Amino acid dipepetide frequency for Mycobacterium phage Loser

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.122AlaAla: 11.122 ± 1.132
0.782AlaCys: 0.782 ± 0.242
5.11AlaAsp: 5.11 ± 0.592
7.275AlaGlu: 7.275 ± 0.656
4.088AlaPhe: 4.088 ± 0.537
7.816AlaGly: 7.816 ± 0.734
1.683AlaHis: 1.683 ± 0.285
4.209AlaIle: 4.209 ± 0.546
5.05AlaLys: 5.05 ± 0.577
8.898AlaLeu: 8.898 ± 0.863
3.667AlaMet: 3.667 ± 0.472
3.126AlaAsn: 3.126 ± 0.52
4.449AlaPro: 4.449 ± 0.511
4.329AlaGln: 4.329 ± 0.575
6.734AlaArg: 6.734 ± 0.636
5.17AlaSer: 5.17 ± 0.649
5.531AlaThr: 5.531 ± 0.583
7.635AlaVal: 7.635 ± 0.636
1.563AlaTrp: 1.563 ± 0.287
2.886AlaTyr: 2.886 ± 0.443
0.0AlaXaa: 0.0 ± 0.0
Cys
0.721CysAla: 0.721 ± 0.222
0.0CysCys: 0.0 ± 0.0
0.361CysAsp: 0.361 ± 0.138
0.782CysGlu: 0.782 ± 0.264
0.24CysPhe: 0.24 ± 0.146
0.661CysGly: 0.661 ± 0.203
0.24CysHis: 0.24 ± 0.136
0.361CysIle: 0.361 ± 0.204
0.24CysLys: 0.24 ± 0.105
0.902CysLeu: 0.902 ± 0.226
0.18CysMet: 0.18 ± 0.105
0.481CysAsn: 0.481 ± 0.157
0.421CysPro: 0.421 ± 0.201
0.06CysGln: 0.06 ± 0.064
0.481CysArg: 0.481 ± 0.181
0.481CysSer: 0.481 ± 0.176
0.481CysThr: 0.481 ± 0.185
0.541CysVal: 0.541 ± 0.193
0.301CysTrp: 0.301 ± 0.148
0.361CysTyr: 0.361 ± 0.156
0.0CysXaa: 0.0 ± 0.0
Asp
6.613AspAla: 6.613 ± 0.783
0.601AspCys: 0.601 ± 0.211
3.968AspAsp: 3.968 ± 0.562
4.269AspGlu: 4.269 ± 0.476
2.585AspPhe: 2.585 ± 0.487
5.591AspGly: 5.591 ± 0.708
1.623AspHis: 1.623 ± 0.358
3.848AspIle: 3.848 ± 0.472
2.164AspLys: 2.164 ± 0.328
5.351AspLeu: 5.351 ± 0.657
1.683AspMet: 1.683 ± 0.317
1.202AspAsn: 1.202 ± 0.229
4.75AspPro: 4.75 ± 0.677
1.864AspGln: 1.864 ± 0.274
3.126AspArg: 3.126 ± 0.434
2.766AspSer: 2.766 ± 0.421
3.547AspThr: 3.547 ± 0.482
4.269AspVal: 4.269 ± 0.501
1.263AspTrp: 1.263 ± 0.285
2.104AspTyr: 2.104 ± 0.357
0.0AspXaa: 0.0 ± 0.0
Glu
8.177GluAla: 8.177 ± 0.755
0.18GluCys: 0.18 ± 0.1
5.11GluAsp: 5.11 ± 0.671
4.75GluGlu: 4.75 ± 0.787
3.006GluPhe: 3.006 ± 0.498
4.99GluGly: 4.99 ± 0.597
1.263GluHis: 1.263 ± 0.307
3.788GluIle: 3.788 ± 0.441
2.345GluLys: 2.345 ± 0.289
6.914GluLeu: 6.914 ± 0.597
2.345GluMet: 2.345 ± 0.359
2.044GluAsn: 2.044 ± 0.325
2.705GluPro: 2.705 ± 0.41
2.525GluGln: 2.525 ± 0.366
4.449GluArg: 4.449 ± 0.57
2.525GluSer: 2.525 ± 0.408
3.848GluThr: 3.848 ± 0.451
5.411GluVal: 5.411 ± 0.621
1.323GluTrp: 1.323 ± 0.263
1.804GluTyr: 1.804 ± 0.306
0.0GluXaa: 0.0 ± 0.0
Phe
3.126PheAla: 3.126 ± 0.455
0.541PheCys: 0.541 ± 0.186
2.405PheAsp: 2.405 ± 0.445
3.186PheGlu: 3.186 ± 0.431
0.721PhePhe: 0.721 ± 0.278
3.487PheGly: 3.487 ± 0.454
0.902PheHis: 0.902 ± 0.268
1.263PheIle: 1.263 ± 0.277
1.383PheLys: 1.383 ± 0.286
2.585PheLeu: 2.585 ± 0.447
0.421PheMet: 0.421 ± 0.155
1.864PheAsn: 1.864 ± 0.333
2.164PhePro: 2.164 ± 0.445
1.022PheGln: 1.022 ± 0.269
1.924PheArg: 1.924 ± 0.406
1.924PheSer: 1.924 ± 0.345
2.405PheThr: 2.405 ± 0.34
2.585PheVal: 2.585 ± 0.316
0.421PheTrp: 0.421 ± 0.155
0.721PheTyr: 0.721 ± 0.198
0.0PheXaa: 0.0 ± 0.0
Gly
6.974GlyAla: 6.974 ± 0.778
0.661GlyCys: 0.661 ± 0.2
6.433GlyAsp: 6.433 ± 0.824
5.11GlyGlu: 5.11 ± 0.659
3.307GlyPhe: 3.307 ± 0.506
8.477GlyGly: 8.477 ± 1.623
1.142GlyHis: 1.142 ± 0.229
4.148GlyIle: 4.148 ± 0.519
3.728GlyLys: 3.728 ± 0.465
6.553GlyLeu: 6.553 ± 0.774
1.744GlyMet: 1.744 ± 0.305
3.427GlyAsn: 3.427 ± 0.45
5.531GlyPro: 5.531 ± 1.822
3.066GlyGln: 3.066 ± 0.446
4.569GlyArg: 4.569 ± 0.482
3.968GlySer: 3.968 ± 0.612
5.471GlyThr: 5.471 ± 0.733
6.914GlyVal: 6.914 ± 0.746
1.022GlyTrp: 1.022 ± 0.248
2.705GlyTyr: 2.705 ± 0.395
0.0GlyXaa: 0.0 ± 0.0
His
1.503HisAla: 1.503 ± 0.281
0.301HisCys: 0.301 ± 0.108
1.323HisAsp: 1.323 ± 0.346
1.623HisGlu: 1.623 ± 0.387
0.481HisPhe: 0.481 ± 0.172
1.503HisGly: 1.503 ± 0.407
0.421HisHis: 0.421 ± 0.15
1.022HisIle: 1.022 ± 0.269
0.962HisLys: 0.962 ± 0.232
1.443HisLeu: 1.443 ± 0.297
0.301HisMet: 0.301 ± 0.176
1.022HisAsn: 1.022 ± 0.243
1.202HisPro: 1.202 ± 0.256
0.721HisGln: 0.721 ± 0.192
1.563HisArg: 1.563 ± 0.352
1.082HisSer: 1.082 ± 0.276
0.902HisThr: 0.902 ± 0.179
1.082HisVal: 1.082 ± 0.264
0.421HisTrp: 0.421 ± 0.17
0.481HisTyr: 0.481 ± 0.225
0.0HisXaa: 0.0 ± 0.0
Ile
5.772IleAla: 5.772 ± 0.537
0.361IleCys: 0.361 ± 0.154
3.848IleAsp: 3.848 ± 0.466
4.389IleGlu: 4.389 ± 0.554
1.323IlePhe: 1.323 ± 0.287
4.449IleGly: 4.449 ± 0.731
1.202IleHis: 1.202 ± 0.338
1.804IleIle: 1.804 ± 0.313
2.044IleLys: 2.044 ± 0.375
3.427IleLeu: 3.427 ± 0.382
0.541IleMet: 0.541 ± 0.164
2.345IleAsn: 2.345 ± 0.379
3.186IlePro: 3.186 ± 0.411
1.503IleGln: 1.503 ± 0.282
3.186IleArg: 3.186 ± 0.472
2.164IleSer: 2.164 ± 0.389
2.886IleThr: 2.886 ± 0.361
3.126IleVal: 3.126 ± 0.433
0.601IleTrp: 0.601 ± 0.191
0.842IleTyr: 0.842 ± 0.217
0.0IleXaa: 0.0 ± 0.0
Lys
5.11LysAla: 5.11 ± 0.623
0.301LysCys: 0.301 ± 0.173
2.224LysAsp: 2.224 ± 0.334
1.984LysGlu: 1.984 ± 0.391
1.082LysPhe: 1.082 ± 0.232
4.088LysGly: 4.088 ± 0.756
0.361LysHis: 0.361 ± 0.164
1.623LysIle: 1.623 ± 0.304
3.126LysLys: 3.126 ± 0.501
3.728LysLeu: 3.728 ± 0.427
0.962LysMet: 0.962 ± 0.263
1.263LysAsn: 1.263 ± 0.282
2.826LysPro: 2.826 ± 0.467
1.323LysGln: 1.323 ± 0.253
3.607LysArg: 3.607 ± 0.599
1.804LysSer: 1.804 ± 0.337
3.006LysThr: 3.006 ± 0.5
3.487LysVal: 3.487 ± 0.444
0.721LysTrp: 0.721 ± 0.208
1.503LysTyr: 1.503 ± 0.279
0.0LysXaa: 0.0 ± 0.0
Leu
9.8LeuAla: 9.8 ± 1.006
0.661LeuCys: 0.661 ± 0.218
4.99LeuAsp: 4.99 ± 0.517
6.132LeuGlu: 6.132 ± 0.647
2.465LeuPhe: 2.465 ± 0.316
5.591LeuGly: 5.591 ± 0.679
1.864LeuHis: 1.864 ± 0.392
4.088LeuIle: 4.088 ± 0.574
3.066LeuLys: 3.066 ± 0.414
5.651LeuLeu: 5.651 ± 0.715
2.525LeuMet: 2.525 ± 0.394
2.465LeuAsn: 2.465 ± 0.449
4.93LeuPro: 4.93 ± 0.51
3.126LeuGln: 3.126 ± 0.658
5.712LeuArg: 5.712 ± 0.647
5.291LeuSer: 5.291 ± 0.526
5.411LeuThr: 5.411 ± 0.771
4.509LeuVal: 4.509 ± 0.69
1.623LeuTrp: 1.623 ± 0.298
2.345LeuTyr: 2.345 ± 0.437
0.0LeuXaa: 0.0 ± 0.0
Met
2.465MetAla: 2.465 ± 0.401
0.06MetCys: 0.06 ± 0.064
1.082MetAsp: 1.082 ± 0.28
1.563MetGlu: 1.563 ± 0.301
0.541MetPhe: 0.541 ± 0.156
1.563MetGly: 1.563 ± 0.294
0.421MetHis: 0.421 ± 0.138
1.202MetIle: 1.202 ± 0.241
1.744MetLys: 1.744 ± 0.33
1.864MetLeu: 1.864 ± 0.388
0.481MetMet: 0.481 ± 0.165
0.782MetAsn: 0.782 ± 0.195
1.443MetPro: 1.443 ± 0.36
1.202MetGln: 1.202 ± 0.323
1.383MetArg: 1.383 ± 0.292
2.585MetSer: 2.585 ± 0.392
2.645MetThr: 2.645 ± 0.446
1.443MetVal: 1.443 ± 0.292
0.24MetTrp: 0.24 ± 0.128
0.902MetTyr: 0.902 ± 0.2
0.0MetXaa: 0.0 ± 0.0
Asn
2.946AsnAla: 2.946 ± 0.428
0.601AsnCys: 0.601 ± 0.198
2.044AsnAsp: 2.044 ± 0.345
2.525AsnGlu: 2.525 ± 0.383
0.721AsnPhe: 0.721 ± 0.261
3.728AsnGly: 3.728 ± 0.513
0.962AsnHis: 0.962 ± 0.243
1.383AsnIle: 1.383 ± 0.259
1.082AsnLys: 1.082 ± 0.227
3.247AsnLeu: 3.247 ± 0.532
0.842AsnMet: 0.842 ± 0.216
0.601AsnAsn: 0.601 ± 0.207
2.585AsnPro: 2.585 ± 0.389
0.601AsnGln: 0.601 ± 0.202
1.984AsnArg: 1.984 ± 0.377
1.323AsnSer: 1.323 ± 0.287
1.623AsnThr: 1.623 ± 0.347
2.465AsnVal: 2.465 ± 0.342
0.962AsnTrp: 0.962 ± 0.245
0.782AsnTyr: 0.782 ± 0.197
0.0AsnXaa: 0.0 ± 0.0
Pro
5.832ProAla: 5.832 ± 0.604
0.361ProCys: 0.361 ± 0.168
3.728ProAsp: 3.728 ± 0.606
4.75ProGlu: 4.75 ± 0.628
1.563ProPhe: 1.563 ± 0.301
4.93ProGly: 4.93 ± 0.647
1.263ProHis: 1.263 ± 0.246
2.766ProIle: 2.766 ± 0.385
2.585ProLys: 2.585 ± 0.699
3.006ProLeu: 3.006 ± 0.442
1.323ProMet: 1.323 ± 0.304
2.525ProAsn: 2.525 ± 0.368
3.126ProPro: 3.126 ± 0.572
2.285ProGln: 2.285 ± 0.727
3.788ProArg: 3.788 ± 0.672
2.826ProSer: 2.826 ± 0.353
3.307ProThr: 3.307 ± 0.466
3.607ProVal: 3.607 ± 0.448
1.082ProTrp: 1.082 ± 0.338
1.443ProTyr: 1.443 ± 0.301
0.0ProXaa: 0.0 ± 0.0
Gln
4.209GlnAla: 4.209 ± 0.661
0.24GlnCys: 0.24 ± 0.13
1.202GlnAsp: 1.202 ± 0.241
2.104GlnGlu: 2.104 ± 0.409
1.744GlnPhe: 1.744 ± 0.407
4.509GlnGly: 4.509 ± 1.361
0.782GlnHis: 0.782 ± 0.188
2.585GlnIle: 2.585 ± 0.374
1.503GlnLys: 1.503 ± 0.339
3.487GlnLeu: 3.487 ± 0.739
1.082GlnMet: 1.082 ± 0.229
0.661GlnAsn: 0.661 ± 0.196
1.263GlnPro: 1.263 ± 0.251
2.044GlnGln: 2.044 ± 0.33
2.104GlnArg: 2.104 ± 0.414
1.503GlnSer: 1.503 ± 0.267
1.864GlnThr: 1.864 ± 0.291
2.645GlnVal: 2.645 ± 0.419
0.842GlnTrp: 0.842 ± 0.256
0.721GlnTyr: 0.721 ± 0.173
0.0GlnXaa: 0.0 ± 0.0
Arg
5.712ArgAla: 5.712 ± 0.824
0.902ArgCys: 0.902 ± 0.269
4.209ArgAsp: 4.209 ± 0.48
4.81ArgGlu: 4.81 ± 0.876
2.405ArgPhe: 2.405 ± 0.498
4.87ArgGly: 4.87 ± 0.603
1.503ArgHis: 1.503 ± 0.272
3.607ArgIle: 3.607 ± 0.46
2.826ArgLys: 2.826 ± 0.465
5.531ArgLeu: 5.531 ± 0.576
2.164ArgMet: 2.164 ± 0.353
1.804ArgAsn: 1.804 ± 0.301
2.886ArgPro: 2.886 ± 0.408
2.525ArgGln: 2.525 ± 0.516
4.99ArgArg: 4.99 ± 0.587
2.345ArgSer: 2.345 ± 0.336
2.946ArgThr: 2.946 ± 0.392
4.569ArgVal: 4.569 ± 0.54
1.263ArgTrp: 1.263 ± 0.302
1.864ArgTyr: 1.864 ± 0.382
0.0ArgXaa: 0.0 ± 0.0
Ser
4.269SerAla: 4.269 ± 0.549
0.361SerCys: 0.361 ± 0.15
2.946SerAsp: 2.946 ± 0.424
2.886SerGlu: 2.886 ± 0.429
2.164SerPhe: 2.164 ± 0.426
4.449SerGly: 4.449 ± 0.596
0.601SerHis: 0.601 ± 0.154
2.946SerIle: 2.946 ± 0.37
2.285SerLys: 2.285 ± 0.492
4.148SerLeu: 4.148 ± 0.654
1.142SerMet: 1.142 ± 0.204
1.443SerAsn: 1.443 ± 0.277
2.946SerPro: 2.946 ± 0.373
2.465SerGln: 2.465 ± 0.391
3.547SerArg: 3.547 ± 0.411
2.104SerSer: 2.104 ± 0.388
3.186SerThr: 3.186 ± 0.379
3.186SerVal: 3.186 ± 0.44
0.661SerTrp: 0.661 ± 0.191
1.563SerTyr: 1.563 ± 0.332
0.0SerXaa: 0.0 ± 0.0
Thr
6.313ThrAla: 6.313 ± 0.581
0.361ThrCys: 0.361 ± 0.14
3.367ThrAsp: 3.367 ± 0.537
3.848ThrGlu: 3.848 ± 0.434
2.345ThrPhe: 2.345 ± 0.313
5.892ThrGly: 5.892 ± 0.834
0.842ThrHis: 0.842 ± 0.191
2.886ThrIle: 2.886 ± 0.486
3.126ThrLys: 3.126 ± 0.393
5.231ThrLeu: 5.231 ± 0.544
1.383ThrMet: 1.383 ± 0.27
1.864ThrAsn: 1.864 ± 0.294
4.569ThrPro: 4.569 ± 0.575
2.285ThrGln: 2.285 ± 0.357
3.066ThrArg: 3.066 ± 0.489
2.766ThrSer: 2.766 ± 0.374
3.667ThrThr: 3.667 ± 0.59
3.728ThrVal: 3.728 ± 0.458
1.323ThrTrp: 1.323 ± 0.29
2.044ThrTyr: 2.044 ± 0.339
0.0ThrXaa: 0.0 ± 0.0
Val
6.072ValAla: 6.072 ± 0.72
0.541ValCys: 0.541 ± 0.173
5.591ValAsp: 5.591 ± 0.532
4.028ValGlu: 4.028 ± 0.573
2.826ValPhe: 2.826 ± 0.484
5.231ValGly: 5.231 ± 0.64
1.263ValHis: 1.263 ± 0.279
2.886ValIle: 2.886 ± 0.427
3.427ValLys: 3.427 ± 0.426
6.433ValLeu: 6.433 ± 0.741
1.683ValMet: 1.683 ± 0.345
2.465ValAsn: 2.465 ± 0.43
2.886ValPro: 2.886 ± 0.515
2.164ValGln: 2.164 ± 0.38
4.209ValArg: 4.209 ± 0.514
3.968ValSer: 3.968 ± 0.563
5.231ValThr: 5.231 ± 0.645
5.471ValVal: 5.471 ± 0.495
1.563ValTrp: 1.563 ± 0.309
2.405ValTyr: 2.405 ± 0.465
0.0ValXaa: 0.0 ± 0.0
Trp
1.623TrpAla: 1.623 ± 0.352
0.24TrpCys: 0.24 ± 0.125
1.142TrpAsp: 1.142 ± 0.255
1.082TrpGlu: 1.082 ± 0.253
0.481TrpPhe: 0.481 ± 0.168
1.323TrpGly: 1.323 ± 0.304
0.661TrpHis: 0.661 ± 0.239
1.082TrpIle: 1.082 ± 0.283
0.721TrpLys: 0.721 ± 0.213
1.142TrpLeu: 1.142 ± 0.321
0.481TrpMet: 0.481 ± 0.152
0.782TrpAsn: 0.782 ± 0.217
0.902TrpPro: 0.902 ± 0.279
0.962TrpGln: 0.962 ± 0.237
1.202TrpArg: 1.202 ± 0.243
1.022TrpSer: 1.022 ± 0.286
1.082TrpThr: 1.082 ± 0.246
1.202TrpVal: 1.202 ± 0.239
0.541TrpTrp: 0.541 ± 0.218
0.601TrpTyr: 0.601 ± 0.248
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.826TyrAla: 2.826 ± 0.35
0.24TyrCys: 0.24 ± 0.126
2.104TyrAsp: 2.104 ± 0.313
2.405TyrGlu: 2.405 ± 0.377
0.962TyrPhe: 0.962 ± 0.221
1.804TyrGly: 1.804 ± 0.301
0.361TyrHis: 0.361 ± 0.15
1.503TyrIle: 1.503 ± 0.25
0.721TyrLys: 0.721 ± 0.178
2.705TyrLeu: 2.705 ± 0.399
0.601TyrMet: 0.601 ± 0.219
0.842TyrAsn: 0.842 ± 0.226
1.323TyrPro: 1.323 ± 0.273
1.022TyrGln: 1.022 ± 0.203
2.104TyrArg: 2.104 ± 0.346
1.683TyrSer: 1.683 ± 0.284
1.864TyrThr: 1.864 ± 0.335
2.465TyrVal: 2.465 ± 0.388
0.541TyrTrp: 0.541 ± 0.248
0.721TyrTyr: 0.721 ± 0.245
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 97 proteins (16634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski