Amino acid dipepetide frequency for Stappia indica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.892AlaAla: 18.892 ± 0.163
1.2AlaCys: 1.2 ± 0.028
7.184AlaAsp: 7.184 ± 0.083
8.351AlaGlu: 8.351 ± 0.095
4.738AlaPhe: 4.738 ± 0.061
12.387AlaGly: 12.387 ± 0.114
2.267AlaHis: 2.267 ± 0.043
6.155AlaIle: 6.155 ± 0.078
3.225AlaLys: 3.225 ± 0.052
14.086AlaLeu: 14.086 ± 0.119
3.739AlaMet: 3.739 ± 0.047
2.697AlaAsn: 2.697 ± 0.048
6.152AlaPro: 6.152 ± 0.098
3.593AlaGln: 3.593 ± 0.057
10.34AlaArg: 10.34 ± 0.115
7.016AlaSer: 7.016 ± 0.071
5.935AlaThr: 5.935 ± 0.069
9.386AlaVal: 9.386 ± 0.094
1.479AlaTrp: 1.479 ± 0.039
2.457AlaTyr: 2.457 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.963CysAla: 0.963 ± 0.028
0.102CysCys: 0.102 ± 0.009
0.536CysAsp: 0.536 ± 0.019
0.485CysGlu: 0.485 ± 0.019
0.283CysPhe: 0.283 ± 0.014
0.955CysGly: 0.955 ± 0.026
0.244CysHis: 0.244 ± 0.015
0.367CysIle: 0.367 ± 0.016
0.171CysLys: 0.171 ± 0.012
0.863CysLeu: 0.863 ± 0.026
0.141CysMet: 0.141 ± 0.009
0.217CysAsn: 0.217 ± 0.012
0.415CysPro: 0.415 ± 0.022
0.234CysGln: 0.234 ± 0.015
0.679CysArg: 0.679 ± 0.025
0.401CysSer: 0.401 ± 0.017
0.364CysThr: 0.364 ± 0.018
0.561CysVal: 0.561 ± 0.021
0.107CysTrp: 0.107 ± 0.008
0.172CysTyr: 0.172 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.999AspAla: 6.999 ± 0.079
0.488AspCys: 0.488 ± 0.018
2.914AspAsp: 2.914 ± 0.052
3.754AspGlu: 3.754 ± 0.057
2.07AspPhe: 2.07 ± 0.04
5.442AspGly: 5.442 ± 0.073
1.212AspHis: 1.212 ± 0.04
2.981AspIle: 2.981 ± 0.055
1.504AspLys: 1.504 ± 0.037
6.126AspLeu: 6.126 ± 0.058
1.442AspMet: 1.442 ± 0.032
1.123AspAsn: 1.123 ± 0.028
3.588AspPro: 3.588 ± 0.047
1.419AspGln: 1.419 ± 0.029
4.452AspArg: 4.452 ± 0.06
1.896AspSer: 1.896 ± 0.038
2.868AspThr: 2.868 ± 0.054
3.958AspVal: 3.958 ± 0.054
0.967AspTrp: 0.967 ± 0.028
1.443AspTyr: 1.443 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
8.907GluAla: 8.907 ± 0.109
0.33GluCys: 0.33 ± 0.016
3.086GluAsp: 3.086 ± 0.054
3.801GluGlu: 3.801 ± 0.066
1.642GluPhe: 1.642 ± 0.039
4.716GluGly: 4.716 ± 0.06
1.124GluHis: 1.124 ± 0.025
3.762GluIle: 3.762 ± 0.062
2.017GluLys: 2.017 ± 0.043
5.774GluLeu: 5.774 ± 0.073
1.624GluMet: 1.624 ± 0.036
1.496GluAsn: 1.496 ± 0.038
2.81GluPro: 2.81 ± 0.057
1.927GluGln: 1.927 ± 0.042
5.448GluArg: 5.448 ± 0.07
2.219GluSer: 2.219 ± 0.043
4.047GluThr: 4.047 ± 0.056
4.235GluVal: 4.235 ± 0.057
0.669GluTrp: 0.669 ± 0.023
0.888GluTyr: 0.888 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.879PheAla: 4.879 ± 0.065
0.397PheCys: 0.397 ± 0.016
2.57PheAsp: 2.57 ± 0.046
2.144PheGlu: 2.144 ± 0.04
1.415PhePhe: 1.415 ± 0.03
3.741PheGly: 3.741 ± 0.054
0.717PheHis: 0.717 ± 0.023
1.502PheIle: 1.502 ± 0.039
0.725PheLys: 0.725 ± 0.022
3.611PheLeu: 3.611 ± 0.054
0.765PheMet: 0.765 ± 0.027
0.936PheAsn: 0.936 ± 0.029
1.564PhePro: 1.564 ± 0.034
0.932PheGln: 0.932 ± 0.022
2.457PheArg: 2.457 ± 0.042
2.213PheSer: 2.213 ± 0.041
1.926PheThr: 1.926 ± 0.045
2.818PheVal: 2.818 ± 0.044
0.503PheTrp: 0.503 ± 0.019
0.83PheTyr: 0.83 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.914GlyAla: 9.914 ± 0.106
0.843GlyCys: 0.843 ± 0.024
4.664GlyAsp: 4.664 ± 0.057
5.897GlyGlu: 5.897 ± 0.067
3.701GlyPhe: 3.701 ± 0.047
7.924GlyGly: 7.924 ± 0.113
1.964GlyHis: 1.964 ± 0.045
4.754GlyIle: 4.754 ± 0.066
2.809GlyLys: 2.809 ± 0.054
9.725GlyLeu: 9.725 ± 0.091
2.403GlyMet: 2.403 ± 0.045
2.121GlyAsn: 2.121 ± 0.059
3.653GlyPro: 3.653 ± 0.053
2.66GlyGln: 2.66 ± 0.053
6.775GlyArg: 6.775 ± 0.072
4.7GlySer: 4.7 ± 0.068
5.018GlyThr: 5.018 ± 0.111
6.122GlyVal: 6.122 ± 0.07
1.328GlyTrp: 1.328 ± 0.031
2.297GlyTyr: 2.297 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.393HisAla: 2.393 ± 0.043
0.22HisCys: 0.22 ± 0.012
1.206HisAsp: 1.206 ± 0.033
1.032HisGlu: 1.032 ± 0.028
0.763HisPhe: 0.763 ± 0.024
1.923HisGly: 1.923 ± 0.04
0.536HisHis: 0.536 ± 0.024
0.799HisIle: 0.799 ± 0.026
0.432HisLys: 0.432 ± 0.017
2.008HisLeu: 2.008 ± 0.04
0.518HisMet: 0.518 ± 0.02
0.389HisAsn: 0.389 ± 0.016
1.316HisPro: 1.316 ± 0.035
0.511HisGln: 0.511 ± 0.019
1.372HisArg: 1.372 ± 0.034
0.834HisSer: 0.834 ± 0.026
0.774HisThr: 0.774 ± 0.026
1.602HisVal: 1.602 ± 0.036
0.276HisTrp: 0.276 ± 0.014
0.513HisTyr: 0.513 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.576IleAla: 7.576 ± 0.083
0.494IleCys: 0.494 ± 0.018
3.374IleAsp: 3.374 ± 0.054
3.35IleGlu: 3.35 ± 0.054
1.636IlePhe: 1.636 ± 0.038
4.892IleGly: 4.892 ± 0.061
0.807IleHis: 0.807 ± 0.024
1.833IleIle: 1.833 ± 0.041
1.049IleLys: 1.049 ± 0.028
4.409IleLeu: 4.409 ± 0.07
0.871IleMet: 0.871 ± 0.024
1.19IleAsn: 1.19 ± 0.037
2.147IlePro: 2.147 ± 0.047
1.038IleGln: 1.038 ± 0.026
3.334IleArg: 3.334 ± 0.042
2.872IleSer: 2.872 ± 0.048
2.353IleThr: 2.353 ± 0.056
4.093IleVal: 4.093 ± 0.052
0.54IleTrp: 0.54 ± 0.021
1.036IleTyr: 1.036 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.73LysAla: 3.73 ± 0.06
0.12LysCys: 0.12 ± 0.009
1.485LysAsp: 1.485 ± 0.037
1.32LysGlu: 1.32 ± 0.031
0.645LysPhe: 0.645 ± 0.023
2.42LysGly: 2.42 ± 0.048
0.485LysHis: 0.485 ± 0.021
1.393LysIle: 1.393 ± 0.032
0.915LysLys: 0.915 ± 0.033
2.767LysLeu: 2.767 ± 0.048
0.681LysMet: 0.681 ± 0.025
0.608LysAsn: 0.608 ± 0.021
1.643LysPro: 1.643 ± 0.038
0.754LysGln: 0.754 ± 0.023
1.961LysArg: 1.961 ± 0.036
1.391LysSer: 1.391 ± 0.033
1.723LysThr: 1.723 ± 0.036
2.332LysVal: 2.332 ± 0.044
0.304LysTrp: 0.304 ± 0.013
0.483LysTyr: 0.483 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
15.713LeuAla: 15.713 ± 0.137
0.89LeuCys: 0.89 ± 0.026
6.247LeuAsp: 6.247 ± 0.077
5.669LeuGlu: 5.669 ± 0.07
3.716LeuPhe: 3.716 ± 0.057
8.606LeuGly: 8.606 ± 0.095
1.818LeuHis: 1.818 ± 0.038
4.611LeuIle: 4.611 ± 0.059
3.305LeuLys: 3.305 ± 0.049
9.962LeuLeu: 9.962 ± 0.123
2.375LeuMet: 2.375 ± 0.047
2.27LeuAsn: 2.27 ± 0.044
5.773LeuPro: 5.773 ± 0.067
2.665LeuGln: 2.665 ± 0.044
6.945LeuArg: 6.945 ± 0.081
6.65LeuSer: 6.65 ± 0.076
5.552LeuThr: 5.552 ± 0.071
8.329LeuVal: 8.329 ± 0.094
1.147LeuTrp: 1.147 ± 0.033
2.025LeuTyr: 2.025 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.108MetAla: 3.108 ± 0.054
0.162MetCys: 0.162 ± 0.011
1.158MetAsp: 1.158 ± 0.028
1.243MetGlu: 1.243 ± 0.034
0.669MetPhe: 0.669 ± 0.021
1.784MetGly: 1.784 ± 0.036
0.386MetHis: 0.386 ± 0.015
1.406MetIle: 1.406 ± 0.036
0.847MetLys: 0.847 ± 0.025
2.516MetLeu: 2.516 ± 0.051
0.65MetMet: 0.65 ± 0.02
0.671MetAsn: 0.671 ± 0.022
1.532MetPro: 1.532 ± 0.03
0.818MetGln: 0.818 ± 0.024
1.949MetArg: 1.949 ± 0.037
1.813MetSer: 1.813 ± 0.033
1.996MetThr: 1.996 ± 0.037
1.79MetVal: 1.79 ± 0.037
0.243MetTrp: 0.243 ± 0.013
0.277MetTyr: 0.277 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.832AsnAla: 2.832 ± 0.059
0.205AsnCys: 0.205 ± 0.012
1.221AsnAsp: 1.221 ± 0.033
1.18AsnGlu: 1.18 ± 0.027
0.845AsnPhe: 0.845 ± 0.028
2.217AsnGly: 2.217 ± 0.059
0.417AsnHis: 0.417 ± 0.017
1.145AsnIle: 1.145 ± 0.034
0.546AsnLys: 0.546 ± 0.019
2.305AsnLeu: 2.305 ± 0.051
0.573AsnMet: 0.573 ± 0.018
0.578AsnAsn: 0.578 ± 0.032
1.583AsnPro: 1.583 ± 0.037
0.622AsnGln: 0.622 ± 0.024
1.772AsnArg: 1.772 ± 0.035
1.091AsnSer: 1.091 ± 0.034
1.141AsnThr: 1.141 ± 0.041
1.796AsnVal: 1.796 ± 0.043
0.368AsnTrp: 0.368 ± 0.016
0.541AsnTyr: 0.541 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
6.906ProAla: 6.906 ± 0.082
0.34ProCys: 0.34 ± 0.017
3.6ProAsp: 3.6 ± 0.057
3.618ProGlu: 3.618 ± 0.049
2.036ProPhe: 2.036 ± 0.04
4.753ProGly: 4.753 ± 0.068
1.08ProHis: 1.08 ± 0.029
1.993ProIle: 1.993 ± 0.041
1.38ProLys: 1.38 ± 0.033
5.057ProLeu: 5.057 ± 0.076
1.195ProMet: 1.195 ± 0.028
1.136ProAsn: 1.136 ± 0.029
2.43ProPro: 2.43 ± 0.054
1.921ProGln: 1.921 ± 0.043
3.096ProArg: 3.096 ± 0.053
2.653ProSer: 2.653 ± 0.046
2.228ProThr: 2.228 ± 0.039
4.606ProVal: 4.606 ± 0.059
0.652ProTrp: 0.652 ± 0.021
1.09ProTyr: 1.09 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.995GlnAla: 3.995 ± 0.058
0.148GlnCys: 0.148 ± 0.01
1.53GlnAsp: 1.53 ± 0.035
1.583GlnGlu: 1.583 ± 0.037
0.917GlnPhe: 0.917 ± 0.024
2.36GlnGly: 2.36 ± 0.039
0.538GlnHis: 0.538 ± 0.017
1.566GlnIle: 1.566 ± 0.031
0.851GlnLys: 0.851 ± 0.022
2.704GlnLeu: 2.704 ± 0.048
0.823GlnMet: 0.823 ± 0.026
0.701GlnAsn: 0.701 ± 0.028
1.595GlnPro: 1.595 ± 0.033
1.058GlnGln: 1.058 ± 0.04
2.128GlnArg: 2.128 ± 0.041
1.524GlnSer: 1.524 ± 0.038
1.657GlnThr: 1.657 ± 0.035
2.256GlnVal: 2.256 ± 0.042
0.308GlnTrp: 0.308 ± 0.013
0.461GlnTyr: 0.461 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
8.456ArgAla: 8.456 ± 0.083
0.503ArgCys: 0.503 ± 0.021
4.225ArgAsp: 4.225 ± 0.05
4.919ArgGlu: 4.919 ± 0.061
3.112ArgPhe: 3.112 ± 0.049
5.172ArgGly: 5.172 ± 0.065
1.742ArgHis: 1.742 ± 0.038
4.319ArgIle: 4.319 ± 0.055
2.3ArgLys: 2.3 ± 0.039
8.805ArgLeu: 8.805 ± 0.099
1.961ArgMet: 1.961 ± 0.035
1.725ArgAsn: 1.725 ± 0.035
3.799ArgPro: 3.799 ± 0.067
2.631ArgGln: 2.631 ± 0.044
6.162ArgArg: 6.162 ± 0.069
3.759ArgSer: 3.759 ± 0.055
3.444ArgThr: 3.444 ± 0.056
4.938ArgVal: 4.938 ± 0.068
0.923ArgTrp: 0.923 ± 0.026
1.61ArgTyr: 1.61 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.328SerAla: 6.328 ± 0.075
0.395SerCys: 0.395 ± 0.017
2.921SerAsp: 2.921 ± 0.051
2.954SerGlu: 2.954 ± 0.052
2.232SerPhe: 2.232 ± 0.042
5.953SerGly: 5.953 ± 0.091
1.036SerHis: 1.036 ± 0.029
2.499SerIle: 2.499 ± 0.049
1.211SerLys: 1.211 ± 0.03
5.575SerLeu: 5.575 ± 0.07
1.314SerMet: 1.314 ± 0.028
1.21SerAsn: 1.21 ± 0.033
2.766SerPro: 2.766 ± 0.048
1.599SerGln: 1.599 ± 0.032
3.885SerArg: 3.885 ± 0.053
2.872SerSer: 2.872 ± 0.059
2.412SerThr: 2.412 ± 0.061
3.987SerVal: 3.987 ± 0.055
0.709SerTrp: 0.709 ± 0.021
1.197SerTyr: 1.197 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.359ThrAla: 6.359 ± 0.073
0.439ThrCys: 0.439 ± 0.017
2.739ThrAsp: 2.739 ± 0.043
2.583ThrGlu: 2.583 ± 0.041
1.984ThrPhe: 1.984 ± 0.042
5.506ThrGly: 5.506 ± 0.11
0.943ThrHis: 0.943 ± 0.026
2.602ThrIle: 2.602 ± 0.06
1.099ThrLys: 1.099 ± 0.031
5.934ThrLeu: 5.934 ± 0.071
1.173ThrMet: 1.173 ± 0.031
1.163ThrAsn: 1.163 ± 0.036
3.207ThrPro: 3.207 ± 0.049
1.3ThrGln: 1.3 ± 0.034
3.676ThrArg: 3.676 ± 0.05
2.8ThrSer: 2.8 ± 0.051
2.734ThrThr: 2.734 ± 0.069
4.546ThrVal: 4.546 ± 0.069
0.606ThrTrp: 0.606 ± 0.022
1.154ThrTyr: 1.154 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.924ValAla: 9.924 ± 0.099
0.626ValCys: 0.626 ± 0.024
4.108ValAsp: 4.108 ± 0.054
4.949ValGlu: 4.949 ± 0.066
2.902ValPhe: 2.902 ± 0.048
5.613ValGly: 5.613 ± 0.062
1.376ValHis: 1.376 ± 0.028
3.759ValIle: 3.759 ± 0.052
1.856ValLys: 1.856 ± 0.042
8.217ValLeu: 8.217 ± 0.088
1.971ValMet: 1.971 ± 0.043
1.863ValAsn: 1.863 ± 0.037
4.084ValPro: 4.084 ± 0.058
1.855ValGln: 1.855 ± 0.034
5.035ValArg: 5.035 ± 0.059
4.48ValSer: 4.48 ± 0.06
4.582ValThr: 4.582 ± 0.072
6.128ValVal: 6.128 ± 0.067
0.944ValTrp: 0.944 ± 0.028
1.466ValTyr: 1.466 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.141TrpAla: 1.141 ± 0.034
0.137TrpCys: 0.137 ± 0.008
0.597TrpAsp: 0.597 ± 0.018
0.521TrpGlu: 0.521 ± 0.019
0.495TrpPhe: 0.495 ± 0.019
0.928TrpGly: 0.928 ± 0.026
0.287TrpHis: 0.287 ± 0.013
0.622TrpIle: 0.622 ± 0.021
0.368TrpLys: 0.368 ± 0.015
1.551TrpLeu: 1.551 ± 0.04
0.358TrpMet: 0.358 ± 0.015
0.37TrpAsn: 0.37 ± 0.015
0.696TrpPro: 0.696 ± 0.025
0.535TrpGln: 0.535 ± 0.02
1.187TrpArg: 1.187 ± 0.033
0.775TrpSer: 0.775 ± 0.024
0.786TrpThr: 0.786 ± 0.026
0.754TrpVal: 0.754 ± 0.023
0.196TrpTrp: 0.196 ± 0.012
0.283TrpTyr: 0.283 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.265TyrAla: 2.265 ± 0.038
0.221TyrCys: 0.221 ± 0.014
1.28TyrAsp: 1.28 ± 0.033
1.172TyrGlu: 1.172 ± 0.033
0.844TyrPhe: 0.844 ± 0.025
1.978TyrGly: 1.978 ± 0.038
0.437TyrHis: 0.437 ± 0.019
0.828TyrIle: 0.828 ± 0.022
0.546TyrLys: 0.546 ± 0.018
2.272TyrLeu: 2.272 ± 0.044
0.442TyrMet: 0.442 ± 0.017
0.515TyrAsn: 0.515 ± 0.021
1.019TyrPro: 1.019 ± 0.024
0.631TyrGln: 0.631 ± 0.02
1.85TyrArg: 1.85 ± 0.04
1.093TyrSer: 1.093 ± 0.027
1.011TyrThr: 1.011 ± 0.028
1.501TyrVal: 1.501 ± 0.032
0.318TyrTrp: 0.318 ± 0.013
0.509TyrTyr: 0.509 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4539 proteins (1479176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski