Amino acid dipepetide frequency for Frankia canadensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.182AlaAla: 25.182 ± 0.196	1.179AlaCys: 1.179 ± 0.026	9.443AlaAsp: 9.443 ± 0.094	7.816AlaGlu: 7.816 ± 0.081	3.473AlaPhe: 3.473 ± 0.04	16.127AlaGly: 16.127 ± 0.122	2.903AlaHis: 2.903 ± 0.039	4.084AlaIle: 4.084 ± 0.054	1.726AlaLys: 1.726 ± 0.033	13.998AlaLeu: 13.998 ± 0.091	2.52AlaMet: 2.52 ± 0.035	1.903AlaAsn: 1.903 ± 0.031	7.937AlaPro: 7.937 ± 0.08	3.51AlaGln: 3.51 ± 0.046	12.645AlaArg: 12.645 ± 0.106	7.071AlaSer: 7.071 ± 0.065	8.166AlaThr: 8.166 ± 0.077	12.61AlaVal: 12.61 ± 0.105	1.813AlaTrp: 1.813 ± 0.027	2.252AlaTyr: 2.252 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.142CysAla: 1.142 ± 0.025	0.101CysCys: 0.101 ± 0.007	0.47CysAsp: 0.47 ± 0.015	0.367CysGlu: 0.367 ± 0.014	0.219CysPhe: 0.219 ± 0.009	0.99CysGly: 0.99 ± 0.024	0.219CysHis: 0.219 ± 0.01	0.136CysIle: 0.136 ± 0.008	0.07CysLys: 0.07 ± 0.005	0.785CysLeu: 0.785 ± 0.017	0.103CysMet: 0.103 ± 0.006	0.122CysAsn: 0.122 ± 0.008	0.578CysPro: 0.578 ± 0.016	0.21CysGln: 0.21 ± 0.01	0.7CysArg: 0.7 ± 0.019	0.45CysSer: 0.45 ± 0.015	0.389CysThr: 0.389 ± 0.015	0.652CysVal: 0.652 ± 0.018	0.146CysTrp: 0.146 ± 0.008	0.157CysTyr: 0.157 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.433AspAla: 8.433 ± 0.088	0.39AspCys: 0.39 ± 0.014	4.022AspAsp: 4.022 ± 0.058	3.671AspGlu: 3.671 ± 0.044	1.331AspPhe: 1.331 ± 0.029	6.744AspGly: 6.744 ± 0.072	1.495AspHis: 1.495 ± 0.027	1.761AspIle: 1.761 ± 0.033	0.64AspLys: 0.64 ± 0.019	6.871AspLeu: 6.871 ± 0.059	0.701AspMet: 0.701 ± 0.02	0.771AspAsn: 0.771 ± 0.022	5.052AspPro: 5.052 ± 0.052	1.707AspGln: 1.707 ± 0.031	5.394AspArg: 5.394 ± 0.058	2.382AspSer: 2.382 ± 0.033	2.902AspThr: 2.902 ± 0.038	5.136AspVal: 5.136 ± 0.052	0.85AspTrp: 0.85 ± 0.02	1.05AspTyr: 1.05 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.155GluAla: 6.155 ± 0.066	0.297GluCys: 0.297 ± 0.011	2.299GluAsp: 2.299 ± 0.036	2.266GluGlu: 2.266 ± 0.041	1.28GluPhe: 1.28 ± 0.025	3.067GluGly: 3.067 ± 0.038	1.378GluHis: 1.378 ± 0.028	2.272GluIle: 2.272 ± 0.031	0.821GluLys: 0.821 ± 0.023	5.897GluLeu: 5.897 ± 0.068	0.754GluMet: 0.754 ± 0.02	0.803GluAsn: 0.803 ± 0.024	3.286GluPro: 3.286 ± 0.045	1.855GluGln: 1.855 ± 0.032	5.169GluArg: 5.169 ± 0.066	2.204GluSer: 2.204 ± 0.032	2.41GluThr: 2.41 ± 0.035	4.143GluVal: 4.143 ± 0.054	0.645GluTrp: 0.645 ± 0.017	0.851GluTyr: 0.851 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.681PheAla: 3.681 ± 0.051	0.243PheCys: 0.243 ± 0.01	1.983PheAsp: 1.983 ± 0.029	1.174PheGlu: 1.174 ± 0.024	0.71PhePhe: 0.71 ± 0.021	2.909PheGly: 2.909 ± 0.038	0.578PheHis: 0.578 ± 0.016	0.64PheIle: 0.64 ± 0.019	0.273PheLys: 0.273 ± 0.012	2.38PheLeu: 2.38 ± 0.038	0.323PheMet: 0.323 ± 0.013	0.442PheAsn: 0.442 ± 0.016	1.385PhePro: 1.385 ± 0.025	0.575PheGln: 0.575 ± 0.016	1.809PheArg: 1.809 ± 0.028	1.281PheSer: 1.281 ± 0.029	1.778PheThr: 1.778 ± 0.036	2.249PheVal: 2.249 ± 0.035	0.372PheTrp: 0.372 ± 0.014	0.504PheTyr: 0.504 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	12.156GlyAla: 12.156 ± 0.11	0.835GlyCys: 0.835 ± 0.019	5.419GlyAsp: 5.419 ± 0.056	4.731GlyGlu: 4.731 ± 0.058	2.652GlyPhe: 2.652 ± 0.038	10.302GlyGly: 10.302 ± 0.113	2.307GlyHis: 2.307 ± 0.037	3.308GlyIle: 3.308 ± 0.046	1.47GlyLys: 1.47 ± 0.03	9.71GlyLeu: 9.71 ± 0.077	1.86GlyMet: 1.86 ± 0.029	1.448GlyAsn: 1.448 ± 0.027	6.433GlyPro: 6.433 ± 0.066	2.929GlyGln: 2.929 ± 0.039	9.512GlyArg: 9.512 ± 0.077	5.671GlySer: 5.671 ± 0.061	5.929GlyThr: 5.929 ± 0.054	7.752GlyVal: 7.752 ± 0.075	1.768GlyTrp: 1.768 ± 0.031	2.081GlyTyr: 2.081 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.754HisAla: 2.754 ± 0.041	0.194HisCys: 0.194 ± 0.01	1.426HisAsp: 1.426 ± 0.026	1.016HisGlu: 1.016 ± 0.018	0.55HisPhe: 0.55 ± 0.016	2.407HisGly: 2.407 ± 0.037	0.699HisHis: 0.699 ± 0.022	0.589HisIle: 0.589 ± 0.017	0.199HisLys: 0.199 ± 0.01	2.463HisLeu: 2.463 ± 0.038	0.271HisMet: 0.271 ± 0.011	0.341HisAsn: 0.341 ± 0.013	2.048HisPro: 2.048 ± 0.037	0.637HisGln: 0.637 ± 0.019	2.346HisArg: 2.346 ± 0.034	0.998HisSer: 0.998 ± 0.023	1.151HisThr: 1.151 ± 0.029	1.655HisVal: 1.655 ± 0.027	0.315HisTrp: 0.315 ± 0.011	0.408HisTyr: 0.408 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.942IleAla: 4.942 ± 0.052	0.295IleCys: 0.295 ± 0.012	2.335IleAsp: 2.335 ± 0.039	1.788IleGlu: 1.788 ± 0.03	0.719IlePhe: 0.719 ± 0.02	3.428IleGly: 3.428 ± 0.046	0.656IleHis: 0.656 ± 0.017	1.053IleIle: 1.053 ± 0.025	0.441IleLys: 0.441 ± 0.015	2.633IleLeu: 2.633 ± 0.039	0.465IleMet: 0.465 ± 0.016	0.653IleAsn: 0.653 ± 0.022	1.899IlePro: 1.899 ± 0.028	0.654IleGln: 0.654 ± 0.018	2.602IleArg: 2.602 ± 0.039	1.728IleSer: 1.728 ± 0.035	2.188IleThr: 2.188 ± 0.035	3.065IleVal: 3.065 ± 0.038	0.347IleTrp: 0.347 ± 0.013	0.531IleTyr: 0.531 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	1.677LysAla: 1.677 ± 0.036	0.074LysCys: 0.074 ± 0.006	0.679LysAsp: 0.679 ± 0.02	0.557LysGlu: 0.557 ± 0.021	0.241LysPhe: 0.241 ± 0.011	0.981LysGly: 0.981 ± 0.026	0.26LysHis: 0.26 ± 0.012	0.707LysIle: 0.707 ± 0.022	0.348LysLys: 0.348 ± 0.018	1.204LysLeu: 1.204 ± 0.025	0.234LysMet: 0.234 ± 0.012	0.292LysAsn: 0.292 ± 0.013	0.813LysPro: 0.813 ± 0.022	0.358LysGln: 0.358 ± 0.014	0.904LysArg: 0.904 ± 0.021	0.671LysSer: 0.671 ± 0.02	0.78LysThr: 0.78 ± 0.023	1.243LysVal: 1.243 ± 0.029	0.143LysTrp: 0.143 ± 0.007	0.237LysTyr: 0.237 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	16.808LeuAla: 16.808 ± 0.124	0.828LeuCys: 0.828 ± 0.023	6.878LeuAsp: 6.878 ± 0.064	3.978LeuGlu: 3.978 ± 0.056	2.394LeuPhe: 2.394 ± 0.041	9.256LeuGly: 9.256 ± 0.077	2.121LeuHis: 2.121 ± 0.032	3.026LeuIle: 3.026 ± 0.045	0.982LeuLys: 0.982 ± 0.029	10.83LeuLeu: 10.83 ± 0.092	1.28LeuMet: 1.28 ± 0.025	1.311LeuAsn: 1.311 ± 0.026	6.569LeuPro: 6.569 ± 0.058	1.653LeuGln: 1.653 ± 0.032	9.662LeuArg: 9.662 ± 0.082	5.014LeuSer: 5.014 ± 0.05	6.471LeuThr: 6.471 ± 0.06	9.346LeuVal: 9.346 ± 0.08	1.187LeuTrp: 1.187 ± 0.027	1.491LeuTyr: 1.491 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.139MetAla: 2.139 ± 0.03	0.136MetCys: 0.136 ± 0.008	0.724MetAsp: 0.724 ± 0.021	0.56MetGlu: 0.56 ± 0.015	0.456MetPhe: 0.456 ± 0.016	1.147MetGly: 1.147 ± 0.024	0.298MetHis: 0.298 ± 0.012	0.753MetIle: 0.753 ± 0.022	0.261MetLys: 0.261 ± 0.012	1.595MetLeu: 1.595 ± 0.028	0.292MetMet: 0.292 ± 0.011	0.348MetAsn: 0.348 ± 0.014	1.156MetPro: 1.156 ± 0.027	0.328MetGln: 0.328 ± 0.013	1.433MetArg: 1.433 ± 0.027	1.284MetSer: 1.284 ± 0.023	1.437MetThr: 1.437 ± 0.024	1.255MetVal: 1.255 ± 0.026	0.185MetTrp: 0.185 ± 0.011	0.241MetTyr: 0.241 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	1.998AsnAla: 1.998 ± 0.032	0.124AsnCys: 0.124 ± 0.01	0.825AsnAsp: 0.825 ± 0.02	0.646AsnGlu: 0.646 ± 0.017	0.383AsnPhe: 0.383 ± 0.015	1.554AsnGly: 1.554 ± 0.033	0.348AsnHis: 0.348 ± 0.014	0.635AsnIle: 0.635 ± 0.018	0.228AsnLys: 0.228 ± 0.011	1.546AsnLeu: 1.546 ± 0.029	0.233AsnMet: 0.233 ± 0.012	0.354AsnAsn: 0.354 ± 0.015	1.304AsnPro: 1.304 ± 0.025	0.455AsnGln: 0.455 ± 0.014	1.246AsnArg: 1.246 ± 0.025	0.777AsnSer: 0.777 ± 0.022	0.897AsnThr: 0.897 ± 0.024	1.208AsnVal: 1.208 ± 0.025	0.21AsnTrp: 0.21 ± 0.01	0.307AsnTyr: 0.307 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	11.337ProAla: 11.337 ± 0.11	0.413ProCys: 0.413 ± 0.014	4.978ProAsp: 4.978 ± 0.056	3.206ProGlu: 3.206 ± 0.047	1.628ProPhe: 1.628 ± 0.029	7.664ProGly: 7.664 ± 0.074	1.43ProHis: 1.43 ± 0.029	1.635ProIle: 1.635 ± 0.028	0.783ProLys: 0.783 ± 0.022	5.293ProLeu: 5.293 ± 0.054	1.028ProMet: 1.028 ± 0.02	0.941ProAsn: 0.941 ± 0.025	5.087ProPro: 5.087 ± 0.071	1.426ProGln: 1.426 ± 0.027	5.277ProArg: 5.277 ± 0.062	3.911ProSer: 3.911 ± 0.051	4.068ProThr: 4.068 ± 0.048	5.544ProVal: 5.544 ± 0.05	0.908ProTrp: 0.908 ± 0.022	1.077ProTyr: 1.077 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.765GlnAla: 3.765 ± 0.046	0.165GlnCys: 0.165 ± 0.009	1.096GlnAsp: 1.096 ± 0.024	1.077GlnGlu: 1.077 ± 0.024	0.602GlnPhe: 0.602 ± 0.016	1.873GlnGly: 1.873 ± 0.032	0.588GlnHis: 0.588 ± 0.019	1.123GlnIle: 1.123 ± 0.028	0.366GlnLys: 0.366 ± 0.013	2.714GlnLeu: 2.714 ± 0.042	0.408GlnMet: 0.408 ± 0.013	0.41GlnAsn: 0.41 ± 0.016	1.838GlnPro: 1.838 ± 0.035	0.881GlnGln: 0.881 ± 0.024	2.465GlnArg: 2.465 ± 0.039	1.077GlnSer: 1.077 ± 0.024	1.287GlnThr: 1.287 ± 0.027	2.49GlnVal: 2.49 ± 0.033	0.38GlnTrp: 0.38 ± 0.014	0.433GlnTyr: 0.433 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	12.041ArgAla: 12.041 ± 0.108	0.734ArgCys: 0.734 ± 0.016	4.997ArgAsp: 4.997 ± 0.063	4.406ArgGlu: 4.406 ± 0.057	2.437ArgPhe: 2.437 ± 0.031	7.263ArgGly: 7.263 ± 0.065	2.415ArgHis: 2.415 ± 0.036	3.177ArgIle: 3.177 ± 0.04	0.991ArgLys: 0.991 ± 0.022	9.83ArgLeu: 9.83 ± 0.093	1.852ArgMet: 1.852 ± 0.026	1.241ArgAsn: 1.241 ± 0.027	6.666ArgPro: 6.666 ± 0.066	2.627ArgGln: 2.627 ± 0.038	10.464ArgArg: 10.464 ± 0.105	4.802ArgSer: 4.802 ± 0.057	5.16ArgThr: 5.16 ± 0.056	6.77ArgVal: 6.77 ± 0.064	1.537ArgTrp: 1.537 ± 0.029	1.855ArgTyr: 1.855 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.479SerAla: 7.479 ± 0.077	0.448SerCys: 0.448 ± 0.014	2.71SerAsp: 2.71 ± 0.037	2.006SerGlu: 2.006 ± 0.029	1.486SerPhe: 1.486 ± 0.03	5.983SerGly: 5.983 ± 0.062	1.007SerHis: 1.007 ± 0.025	1.609SerIle: 1.609 ± 0.027	0.664SerLys: 0.664 ± 0.018	4.727SerLeu: 4.727 ± 0.045	1.04SerMet: 1.04 ± 0.024	0.772SerAsn: 0.772 ± 0.021	3.983SerPro: 3.983 ± 0.049	1.206SerGln: 1.206 ± 0.026	4.433SerArg: 4.433 ± 0.047	3.185SerSer: 3.185 ± 0.05	3.398SerThr: 3.398 ± 0.048	4.145SerVal: 4.145 ± 0.053	0.919SerTrp: 0.919 ± 0.023	1.04SerTyr: 1.04 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.824ThrAla: 8.824 ± 0.076	0.472ThrCys: 0.472 ± 0.016	3.362ThrAsp: 3.362 ± 0.039	2.601ThrGlu: 2.601 ± 0.035	1.609ThrPhe: 1.609 ± 0.031	6.442ThrGly: 6.442 ± 0.065	1.137ThrHis: 1.137 ± 0.025	2.045ThrIle: 2.045 ± 0.04	0.729ThrLys: 0.729 ± 0.023	5.569ThrLeu: 5.569 ± 0.059	0.988ThrMet: 0.988 ± 0.023	0.926ThrAsn: 0.926 ± 0.026	4.209ThrPro: 4.209 ± 0.053	1.218ThrGln: 1.218 ± 0.025	4.547ThrArg: 4.547 ± 0.047	3.532ThrSer: 3.532 ± 0.05	3.91ThrThr: 3.91 ± 0.058	5.675ThrVal: 5.675 ± 0.065	0.845ThrTrp: 0.845 ± 0.02	1.102ThrTyr: 1.102 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	12.069ValAla: 12.069 ± 0.085	0.746ValCys: 0.746 ± 0.021	5.685ValAsp: 5.685 ± 0.05	4.506ValGlu: 4.506 ± 0.058	2.179ValPhe: 2.179 ± 0.033	7.49ValGly: 7.49 ± 0.071	1.853ValHis: 1.853 ± 0.027	2.904ValIle: 2.904 ± 0.042	0.98ValLys: 0.98 ± 0.023	9.201ValLeu: 9.201 ± 0.08	1.224ValMet: 1.224 ± 0.026	1.552ValAsn: 1.552 ± 0.033	5.381ValPro: 5.381 ± 0.062	1.694ValGln: 1.694 ± 0.031	7.422ValArg: 7.422 ± 0.068	4.39ValSer: 4.39 ± 0.051	5.501ValThr: 5.501 ± 0.068	8.319ValVal: 8.319 ± 0.088	1.068ValTrp: 1.068 ± 0.026	1.312ValTyr: 1.312 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.588TrpAla: 1.588 ± 0.028	0.165TrpCys: 0.165 ± 0.008	0.803TrpAsp: 0.803 ± 0.022	0.606TrpGlu: 0.606 ± 0.016	0.413TrpPhe: 0.413 ± 0.015	0.901TrpGly: 0.901 ± 0.021	0.379TrpHis: 0.379 ± 0.015	0.539TrpIle: 0.539 ± 0.016	0.216TrpLys: 0.216 ± 0.011	1.723TrpLeu: 1.723 ± 0.03	0.271TrpMet: 0.271 ± 0.011	0.344TrpAsn: 0.344 ± 0.014	0.893TrpPro: 0.893 ± 0.023	0.517TrpGln: 0.517 ± 0.017	1.46TrpArg: 1.46 ± 0.025	0.985TrpSer: 0.985 ± 0.022	0.93TrpThr: 0.93 ± 0.021	0.9TrpVal: 0.9 ± 0.02	0.32TrpTrp: 0.32 ± 0.013	0.285TrpTyr: 0.285 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.187TyrAla: 2.187 ± 0.032	0.168TyrCys: 0.168 ± 0.009	1.167TyrAsp: 1.167 ± 0.029	0.871TyrGlu: 0.871 ± 0.022	0.528TyrPhe: 0.528 ± 0.013	1.75TyrGly: 1.75 ± 0.029	0.396TyrHis: 0.396 ± 0.014	0.425TyrIle: 0.425 ± 0.015	0.214TyrLys: 0.214 ± 0.01	2.115TyrLeu: 2.115 ± 0.035	0.182TyrMet: 0.182 ± 0.01	0.304TyrAsn: 0.304 ± 0.014	1.114TyrPro: 1.114 ± 0.025	0.597TyrGln: 0.597 ± 0.017	1.774TyrArg: 1.774 ± 0.029	0.827TyrSer: 0.827 ± 0.021	0.99TyrThr: 0.99 ± 0.025	1.32TyrVal: 1.32 ± 0.026	0.282TyrTrp: 0.282 ± 0.011	0.391TyrTyr: 0.391 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7042 proteins (2157780 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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