Amino acid dipepetide frequency for Firmicutes bacterium CAG:536

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.473AlaAla: 4.473 ± 0.123
1.629AlaCys: 1.629 ± 0.053
3.77AlaAsp: 3.77 ± 0.083
3.371AlaGlu: 3.371 ± 0.087
3.347AlaPhe: 3.347 ± 0.084
4.414AlaGly: 4.414 ± 0.086
1.565AlaHis: 1.565 ± 0.057
6.017AlaIle: 6.017 ± 0.125
5.977AlaLys: 5.977 ± 0.113
7.614AlaLeu: 7.614 ± 0.129
2.467AlaMet: 2.467 ± 0.08
3.27AlaAsn: 3.27 ± 0.091
1.663AlaPro: 1.663 ± 0.057
3.264AlaGln: 3.264 ± 0.094
2.463AlaArg: 2.463 ± 0.068
4.551AlaSer: 4.551 ± 0.101
3.448AlaThr: 3.448 ± 0.096
4.249AlaVal: 4.249 ± 0.109
0.644AlaTrp: 0.644 ± 0.037
3.214AlaTyr: 3.214 ± 0.089
0.002AlaXaa: 0.002 ± 0.002
Cys
1.228CysAla: 1.228 ± 0.054
0.27CysCys: 0.27 ± 0.024
0.963CysAsp: 0.963 ± 0.044
0.844CysGlu: 0.844 ± 0.041
0.842CysPhe: 0.842 ± 0.045
1.249CysGly: 1.249 ± 0.056
0.423CysHis: 0.423 ± 0.032
1.349CysIle: 1.349 ± 0.06
1.077CysLys: 1.077 ± 0.047
1.486CysLeu: 1.486 ± 0.056
0.574CysMet: 0.574 ± 0.034
0.624CysAsn: 0.624 ± 0.035
0.725CysPro: 0.725 ± 0.043
0.675CysGln: 0.675 ± 0.034
0.534CysArg: 0.534 ± 0.039
0.985CysSer: 0.985 ± 0.044
0.975CysThr: 0.975 ± 0.047
1.184CysVal: 1.184 ± 0.049
0.109CysTrp: 0.109 ± 0.014
0.483CysTyr: 0.483 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
4.692AspAla: 4.692 ± 0.103
1.204AspCys: 1.204 ± 0.055
3.125AspAsp: 3.125 ± 0.094
4.241AspGlu: 4.241 ± 0.106
2.972AspPhe: 2.972 ± 0.079
3.983AspGly: 3.983 ± 0.102
1.249AspHis: 1.249 ± 0.049
4.38AspIle: 4.38 ± 0.102
3.548AspLys: 3.548 ± 0.088
5.651AspLeu: 5.651 ± 0.104
1.706AspMet: 1.706 ± 0.058
1.869AspAsn: 1.869 ± 0.069
2.014AspPro: 2.014 ± 0.075
2.713AspGln: 2.713 ± 0.083
2.084AspArg: 2.084 ± 0.071
3.389AspSer: 3.389 ± 0.085
3.192AspThr: 3.192 ± 0.081
4.352AspVal: 4.352 ± 0.096
0.606AspTrp: 0.606 ± 0.037
2.835AspTyr: 2.835 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
4.998GluAla: 4.998 ± 0.099
0.789GluCys: 0.789 ± 0.042
4.157GluAsp: 4.157 ± 0.103
5.28GluGlu: 5.28 ± 0.157
2.231GluPhe: 2.231 ± 0.075
3.415GluGly: 3.415 ± 0.088
1.313GluHis: 1.313 ± 0.059
5.29GluIle: 5.29 ± 0.119
6.597GluLys: 6.597 ± 0.138
5.538GluLeu: 5.538 ± 0.118
2.469GluMet: 2.469 ± 0.071
3.975GluAsn: 3.975 ± 0.116
1.623GluPro: 1.623 ± 0.079
2.908GluGln: 2.908 ± 0.091
2.328GluArg: 2.328 ± 0.07
3.035GluSer: 3.035 ± 0.079
3.244GluThr: 3.244 ± 0.088
4.65GluVal: 4.65 ± 0.108
0.546GluTrp: 0.546 ± 0.036
2.374GluTyr: 2.374 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
3.057PheAla: 3.057 ± 0.08
0.739PheCys: 0.739 ± 0.038
3.109PheAsp: 3.109 ± 0.085
2.761PheGlu: 2.761 ± 0.078
2.044PhePhe: 2.044 ± 0.083
3.079PheGly: 3.079 ± 0.099
1.081PheHis: 1.081 ± 0.051
3.039PheIle: 3.039 ± 0.092
2.33PheLys: 2.33 ± 0.084
4.038PheLeu: 4.038 ± 0.105
1.283PheMet: 1.283 ± 0.048
1.726PheAsn: 1.726 ± 0.065
1.275PhePro: 1.275 ± 0.048
1.682PheGln: 1.682 ± 0.062
1.355PheArg: 1.355 ± 0.057
2.928PheSer: 2.928 ± 0.081
2.469PheThr: 2.469 ± 0.07
3.371PheVal: 3.371 ± 0.085
0.36PheTrp: 0.36 ± 0.029
1.784PheTyr: 1.784 ± 0.068
0.002PheXaa: 0.002 ± 0.002
Gly
4.263GlyAla: 4.263 ± 0.122
1.224GlyCys: 1.224 ± 0.049
3.003GlyAsp: 3.003 ± 0.076
2.789GlyGlu: 2.789 ± 0.074
3.063GlyPhe: 3.063 ± 0.079
3.925GlyGly: 3.925 ± 0.119
1.396GlyHis: 1.396 ± 0.053
5.586GlyIle: 5.586 ± 0.112
5.083GlyLys: 5.083 ± 0.104
6.037GlyLeu: 6.037 ± 0.111
2.247GlyMet: 2.247 ± 0.072
2.69GlyAsn: 2.69 ± 0.072
1.458GlyPro: 1.458 ± 0.05
2.586GlyGln: 2.586 ± 0.069
2.264GlyArg: 2.264 ± 0.07
3.669GlySer: 3.669 ± 0.096
3.55GlyThr: 3.55 ± 0.078
4.386GlyVal: 4.386 ± 0.096
0.59GlyTrp: 0.59 ± 0.044
3.132GlyTyr: 3.132 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.643HisAla: 1.643 ± 0.057
0.469HisCys: 0.469 ± 0.033
1.11HisAsp: 1.11 ± 0.052
1.096HisGlu: 1.096 ± 0.054
1.23HisPhe: 1.23 ± 0.046
1.547HisGly: 1.547 ± 0.06
0.626HisHis: 0.626 ± 0.034
1.615HisIle: 1.615 ± 0.052
1.319HisLys: 1.319 ± 0.051
2.042HisLeu: 2.042 ± 0.061
0.6HisMet: 0.6 ± 0.035
0.808HisAsn: 0.808 ± 0.04
1.226HisPro: 1.226 ± 0.051
0.928HisGln: 0.928 ± 0.048
0.898HisArg: 0.898 ± 0.043
1.299HisSer: 1.299 ± 0.056
1.269HisThr: 1.269 ± 0.047
1.583HisVal: 1.583 ± 0.053
0.234HisTrp: 0.234 ± 0.022
0.87HisTyr: 0.87 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.75IleAla: 5.75 ± 0.114
1.337IleCys: 1.337 ± 0.046
4.648IleAsp: 4.648 ± 0.119
5.157IleGlu: 5.157 ± 0.106
3.011IlePhe: 3.011 ± 0.093
4.948IleGly: 4.948 ± 0.113
2.03IleHis: 2.03 ± 0.072
4.632IleIle: 4.632 ± 0.134
4.028IleLys: 4.028 ± 0.1
7.139IleLeu: 7.139 ± 0.138
1.73IleMet: 1.73 ± 0.067
2.934IleAsn: 2.934 ± 0.082
3.212IlePro: 3.212 ± 0.088
3.714IleGln: 3.714 ± 0.091
2.999IleArg: 2.999 ± 0.08
4.825IleSer: 4.825 ± 0.106
3.734IleThr: 3.734 ± 0.101
5.518IleVal: 5.518 ± 0.11
0.558IleTrp: 0.558 ± 0.039
2.829IleTyr: 2.829 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
5.776LysAla: 5.776 ± 0.129
0.65LysCys: 0.65 ± 0.039
5.321LysAsp: 5.321 ± 0.111
7.649LysGlu: 7.649 ± 0.124
1.863LysPhe: 1.863 ± 0.053
4.199LysGly: 4.199 ± 0.081
1.448LysHis: 1.448 ± 0.05
4.743LysIle: 4.743 ± 0.088
7.093LysLys: 7.093 ± 0.145
4.9LysLeu: 4.9 ± 0.111
2.519LysMet: 2.519 ± 0.078
3.673LysAsn: 3.673 ± 0.09
2.145LysPro: 2.145 ± 0.07
3.111LysGln: 3.111 ± 0.078
3.077LysArg: 3.077 ± 0.093
3.442LysSer: 3.442 ± 0.085
3.84LysThr: 3.84 ± 0.098
4.978LysVal: 4.978 ± 0.1
0.544LysTrp: 0.544 ± 0.034
2.783LysTyr: 2.783 ± 0.085
0.0LysXaa: 0.0 ± 0.0
Leu
7.04LeuAla: 7.04 ± 0.127
1.577LeuCys: 1.577 ± 0.063
6.094LeuAsp: 6.094 ± 0.119
6.575LeuGlu: 6.575 ± 0.141
4.185LeuPhe: 4.185 ± 0.125
5.705LeuGly: 5.705 ± 0.134
2.062LeuHis: 2.062 ± 0.069
5.905LeuIle: 5.905 ± 0.13
6.678LeuLys: 6.678 ± 0.126
8.506LeuLeu: 8.506 ± 0.164
2.773LeuMet: 2.773 ± 0.066
4.086LeuAsn: 4.086 ± 0.1
3.184LeuPro: 3.184 ± 0.083
3.293LeuGln: 3.293 ± 0.078
3.202LeuArg: 3.202 ± 0.087
6.537LeuSer: 6.537 ± 0.128
4.281LeuThr: 4.281 ± 0.095
6.114LeuVal: 6.114 ± 0.13
0.697LeuTrp: 0.697 ± 0.041
3.325LeuTyr: 3.325 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
2.425MetAla: 2.425 ± 0.072
0.31MetCys: 0.31 ± 0.025
2.288MetAsp: 2.288 ± 0.071
2.308MetGlu: 2.308 ± 0.071
0.983MetPhe: 0.983 ± 0.05
1.963MetGly: 1.963 ± 0.062
0.725MetHis: 0.725 ± 0.041
2.262MetIle: 2.262 ± 0.069
2.554MetLys: 2.554 ± 0.067
2.322MetLeu: 2.322 ± 0.077
1.069MetMet: 1.069 ± 0.055
1.79MetAsn: 1.79 ± 0.06
1.098MetPro: 1.098 ± 0.051
1.365MetGln: 1.365 ± 0.06
1.214MetArg: 1.214 ± 0.052
1.758MetSer: 1.758 ± 0.062
1.478MetThr: 1.478 ± 0.057
2.084MetVal: 2.084 ± 0.067
0.151MetTrp: 0.151 ± 0.016
0.949MetTyr: 0.949 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.504AsnAla: 3.504 ± 0.092
0.654AsnCys: 0.654 ± 0.034
2.461AsnAsp: 2.461 ± 0.076
3.105AsnGlu: 3.105 ± 0.092
1.647AsnPhe: 1.647 ± 0.058
3.027AsnGly: 3.027 ± 0.078
1.19AsnHis: 1.19 ± 0.051
3.101AsnIle: 3.101 ± 0.083
2.954AsnLys: 2.954 ± 0.081
3.732AsnLeu: 3.732 ± 0.098
1.257AsnMet: 1.257 ± 0.045
1.853AsnAsn: 1.853 ± 0.085
2.147AsnPro: 2.147 ± 0.055
2.352AsnGln: 2.352 ± 0.071
1.881AsnArg: 1.881 ± 0.068
2.173AsnSer: 2.173 ± 0.068
2.382AsnThr: 2.382 ± 0.07
3.089AsnVal: 3.089 ± 0.068
0.427AsnTrp: 0.427 ± 0.032
1.861AsnTyr: 1.861 ± 0.075
0.0AsnXaa: 0.0 ± 0.0
Pro
1.897ProAla: 1.897 ± 0.062
0.548ProCys: 0.548 ± 0.037
2.028ProAsp: 2.028 ± 0.059
2.487ProGlu: 2.487 ± 0.077
1.667ProPhe: 1.667 ± 0.059
1.959ProGly: 1.959 ± 0.064
0.618ProHis: 0.618 ± 0.035
2.55ProIle: 2.55 ± 0.07
2.34ProLys: 2.34 ± 0.069
2.856ProLeu: 2.856 ± 0.084
0.959ProMet: 0.959 ± 0.042
1.71ProAsn: 1.71 ± 0.058
0.493ProPro: 0.493 ± 0.039
1.007ProGln: 1.007 ± 0.05
0.928ProArg: 0.928 ± 0.047
2.028ProSer: 2.028 ± 0.066
1.68ProThr: 1.68 ± 0.056
2.612ProVal: 2.612 ± 0.079
0.28ProTrp: 0.28 ± 0.022
1.478ProTyr: 1.478 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
3.873GlnAla: 3.873 ± 0.087
0.528GlnCys: 0.528 ± 0.032
2.332GlnAsp: 2.332 ± 0.071
3.577GlnGlu: 3.577 ± 0.099
1.496GlnPhe: 1.496 ± 0.054
2.461GlnGly: 2.461 ± 0.071
0.749GlnHis: 0.749 ± 0.035
3.047GlnIle: 3.047 ± 0.083
3.593GlnLys: 3.593 ± 0.092
3.552GlnLeu: 3.552 ± 0.094
1.323GlnMet: 1.323 ± 0.051
1.8GlnAsn: 1.8 ± 0.061
1.212GlnPro: 1.212 ± 0.058
1.524GlnGln: 1.524 ± 0.067
1.738GlnArg: 1.738 ± 0.066
2.394GlnSer: 2.394 ± 0.068
2.396GlnThr: 2.396 ± 0.075
2.781GlnVal: 2.781 ± 0.078
0.453GlnTrp: 0.453 ± 0.031
1.557GlnTyr: 1.557 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
2.135ArgAla: 2.135 ± 0.072
0.564ArgCys: 0.564 ± 0.032
1.865ArgAsp: 1.865 ± 0.069
2.27ArgGlu: 2.27 ± 0.068
1.905ArgPhe: 1.905 ± 0.064
1.877ArgGly: 1.877 ± 0.059
0.737ArgHis: 0.737 ± 0.035
3.136ArgIle: 3.136 ± 0.085
3.182ArgLys: 3.182 ± 0.096
3.593ArgLeu: 3.593 ± 0.079
1.345ArgMet: 1.345 ± 0.053
1.847ArgAsn: 1.847 ± 0.061
1.148ArgPro: 1.148 ± 0.057
1.563ArgGln: 1.563 ± 0.051
1.466ArgArg: 1.466 ± 0.063
2.02ArgSer: 2.02 ± 0.061
1.758ArgThr: 1.758 ± 0.052
2.403ArgVal: 2.403 ± 0.075
0.324ArgTrp: 0.324 ± 0.028
1.611ArgTyr: 1.611 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
3.583SerAla: 3.583 ± 0.087
0.955SerCys: 0.955 ± 0.049
3.262SerAsp: 3.262 ± 0.088
3.508SerGlu: 3.508 ± 0.088
3.031SerPhe: 3.031 ± 0.08
3.891SerGly: 3.891 ± 0.099
1.323SerHis: 1.323 ± 0.052
4.976SerIle: 4.976 ± 0.116
4.142SerLys: 4.142 ± 0.096
6.126SerLeu: 6.126 ± 0.115
1.869SerMet: 1.869 ± 0.057
2.745SerAsn: 2.745 ± 0.082
1.545SerPro: 1.545 ± 0.052
2.646SerGln: 2.646 ± 0.079
2.133SerArg: 2.133 ± 0.078
3.838SerSer: 3.838 ± 0.11
3.059SerThr: 3.059 ± 0.095
3.919SerVal: 3.919 ± 0.092
0.477SerTrp: 0.477 ± 0.031
2.374SerTyr: 2.374 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
2.936ThrAla: 2.936 ± 0.087
0.88ThrCys: 0.88 ± 0.044
2.723ThrAsp: 2.723 ± 0.074
2.515ThrGlu: 2.515 ± 0.076
2.405ThrPhe: 2.405 ± 0.063
3.665ThrGly: 3.665 ± 0.087
1.128ThrHis: 1.128 ± 0.044
4.779ThrIle: 4.779 ± 0.11
3.871ThrLys: 3.871 ± 0.089
5.123ThrLeu: 5.123 ± 0.1
1.569ThrMet: 1.569 ± 0.06
2.37ThrAsn: 2.37 ± 0.066
1.891ThrPro: 1.891 ± 0.059
1.829ThrGln: 1.829 ± 0.071
1.647ThrArg: 1.647 ± 0.066
3.303ThrSer: 3.303 ± 0.082
2.638ThrThr: 2.638 ± 0.086
3.571ThrVal: 3.571 ± 0.09
0.491ThrTrp: 0.491 ± 0.038
2.288ThrTyr: 2.288 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
4.787ValAla: 4.787 ± 0.127
1.442ValCys: 1.442 ± 0.05
4.42ValAsp: 4.42 ± 0.095
4.443ValGlu: 4.443 ± 0.099
3.162ValPhe: 3.162 ± 0.081
4.422ValGly: 4.422 ± 0.107
1.512ValHis: 1.512 ± 0.051
4.876ValIle: 4.876 ± 0.091
4.324ValLys: 4.324 ± 0.084
7.129ValLeu: 7.129 ± 0.142
1.903ValMet: 1.903 ± 0.076
2.831ValAsn: 2.831 ± 0.076
2.266ValPro: 2.266 ± 0.075
2.769ValGln: 2.769 ± 0.073
2.479ValArg: 2.479 ± 0.079
4.519ValSer: 4.519 ± 0.103
3.474ValThr: 3.474 ± 0.09
5.063ValVal: 5.063 ± 0.107
0.526ValTrp: 0.526 ± 0.033
2.69ValTyr: 2.69 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.461TrpAla: 0.461 ± 0.028
0.131TrpCys: 0.131 ± 0.016
0.51TrpAsp: 0.51 ± 0.029
0.375TrpGlu: 0.375 ± 0.029
0.467TrpPhe: 0.467 ± 0.034
0.441TrpGly: 0.441 ± 0.033
0.213TrpHis: 0.213 ± 0.019
0.858TrpIle: 0.858 ± 0.042
0.671TrpLys: 0.671 ± 0.038
0.808TrpLeu: 0.808 ± 0.036
0.354TrpMet: 0.354 ± 0.027
0.451TrpAsn: 0.451 ± 0.029
0.213TrpPro: 0.213 ± 0.021
0.447TrpGln: 0.447 ± 0.032
0.248TrpArg: 0.248 ± 0.022
0.437TrpSer: 0.437 ± 0.033
0.417TrpThr: 0.417 ± 0.028
0.534TrpVal: 0.534 ± 0.03
0.087TrpTrp: 0.087 ± 0.016
0.308TrpTyr: 0.308 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.894TyrAla: 2.894 ± 0.077
0.697TyrCys: 0.697 ± 0.04
2.62TyrAsp: 2.62 ± 0.081
2.413TyrGlu: 2.413 ± 0.075
1.961TyrPhe: 1.961 ± 0.061
2.771TyrGly: 2.771 ± 0.076
1.023TyrHis: 1.023 ± 0.051
2.592TyrIle: 2.592 ± 0.066
2.394TyrLys: 2.394 ± 0.078
3.625TyrLeu: 3.625 ± 0.085
1.077TyrMet: 1.077 ± 0.051
1.744TyrAsn: 1.744 ± 0.059
1.585TyrPro: 1.585 ± 0.057
2.012TyrGln: 2.012 ± 0.079
1.808TyrArg: 1.808 ± 0.055
2.272TyrSer: 2.272 ± 0.066
2.336TyrThr: 2.336 ± 0.069
2.596TyrVal: 2.596 ± 0.067
0.326TyrTrp: 0.326 ± 0.025
1.849TyrTyr: 1.849 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.002XaaPro: 0.002 ± 0.002
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.006XaaXaa: 0.006 ± 0.004
Statistics based on 1621 proteins (496565 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski