Amino acid dipepetide frequency for Cohnella sp. G13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.816AlaAla: 8.816 ± 0.115
0.736AlaCys: 0.736 ± 0.021
4.62AlaAsp: 4.62 ± 0.064
5.79AlaGlu: 5.79 ± 0.075
3.585AlaPhe: 3.585 ± 0.053
6.762AlaGly: 6.762 ± 0.075
1.399AlaHis: 1.399 ± 0.032
5.928AlaIle: 5.928 ± 0.072
4.394AlaLys: 4.394 ± 0.062
8.598AlaLeu: 8.598 ± 0.104
2.414AlaMet: 2.414 ± 0.044
2.924AlaAsn: 2.924 ± 0.052
2.764AlaPro: 2.764 ± 0.048
2.588AlaGln: 2.588 ± 0.04
4.061AlaArg: 4.061 ± 0.061
5.509AlaSer: 5.509 ± 0.063
3.916AlaThr: 3.916 ± 0.061
6.517AlaVal: 6.517 ± 0.069
1.013AlaTrp: 1.013 ± 0.025
2.667AlaTyr: 2.667 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.524CysAla: 0.524 ± 0.019
0.104CysCys: 0.104 ± 0.008
0.4CysAsp: 0.4 ± 0.022
0.479CysGlu: 0.479 ± 0.021
0.306CysPhe: 0.306 ± 0.016
0.817CysGly: 0.817 ± 0.025
0.174CysHis: 0.174 ± 0.01
0.488CysIle: 0.488 ± 0.019
0.283CysLys: 0.283 ± 0.014
0.69CysLeu: 0.69 ± 0.024
0.2CysMet: 0.2 ± 0.011
0.249CysAsn: 0.249 ± 0.013
0.319CysPro: 0.319 ± 0.016
0.195CysGln: 0.195 ± 0.012
0.482CysArg: 0.482 ± 0.022
0.534CysSer: 0.534 ± 0.021
0.345CysThr: 0.345 ± 0.016
0.459CysVal: 0.459 ± 0.015
0.095CysTrp: 0.095 ± 0.008
0.258CysTyr: 0.258 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.032AspAla: 4.032 ± 0.055
0.373AspCys: 0.373 ± 0.016
2.636AspAsp: 2.636 ± 0.045
3.924AspGlu: 3.924 ± 0.055
2.125AspPhe: 2.125 ± 0.04
4.262AspGly: 4.262 ± 0.074
1.034AspHis: 1.034 ± 0.026
3.587AspIle: 3.587 ± 0.05
2.874AspLys: 2.874 ± 0.051
4.981AspLeu: 4.981 ± 0.056
1.361AspMet: 1.361 ± 0.032
2.017AspAsn: 2.017 ± 0.034
2.517AspPro: 2.517 ± 0.053
1.738AspGln: 1.738 ± 0.036
3.361AspArg: 3.361 ± 0.054
2.946AspSer: 2.946 ± 0.048
2.394AspThr: 2.394 ± 0.04
3.65AspVal: 3.65 ± 0.053
0.873AspTrp: 0.873 ± 0.027
2.046AspTyr: 2.046 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
6.112GluAla: 6.112 ± 0.077
0.351GluCys: 0.351 ± 0.015
3.154GluAsp: 3.154 ± 0.045
5.204GluGlu: 5.204 ± 0.08
2.221GluPhe: 2.221 ± 0.04
4.316GluGly: 4.316 ± 0.055
1.413GluHis: 1.413 ± 0.036
4.525GluIle: 4.525 ± 0.063
3.908GluLys: 3.908 ± 0.058
6.991GluLeu: 6.991 ± 0.075
2.017GluMet: 2.017 ± 0.033
2.555GluAsn: 2.555 ± 0.044
2.301GluPro: 2.301 ± 0.043
3.071GluGln: 3.071 ± 0.045
4.433GluArg: 4.433 ± 0.071
3.763GluSer: 3.763 ± 0.056
3.495GluThr: 3.495 ± 0.051
4.135GluVal: 4.135 ± 0.061
1.054GluTrp: 1.054 ± 0.027
1.993GluTyr: 1.993 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.567PheAla: 3.567 ± 0.048
0.376PheCys: 0.376 ± 0.021
2.403PheAsp: 2.403 ± 0.038
2.449PheGlu: 2.449 ± 0.043
1.749PhePhe: 1.749 ± 0.04
3.457PheGly: 3.457 ± 0.052
0.873PheHis: 0.873 ± 0.025
2.681PheIle: 2.681 ± 0.059
1.932PheLys: 1.932 ± 0.035
3.942PheLeu: 3.942 ± 0.059
1.099PheMet: 1.099 ± 0.026
1.523PheAsn: 1.523 ± 0.032
1.708PhePro: 1.708 ± 0.041
1.298PheGln: 1.298 ± 0.036
2.212PheArg: 2.212 ± 0.04
2.651PheSer: 2.651 ± 0.049
2.211PheThr: 2.211 ± 0.042
3.196PheVal: 3.196 ± 0.057
0.513PheTrp: 0.513 ± 0.021
1.465PheTyr: 1.465 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
5.817GlyAla: 5.817 ± 0.063
0.691GlyCys: 0.691 ± 0.023
3.675GlyAsp: 3.675 ± 0.052
4.677GlyGlu: 4.677 ± 0.052
3.271GlyPhe: 3.271 ± 0.049
5.719GlyGly: 5.719 ± 0.093
1.434GlyHis: 1.434 ± 0.031
5.722GlyIle: 5.722 ± 0.055
4.686GlyLys: 4.686 ± 0.072
7.406GlyLeu: 7.406 ± 0.073
2.302GlyMet: 2.302 ± 0.038
2.898GlyAsn: 2.898 ± 0.063
1.97GlyPro: 1.97 ± 0.038
2.57GlyGln: 2.57 ± 0.048
3.81GlyArg: 3.81 ± 0.059
4.709GlySer: 4.709 ± 0.066
4.461GlyThr: 4.461 ± 0.074
5.417GlyVal: 5.417 ± 0.063
1.178GlyTrp: 1.178 ± 0.028
2.909GlyTyr: 2.909 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.494HisAla: 1.494 ± 0.031
0.178HisCys: 0.178 ± 0.012
1.015HisAsp: 1.015 ± 0.028
1.201HisGlu: 1.201 ± 0.03
0.933HisPhe: 0.933 ± 0.025
1.469HisGly: 1.469 ± 0.037
0.532HisHis: 0.532 ± 0.019
1.216HisIle: 1.216 ± 0.029
0.799HisLys: 0.799 ± 0.024
1.998HisLeu: 1.998 ± 0.046
0.494HisMet: 0.494 ± 0.017
0.651HisAsn: 0.651 ± 0.021
1.193HisPro: 1.193 ± 0.03
0.651HisGln: 0.651 ± 0.022
1.125HisArg: 1.125 ± 0.03
1.171HisSer: 1.171 ± 0.028
0.948HisThr: 0.948 ± 0.025
1.291HisVal: 1.291 ± 0.028
0.3HisTrp: 0.3 ± 0.014
0.793HisTyr: 0.793 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.508IleAla: 6.508 ± 0.071
0.574IleCys: 0.574 ± 0.021
3.822IleAsp: 3.822 ± 0.05
4.41IleGlu: 4.41 ± 0.062
2.299IlePhe: 2.299 ± 0.04
5.73IleGly: 5.73 ± 0.067
1.312IleHis: 1.312 ± 0.032
3.783IleIle: 3.783 ± 0.057
2.962IleLys: 2.962 ± 0.045
5.686IleLeu: 5.686 ± 0.071
1.51IleMet: 1.51 ± 0.037
2.319IleAsn: 2.319 ± 0.044
3.066IlePro: 3.066 ± 0.045
2.311IleGln: 2.311 ± 0.037
4.253IleArg: 4.253 ± 0.061
4.283IleSer: 4.283 ± 0.064
3.357IleThr: 3.357 ± 0.056
5.899IleVal: 5.899 ± 0.074
0.743IleTrp: 0.743 ± 0.028
2.104IleTyr: 2.104 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.304LysAla: 4.304 ± 0.054
0.24LysCys: 0.24 ± 0.012
2.92LysAsp: 2.92 ± 0.049
4.045LysGlu: 4.045 ± 0.06
1.696LysPhe: 1.696 ± 0.035
3.517LysGly: 3.517 ± 0.057
1.047LysHis: 1.047 ± 0.027
3.264LysIle: 3.264 ± 0.051
3.161LysLys: 3.161 ± 0.052
5.666LysLeu: 5.666 ± 0.07
1.525LysMet: 1.525 ± 0.031
2.004LysAsn: 2.004 ± 0.044
2.354LysPro: 2.354 ± 0.043
2.212LysGln: 2.212 ± 0.038
2.841LysArg: 2.841 ± 0.047
3.163LysSer: 3.163 ± 0.052
2.787LysThr: 2.787 ± 0.047
3.47LysVal: 3.47 ± 0.055
0.782LysTrp: 0.782 ± 0.023
1.789LysTyr: 1.789 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
8.784LeuAla: 8.784 ± 0.106
0.768LeuCys: 0.768 ± 0.023
5.082LeuAsp: 5.082 ± 0.058
6.137LeuGlu: 6.137 ± 0.087
4.552LeuPhe: 4.552 ± 0.073
6.761LeuGly: 6.761 ± 0.073
1.965LeuHis: 1.965 ± 0.037
6.619LeuIle: 6.619 ± 0.074
5.308LeuLys: 5.308 ± 0.058
11.043LeuLeu: 11.043 ± 0.144
2.485LeuMet: 2.485 ± 0.046
3.962LeuAsn: 3.962 ± 0.052
4.483LeuPro: 4.483 ± 0.07
3.671LeuGln: 3.671 ± 0.055
5.448LeuArg: 5.448 ± 0.075
7.275LeuSer: 7.275 ± 0.075
5.542LeuThr: 5.542 ± 0.056
6.451LeuVal: 6.451 ± 0.071
1.039LeuTrp: 1.039 ± 0.03
3.062LeuTyr: 3.062 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.214MetAla: 2.214 ± 0.04
0.138MetCys: 0.138 ± 0.01
1.449MetAsp: 1.449 ± 0.029
1.733MetGlu: 1.733 ± 0.035
1.015MetPhe: 1.015 ± 0.027
1.713MetGly: 1.713 ± 0.035
0.443MetHis: 0.443 ± 0.019
1.883MetIle: 1.883 ± 0.041
1.915MetLys: 1.915 ± 0.036
2.792MetLeu: 2.792 ± 0.046
0.816MetMet: 0.816 ± 0.025
1.481MetAsn: 1.481 ± 0.031
1.192MetPro: 1.192 ± 0.03
0.937MetGln: 0.937 ± 0.024
1.433MetArg: 1.433 ± 0.032
1.826MetSer: 1.826 ± 0.035
1.648MetThr: 1.648 ± 0.033
1.57MetVal: 1.57 ± 0.034
0.218MetTrp: 0.218 ± 0.013
0.664MetTyr: 0.664 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.131AsnAla: 3.131 ± 0.047
0.229AsnCys: 0.229 ± 0.014
2.019AsnAsp: 2.019 ± 0.042
2.723AsnGlu: 2.723 ± 0.042
1.306AsnPhe: 1.306 ± 0.032
3.612AsnGly: 3.612 ± 0.072
0.793AsnHis: 0.793 ± 0.026
2.326AsnIle: 2.326 ± 0.042
2.083AsnLys: 2.083 ± 0.043
3.369AsnLeu: 3.369 ± 0.044
0.956AsnMet: 0.956 ± 0.025
1.625AsnAsn: 1.625 ± 0.047
2.054AsnPro: 2.054 ± 0.038
1.327AsnGln: 1.327 ± 0.035
2.379AsnArg: 2.379 ± 0.043
2.133AsnSer: 2.133 ± 0.046
1.814AsnThr: 1.814 ± 0.041
2.832AsnVal: 2.832 ± 0.045
0.529AsnTrp: 0.529 ± 0.018
1.376AsnTyr: 1.376 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
3.264ProAla: 3.264 ± 0.047
0.245ProCys: 0.245 ± 0.012
2.796ProAsp: 2.796 ± 0.048
3.351ProGlu: 3.351 ± 0.052
1.899ProPhe: 1.899 ± 0.036
2.961ProGly: 2.961 ± 0.05
0.829ProHis: 0.829 ± 0.024
2.723ProIle: 2.723 ± 0.041
1.854ProLys: 1.854 ± 0.037
3.941ProLeu: 3.941 ± 0.054
0.996ProMet: 0.996 ± 0.027
1.648ProAsn: 1.648 ± 0.033
1.345ProPro: 1.345 ± 0.034
1.297ProGln: 1.297 ± 0.035
1.67ProArg: 1.67 ± 0.033
2.841ProSer: 2.841 ± 0.049
1.983ProThr: 1.983 ± 0.045
3.13ProVal: 3.13 ± 0.049
0.545ProTrp: 0.545 ± 0.021
1.48ProTyr: 1.48 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.313GlnAla: 3.313 ± 0.047
0.182GlnCys: 0.182 ± 0.011
1.506GlnAsp: 1.506 ± 0.029
2.284GlnGlu: 2.284 ± 0.041
1.429GlnPhe: 1.429 ± 0.033
2.437GlnGly: 2.437 ± 0.051
0.655GlnHis: 0.655 ± 0.024
2.362GlnIle: 2.362 ± 0.043
1.656GlnLys: 1.656 ± 0.039
3.844GlnLeu: 3.844 ± 0.048
1.016GlnMet: 1.016 ± 0.027
1.233GlnAsn: 1.233 ± 0.032
1.419GlnPro: 1.419 ± 0.031
1.506GlnGln: 1.506 ± 0.036
1.834GlnArg: 1.834 ± 0.038
2.203GlnSer: 2.203 ± 0.045
1.906GlnThr: 1.906 ± 0.041
2.248GlnVal: 2.248 ± 0.042
0.538GlnTrp: 0.538 ± 0.021
1.229GlnTyr: 1.229 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
3.762ArgAla: 3.762 ± 0.052
0.366ArgCys: 0.366 ± 0.016
2.776ArgAsp: 2.776 ± 0.047
4.122ArgGlu: 4.122 ± 0.063
2.462ArgPhe: 2.462 ± 0.041
3.253ArgGly: 3.253 ± 0.049
1.109ArgHis: 1.109 ± 0.028
4.096ArgIle: 4.096 ± 0.06
3.416ArgLys: 3.416 ± 0.049
5.897ArgLeu: 5.897 ± 0.075
1.868ArgMet: 1.868 ± 0.037
2.32ArgAsn: 2.32 ± 0.036
1.891ArgPro: 1.891 ± 0.04
2.116ArgGln: 2.116 ± 0.047
3.345ArgArg: 3.345 ± 0.055
3.495ArgSer: 3.495 ± 0.055
2.856ArgThr: 2.856 ± 0.044
3.406ArgVal: 3.406 ± 0.048
0.744ArgTrp: 0.744 ± 0.024
2.008ArgTyr: 2.008 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
5.363SerAla: 5.363 ± 0.063
0.432SerCys: 0.432 ± 0.017
3.352SerAsp: 3.352 ± 0.05
4.032SerGlu: 4.032 ± 0.068
2.949SerPhe: 2.949 ± 0.043
5.586SerGly: 5.586 ± 0.073
1.248SerHis: 1.248 ± 0.028
4.24SerIle: 4.24 ± 0.061
3.17SerLys: 3.17 ± 0.051
6.337SerLeu: 6.337 ± 0.073
1.659SerMet: 1.659 ± 0.036
2.389SerAsn: 2.389 ± 0.048
2.667SerPro: 2.667 ± 0.045
1.973SerGln: 1.973 ± 0.035
3.445SerArg: 3.445 ± 0.05
4.467SerSer: 4.467 ± 0.061
3.08SerThr: 3.08 ± 0.056
4.777SerVal: 4.777 ± 0.085
0.827SerTrp: 0.827 ± 0.023
2.196SerTyr: 2.196 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.525ThrAla: 4.525 ± 0.077
0.305ThrCys: 0.305 ± 0.014
2.898ThrAsp: 2.898 ± 0.044
3.14ThrGlu: 3.14 ± 0.046
2.327ThrPhe: 2.327 ± 0.037
4.424ThrGly: 4.424 ± 0.061
0.93ThrHis: 0.93 ± 0.026
3.906ThrIle: 3.906 ± 0.058
2.417ThrLys: 2.417 ± 0.041
5.227ThrLeu: 5.227 ± 0.063
1.279ThrMet: 1.279 ± 0.027
1.948ThrAsn: 1.948 ± 0.048
2.428ThrPro: 2.428 ± 0.041
1.429ThrGln: 1.429 ± 0.026
2.39ThrArg: 2.39 ± 0.039
3.255ThrSer: 3.255 ± 0.052
2.766ThrThr: 2.766 ± 0.054
4.487ThrVal: 4.487 ± 0.068
0.617ThrTrp: 0.617 ± 0.022
1.74ThrTyr: 1.74 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
5.795ValAla: 5.795 ± 0.073
0.719ValCys: 0.719 ± 0.03
3.61ValAsp: 3.61 ± 0.046
4.209ValGlu: 4.209 ± 0.055
3.084ValPhe: 3.084 ± 0.053
4.834ValGly: 4.834 ± 0.063
1.342ValHis: 1.342 ± 0.032
4.676ValIle: 4.676 ± 0.06
3.7ValLys: 3.7 ± 0.055
7.257ValLeu: 7.257 ± 0.082
1.821ValMet: 1.821 ± 0.039
2.858ValAsn: 2.858 ± 0.045
3.235ValPro: 3.235 ± 0.052
2.364ValGln: 2.364 ± 0.036
3.834ValArg: 3.834 ± 0.058
4.943ValSer: 4.943 ± 0.058
4.496ValThr: 4.496 ± 0.081
5.402ValVal: 5.402 ± 0.065
0.883ValTrp: 0.883 ± 0.028
2.353ValTyr: 2.353 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.899TrpAla: 0.899 ± 0.027
0.096TrpCys: 0.096 ± 0.008
0.675TrpAsp: 0.675 ± 0.02
0.811TrpGlu: 0.811 ± 0.026
0.554TrpPhe: 0.554 ± 0.023
0.884TrpGly: 0.884 ± 0.026
0.285TrpHis: 0.285 ± 0.017
0.973TrpIle: 0.973 ± 0.027
0.764TrpLys: 0.764 ± 0.023
1.512TrpLeu: 1.512 ± 0.035
0.421TrpMet: 0.421 ± 0.018
0.713TrpAsn: 0.713 ± 0.022
0.389TrpPro: 0.389 ± 0.021
0.489TrpGln: 0.489 ± 0.018
0.682TrpArg: 0.682 ± 0.022
0.838TrpSer: 0.838 ± 0.024
0.759TrpThr: 0.759 ± 0.026
0.799TrpVal: 0.799 ± 0.025
0.188TrpTrp: 0.188 ± 0.011
0.413TrpTyr: 0.413 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.778TyrAla: 2.778 ± 0.044
0.298TyrCys: 0.298 ± 0.015
1.923TyrAsp: 1.923 ± 0.034
2.292TyrGlu: 2.292 ± 0.041
1.541TyrPhe: 1.541 ± 0.034
2.808TyrGly: 2.808 ± 0.045
0.634TyrHis: 0.634 ± 0.02
1.934TyrIle: 1.934 ± 0.034
1.507TyrLys: 1.507 ± 0.033
3.26TyrLeu: 3.26 ± 0.06
0.841TyrMet: 0.841 ± 0.024
1.297TyrAsn: 1.297 ± 0.033
1.506TyrPro: 1.506 ± 0.034
1.061TyrGln: 1.061 ± 0.027
2.268TyrArg: 2.268 ± 0.044
2.182TyrSer: 2.182 ± 0.04
1.673TyrThr: 1.673 ± 0.037
2.279TyrVal: 2.279 ± 0.046
0.464TyrTrp: 0.464 ± 0.02
1.29TyrTyr: 1.29 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4843 proteins (1556618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski