Amino acid dipepetide frequency for hepatovirus D2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.23AlaAla: 2.23 ± 0.0
1.338AlaCys: 1.338 ± 0.0
1.784AlaAsp: 1.784 ± 0.0
2.23AlaGlu: 2.23 ± 0.0
1.338AlaPhe: 1.338 ± 0.0
4.014AlaGly: 4.014 ± 0.0
0.446AlaHis: 0.446 ± 0.0
4.906AlaIle: 4.906 ± 0.0
3.122AlaLys: 3.122 ± 0.0
4.906AlaLeu: 4.906 ± 0.0
3.122AlaMet: 3.122 ± 0.0
1.338AlaAsn: 1.338 ± 0.0
1.338AlaPro: 1.338 ± 0.0
0.892AlaGln: 0.892 ± 0.0
2.23AlaArg: 2.23 ± 0.0
5.352AlaSer: 5.352 ± 0.0
4.014AlaThr: 4.014 ± 0.0
5.798AlaVal: 5.798 ± 0.0
0.892AlaTrp: 0.892 ± 0.0
2.23AlaTyr: 2.23 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.892CysAla: 0.892 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.446CysAsp: 0.446 ± 0.0
1.338CysGlu: 1.338 ± 0.0
1.338CysPhe: 1.338 ± 0.0
0.892CysGly: 0.892 ± 0.0
0.0CysHis: 0.0 ± 0.0
1.784CysIle: 1.784 ± 0.0
0.892CysLys: 0.892 ± 0.0
0.892CysLeu: 0.892 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.892CysAsn: 0.892 ± 0.0
1.338CysPro: 1.338 ± 0.0
0.892CysGln: 0.892 ± 0.0
0.892CysArg: 0.892 ± 0.0
0.446CysSer: 0.446 ± 0.0
0.892CysThr: 0.892 ± 0.0
0.446CysVal: 0.446 ± 0.0
0.446CysTrp: 0.446 ± 0.0
0.892CysTyr: 0.892 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.014AspAla: 4.014 ± 0.0
0.0AspCys: 0.0 ± 0.0
4.014AspAsp: 4.014 ± 0.0
4.906AspGlu: 4.906 ± 0.0
5.352AspPhe: 5.352 ± 0.0
3.568AspGly: 3.568 ± 0.0
1.338AspHis: 1.338 ± 0.0
2.676AspIle: 2.676 ± 0.0
1.784AspLys: 1.784 ± 0.0
7.583AspLeu: 7.583 ± 0.0
1.784AspMet: 1.784 ± 0.0
0.892AspAsn: 0.892 ± 0.0
4.014AspPro: 4.014 ± 0.0
2.676AspGln: 2.676 ± 0.0
3.122AspArg: 3.122 ± 0.0
2.676AspSer: 2.676 ± 0.0
2.676AspThr: 2.676 ± 0.0
3.568AspVal: 3.568 ± 0.0
2.23AspTrp: 2.23 ± 0.0
1.784AspTyr: 1.784 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
0.892GluAla: 0.892 ± 0.0
0.446GluCys: 0.446 ± 0.0
4.014GluAsp: 4.014 ± 0.0
3.122GluGlu: 3.122 ± 0.0
4.46GluPhe: 4.46 ± 0.0
3.568GluGly: 3.568 ± 0.0
0.0GluHis: 0.0 ± 0.0
2.23GluIle: 2.23 ± 0.0
4.46GluLys: 4.46 ± 0.0
4.46GluLeu: 4.46 ± 0.0
2.23GluMet: 2.23 ± 0.0
2.23GluAsn: 2.23 ± 0.0
3.122GluPro: 3.122 ± 0.0
2.676GluGln: 2.676 ± 0.0
2.676GluArg: 2.676 ± 0.0
4.014GluSer: 4.014 ± 0.0
1.784GluThr: 1.784 ± 0.0
3.568GluVal: 3.568 ± 0.0
0.446GluTrp: 0.446 ± 0.0
2.676GluTyr: 2.676 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.784PheAla: 1.784 ± 0.0
1.784PheCys: 1.784 ± 0.0
0.892PheAsp: 0.892 ± 0.0
1.784PheGlu: 1.784 ± 0.0
2.23PhePhe: 2.23 ± 0.0
3.568PheGly: 3.568 ± 0.0
0.892PheHis: 0.892 ± 0.0
1.784PheIle: 1.784 ± 0.0
2.23PheLys: 2.23 ± 0.0
4.906PheLeu: 4.906 ± 0.0
1.784PheMet: 1.784 ± 0.0
2.676PheAsn: 2.676 ± 0.0
2.676PhePro: 2.676 ± 0.0
4.014PheGln: 4.014 ± 0.0
3.122PheArg: 3.122 ± 0.0
6.69PheSer: 6.69 ± 0.0
2.676PheThr: 2.676 ± 0.0
2.23PheVal: 2.23 ± 0.0
1.784PheTrp: 1.784 ± 0.0
3.122PheTyr: 3.122 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.906GlyAla: 4.906 ± 0.0
0.446GlyCys: 0.446 ± 0.0
4.46GlyAsp: 4.46 ± 0.0
2.676GlyGlu: 2.676 ± 0.0
2.676GlyPhe: 2.676 ± 0.0
6.69GlyGly: 6.69 ± 0.0
0.446GlyHis: 0.446 ± 0.0
5.798GlyIle: 5.798 ± 0.0
4.014GlyLys: 4.014 ± 0.0
7.136GlyLeu: 7.136 ± 0.0
1.338GlyMet: 1.338 ± 0.0
2.676GlyAsn: 2.676 ± 0.0
2.676GlyPro: 2.676 ± 0.0
1.784GlyGln: 1.784 ± 0.0
3.122GlyArg: 3.122 ± 0.0
3.568GlySer: 3.568 ± 0.0
4.906GlyThr: 4.906 ± 0.0
4.906GlyVal: 4.906 ± 0.0
0.892GlyTrp: 0.892 ± 0.0
1.338GlyTyr: 1.338 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
1.338HisAla: 1.338 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.892HisGlu: 0.892 ± 0.0
1.784HisPhe: 1.784 ± 0.0
1.784HisGly: 1.784 ± 0.0
1.338HisHis: 1.338 ± 0.0
0.892HisIle: 0.892 ± 0.0
1.784HisLys: 1.784 ± 0.0
0.892HisLeu: 0.892 ± 0.0
0.446HisMet: 0.446 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.446HisPro: 0.446 ± 0.0
0.892HisGln: 0.892 ± 0.0
0.0HisArg: 0.0 ± 0.0
2.676HisSer: 2.676 ± 0.0
1.338HisThr: 1.338 ± 0.0
2.23HisVal: 2.23 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.892HisTyr: 0.892 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
1.784IleAla: 1.784 ± 0.0
1.784IleCys: 1.784 ± 0.0
4.46IleAsp: 4.46 ± 0.0
4.906IleGlu: 4.906 ± 0.0
1.784IlePhe: 1.784 ± 0.0
4.014IleGly: 4.014 ± 0.0
2.23IleHis: 2.23 ± 0.0
3.122IleIle: 3.122 ± 0.0
4.906IleLys: 4.906 ± 0.0
2.676IleLeu: 2.676 ± 0.0
0.892IleMet: 0.892 ± 0.0
4.906IleAsn: 4.906 ± 0.0
2.676IlePro: 2.676 ± 0.0
4.014IleGln: 4.014 ± 0.0
2.676IleArg: 2.676 ± 0.0
5.352IleSer: 5.352 ± 0.0
8.029IleThr: 8.029 ± 0.0
3.568IleVal: 3.568 ± 0.0
1.338IleTrp: 1.338 ± 0.0
2.23IleTyr: 2.23 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
1.784LysAla: 1.784 ± 0.0
0.892LysCys: 0.892 ± 0.0
4.46LysAsp: 4.46 ± 0.0
1.784LysGlu: 1.784 ± 0.0
4.46LysPhe: 4.46 ± 0.0
2.676LysGly: 2.676 ± 0.0
2.23LysHis: 2.23 ± 0.0
3.122LysIle: 3.122 ± 0.0
3.122LysLys: 3.122 ± 0.0
4.906LysLeu: 4.906 ± 0.0
2.23LysMet: 2.23 ± 0.0
4.906LysAsn: 4.906 ± 0.0
3.122LysPro: 3.122 ± 0.0
2.676LysGln: 2.676 ± 0.0
1.784LysArg: 1.784 ± 0.0
5.352LysSer: 5.352 ± 0.0
4.46LysThr: 4.46 ± 0.0
3.568LysVal: 3.568 ± 0.0
0.892LysTrp: 0.892 ± 0.0
0.892LysTyr: 0.892 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
7.136LeuAla: 7.136 ± 0.0
0.446LeuCys: 0.446 ± 0.0
9.813LeuAsp: 9.813 ± 0.0
8.029LeuGlu: 8.029 ± 0.0
2.676LeuPhe: 2.676 ± 0.0
5.352LeuGly: 5.352 ± 0.0
1.784LeuHis: 1.784 ± 0.0
5.798LeuIle: 5.798 ± 0.0
7.583LeuLys: 7.583 ± 0.0
7.136LeuLeu: 7.136 ± 0.0
0.892LeuMet: 0.892 ± 0.0
5.352LeuAsn: 5.352 ± 0.0
1.784LeuPro: 1.784 ± 0.0
2.23LeuGln: 2.23 ± 0.0
4.46LeuArg: 4.46 ± 0.0
6.69LeuSer: 6.69 ± 0.0
5.798LeuThr: 5.798 ± 0.0
4.906LeuVal: 4.906 ± 0.0
0.892LeuTrp: 0.892 ± 0.0
2.676LeuTyr: 2.676 ± 0.0
0.0LeuXaa: 0.0 ± 0.0
Met
2.23MetAla: 2.23 ± 0.0
0.892MetCys: 0.892 ± 0.0
2.23MetAsp: 2.23 ± 0.0
1.338MetGlu: 1.338 ± 0.0
1.338MetPhe: 1.338 ± 0.0
0.892MetGly: 0.892 ± 0.0
0.446MetHis: 0.446 ± 0.0
4.014MetIle: 4.014 ± 0.0
0.892MetLys: 0.892 ± 0.0
3.122MetLeu: 3.122 ± 0.0
1.784MetMet: 1.784 ± 0.0
2.23MetAsn: 2.23 ± 0.0
0.892MetPro: 0.892 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.784MetArg: 1.784 ± 0.0
1.784MetSer: 1.784 ± 0.0
1.784MetThr: 1.784 ± 0.0
2.23MetVal: 2.23 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.446MetTyr: 0.446 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.23AsnAla: 2.23 ± 0.0
0.892AsnCys: 0.892 ± 0.0
0.446AsnAsp: 0.446 ± 0.0
2.676AsnGlu: 2.676 ± 0.0
1.338AsnPhe: 1.338 ± 0.0
1.784AsnGly: 1.784 ± 0.0
0.446AsnHis: 0.446 ± 0.0
4.46AsnIle: 4.46 ± 0.0
1.338AsnLys: 1.338 ± 0.0
6.244AsnLeu: 6.244 ± 0.0
3.122AsnMet: 3.122 ± 0.0
1.338AsnAsn: 1.338 ± 0.0
1.338AsnPro: 1.338 ± 0.0
2.23AsnGln: 2.23 ± 0.0
1.784AsnArg: 1.784 ± 0.0
3.122AsnSer: 3.122 ± 0.0
3.122AsnThr: 3.122 ± 0.0
6.244AsnVal: 6.244 ± 0.0
0.892AsnTrp: 0.892 ± 0.0
1.784AsnTyr: 1.784 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.23ProAla: 2.23 ± 0.0
0.892ProCys: 0.892 ± 0.0
1.784ProAsp: 1.784 ± 0.0
0.892ProGlu: 0.892 ± 0.0
2.23ProPhe: 2.23 ± 0.0
2.23ProGly: 2.23 ± 0.0
0.446ProHis: 0.446 ± 0.0
3.568ProIle: 3.568 ± 0.0
4.014ProLys: 4.014 ± 0.0
4.014ProLeu: 4.014 ± 0.0
1.338ProMet: 1.338 ± 0.0
0.446ProAsn: 0.446 ± 0.0
0.892ProPro: 0.892 ± 0.0
0.892ProGln: 0.892 ± 0.0
3.122ProArg: 3.122 ± 0.0
2.23ProSer: 2.23 ± 0.0
1.784ProThr: 1.784 ± 0.0
4.014ProVal: 4.014 ± 0.0
1.338ProTrp: 1.338 ± 0.0
2.676ProTyr: 2.676 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
2.676GlnAla: 2.676 ± 0.0
0.892GlnCys: 0.892 ± 0.0
0.892GlnAsp: 0.892 ± 0.0
3.568GlnGlu: 3.568 ± 0.0
1.784GlnPhe: 1.784 ± 0.0
3.568GlnGly: 3.568 ± 0.0
0.0GlnHis: 0.0 ± 0.0
3.568GlnIle: 3.568 ± 0.0
1.338GlnLys: 1.338 ± 0.0
2.676GlnLeu: 2.676 ± 0.0
1.784GlnMet: 1.784 ± 0.0
2.676GlnAsn: 2.676 ± 0.0
0.446GlnPro: 0.446 ± 0.0
1.338GlnGln: 1.338 ± 0.0
1.338GlnArg: 1.338 ± 0.0
5.352GlnSer: 5.352 ± 0.0
0.0GlnThr: 0.0 ± 0.0
1.784GlnVal: 1.784 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
1.338GlnTyr: 1.338 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.676ArgAla: 2.676 ± 0.0
1.338ArgCys: 1.338 ± 0.0
3.568ArgAsp: 3.568 ± 0.0
0.892ArgGlu: 0.892 ± 0.0
3.568ArgPhe: 3.568 ± 0.0
4.014ArgGly: 4.014 ± 0.0
0.892ArgHis: 0.892 ± 0.0
4.906ArgIle: 4.906 ± 0.0
1.784ArgLys: 1.784 ± 0.0
5.352ArgLeu: 5.352 ± 0.0
0.892ArgMet: 0.892 ± 0.0
2.23ArgAsn: 2.23 ± 0.0
1.784ArgPro: 1.784 ± 0.0
0.446ArgGln: 0.446 ± 0.0
0.892ArgArg: 0.892 ± 0.0
1.338ArgSer: 1.338 ± 0.0
1.784ArgThr: 1.784 ± 0.0
4.014ArgVal: 4.014 ± 0.0
0.446ArgTrp: 0.446 ± 0.0
1.784ArgTyr: 1.784 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
6.244SerAla: 6.244 ± 0.0
0.892SerCys: 0.892 ± 0.0
4.46SerAsp: 4.46 ± 0.0
4.014SerGlu: 4.014 ± 0.0
3.568SerPhe: 3.568 ± 0.0
5.352SerGly: 5.352 ± 0.0
1.338SerHis: 1.338 ± 0.0
5.798SerIle: 5.798 ± 0.0
5.798SerLys: 5.798 ± 0.0
8.475SerLeu: 8.475 ± 0.0
0.892SerMet: 0.892 ± 0.0
3.568SerAsn: 3.568 ± 0.0
3.568SerPro: 3.568 ± 0.0
3.122SerGln: 3.122 ± 0.0
2.23SerArg: 2.23 ± 0.0
7.136SerSer: 7.136 ± 0.0
3.568SerThr: 3.568 ± 0.0
4.46SerVal: 4.46 ± 0.0
0.446SerTrp: 0.446 ± 0.0
2.676SerTyr: 2.676 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
3.122ThrAla: 3.122 ± 0.0
0.892ThrCys: 0.892 ± 0.0
2.676ThrAsp: 2.676 ± 0.0
2.676ThrGlu: 2.676 ± 0.0
3.568ThrPhe: 3.568 ± 0.0
3.122ThrGly: 3.122 ± 0.0
0.446ThrHis: 0.446 ± 0.0
4.014ThrIle: 4.014 ± 0.0
3.568ThrLys: 3.568 ± 0.0
8.921ThrLeu: 8.921 ± 0.0
1.338ThrMet: 1.338 ± 0.0
1.784ThrAsn: 1.784 ± 0.0
3.122ThrPro: 3.122 ± 0.0
2.23ThrGln: 2.23 ± 0.0
3.122ThrArg: 3.122 ± 0.0
4.906ThrSer: 4.906 ± 0.0
4.014ThrThr: 4.014 ± 0.0
4.014ThrVal: 4.014 ± 0.0
0.446ThrTrp: 0.446 ± 0.0
1.338ThrTyr: 1.338 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
3.122ValAla: 3.122 ± 0.0
1.338ValCys: 1.338 ± 0.0
6.244ValAsp: 6.244 ± 0.0
3.122ValGlu: 3.122 ± 0.0
3.122ValPhe: 3.122 ± 0.0
5.798ValGly: 5.798 ± 0.0
1.784ValHis: 1.784 ± 0.0
3.568ValIle: 3.568 ± 0.0
2.676ValLys: 2.676 ± 0.0
3.568ValLeu: 3.568 ± 0.0
3.122ValMet: 3.122 ± 0.0
4.014ValAsn: 4.014 ± 0.0
4.46ValPro: 4.46 ± 0.0
3.122ValGln: 3.122 ± 0.0
3.122ValArg: 3.122 ± 0.0
4.906ValSer: 4.906 ± 0.0
2.23ValThr: 2.23 ± 0.0
6.69ValVal: 6.69 ± 0.0
1.338ValTrp: 1.338 ± 0.0
3.568ValTyr: 3.568 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.892TrpAsp: 0.892 ± 0.0
0.446TrpGlu: 0.446 ± 0.0
2.23TrpPhe: 2.23 ± 0.0
0.892TrpGly: 0.892 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.338TrpIle: 1.338 ± 0.0
0.892TrpLys: 0.892 ± 0.0
1.338TrpLeu: 1.338 ± 0.0
0.446TrpMet: 0.446 ± 0.0
0.446TrpAsn: 0.446 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.446TrpGln: 0.446 ± 0.0
1.338TrpArg: 1.338 ± 0.0
1.784TrpSer: 1.784 ± 0.0
0.892TrpThr: 0.892 ± 0.0
0.446TrpVal: 0.446 ± 0.0
0.446TrpTrp: 0.446 ± 0.0
1.338TrpTyr: 1.338 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.23TyrAla: 2.23 ± 0.0
0.446TyrCys: 0.446 ± 0.0
3.568TyrAsp: 3.568 ± 0.0
1.784TyrGlu: 1.784 ± 0.0
1.784TyrPhe: 1.784 ± 0.0
2.676TyrGly: 2.676 ± 0.0
3.122TyrHis: 3.122 ± 0.0
0.0TyrIle: 0.0 ± 0.0
3.122TyrLys: 3.122 ± 0.0
2.23TyrLeu: 2.23 ± 0.0
0.446TyrMet: 0.446 ± 0.0
2.23TyrAsn: 2.23 ± 0.0
1.338TyrPro: 1.338 ± 0.0
0.446TyrGln: 0.446 ± 0.0
1.784TyrArg: 1.784 ± 0.0
2.23TyrSer: 2.23 ± 0.0
3.568TyrThr: 3.568 ± 0.0
2.23TyrVal: 2.23 ± 0.0
0.446TyrTrp: 0.446 ± 0.0
1.338TyrTyr: 1.338 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1 proteins (2243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski