Amino acid dipepetide frequency for Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.348AlaAla: 15.348 ± 0.149
1.415AlaCys: 1.415 ± 0.037
5.897AlaAsp: 5.897 ± 0.061
5.625AlaGlu: 5.625 ± 0.069
3.888AlaPhe: 3.888 ± 0.045
9.551AlaGly: 9.551 ± 0.083
2.568AlaHis: 2.568 ± 0.05
5.469AlaIle: 5.469 ± 0.062
4.423AlaLys: 4.423 ± 0.073
14.293AlaLeu: 14.293 ± 0.129
3.525AlaMet: 3.525 ± 0.053
3.152AlaAsn: 3.152 ± 0.053
5.37AlaPro: 5.37 ± 0.088
6.124AlaGln: 6.124 ± 0.087
7.641AlaArg: 7.641 ± 0.085
6.961AlaSer: 6.961 ± 0.081
6.097AlaThr: 6.097 ± 0.076
8.701AlaVal: 8.701 ± 0.081
1.715AlaTrp: 1.715 ± 0.037
2.462AlaTyr: 2.462 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.205CysAla: 1.205 ± 0.032
0.12CysCys: 0.12 ± 0.01
0.576CysAsp: 0.576 ± 0.019
0.553CysGlu: 0.553 ± 0.019
0.338CysPhe: 0.338 ± 0.016
0.985CysGly: 0.985 ± 0.03
0.395CysHis: 0.395 ± 0.027
0.481CysIle: 0.481 ± 0.02
0.304CysLys: 0.304 ± 0.015
0.975CysLeu: 0.975 ± 0.026
0.227CysMet: 0.227 ± 0.013
0.307CysAsn: 0.307 ± 0.016
0.543CysPro: 0.543 ± 0.022
0.377CysGln: 0.377 ± 0.016
0.566CysArg: 0.566 ± 0.019
0.617CysSer: 0.617 ± 0.022
0.525CysThr: 0.525 ± 0.02
0.792CysVal: 0.792 ± 0.026
0.132CysTrp: 0.132 ± 0.011
0.233CysTyr: 0.233 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.491AspAla: 6.491 ± 0.067
0.534AspCys: 0.534 ± 0.022
2.596AspAsp: 2.596 ± 0.05
3.059AspGlu: 3.059 ± 0.056
2.111AspPhe: 2.111 ± 0.04
4.078AspGly: 4.078 ± 0.059
1.061AspHis: 1.061 ± 0.027
2.661AspIle: 2.661 ± 0.046
1.999AspLys: 1.999 ± 0.038
5.475AspLeu: 5.475 ± 0.073
1.258AspMet: 1.258 ± 0.026
1.325AspAsn: 1.325 ± 0.031
2.658AspPro: 2.658 ± 0.037
1.855AspGln: 1.855 ± 0.032
2.768AspArg: 2.768 ± 0.046
2.551AspSer: 2.551 ± 0.044
2.503AspThr: 2.503 ± 0.047
3.959AspVal: 3.959 ± 0.047
0.953AspTrp: 0.953 ± 0.022
1.402AspTyr: 1.402 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
5.974GluAla: 5.974 ± 0.076
0.402GluCys: 0.402 ± 0.019
2.065GluAsp: 2.065 ± 0.038
2.404GluGlu: 2.404 ± 0.05
1.959GluPhe: 1.959 ± 0.039
3.272GluGly: 3.272 ± 0.055
1.294GluHis: 1.294 ± 0.032
2.88GluIle: 2.88 ± 0.049
2.231GluLys: 2.231 ± 0.046
6.011GluLeu: 6.011 ± 0.083
1.281GluMet: 1.281 ± 0.032
1.432GluAsn: 1.432 ± 0.031
2.381GluPro: 2.381 ± 0.044
2.571GluGln: 2.571 ± 0.044
3.951GluArg: 3.951 ± 0.058
2.708GluSer: 2.708 ± 0.047
2.55GluThr: 2.55 ± 0.039
4.002GluVal: 4.002 ± 0.058
0.613GluTrp: 0.613 ± 0.024
0.964GluTyr: 0.964 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
4.159PheAla: 4.159 ± 0.058
0.442PheCys: 0.442 ± 0.019
2.574PheAsp: 2.574 ± 0.049
2.225PheGlu: 2.225 ± 0.037
1.464PhePhe: 1.464 ± 0.037
3.384PheGly: 3.384 ± 0.057
0.709PheHis: 0.709 ± 0.021
1.677PheIle: 1.677 ± 0.033
1.538PheLys: 1.538 ± 0.035
3.199PheLeu: 3.199 ± 0.053
0.923PheMet: 0.923 ± 0.027
1.28PheAsn: 1.28 ± 0.031
1.435PhePro: 1.435 ± 0.03
1.134PheGln: 1.134 ± 0.028
1.794PheArg: 1.794 ± 0.033
2.432PheSer: 2.432 ± 0.044
1.927PheThr: 1.927 ± 0.034
2.828PheVal: 2.828 ± 0.048
0.514PheTrp: 0.514 ± 0.024
0.945PheTyr: 0.945 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
8.684GlyAla: 8.684 ± 0.078
0.939GlyCys: 0.939 ± 0.029
3.722GlyAsp: 3.722 ± 0.072
3.997GlyGlu: 3.997 ± 0.053
3.243GlyPhe: 3.243 ± 0.048
6.326GlyGly: 6.326 ± 0.103
1.881GlyHis: 1.881 ± 0.036
4.122GlyIle: 4.122 ± 0.056
3.552GlyLys: 3.552 ± 0.059
8.928GlyLeu: 8.928 ± 0.09
2.231GlyMet: 2.231 ± 0.04
2.218GlyAsn: 2.218 ± 0.056
2.752GlyPro: 2.752 ± 0.048
3.498GlyGln: 3.498 ± 0.061
4.691GlyArg: 4.691 ± 0.062
4.592GlySer: 4.592 ± 0.074
4.162GlyThr: 4.162 ± 0.073
6.588GlyVal: 6.588 ± 0.071
1.277GlyTrp: 1.277 ± 0.033
2.29GlyTyr: 2.29 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.527HisAla: 2.527 ± 0.044
0.314HisCys: 0.314 ± 0.014
1.175HisAsp: 1.175 ± 0.028
1.152HisGlu: 1.152 ± 0.027
0.938HisPhe: 0.938 ± 0.023
2.013HisGly: 2.013 ± 0.044
0.597HisHis: 0.597 ± 0.02
1.017HisIle: 1.017 ± 0.027
0.7HisLys: 0.7 ± 0.021
2.274HisLeu: 2.274 ± 0.043
0.534HisMet: 0.534 ± 0.02
0.556HisAsn: 0.556 ± 0.02
1.434HisPro: 1.434 ± 0.032
0.903HisGln: 0.903 ± 0.022
1.324HisArg: 1.324 ± 0.031
1.119HisSer: 1.119 ± 0.03
1.072HisThr: 1.072 ± 0.028
1.527HisVal: 1.527 ± 0.031
0.385HisTrp: 0.385 ± 0.015
0.634HisTyr: 0.634 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.103IleAla: 6.103 ± 0.07
0.514IleCys: 0.514 ± 0.02
3.076IleAsp: 3.076 ± 0.044
3.314IleGlu: 3.314 ± 0.05
1.599IlePhe: 1.599 ± 0.035
4.265IleGly: 4.265 ± 0.063
0.985IleHis: 0.985 ± 0.029
1.91IleIle: 1.91 ± 0.046
2.119IleLys: 2.119 ± 0.044
3.805IleLeu: 3.805 ± 0.056
0.956IleMet: 0.956 ± 0.029
1.754IleAsn: 1.754 ± 0.039
2.139IlePro: 2.139 ± 0.043
1.55IleGln: 1.55 ± 0.032
2.655IleArg: 2.655 ± 0.046
2.967IleSer: 2.967 ± 0.045
2.733IleThr: 2.733 ± 0.049
3.544IleVal: 3.544 ± 0.055
0.549IleTrp: 0.549 ± 0.017
1.114IleTyr: 1.114 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.302LysAla: 4.302 ± 0.082
0.261LysCys: 0.261 ± 0.013
1.942LysAsp: 1.942 ± 0.045
1.769LysGlu: 1.769 ± 0.038
1.209LysPhe: 1.209 ± 0.029
2.725LysGly: 2.725 ± 0.05
0.778LysHis: 0.778 ± 0.025
1.983LysIle: 1.983 ± 0.043
1.828LysLys: 1.828 ± 0.047
4.156LysLeu: 4.156 ± 0.061
1.1LysMet: 1.1 ± 0.028
1.323LysAsn: 1.323 ± 0.033
2.23LysPro: 2.23 ± 0.042
1.458LysGln: 1.458 ± 0.034
2.408LysArg: 2.408 ± 0.041
2.289LysSer: 2.289 ± 0.04
2.465LysThr: 2.465 ± 0.047
2.979LysVal: 2.979 ± 0.051
0.433LysTrp: 0.433 ± 0.018
0.829LysTyr: 0.829 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.34LeuAla: 14.34 ± 0.131
1.112LeuCys: 1.112 ± 0.027
5.835LeuAsp: 5.835 ± 0.066
5.217LeuGlu: 5.217 ± 0.071
3.608LeuPhe: 3.608 ± 0.055
8.726LeuGly: 8.726 ± 0.088
2.27LeuHis: 2.27 ± 0.046
4.903LeuIle: 4.903 ± 0.061
4.367LeuLys: 4.367 ± 0.064
11.812LeuLeu: 11.812 ± 0.12
2.828LeuMet: 2.828 ± 0.045
3.106LeuAsn: 3.106 ± 0.043
5.755LeuPro: 5.755 ± 0.069
4.678LeuGln: 4.678 ± 0.065
6.888LeuArg: 6.888 ± 0.085
6.753LeuSer: 6.753 ± 0.074
5.919LeuThr: 5.919 ± 0.064
7.834LeuVal: 7.834 ± 0.09
1.292LeuTrp: 1.292 ± 0.037
2.065LeuTyr: 2.065 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.26MetAla: 3.26 ± 0.047
0.196MetCys: 0.196 ± 0.011
1.22MetAsp: 1.22 ± 0.03
1.134MetGlu: 1.134 ± 0.03
0.754MetPhe: 0.754 ± 0.024
2.013MetGly: 2.013 ± 0.042
0.545MetHis: 0.545 ± 0.02
1.126MetIle: 1.126 ± 0.03
1.24MetLys: 1.24 ± 0.032
2.827MetLeu: 2.827 ± 0.043
0.671MetMet: 0.671 ± 0.021
0.988MetAsn: 0.988 ± 0.026
1.473MetPro: 1.473 ± 0.034
1.163MetGln: 1.163 ± 0.028
1.6MetArg: 1.6 ± 0.033
1.67MetSer: 1.67 ± 0.037
1.738MetThr: 1.738 ± 0.033
1.866MetVal: 1.866 ± 0.04
0.208MetTrp: 0.208 ± 0.012
0.413MetTyr: 0.413 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.518AsnAla: 3.518 ± 0.062
0.343AsnCys: 0.343 ± 0.014
1.481AsnAsp: 1.481 ± 0.039
1.371AsnGlu: 1.371 ± 0.03
1.156AsnPhe: 1.156 ± 0.026
2.305AsnGly: 2.305 ± 0.04
0.575AsnHis: 0.575 ± 0.022
1.464AsnIle: 1.464 ± 0.033
1.067AsnLys: 1.067 ± 0.031
2.982AsnLeu: 2.982 ± 0.05
0.721AsnMet: 0.721 ± 0.024
0.876AsnAsn: 0.876 ± 0.03
1.957AsnPro: 1.957 ± 0.038
1.18AsnGln: 1.18 ± 0.033
1.681AsnArg: 1.681 ± 0.033
1.522AsnSer: 1.522 ± 0.037
1.683AsnThr: 1.683 ± 0.038
2.077AsnVal: 2.077 ± 0.036
0.471AsnTrp: 0.471 ± 0.018
0.787AsnTyr: 0.787 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.977ProAla: 5.977 ± 0.086
0.397ProCys: 0.397 ± 0.015
2.994ProAsp: 2.994 ± 0.049
3.002ProGlu: 3.002 ± 0.047
1.769ProPhe: 1.769 ± 0.038
4.229ProGly: 4.229 ± 0.055
1.023ProHis: 1.023 ± 0.027
2.124ProIle: 2.124 ± 0.044
1.757ProLys: 1.757 ± 0.034
4.915ProLeu: 4.915 ± 0.071
1.32ProMet: 1.32 ± 0.029
1.403ProAsn: 1.403 ± 0.035
2.274ProPro: 2.274 ± 0.051
2.147ProGln: 2.147 ± 0.04
2.389ProArg: 2.389 ± 0.047
2.704ProSer: 2.704 ± 0.044
2.59ProThr: 2.59 ± 0.049
4.236ProVal: 4.236 ± 0.052
0.737ProTrp: 0.737 ± 0.021
1.103ProTyr: 1.103 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
6.015GlnAla: 6.015 ± 0.085
0.337GlnCys: 0.337 ± 0.017
1.855GlnAsp: 1.855 ± 0.034
1.82GlnGlu: 1.82 ± 0.037
1.449GlnPhe: 1.449 ± 0.032
3.167GlnGly: 3.167 ± 0.054
1.07GlnHis: 1.07 ± 0.028
2.107GlnIle: 2.107 ± 0.035
1.408GlnLys: 1.408 ± 0.034
4.624GlnLeu: 4.624 ± 0.058
1.082GlnMet: 1.082 ± 0.029
1.093GlnAsn: 1.093 ± 0.029
2.091GlnPro: 2.091 ± 0.043
2.153GlnGln: 2.153 ± 0.044
3.297GlnArg: 3.297 ± 0.055
2.38GlnSer: 2.38 ± 0.044
2.36GlnThr: 2.36 ± 0.039
3.258GlnVal: 3.258 ± 0.051
0.673GlnTrp: 0.673 ± 0.022
0.801GlnTyr: 0.801 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
6.691ArgAla: 6.691 ± 0.082
0.6ArgCys: 0.6 ± 0.023
3.249ArgAsp: 3.249 ± 0.046
3.525ArgGlu: 3.525 ± 0.055
2.522ArgPhe: 2.522 ± 0.041
4.052ArgGly: 4.052 ± 0.056
1.571ArgHis: 1.571 ± 0.039
3.266ArgIle: 3.266 ± 0.045
2.167ArgLys: 2.167 ± 0.04
7.171ArgLeu: 7.171 ± 0.082
1.723ArgMet: 1.723 ± 0.033
1.713ArgAsn: 1.713 ± 0.033
2.67ArgPro: 2.67 ± 0.048
2.895ArgGln: 2.895 ± 0.049
4.076ArgArg: 4.076 ± 0.061
3.396ArgSer: 3.396 ± 0.05
2.861ArgThr: 2.861 ± 0.046
4.716ArgVal: 4.716 ± 0.058
1.01ArgTrp: 1.01 ± 0.028
1.63ArgTyr: 1.63 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.71SerAla: 6.71 ± 0.076
0.573SerCys: 0.573 ± 0.023
2.832SerAsp: 2.832 ± 0.051
2.713SerGlu: 2.713 ± 0.046
2.251SerPhe: 2.251 ± 0.04
5.323SerGly: 5.323 ± 0.058
1.267SerHis: 1.267 ± 0.028
2.764SerIle: 2.764 ± 0.049
1.988SerLys: 1.988 ± 0.036
6.199SerLeu: 6.199 ± 0.065
1.56SerMet: 1.56 ± 0.034
1.759SerAsn: 1.759 ± 0.036
2.876SerPro: 2.876 ± 0.054
2.188SerGln: 2.188 ± 0.041
3.371SerArg: 3.371 ± 0.05
3.584SerSer: 3.584 ± 0.06
3.262SerThr: 3.262 ± 0.058
4.359SerVal: 4.359 ± 0.06
0.745SerTrp: 0.745 ± 0.022
1.381SerTyr: 1.381 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
5.894ThrAla: 5.894 ± 0.076
0.499ThrCys: 0.499 ± 0.018
2.58ThrAsp: 2.58 ± 0.045
2.556ThrGlu: 2.556 ± 0.038
1.835ThrPhe: 1.835 ± 0.032
4.727ThrGly: 4.727 ± 0.069
1.253ThrHis: 1.253 ± 0.032
2.286ThrIle: 2.286 ± 0.044
1.587ThrLys: 1.587 ± 0.04
6.695ThrLeu: 6.695 ± 0.079
1.198ThrMet: 1.198 ± 0.033
1.415ThrAsn: 1.415 ± 0.035
3.461ThrPro: 3.461 ± 0.058
2.389ThrGln: 2.389 ± 0.04
3.191ThrArg: 3.191 ± 0.053
2.998ThrSer: 2.998 ± 0.052
2.908ThrThr: 2.908 ± 0.05
4.298ThrVal: 4.298 ± 0.056
0.637ThrTrp: 0.637 ± 0.02
1.139ThrTyr: 1.139 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
9.233ValAla: 9.233 ± 0.082
0.793ValCys: 0.793 ± 0.025
3.903ValAsp: 3.903 ± 0.05
3.903ValGlu: 3.903 ± 0.056
2.868ValPhe: 2.868 ± 0.042
5.618ValGly: 5.618 ± 0.061
1.562ValHis: 1.562 ± 0.035
3.842ValIle: 3.842 ± 0.062
2.931ValLys: 2.931 ± 0.047
8.435ValLeu: 8.435 ± 0.092
2.155ValMet: 2.155 ± 0.042
2.476ValAsn: 2.476 ± 0.045
3.707ValPro: 3.707 ± 0.048
2.97ValGln: 2.97 ± 0.051
4.534ValArg: 4.534 ± 0.061
4.395ValSer: 4.395 ± 0.06
4.287ValThr: 4.287 ± 0.054
6.23ValVal: 6.23 ± 0.078
0.996ValTrp: 0.996 ± 0.03
1.624ValTyr: 1.624 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.23TrpAla: 1.23 ± 0.028
0.17TrpCys: 0.17 ± 0.012
0.611TrpAsp: 0.611 ± 0.021
0.517TrpGlu: 0.517 ± 0.02
0.562TrpPhe: 0.562 ± 0.019
0.948TrpGly: 0.948 ± 0.026
0.348TrpHis: 0.348 ± 0.017
0.686TrpIle: 0.686 ± 0.022
0.483TrpLys: 0.483 ± 0.02
2.02TrpLeu: 2.02 ± 0.045
0.386TrpMet: 0.386 ± 0.018
0.425TrpAsn: 0.425 ± 0.018
0.652TrpPro: 0.652 ± 0.026
0.808TrpGln: 0.808 ± 0.027
1.116TrpArg: 1.116 ± 0.033
0.749TrpSer: 0.749 ± 0.024
0.707TrpThr: 0.707 ± 0.021
1.007TrpVal: 1.007 ± 0.027
0.269TrpTrp: 0.269 ± 0.015
0.305TrpTyr: 0.305 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.565TyrAla: 2.565 ± 0.041
0.29TyrCys: 0.29 ± 0.014
1.116TyrAsp: 1.116 ± 0.03
1.089TyrGlu: 1.089 ± 0.026
1.061TyrPhe: 1.061 ± 0.026
1.987TyrGly: 1.987 ± 0.041
0.44TyrHis: 0.44 ± 0.02
0.882TyrIle: 0.882 ± 0.025
0.778TyrLys: 0.778 ± 0.024
2.51TyrLeu: 2.51 ± 0.043
0.427TyrMet: 0.427 ± 0.016
0.617TyrAsn: 0.617 ± 0.021
1.233TyrPro: 1.233 ± 0.031
0.998TyrGln: 0.998 ± 0.025
1.565TyrArg: 1.565 ± 0.029
1.318TyrSer: 1.318 ± 0.035
1.198TyrThr: 1.198 ± 0.028
1.661TyrVal: 1.661 ± 0.035
0.389TyrTrp: 0.389 ± 0.014
0.592TyrTyr: 0.592 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4401 proteins (1474409 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski