Amino acid dipepetide frequency for Candidatus Acidianus copahuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.974AlaAla: 2.974 ± 0.097
0.394AlaCys: 0.394 ± 0.027
2.431AlaAsp: 2.431 ± 0.068
3.686AlaGlu: 3.686 ± 0.095
2.859AlaPhe: 2.859 ± 0.072
3.995AlaGly: 3.995 ± 0.087
0.78AlaHis: 0.78 ± 0.035
6.118AlaIle: 6.118 ± 0.109
4.252AlaLys: 4.252 ± 0.095
6.302AlaLeu: 6.302 ± 0.13
1.495AlaMet: 1.495 ± 0.056
2.033AlaAsn: 2.033 ± 0.062
1.573AlaPro: 1.573 ± 0.054
1.204AlaGln: 1.204 ± 0.048
2.385AlaArg: 2.385 ± 0.069
4.244AlaSer: 4.244 ± 0.087
2.707AlaThr: 2.707 ± 0.065
4.338AlaVal: 4.338 ± 0.087
0.6AlaTrp: 0.6 ± 0.032
2.567AlaTyr: 2.567 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.294CysAla: 0.294 ± 0.024
0.085CysCys: 0.085 ± 0.011
0.343CysAsp: 0.343 ± 0.025
0.429CysGlu: 0.429 ± 0.024
0.189CysPhe: 0.189 ± 0.018
0.7CysGly: 0.7 ± 0.041
0.103CysHis: 0.103 ± 0.012
0.443CysIle: 0.443 ± 0.025
0.486CysLys: 0.486 ± 0.033
0.452CysLeu: 0.452 ± 0.029
0.128CysMet: 0.128 ± 0.014
0.352CysAsn: 0.352 ± 0.024
0.577CysPro: 0.577 ± 0.034
0.132CysGln: 0.132 ± 0.015
0.258CysArg: 0.258 ± 0.021
0.415CysSer: 0.415 ± 0.026
0.298CysThr: 0.298 ± 0.024
0.354CysVal: 0.354 ± 0.022
0.072CysTrp: 0.072 ± 0.012
0.251CysTyr: 0.251 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
2.441AspAla: 2.441 ± 0.064
0.324AspCys: 0.324 ± 0.024
2.164AspAsp: 2.164 ± 0.068
3.986AspGlu: 3.986 ± 0.095
2.347AspPhe: 2.347 ± 0.057
2.92AspGly: 2.92 ± 0.077
0.575AspHis: 0.575 ± 0.029
5.018AspIle: 5.018 ± 0.09
3.611AspLys: 3.611 ± 0.073
5.227AspLeu: 5.227 ± 0.093
1.173AspMet: 1.173 ± 0.04
1.962AspAsn: 1.962 ± 0.058
2.373AspPro: 2.373 ± 0.063
1.064AspGln: 1.064 ± 0.043
1.907AspArg: 1.907 ± 0.053
2.927AspSer: 2.927 ± 0.069
1.865AspThr: 1.865 ± 0.052
4.051AspVal: 4.051 ± 0.089
0.526AspTrp: 0.526 ± 0.029
2.348AspTyr: 2.348 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
3.991GluAla: 3.991 ± 0.085
0.391GluCys: 0.391 ± 0.027
3.568GluAsp: 3.568 ± 0.082
6.328GluGlu: 6.328 ± 0.139
2.727GluPhe: 2.727 ± 0.06
4.757GluGly: 4.757 ± 0.103
0.701GluHis: 0.701 ± 0.03
7.262GluIle: 7.262 ± 0.126
6.654GluLys: 6.654 ± 0.127
6.258GluLeu: 6.258 ± 0.103
1.779GluMet: 1.779 ± 0.061
3.277GluAsn: 3.277 ± 0.072
1.807GluPro: 1.807 ± 0.051
1.213GluGln: 1.213 ± 0.047
3.485GluArg: 3.485 ± 0.084
3.429GluSer: 3.429 ± 0.084
2.491GluThr: 2.491 ± 0.054
5.735GluVal: 5.735 ± 0.099
0.674GluTrp: 0.674 ± 0.034
2.517GluTyr: 2.517 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
2.541PheAla: 2.541 ± 0.077
0.268PheCys: 0.268 ± 0.019
2.211PheAsp: 2.211 ± 0.059
2.093PheGlu: 2.093 ± 0.057
2.381PhePhe: 2.381 ± 0.074
2.925PheGly: 2.925 ± 0.082
0.717PheHis: 0.717 ± 0.032
3.849PheIle: 3.849 ± 0.072
2.797PheLys: 2.797 ± 0.067
5.244PheLeu: 5.244 ± 0.121
1.138PheMet: 1.138 ± 0.045
2.341PheAsn: 2.341 ± 0.066
2.133PhePro: 2.133 ± 0.051
0.953PheGln: 0.953 ± 0.037
1.638PheArg: 1.638 ± 0.054
4.604PheSer: 4.604 ± 0.103
2.47PheThr: 2.47 ± 0.072
2.831PheVal: 2.831 ± 0.071
0.509PheTrp: 0.509 ± 0.032
2.193PheTyr: 2.193 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
3.216GlyAla: 3.216 ± 0.091
0.483GlyCys: 0.483 ± 0.027
3.306GlyAsp: 3.306 ± 0.082
4.735GlyGlu: 4.735 ± 0.089
3.545GlyPhe: 3.545 ± 0.065
4.906GlyGly: 4.906 ± 0.112
1.026GlyHis: 1.026 ± 0.04
8.151GlyIle: 8.151 ± 0.116
6.556GlyLys: 6.556 ± 0.112
6.461GlyLeu: 6.461 ± 0.115
1.707GlyMet: 1.707 ± 0.057
3.249GlyAsn: 3.249 ± 0.076
1.782GlyPro: 1.782 ± 0.052
1.27GlyGln: 1.27 ± 0.052
2.874GlyArg: 2.874 ± 0.068
4.635GlySer: 4.635 ± 0.09
3.293GlyThr: 3.293 ± 0.075
4.89GlyVal: 4.89 ± 0.087
0.801GlyTrp: 0.801 ± 0.04
3.408GlyTyr: 3.408 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
0.777HisAla: 0.777 ± 0.036
0.115HisCys: 0.115 ± 0.012
0.563HisAsp: 0.563 ± 0.03
0.823HisGlu: 0.823 ± 0.033
0.674HisPhe: 0.674 ± 0.037
1.156HisGly: 1.156 ± 0.038
0.283HisHis: 0.283 ± 0.022
0.96HisIle: 0.96 ± 0.041
0.655HisLys: 0.655 ± 0.037
1.143HisLeu: 1.143 ± 0.039
0.286HisMet: 0.286 ± 0.02
0.487HisAsn: 0.487 ± 0.026
0.757HisPro: 0.757 ± 0.032
0.252HisGln: 0.252 ± 0.021
0.544HisArg: 0.544 ± 0.028
0.901HisSer: 0.901 ± 0.034
0.563HisThr: 0.563 ± 0.029
1.067HisVal: 1.067 ± 0.04
0.132HisTrp: 0.132 ± 0.014
0.572HisTyr: 0.572 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.221IleAla: 6.221 ± 0.11
0.498IleCys: 0.498 ± 0.025
4.863IleAsp: 4.863 ± 0.101
5.796IleGlu: 5.796 ± 0.105
4.086IlePhe: 4.086 ± 0.093
6.421IleGly: 6.421 ± 0.128
1.198IleHis: 1.198 ± 0.047
8.414IleIle: 8.414 ± 0.135
6.559IleLys: 6.559 ± 0.112
8.81IleLeu: 8.81 ± 0.134
2.211IleMet: 2.211 ± 0.054
4.297IleAsn: 4.297 ± 0.079
4.42IlePro: 4.42 ± 0.086
1.855IleGln: 1.855 ± 0.057
4.12IleArg: 4.12 ± 0.079
8.404IleSer: 8.404 ± 0.132
4.689IleThr: 4.689 ± 0.086
6.587IleVal: 6.587 ± 0.083
0.737IleTrp: 0.737 ± 0.03
3.866IleTyr: 3.866 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
4.331LysAla: 4.331 ± 0.097
0.529LysCys: 0.529 ± 0.033
4.406LysAsp: 4.406 ± 0.091
7.048LysGlu: 7.048 ± 0.12
2.705LysPhe: 2.705 ± 0.068
5.475LysGly: 5.475 ± 0.095
0.64LysHis: 0.64 ± 0.032
7.332LysIle: 7.332 ± 0.126
5.605LysLys: 5.605 ± 0.105
6.828LysLeu: 6.828 ± 0.109
1.872LysMet: 1.872 ± 0.055
3.193LysAsn: 3.193 ± 0.067
2.407LysPro: 2.407 ± 0.066
1.409LysGln: 1.409 ± 0.049
3.891LysArg: 3.891 ± 0.089
4.017LysSer: 4.017 ± 0.078
3.253LysThr: 3.253 ± 0.065
6.767LysVal: 6.767 ± 0.122
0.832LysTrp: 0.832 ± 0.042
3.062LysTyr: 3.062 ± 0.079
0.0LysXaa: 0.0 ± 0.0
Leu
6.428LeuAla: 6.428 ± 0.117
0.543LeuCys: 0.543 ± 0.032
5.03LeuAsp: 5.03 ± 0.104
6.171LeuGlu: 6.171 ± 0.104
4.371LeuPhe: 4.371 ± 0.103
7.734LeuGly: 7.734 ± 0.116
1.241LeuHis: 1.241 ± 0.048
8.335LeuIle: 8.335 ± 0.152
7.276LeuLys: 7.276 ± 0.113
9.212LeuLeu: 9.212 ± 0.151
2.388LeuMet: 2.388 ± 0.06
4.554LeuAsn: 4.554 ± 0.082
3.995LeuPro: 3.995 ± 0.084
2.219LeuGln: 2.219 ± 0.068
4.727LeuArg: 4.727 ± 0.09
8.161LeuSer: 8.161 ± 0.14
4.787LeuThr: 4.787 ± 0.094
6.525LeuVal: 6.525 ± 0.119
0.861LeuTrp: 0.861 ± 0.039
3.677LeuTyr: 3.677 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.664MetAla: 1.664 ± 0.056
0.12MetCys: 0.12 ± 0.011
1.275MetAsp: 1.275 ± 0.043
1.893MetGlu: 1.893 ± 0.052
0.866MetPhe: 0.866 ± 0.035
1.805MetGly: 1.805 ± 0.056
0.277MetHis: 0.277 ± 0.018
2.231MetIle: 2.231 ± 0.063
2.205MetLys: 2.205 ± 0.06
2.091MetLeu: 2.091 ± 0.054
0.623MetMet: 0.623 ± 0.034
1.11MetAsn: 1.11 ± 0.041
0.91MetPro: 0.91 ± 0.04
0.491MetGln: 0.491 ± 0.027
1.375MetArg: 1.375 ± 0.048
1.785MetSer: 1.785 ± 0.053
1.093MetThr: 1.093 ± 0.042
1.433MetVal: 1.433 ± 0.052
0.26MetTrp: 0.26 ± 0.019
0.77MetTyr: 0.77 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.654AsnAla: 2.654 ± 0.063
0.377AsnCys: 0.377 ± 0.023
1.982AsnAsp: 1.982 ± 0.057
2.963AsnGlu: 2.963 ± 0.076
2.278AsnPhe: 2.278 ± 0.05
3.237AsnGly: 3.237 ± 0.083
0.426AsnHis: 0.426 ± 0.025
3.855AsnIle: 3.855 ± 0.075
2.922AsnLys: 2.922 ± 0.061
4.61AsnLeu: 4.61 ± 0.081
1.035AsnMet: 1.035 ± 0.038
2.002AsnAsn: 2.002 ± 0.063
2.334AsnPro: 2.334 ± 0.067
0.977AsnGln: 0.977 ± 0.04
1.616AsnArg: 1.616 ± 0.052
3.376AsnSer: 3.376 ± 0.085
1.887AsnThr: 1.887 ± 0.064
3.785AsnVal: 3.785 ± 0.09
0.494AsnTrp: 0.494 ± 0.031
2.155AsnTyr: 2.155 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
1.984ProAla: 1.984 ± 0.05
0.24ProCys: 0.24 ± 0.02
1.79ProAsp: 1.79 ± 0.052
2.805ProGlu: 2.805 ± 0.071
2.142ProPhe: 2.142 ± 0.063
2.601ProGly: 2.601 ± 0.079
0.592ProHis: 0.592 ± 0.034
3.429ProIle: 3.429 ± 0.074
2.605ProLys: 2.605 ± 0.061
4.054ProLeu: 4.054 ± 0.084
0.783ProMet: 0.783 ± 0.037
1.73ProAsn: 1.73 ± 0.051
1.787ProPro: 1.787 ± 0.059
1.064ProGln: 1.064 ± 0.045
1.576ProArg: 1.576 ± 0.051
3.116ProSer: 3.116 ± 0.072
2.121ProThr: 2.121 ± 0.052
2.883ProVal: 2.883 ± 0.072
0.537ProTrp: 0.537 ± 0.029
2.002ProTyr: 2.002 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
1.224GlnAla: 1.224 ± 0.047
0.123GlnCys: 0.123 ± 0.015
1.033GlnAsp: 1.033 ± 0.04
1.567GlnGlu: 1.567 ± 0.049
0.881GlnPhe: 0.881 ± 0.039
1.761GlnGly: 1.761 ± 0.05
0.251GlnHis: 0.251 ± 0.02
1.916GlnIle: 1.916 ± 0.054
1.596GlnLys: 1.596 ± 0.052
1.995GlnLeu: 1.995 ± 0.063
0.554GlnMet: 0.554 ± 0.027
0.921GlnAsn: 0.921 ± 0.038
0.76GlnPro: 0.76 ± 0.035
0.6GlnGln: 0.6 ± 0.028
0.972GlnArg: 0.972 ± 0.043
1.169GlnSer: 1.169 ± 0.046
0.903GlnThr: 0.903 ± 0.034
1.739GlnVal: 1.739 ± 0.054
0.22GlnTrp: 0.22 ± 0.018
0.907GlnTyr: 0.907 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.141ArgAla: 2.141 ± 0.065
0.288ArgCys: 0.288 ± 0.023
2.347ArgAsp: 2.347 ± 0.058
3.817ArgGlu: 3.817 ± 0.081
1.741ArgPhe: 1.741 ± 0.055
3.222ArgGly: 3.222 ± 0.077
0.558ArgHis: 0.558 ± 0.025
3.891ArgIle: 3.891 ± 0.082
4.055ArgLys: 4.055 ± 0.087
4.229ArgLeu: 4.229 ± 0.098
0.987ArgMet: 0.987 ± 0.041
1.93ArgAsn: 1.93 ± 0.052
1.429ArgPro: 1.429 ± 0.044
0.92ArgGln: 0.92 ± 0.037
2.497ArgArg: 2.497 ± 0.077
2.725ArgSer: 2.725 ± 0.063
2.021ArgThr: 2.021 ± 0.058
3.254ArgVal: 3.254 ± 0.073
0.446ArgTrp: 0.446 ± 0.024
1.653ArgTyr: 1.653 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.843SerAla: 3.843 ± 0.09
0.458SerCys: 0.458 ± 0.029
2.997SerAsp: 2.997 ± 0.082
4.154SerGlu: 4.154 ± 0.085
3.82SerPhe: 3.82 ± 0.089
4.855SerGly: 4.855 ± 0.1
1.01SerHis: 1.01 ± 0.04
6.602SerIle: 6.602 ± 0.112
5.126SerLys: 5.126 ± 0.095
8.503SerLeu: 8.503 ± 0.151
1.924SerMet: 1.924 ± 0.062
3.096SerAsn: 3.096 ± 0.075
3.328SerPro: 3.328 ± 0.081
1.85SerGln: 1.85 ± 0.06
3.114SerArg: 3.114 ± 0.07
6.723SerSer: 6.723 ± 0.124
3.8SerThr: 3.8 ± 0.08
4.541SerVal: 4.541 ± 0.084
0.91SerTrp: 0.91 ± 0.04
3.056SerTyr: 3.056 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
2.879ThrAla: 2.879 ± 0.074
0.328ThrCys: 0.328 ± 0.022
1.996ThrAsp: 1.996 ± 0.052
2.519ThrGlu: 2.519 ± 0.066
2.414ThrPhe: 2.414 ± 0.072
3.426ThrGly: 3.426 ± 0.081
0.697ThrHis: 0.697 ± 0.033
4.364ThrIle: 4.364 ± 0.099
2.814ThrLys: 2.814 ± 0.07
4.906ThrLeu: 4.906 ± 0.096
1.16ThrMet: 1.16 ± 0.043
1.905ThrAsn: 1.905 ± 0.063
2.316ThrPro: 2.316 ± 0.07
1.08ThrGln: 1.08 ± 0.044
1.905ThrArg: 1.905 ± 0.056
3.78ThrSer: 3.78 ± 0.079
2.759ThrThr: 2.759 ± 0.084
3.523ThrVal: 3.523 ± 0.077
0.546ThrTrp: 0.546 ± 0.027
2.111ThrTyr: 2.111 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
4.157ValAla: 4.157 ± 0.08
0.415ValCys: 0.415 ± 0.027
3.902ValAsp: 3.902 ± 0.078
5.095ValGlu: 5.095 ± 0.094
3.05ValPhe: 3.05 ± 0.082
4.7ValGly: 4.7 ± 0.094
0.96ValHis: 0.96 ± 0.039
7.319ValIle: 7.319 ± 0.101
6.382ValLys: 6.382 ± 0.115
6.594ValLeu: 6.594 ± 0.108
1.782ValMet: 1.782 ± 0.052
3.785ValAsn: 3.785 ± 0.088
2.882ValPro: 2.882 ± 0.074
1.396ValGln: 1.396 ± 0.046
3.142ValArg: 3.142 ± 0.069
5.172ValSer: 5.172 ± 0.087
3.742ValThr: 3.742 ± 0.079
5.267ValVal: 5.267 ± 0.089
0.591ValTrp: 0.591 ± 0.028
3.082ValTyr: 3.082 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.612TrpAla: 0.612 ± 0.033
0.06TrpCys: 0.06 ± 0.009
0.52TrpAsp: 0.52 ± 0.027
0.689TrpGlu: 0.689 ± 0.034
0.5TrpPhe: 0.5 ± 0.029
0.701TrpGly: 0.701 ± 0.031
0.151TrpHis: 0.151 ± 0.014
1.044TrpIle: 1.044 ± 0.045
0.944TrpLys: 0.944 ± 0.039
1.01TrpLeu: 1.01 ± 0.042
0.249TrpMet: 0.249 ± 0.02
0.557TrpAsn: 0.557 ± 0.031
0.277TrpPro: 0.277 ± 0.022
0.189TrpGln: 0.189 ± 0.018
0.518TrpArg: 0.518 ± 0.029
0.658TrpSer: 0.658 ± 0.031
0.503TrpThr: 0.503 ± 0.029
0.571TrpVal: 0.571 ± 0.031
0.138TrpTrp: 0.138 ± 0.017
0.471TrpTyr: 0.471 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.568TyrAla: 2.568 ± 0.061
0.323TyrCys: 0.323 ± 0.024
2.082TyrAsp: 2.082 ± 0.058
2.447TyrGlu: 2.447 ± 0.06
2.262TyrPhe: 2.262 ± 0.062
2.997TyrGly: 2.997 ± 0.071
0.526TyrHis: 0.526 ± 0.028
3.517TyrIle: 3.517 ± 0.082
2.497TyrLys: 2.497 ± 0.063
4.308TyrLeu: 4.308 ± 0.094
1.004TyrMet: 1.004 ± 0.04
2.184TyrAsn: 2.184 ± 0.057
1.995TyrPro: 1.995 ± 0.063
0.953TyrGln: 0.953 ± 0.042
1.604TyrArg: 1.604 ± 0.052
3.468TyrSer: 3.468 ± 0.093
2.185TyrThr: 2.185 ± 0.056
3.271TyrVal: 3.271 ± 0.088
0.477TyrTrp: 0.477 ± 0.03
2.215TyrTyr: 2.215 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2328 proteins (650260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski