Amino acid dipepetide frequency for Mycobacterium phage Corazon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.451AlaAla: 12.451 ± 1.24
0.988AlaCys: 0.988 ± 0.253
6.571AlaAsp: 6.571 ± 0.639
6.966AlaGlu: 6.966 ± 0.694
2.866AlaPhe: 2.866 ± 0.452
6.472AlaGly: 6.472 ± 0.651
2.125AlaHis: 2.125 ± 0.298
4.545AlaIle: 4.545 ± 0.414
4.298AlaLys: 4.298 ± 0.551
8.844AlaLeu: 8.844 ± 0.722
2.717AlaMet: 2.717 ± 0.303
3.656AlaAsn: 3.656 ± 0.533
5.04AlaPro: 5.04 ± 0.545
3.656AlaGln: 3.656 ± 0.49
6.126AlaArg: 6.126 ± 0.586
3.854AlaSer: 3.854 ± 0.474
5.83AlaThr: 5.83 ± 0.606
6.225AlaVal: 6.225 ± 0.669
2.174AlaTrp: 2.174 ± 0.314
2.866AlaTyr: 2.866 ± 0.386
0.0AlaXaa: 0.0 ± 0.0
Cys
1.038CysAla: 1.038 ± 0.244
0.247CysCys: 0.247 ± 0.125
1.433CysAsp: 1.433 ± 0.333
0.692CysGlu: 0.692 ± 0.199
0.247CysPhe: 0.247 ± 0.102
1.63CysGly: 1.63 ± 0.369
0.395CysHis: 0.395 ± 0.163
0.84CysIle: 0.84 ± 0.217
0.296CysLys: 0.296 ± 0.142
0.445CysLeu: 0.445 ± 0.15
0.099CysMet: 0.099 ± 0.075
0.543CysAsn: 0.543 ± 0.153
0.791CysPro: 0.791 ± 0.196
0.642CysGln: 0.642 ± 0.184
0.791CysArg: 0.791 ± 0.203
0.593CysSer: 0.593 ± 0.162
0.494CysThr: 0.494 ± 0.143
0.692CysVal: 0.692 ± 0.19
0.198CysTrp: 0.198 ± 0.111
0.445CysTyr: 0.445 ± 0.168
0.0CysXaa: 0.0 ± 0.0
Asp
5.583AspAla: 5.583 ± 0.498
0.692AspCys: 0.692 ± 0.229
5.138AspAsp: 5.138 ± 0.65
5.484AspGlu: 5.484 ± 0.638
2.223AspPhe: 2.223 ± 0.35
4.595AspGly: 4.595 ± 0.525
1.087AspHis: 1.087 ± 0.245
3.804AspIle: 3.804 ± 0.513
2.075AspLys: 2.075 ± 0.354
5.781AspLeu: 5.781 ± 0.524
1.927AspMet: 1.927 ± 0.349
1.828AspAsn: 1.828 ± 0.329
5.188AspPro: 5.188 ± 0.652
1.68AspGln: 1.68 ± 0.277
4.051AspArg: 4.051 ± 0.504
2.47AspSer: 2.47 ± 0.448
3.014AspThr: 3.014 ± 0.454
4.941AspVal: 4.941 ± 0.468
1.433AspTrp: 1.433 ± 0.23
2.569AspTyr: 2.569 ± 0.298
0.0AspXaa: 0.0 ± 0.0
Glu
6.868GluAla: 6.868 ± 0.683
0.741GluCys: 0.741 ± 0.28
3.706GluAsp: 3.706 ± 0.462
4.792GluGlu: 4.792 ± 0.586
3.409GluPhe: 3.409 ± 0.384
5.237GluGly: 5.237 ± 0.531
1.63GluHis: 1.63 ± 0.336
2.619GluIle: 2.619 ± 0.31
2.174GluLys: 2.174 ± 0.352
5.929GluLeu: 5.929 ± 0.676
2.52GluMet: 2.52 ± 0.397
1.927GluAsn: 1.927 ± 0.403
2.866GluPro: 2.866 ± 0.466
2.767GluGln: 2.767 ± 0.426
5.336GluArg: 5.336 ± 0.679
3.458GluSer: 3.458 ± 0.439
2.964GluThr: 2.964 ± 0.405
4.99GluVal: 4.99 ± 0.554
1.63GluTrp: 1.63 ± 0.266
1.779GluTyr: 1.779 ± 0.312
0.0GluXaa: 0.0 ± 0.0
Phe
2.174PheAla: 2.174 ± 0.292
0.593PheCys: 0.593 ± 0.209
2.767PheAsp: 2.767 ± 0.381
2.372PheGlu: 2.372 ± 0.394
1.038PhePhe: 1.038 ± 0.199
3.36PheGly: 3.36 ± 0.443
0.791PheHis: 0.791 ± 0.212
1.63PheIle: 1.63 ± 0.261
1.63PheLys: 1.63 ± 0.317
2.866PheLeu: 2.866 ± 0.398
0.791PheMet: 0.791 ± 0.196
1.334PheAsn: 1.334 ± 0.208
1.136PhePro: 1.136 ± 0.269
1.038PheGln: 1.038 ± 0.235
2.125PheArg: 2.125 ± 0.327
1.482PheSer: 1.482 ± 0.337
2.273PheThr: 2.273 ± 0.453
2.125PheVal: 2.125 ± 0.357
0.84PheTrp: 0.84 ± 0.222
1.186PheTyr: 1.186 ± 0.218
0.0PheXaa: 0.0 ± 0.0
Gly
6.374GlyAla: 6.374 ± 0.747
0.692GlyCys: 0.692 ± 0.212
5.83GlyAsp: 5.83 ± 0.669
4.298GlyGlu: 4.298 ± 0.495
3.706GlyPhe: 3.706 ± 0.442
8.992GlyGly: 8.992 ± 1.209
1.63GlyHis: 1.63 ± 0.288
3.508GlyIle: 3.508 ± 0.466
3.854GlyLys: 3.854 ± 0.527
6.423GlyLeu: 6.423 ± 0.703
2.026GlyMet: 2.026 ± 0.32
3.063GlyAsn: 3.063 ± 0.456
4.051GlyPro: 4.051 ± 0.545
3.014GlyGln: 3.014 ± 0.46
5.385GlyArg: 5.385 ± 0.625
5.484GlySer: 5.484 ± 0.605
4.891GlyThr: 4.891 ± 0.733
5.83GlyVal: 5.83 ± 0.651
2.223GlyTrp: 2.223 ± 0.401
2.619GlyTyr: 2.619 ± 0.413
0.0GlyXaa: 0.0 ± 0.0
His
2.026HisAla: 2.026 ± 0.396
0.247HisCys: 0.247 ± 0.11
1.532HisAsp: 1.532 ± 0.384
1.779HisGlu: 1.779 ± 0.359
0.296HisPhe: 0.296 ± 0.128
1.927HisGly: 1.927 ± 0.268
0.889HisHis: 0.889 ± 0.255
0.988HisIle: 0.988 ± 0.255
0.494HisLys: 0.494 ± 0.13
2.223HisLeu: 2.223 ± 0.337
0.395HisMet: 0.395 ± 0.134
0.84HisAsn: 0.84 ± 0.191
1.779HisPro: 1.779 ± 0.257
0.84HisGln: 0.84 ± 0.219
1.087HisArg: 1.087 ± 0.248
0.939HisSer: 0.939 ± 0.242
0.939HisThr: 0.939 ± 0.226
1.087HisVal: 1.087 ± 0.226
0.296HisTrp: 0.296 ± 0.117
0.84HisTyr: 0.84 ± 0.227
0.0HisXaa: 0.0 ± 0.0
Ile
5.188IleAla: 5.188 ± 0.587
0.84IleCys: 0.84 ± 0.207
3.903IleAsp: 3.903 ± 0.485
3.706IleGlu: 3.706 ± 0.414
1.186IlePhe: 1.186 ± 0.258
3.854IleGly: 3.854 ± 0.444
1.235IleHis: 1.235 ± 0.25
1.779IleIle: 1.779 ± 0.307
1.532IleLys: 1.532 ± 0.253
3.409IleLeu: 3.409 ± 0.466
0.741IleMet: 0.741 ± 0.181
1.63IleAsn: 1.63 ± 0.315
2.767IlePro: 2.767 ± 0.478
1.68IleGln: 1.68 ± 0.255
3.063IleArg: 3.063 ± 0.353
2.52IleSer: 2.52 ± 0.366
2.174IleThr: 2.174 ± 0.467
2.866IleVal: 2.866 ± 0.469
0.692IleTrp: 0.692 ± 0.228
1.087IleTyr: 1.087 ± 0.252
0.0IleXaa: 0.0 ± 0.0
Lys
4.694LysAla: 4.694 ± 0.569
0.593LysCys: 0.593 ± 0.177
1.285LysAsp: 1.285 ± 0.273
1.779LysGlu: 1.779 ± 0.412
1.433LysPhe: 1.433 ± 0.31
2.915LysGly: 2.915 ± 0.328
0.988LysHis: 0.988 ± 0.249
1.581LysIle: 1.581 ± 0.28
2.273LysLys: 2.273 ± 0.454
3.211LysLeu: 3.211 ± 0.497
1.038LysMet: 1.038 ± 0.212
1.136LysAsn: 1.136 ± 0.285
2.717LysPro: 2.717 ± 0.413
1.729LysGln: 1.729 ± 0.33
3.063LysArg: 3.063 ± 0.492
1.581LysSer: 1.581 ± 0.292
1.68LysThr: 1.68 ± 0.349
2.322LysVal: 2.322 ± 0.375
0.791LysTrp: 0.791 ± 0.173
0.642LysTyr: 0.642 ± 0.25
0.0LysXaa: 0.0 ± 0.0
Leu
7.856LeuAla: 7.856 ± 0.698
0.988LeuCys: 0.988 ± 0.29
6.423LeuAsp: 6.423 ± 0.655
5.731LeuGlu: 5.731 ± 0.574
2.668LeuPhe: 2.668 ± 0.55
6.324LeuGly: 6.324 ± 0.786
1.383LeuHis: 1.383 ± 0.264
3.903LeuIle: 3.903 ± 0.462
2.866LeuLys: 2.866 ± 0.419
6.621LeuLeu: 6.621 ± 0.61
1.877LeuMet: 1.877 ± 0.255
2.767LeuAsn: 2.767 ± 0.438
5.781LeuPro: 5.781 ± 0.591
2.767LeuGln: 2.767 ± 0.351
5.879LeuArg: 5.879 ± 0.461
4.941LeuSer: 4.941 ± 0.554
5.287LeuThr: 5.287 ± 0.445
5.484LeuVal: 5.484 ± 0.516
1.087LeuTrp: 1.087 ± 0.213
2.174LeuTyr: 2.174 ± 0.327
0.0LeuXaa: 0.0 ± 0.0
Met
3.211MetAla: 3.211 ± 0.376
0.445MetCys: 0.445 ± 0.152
0.988MetAsp: 0.988 ± 0.233
1.235MetGlu: 1.235 ± 0.3
1.285MetPhe: 1.285 ± 0.245
1.927MetGly: 1.927 ± 0.279
0.494MetHis: 0.494 ± 0.183
1.186MetIle: 1.186 ± 0.222
0.939MetLys: 0.939 ± 0.203
1.63MetLeu: 1.63 ± 0.264
0.642MetMet: 0.642 ± 0.183
1.038MetAsn: 1.038 ± 0.265
1.729MetPro: 1.729 ± 0.298
0.346MetGln: 0.346 ± 0.137
1.828MetArg: 1.828 ± 0.273
2.47MetSer: 2.47 ± 0.373
2.421MetThr: 2.421 ± 0.341
1.383MetVal: 1.383 ± 0.325
0.939MetTrp: 0.939 ± 0.174
0.198MetTyr: 0.198 ± 0.094
0.0MetXaa: 0.0 ± 0.0
Asn
4.051AsnAla: 4.051 ± 0.386
0.543AsnCys: 0.543 ± 0.186
1.927AsnAsp: 1.927 ± 0.267
1.927AsnGlu: 1.927 ± 0.301
1.136AsnPhe: 1.136 ± 0.239
3.557AsnGly: 3.557 ± 0.458
0.494AsnHis: 0.494 ± 0.157
1.482AsnIle: 1.482 ± 0.303
1.136AsnLys: 1.136 ± 0.278
2.866AsnLeu: 2.866 ± 0.386
0.494AsnMet: 0.494 ± 0.139
1.285AsnAsn: 1.285 ± 0.256
2.767AsnPro: 2.767 ± 0.38
1.581AsnGln: 1.581 ± 0.289
2.026AsnArg: 2.026 ± 0.355
1.927AsnSer: 1.927 ± 0.42
2.075AsnThr: 2.075 ± 0.3
1.976AsnVal: 1.976 ± 0.32
0.988AsnTrp: 0.988 ± 0.193
0.791AsnTyr: 0.791 ± 0.268
0.0AsnXaa: 0.0 ± 0.0
Pro
4.842ProAla: 4.842 ± 0.766
0.543ProCys: 0.543 ± 0.175
3.706ProAsp: 3.706 ± 0.46
4.694ProGlu: 4.694 ± 0.642
1.976ProPhe: 1.976 ± 0.303
5.83ProGly: 5.83 ± 0.801
1.532ProHis: 1.532 ± 0.323
2.421ProIle: 2.421 ± 0.372
2.026ProLys: 2.026 ± 0.333
4.051ProLeu: 4.051 ± 0.403
1.334ProMet: 1.334 ± 0.27
2.52ProAsn: 2.52 ± 0.331
3.706ProPro: 3.706 ± 0.505
2.223ProGln: 2.223 ± 0.348
3.211ProArg: 3.211 ± 0.491
4.694ProSer: 4.694 ± 0.514
3.607ProThr: 3.607 ± 0.495
3.557ProVal: 3.557 ± 0.492
1.087ProTrp: 1.087 ± 0.232
1.532ProTyr: 1.532 ± 0.239
0.0ProXaa: 0.0 ± 0.0
Gln
3.557GlnAla: 3.557 ± 0.502
0.692GlnCys: 0.692 ± 0.211
1.63GlnAsp: 1.63 ± 0.238
2.223GlnGlu: 2.223 ± 0.314
0.889GlnPhe: 0.889 ± 0.191
2.322GlnGly: 2.322 ± 0.33
0.642GlnHis: 0.642 ± 0.18
2.125GlnIle: 2.125 ± 0.329
1.581GlnLys: 1.581 ± 0.291
3.953GlnLeu: 3.953 ± 0.504
1.186GlnMet: 1.186 ± 0.259
0.741GlnAsn: 0.741 ± 0.17
1.976GlnPro: 1.976 ± 0.263
2.026GlnGln: 2.026 ± 0.393
3.211GlnArg: 3.211 ± 0.453
2.026GlnSer: 2.026 ± 0.317
1.68GlnThr: 1.68 ± 0.286
2.52GlnVal: 2.52 ± 0.378
0.988GlnTrp: 0.988 ± 0.25
0.692GlnTyr: 0.692 ± 0.156
0.0GlnXaa: 0.0 ± 0.0
Arg
6.522ArgAla: 6.522 ± 0.611
0.988ArgCys: 0.988 ± 0.28
4.15ArgAsp: 4.15 ± 0.481
4.496ArgGlu: 4.496 ± 0.576
2.322ArgPhe: 2.322 ± 0.385
5.04ArgGly: 5.04 ± 0.573
1.383ArgHis: 1.383 ± 0.32
3.36ArgIle: 3.36 ± 0.366
3.113ArgLys: 3.113 ± 0.472
6.077ArgLeu: 6.077 ± 0.508
1.482ArgMet: 1.482 ± 0.294
2.322ArgAsn: 2.322 ± 0.339
3.409ArgPro: 3.409 ± 0.418
2.619ArgGln: 2.619 ± 0.381
6.275ArgArg: 6.275 ± 0.803
2.915ArgSer: 2.915 ± 0.424
2.47ArgThr: 2.47 ± 0.342
4.249ArgVal: 4.249 ± 0.598
2.125ArgTrp: 2.125 ± 0.396
1.976ArgTyr: 1.976 ± 0.354
0.0ArgXaa: 0.0 ± 0.0
Ser
5.237SerAla: 5.237 ± 0.653
0.395SerCys: 0.395 ± 0.149
4.101SerAsp: 4.101 ± 0.525
3.162SerGlu: 3.162 ± 0.462
1.779SerPhe: 1.779 ± 0.311
5.336SerGly: 5.336 ± 0.765
1.186SerHis: 1.186 ± 0.309
2.619SerIle: 2.619 ± 0.393
1.532SerLys: 1.532 ± 0.285
4.397SerLeu: 4.397 ± 0.612
1.927SerMet: 1.927 ± 0.275
1.729SerAsn: 1.729 ± 0.279
3.113SerPro: 3.113 ± 0.352
1.828SerGln: 1.828 ± 0.304
3.706SerArg: 3.706 ± 0.516
3.755SerSer: 3.755 ± 0.501
3.261SerThr: 3.261 ± 0.339
3.409SerVal: 3.409 ± 0.405
1.235SerTrp: 1.235 ± 0.23
1.038SerTyr: 1.038 ± 0.205
0.0SerXaa: 0.0 ± 0.0
Thr
5.583ThrAla: 5.583 ± 0.549
0.543ThrCys: 0.543 ± 0.162
3.36ThrAsp: 3.36 ± 0.359
2.816ThrGlu: 2.816 ± 0.447
1.729ThrPhe: 1.729 ± 0.324
5.138ThrGly: 5.138 ± 0.647
1.285ThrHis: 1.285 ± 0.267
2.668ThrIle: 2.668 ± 0.377
1.828ThrLys: 1.828 ± 0.271
4.941ThrLeu: 4.941 ± 0.658
1.532ThrMet: 1.532 ± 0.303
2.322ThrAsn: 2.322 ± 0.447
3.755ThrPro: 3.755 ± 0.528
2.174ThrGln: 2.174 ± 0.284
3.458ThrArg: 3.458 ± 0.414
2.421ThrSer: 2.421 ± 0.397
3.261ThrThr: 3.261 ± 0.527
4.15ThrVal: 4.15 ± 0.605
1.136ThrTrp: 1.136 ± 0.233
1.136ThrTyr: 1.136 ± 0.262
0.0ThrXaa: 0.0 ± 0.0
Val
7.213ValAla: 7.213 ± 0.672
0.889ValCys: 0.889 ± 0.231
3.508ValAsp: 3.508 ± 0.456
5.435ValGlu: 5.435 ± 0.529
2.026ValPhe: 2.026 ± 0.306
5.188ValGly: 5.188 ± 0.625
0.889ValHis: 0.889 ± 0.204
2.866ValIle: 2.866 ± 0.445
2.372ValLys: 2.372 ± 0.303
5.287ValLeu: 5.287 ± 0.52
2.026ValMet: 2.026 ± 0.346
2.668ValAsn: 2.668 ± 0.384
4.447ValPro: 4.447 ± 0.528
2.174ValGln: 2.174 ± 0.386
4.002ValArg: 4.002 ± 0.455
4.348ValSer: 4.348 ± 0.475
3.953ValThr: 3.953 ± 0.516
6.077ValVal: 6.077 ± 0.561
0.84ValTrp: 0.84 ± 0.26
1.532ValTyr: 1.532 ± 0.254
0.0ValXaa: 0.0 ± 0.0
Trp
1.383TrpAla: 1.383 ± 0.295
0.593TrpCys: 0.593 ± 0.162
1.729TrpAsp: 1.729 ± 0.25
1.581TrpGlu: 1.581 ± 0.301
0.494TrpPhe: 0.494 ± 0.159
1.729TrpGly: 1.729 ± 0.286
0.84TrpHis: 0.84 ± 0.251
0.642TrpIle: 0.642 ± 0.2
0.791TrpLys: 0.791 ± 0.193
1.976TrpLeu: 1.976 ± 0.347
0.791TrpMet: 0.791 ± 0.174
0.692TrpAsn: 0.692 ± 0.138
0.791TrpPro: 0.791 ± 0.189
0.939TrpGln: 0.939 ± 0.215
1.334TrpArg: 1.334 ± 0.282
1.383TrpSer: 1.383 ± 0.269
1.433TrpThr: 1.433 ± 0.275
1.877TrpVal: 1.877 ± 0.336
0.642TrpTrp: 0.642 ± 0.169
0.741TrpTyr: 0.741 ± 0.197
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.421TyrAla: 2.421 ± 0.383
0.296TyrCys: 0.296 ± 0.129
1.877TyrAsp: 1.877 ± 0.299
2.174TyrGlu: 2.174 ± 0.369
0.84TyrPhe: 0.84 ± 0.24
2.52TyrGly: 2.52 ± 0.378
0.543TyrHis: 0.543 ± 0.206
1.285TyrIle: 1.285 ± 0.27
0.642TyrLys: 0.642 ± 0.223
1.877TyrLeu: 1.877 ± 0.404
0.741TyrMet: 0.741 ± 0.16
0.988TyrAsn: 0.988 ± 0.195
1.285TyrPro: 1.285 ± 0.313
0.939TyrGln: 0.939 ± 0.215
1.334TyrArg: 1.334 ± 0.271
1.532TyrSer: 1.532 ± 0.319
1.532TyrThr: 1.532 ± 0.238
1.976TyrVal: 1.976 ± 0.282
1.038TyrTrp: 1.038 ± 0.245
0.939TyrTyr: 0.939 ± 0.194
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 108 proteins (20241 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski