0.851PheHis: 0.851 ± 0.03	3.404PheIle: 3.404 ± 0.082	2.772PheLys: 2.772 ± 0.059	3.842PheLeu: 3.842 ± 0.079	1.017PheMet: 1.017 ± 0.038	2.511PheAsn: 2.511 ± 0.059	1.326PhePro: 1.326 ± 0.044	1.258PheGln: 1.258 ± 0.044	1.36PheArg: 1.36 ± 0.042	3.752PheSer: 3.752 ± 0.071	2.237PheThr: 2.237 ± 0.063	2.309PheVal: 2.309 ± 0.061	0.486PheTrp: 0.486 ± 0.027	1.704PheTyr: 1.704 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.836GlyAla: 4.836 ± 0.103	0.86GlyCys: 0.86 ± 0.028	3.189GlyAsp: 3.189 ± 0.083	3.517GlyGlu: 3.517 ± 0.087	3.15GlyPhe: 3.15 ± 0.067	4.257GlyGly: 4.257 ± 0.119	1.519GlyHis: 1.519 ± 0.044	4.3GlyIle: 4.3 ± 0.086	3.969GlyLys: 3.969 ± 0.082	6.568GlyLeu: 6.568 ± 0.091	1.632GlyMet: 1.632 ± 0.047	2.484GlyAsn: 2.484 ± 0.073	1.676GlyPro: 1.676 ± 0.041	2.951GlyGln: 2.951 ± 0.072	2.761GlyArg: 2.761 ± 0.071	4.073GlySer: 4.073 ± 0.088	3.017GlyThr: 3.017 ± 0.087	4.785GlyVal: 4.785 ± 0.09	0.842GlyTrp: 0.842 ± 0.038	2.439GlyTyr: 2.439 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.797HisAla: 1.797 ± 0.048	0.358HisCys: 0.358 ± 0.022	1.112HisAsp: 1.112 ± 0.039	1.164HisGlu: 1.164 ± 0.039	1.149HisPhe: 1.149 ± 0.043	1.439HisGly: 1.439 ± 0.044	0.777HisHis: 0.777 ± 0.037	1.694HisIle: 1.694 ± 0.051	1.238HisLys: 1.238 ± 0.043	2.416HisLeu: 2.416 ± 0.054	0.514HisMet: 0.514 ± 0.024	1.067HisAsn: 1.067 ± 0.038	1.099HisPro: 1.099 ± 0.038	1.183HisGln: 1.183 ± 0.038	1.005HisArg: 1.005 ± 0.036	1.6HisSer: 1.6 ± 0.044	1.121HisThr: 1.121 ± 0.041	1.368HisVal: 1.368 ± 0.043	0.354HisTrp: 0.354 ± 0.021	1.163HisTyr: 1.163 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.24IleAla: 6.24 ± 0.103	0.887IleCys: 0.887 ± 0.033	4.514IleAsp: 4.514 ± 0.08	4.408IleGlu: 4.408 ± 0.088	2.843IlePhe: 2.843 ± 0.058	4.399IleGly: 4.399 ± 0.079	1.49IleHis: 1.49 ± 0.041	5.046IleIle: 5.046 ± 0.096	4.751IleLys: 4.751 ± 0.088	6.105IleLeu: 6.105 ± 0.093	1.262IleMet: 1.262 ± 0.036	4.387IleAsn: 4.387 ± 0.088	2.584IlePro: 2.584 ± 0.058	2.776IleGln: 2.776 ± 0.051	2.724IleArg: 2.724 ± 0.061	5.323IleSer: 5.323 ± 0.091	4.134IleThr: 4.134 ± 0.098	4.065IleVal: 4.065 ± 0.071	0.516IleTrp: 0.516 ± 0.024	2.206IleTyr: 2.206 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	5.063LysAla: 5.063 ± 0.1	0.486LysCys: 0.486 ± 0.024	3.081LysAsp: 3.081 ± 0.069	4.458LysGlu: 4.458 ± 0.093	1.993LysPhe: 1.993 ± 0.055	3.385LysGly: 3.385 ± 0.068	1.456LysHis: 1.456 ± 0.04	4.674LysIle: 4.674 ± 0.079	5.379LysLys: 5.379 ± 0.094	6.381LysLeu: 6.381 ± 0.104	1.596LysMet: 1.596 ± 0.046	3.849LysAsn: 3.849 ± 0.077	2.36LysPro: 2.36 ± 0.064	3.241LysGln: 3.241 ± 0.08	3.045LysArg: 3.045 ± 0.066	4.35LysSer: 4.35 ± 0.085	3.785LysThr: 3.785 ± 0.062	4.364LysVal: 4.364 ± 0.078	0.52LysTrp: 0.52 ± 0.026	2.015LysTyr: 2.015 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	8.75LeuAla: 8.75 ± 0.114	1.267LeuCys: 1.267 ± 0.044	5.162LeuAsp: 5.162 ± 0.1	6.06LeuGlu: 6.06 ± 0.104	4.427LeuPhe: 4.427 ± 0.09	6.541LeuGly: 6.541 ± 0.113	2.094LeuHis: 2.094 ± 0.05	7.302LeuIle: 7.302 ± 0.102	7.006LeuLys: 7.006 ± 0.103	10.37LeuLeu: 10.37 ± 0.149	2.426LeuMet: 2.426 ± 0.06	5.342LeuAsn: 5.342 ± 0.09	4.183LeuPro: 4.183 ± 0.073	4.044LeuGln: 4.044 ± 0.063	3.925LeuArg: 3.925 ± 0.067	8.397LeuSer: 8.397 ± 0.112	6.063LeuThr: 6.063 ± 0.097	6.082LeuVal: 6.082 ± 0.095	0.994LeuTrp: 0.994 ± 0.041	3.229LeuTyr: 3.229 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.048MetAla: 2.048 ± 0.053	0.206MetCys: 0.206 ± 0.014	1.015MetAsp: 1.015 ± 0.036	0.95MetGlu: 0.95 ± 0.037	0.737MetPhe: 0.737 ± 0.034	1.394MetGly: 1.394 ± 0.041	0.458MetHis: 0.458 ± 0.023	1.655MetIle: 1.655 ± 0.047	1.706MetLys: 1.706 ± 0.047	2.471MetLeu: 2.471 ± 0.053	0.681MetMet: 0.681 ± 0.032	1.101MetAsn: 1.101 ± 0.04	1.078MetPro: 1.078 ± 0.039	1.189MetGln: 1.189 ± 0.038	1.119MetArg: 1.119 ± 0.04	1.836MetSer: 1.836 ± 0.045	1.417MetThr: 1.417 ± 0.042	1.407MetVal: 1.407 ± 0.047	0.165MetTrp: 0.165 ± 0.015	0.55MetTyr: 0.55 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.42AsnAla: 3.42 ± 0.082	0.496AsnCys: 0.496 ± 0.024	2.415AsnAsp: 2.415 ± 0.062	2.597AsnGlu: 2.597 ± 0.061	2.071AsnPhe: 2.071 ± 0.047	2.575AsnGly: 2.575 ± 0.065	1.3AsnHis: 1.3 ± 0.043	4.049AsnIle: 4.049 ± 0.085	3.623AsnLys: 3.623 ± 0.086	4.734AsnLeu: 4.734 ± 0.093	1.104AsnMet: 1.104 ± 0.036	3.144AsnAsn: 3.144 ± 0.086	2.212AsnPro: 2.212 ± 0.058	2.669AsnGln: 2.669 ± 0.061	1.909AsnArg: 1.909 ± 0.048	3.481AsnSer: 3.481 ± 0.073	2.703AsnThr: 2.703 ± 0.084	2.444AsnVal: 2.444 ± 0.061	0.589AsnTrp: 0.589 ± 0.027	2.008AsnTyr: 2.008 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	2.713ProAla: 2.713 ± 0.06	0.374ProCys: 0.374 ± 0.024	1.936ProAsp: 1.936 ± 0.047	2.786ProGlu: 2.786 ± 0.065	1.666ProPhe: 1.666 ± 0.038	2.243ProGly: 2.243 ± 0.055	0.799ProHis: 0.799 ± 0.031	2.383ProIle: 2.383 ± 0.06	2.352ProLys: 2.352 ± 0.059	3.699ProLeu: 3.699 ± 0.07	0.788ProMet: 0.788 ± 0.032	1.778ProAsn: 1.778 ± 0.048	1.184ProPro: 1.184 ± 0.046	1.419ProGln: 1.419 ± 0.043	1.211ProArg: 1.211 ± 0.041	2.264ProSer: 2.264 ± 0.052	2.029ProThr: 2.029 ± 0.044	2.797ProVal: 2.797 ± 0.072	0.474ProTrp: 0.474 ± 0.028	1.408ProTyr: 1.408 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.309GlnAla: 4.309 ± 0.085	0.491GlnCys: 0.491 ± 0.024	2.011GlnAsp: 2.011 ± 0.051	2.76GlnGlu: 2.76 ± 0.064	1.738GlnPhe: 1.738 ± 0.046	3.202GlnGly: 3.202 ± 0.061	1.242GlnHis: 1.242 ± 0.038	2.606GlnIle: 2.606 ± 0.063	2.78GlnLys: 2.78 ± 0.075	5.139GlnLeu: 5.139 ± 0.109	1.006GlnMet: 1.006 ± 0.036	1.889GlnAsn: 1.889 ± 0.054	1.706GlnPro: 1.706 ± 0.046	2.936GlnGln: 2.936 ± 0.078	2.131GlnArg: 2.131 ± 0.054	3.089GlnSer: 3.089 ± 0.058	2.274GlnThr: 2.274 ± 0.062	2.981GlnVal: 2.981 ± 0.058	0.519GlnTrp: 0.519 ± 0.028	1.581GlnTyr: 1.581 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.112ArgAla: 3.112 ± 0.057	0.492ArgCys: 0.492 ± 0.027	2.072ArgAsp: 2.072 ± 0.057	2.671ArgGlu: 2.671 ± 0.063	1.99ArgPhe: 1.99 ± 0.052	2.321ArgGly: 2.321 ± 0.057	1.146ArgHis: 1.146 ± 0.037	2.737ArgIle: 2.737 ± 0.046	2.468ArgLys: 2.468 ± 0.056	4.934ArgLeu: 4.934 ± 0.09	0.972ArgMet: 0.972 ± 0.032	1.704ArgAsn: 1.704 ± 0.046	1.429ArgPro: 1.429 ± 0.05	1.984ArgGln: 1.984 ± 0.056	2.191ArgArg: 2.191 ± 0.057	2.544ArgSer: 2.544 ± 0.053	1.855ArgThr: 1.855 ± 0.051	2.812ArgVal: 2.812 ± 0.06	0.571ArgTrp: 0.571 ± 0.028	1.826ArgTyr: 1.826 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.395SerAla: 5.395 ± 0.086	0.887SerCys: 0.887 ± 0.033	3.644SerAsp: 3.644 ± 0.076	3.861SerGlu: 3.861 ± 0.078	3.257SerPhe: 3.257 ± 0.071	4.935SerGly: 4.935 ± 0.093	1.786SerHis: 1.786 ± 0.048	4.871SerIle: 4.871 ± 0.088	4.205SerLys: 4.205 ± 0.08	7.872SerLeu: 7.872 ± 0.126	1.799SerMet: 1.799 ± 0.043	3.124SerAsn: 3.124 ± 0.074	2.48SerPro: 2.48 ± 0.054	3.28SerGln: 3.28 ± 0.069	2.765SerArg: 2.765 ± 0.067	5.504SerSer: 5.504 ± 0.109	3.658SerThr: 3.658 ± 0.078	4.256SerVal: 4.256 ± 0.08	0.81SerTrp: 0.81 ± 0.034	2.74SerTyr: 2.74 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	4.572ThrAla: 4.572 ± 0.093	0.465ThrCys: 0.465 ± 0.025	2.553ThrAsp: 2.553 ± 0.062	2.806ThrGlu: 2.806 ± 0.064	2.005ThrPhe: 2.005 ± 0.057	3.922ThrGly: 3.922 ± 0.114	1.318ThrHis: 1.318 ± 0.046	3.567ThrIle: 3.567 ± 0.076	2.749ThrLys: 2.749 ± 0.058	6.043ThrLeu: 6.043 ± 0.106	1.001ThrMet: 1.001 ± 0.038	2.279ThrAsn: 2.279 ± 0.067	2.528ThrPro: 2.528 ± 0.061	2.425ThrGln: 2.425 ± 0.058	2.045ThrArg: 2.045 ± 0.052	3.612ThrSer: 3.612 ± 0.082	3.125ThrThr: 3.125 ± 0.087	3.818ThrVal: 3.818 ± 0.08	0.525ThrTrp: 0.525 ± 0.03	1.565ThrTyr: 1.565 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	5.296ValAla: 5.296 ± 0.103	0.783ValCys: 0.783 ± 0.031	3.683ValAsp: 3.683 ± 0.072	3.578ValGlu: 3.578 ± 0.081	2.542ValPhe: 2.542 ± 0.065	4.07ValGly: 4.07 ± 0.083	1.201ValHis: 1.201 ± 0.037	5.021ValIle: 5.021 ± 0.065	3.999ValLys: 3.999 ± 0.077	6.134ValLeu: 6.134 ± 0.096	1.667ValMet: 1.667 ± 0.045	3.35ValAsn: 3.35 ± 0.071	2.191ValPro: 2.191 ± 0.06	2.201ValGln: 2.201 ± 0.052	2.633ValArg: 2.633 ± 0.054	4.614ValSer: 4.614 ± 0.08	3.736ValThr: 3.736 ± 0.088	4.249ValVal: 4.249 ± 0.098	0.592ValTrp: 0.592 ± 0.027	1.93ValTyr: 1.93 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.684TrpAla: 0.684 ± 0.029	0.148TrpCys: 0.148 ± 0.013	0.438TrpAsp: 0.438 ± 0.02	0.442TrpGlu: 0.442 ± 0.024	0.474TrpPhe: 0.474 ± 0.025	0.688TrpGly: 0.688 ± 0.028	0.306TrpHis: 0.306 ± 0.018	0.552TrpIle: 0.552 ± 0.028	0.538TrpLys: 0.538 ± 0.025	1.507TrpLeu: 1.507 ± 0.048	0.232TrpMet: 0.232 ± 0.018	0.462TrpAsn: 0.462 ± 0.028	0.428TrpPro: 0.428 ± 0.023	0.916TrpGln: 0.916 ± 0.037	0.569TrpArg: 0.569 ± 0.028	0.766TrpSer: 0.766 ± 0.031	0.376TrpThr: 0.376 ± 0.025	0.688TrpVal: 0.688 ± 0.032	0.152TrpTrp: 0.152 ± 0.015	0.292TrpTyr: 0.292 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.385TyrAla: 2.385 ± 0.06	0.519TyrCys: 0.519 ± 0.027	1.907TyrAsp: 1.907 ± 0.056	1.704TyrGlu: 1.704 ± 0.046	1.678TyrPhe: 1.678 ± 0.049	2.269TyrGly: 2.269 ± 0.056	0.995TyrHis: 0.995 ± 0.035	2.323TyrIle: 2.323 ± 0.058	2.085TyrLys: 2.085 ± 0.052	3.79TyrLeu: 3.79 ± 0.081	0.675TyrMet: 0.675 ± 0.026	1.675TyrAsn: 1.675 ± 0.056	1.426TyrPro: 1.426 ± 0.042	2.1TyrGln: 2.1 ± 0.059	1.644TyrArg: 1.644 ± 0.047	2.76TyrSer: 2.76 ± 0.071	1.688TyrThr: 1.688 ± 0.055	1.733TyrVal: 1.733 ± 0.05	0.405TyrTrp: 0.405 ± 0.024	1.406TyrTyr: 1.406 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3188 proteins (810863 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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