Amino acid dipepetide frequency for Dorea longicatena CAG:42

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.696AlaAla: 6.696 ± 0.143
1.169AlaCys: 1.169 ± 0.048
4.525AlaAsp: 4.525 ± 0.087
5.265AlaGlu: 5.265 ± 0.102
2.994AlaPhe: 2.994 ± 0.076
6.367AlaGly: 6.367 ± 0.115
1.228AlaHis: 1.228 ± 0.051
5.262AlaIle: 5.262 ± 0.103
5.499AlaLys: 5.499 ± 0.112
6.519AlaLeu: 6.519 ± 0.118
2.556AlaMet: 2.556 ± 0.066
2.529AlaAsn: 2.529 ± 0.065
1.915AlaPro: 1.915 ± 0.055
2.073AlaGln: 2.073 ± 0.055
2.837AlaArg: 2.837 ± 0.07
3.738AlaSer: 3.738 ± 0.087
3.237AlaThr: 3.237 ± 0.077
6.283AlaVal: 6.283 ± 0.11
0.589AlaTrp: 0.589 ± 0.036
2.768AlaTyr: 2.768 ± 0.069
0.001AlaXaa: 0.001 ± 0.002
Cys
1.05CysAla: 1.05 ± 0.038
0.265CysCys: 0.265 ± 0.024
0.764CysAsp: 0.764 ± 0.037
1.025CysGlu: 1.025 ± 0.039
0.584CysPhe: 0.584 ± 0.027
1.475CysGly: 1.475 ± 0.059
0.322CysHis: 0.322 ± 0.023
1.17CysIle: 1.17 ± 0.043
0.895CysLys: 0.895 ± 0.035
1.076CysLeu: 1.076 ± 0.044
0.517CysMet: 0.517 ± 0.03
0.559CysAsn: 0.559 ± 0.028
0.63CysPro: 0.63 ± 0.033
0.352CysGln: 0.352 ± 0.022
0.592CysArg: 0.592 ± 0.032
0.743CysSer: 0.743 ± 0.036
0.779CysThr: 0.779 ± 0.037
1.162CysVal: 1.162 ± 0.049
0.106CysTrp: 0.106 ± 0.012
0.523CysTyr: 0.523 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
4.141AspAla: 4.141 ± 0.074
0.76AspCys: 0.76 ± 0.035
3.062AspAsp: 3.062 ± 0.089
4.77AspGlu: 4.77 ± 0.091
2.282AspPhe: 2.282 ± 0.059
4.259AspGly: 4.259 ± 0.094
1.016AspHis: 1.016 ± 0.059
4.69AspIle: 4.69 ± 0.084
3.938AspLys: 3.938 ± 0.08
4.456AspLeu: 4.456 ± 0.079
2.091AspMet: 2.091 ± 0.05
2.127AspAsn: 2.127 ± 0.065
1.793AspPro: 1.793 ± 0.054
1.584AspGln: 1.584 ± 0.05
2.317AspArg: 2.317 ± 0.062
2.8AspSer: 2.8 ± 0.074
3.134AspThr: 3.134 ± 0.066
4.233AspVal: 4.233 ± 0.082
0.502AspTrp: 0.502 ± 0.032
2.747AspTyr: 2.747 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
5.619GluAla: 5.619 ± 0.11
0.916GluCys: 0.916 ± 0.04
4.649GluAsp: 4.649 ± 0.106
8.277GluGlu: 8.277 ± 0.158
2.534GluPhe: 2.534 ± 0.065
4.648GluGly: 4.648 ± 0.085
1.524GluHis: 1.524 ± 0.049
5.761GluIle: 5.761 ± 0.094
7.549GluLys: 7.549 ± 0.131
7.133GluLeu: 7.133 ± 0.111
2.572GluMet: 2.572 ± 0.059
3.926GluAsn: 3.926 ± 0.078
1.823GluPro: 1.823 ± 0.065
2.913GluGln: 2.913 ± 0.069
3.324GluArg: 3.324 ± 0.073
3.348GluSer: 3.348 ± 0.079
3.692GluThr: 3.692 ± 0.073
4.983GluVal: 4.983 ± 0.102
0.614GluTrp: 0.614 ± 0.031
3.379GluTyr: 3.379 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
2.89PheAla: 2.89 ± 0.071
0.654PheCys: 0.654 ± 0.028
2.447PheAsp: 2.447 ± 0.063
2.484PheGlu: 2.484 ± 0.064
1.584PhePhe: 1.584 ± 0.054
3.089PheGly: 3.089 ± 0.074
0.854PheHis: 0.854 ± 0.031
2.693PheIle: 2.693 ± 0.072
2.032PheLys: 2.032 ± 0.052
3.661PheLeu: 3.661 ± 0.083
1.24PheMet: 1.24 ± 0.044
1.337PheAsn: 1.337 ± 0.044
1.359PhePro: 1.359 ± 0.048
1.179PheGln: 1.179 ± 0.037
1.505PheArg: 1.505 ± 0.047
2.434PheSer: 2.434 ± 0.067
2.138PheThr: 2.138 ± 0.068
2.759PheVal: 2.759 ± 0.066
0.374PheTrp: 0.374 ± 0.024
1.538PheTyr: 1.538 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
5.216GlyAla: 5.216 ± 0.103
1.331GlyCys: 1.331 ± 0.049
3.426GlyAsp: 3.426 ± 0.076
4.855GlyGlu: 4.855 ± 0.09
3.115GlyPhe: 3.115 ± 0.071
4.924GlyGly: 4.924 ± 0.108
1.375GlyHis: 1.375 ± 0.049
6.74GlyIle: 6.74 ± 0.109
5.99GlyLys: 5.99 ± 0.122
5.836GlyLeu: 5.836 ± 0.124
2.816GlyMet: 2.816 ± 0.072
3.092GlyAsn: 3.092 ± 0.063
1.44GlyPro: 1.44 ± 0.051
2.026GlyGln: 2.026 ± 0.061
3.093GlyArg: 3.093 ± 0.073
3.764GlySer: 3.764 ± 0.077
4.555GlyThr: 4.555 ± 0.091
5.372GlyVal: 5.372 ± 0.092
0.618GlyTrp: 0.618 ± 0.041
3.282GlyTyr: 3.282 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.291HisAla: 1.291 ± 0.041
0.314HisCys: 0.314 ± 0.023
1.01HisAsp: 1.01 ± 0.044
1.126HisGlu: 1.126 ± 0.042
0.785HisPhe: 0.785 ± 0.032
1.325HisGly: 1.325 ± 0.045
0.433HisHis: 0.433 ± 0.03
1.457HisIle: 1.457 ± 0.05
1.144HisLys: 1.144 ± 0.045
1.603HisLeu: 1.603 ± 0.044
0.665HisMet: 0.665 ± 0.033
0.673HisAsn: 0.673 ± 0.034
0.932HisPro: 0.932 ± 0.041
0.577HisGln: 0.577 ± 0.028
0.798HisArg: 0.798 ± 0.032
0.966HisSer: 0.966 ± 0.039
1.029HisThr: 1.029 ± 0.041
1.29HisVal: 1.29 ± 0.047
0.163HisTrp: 0.163 ± 0.016
0.81HisTyr: 0.81 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.11IleAla: 6.11 ± 0.084
1.421IleCys: 1.421 ± 0.044
4.072IleAsp: 4.072 ± 0.081
5.306IleGlu: 5.306 ± 0.087
3.159IlePhe: 3.159 ± 0.093
5.718IleGly: 5.718 ± 0.098
1.494IleHis: 1.494 ± 0.051
5.449IleIle: 5.449 ± 0.1
4.381IleLys: 4.381 ± 0.087
7.249IleLeu: 7.249 ± 0.122
2.31IleMet: 2.31 ± 0.062
2.554IleAsn: 2.554 ± 0.063
3.256IlePro: 3.256 ± 0.065
2.373IleGln: 2.373 ± 0.047
3.778IleArg: 3.778 ± 0.08
4.499IleSer: 4.499 ± 0.095
4.268IleThr: 4.268 ± 0.089
5.474IleVal: 5.474 ± 0.093
0.596IleTrp: 0.596 ± 0.036
2.877IleTyr: 2.877 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
5.484LysAla: 5.484 ± 0.105
0.751LysCys: 0.751 ± 0.037
4.518LysAsp: 4.518 ± 0.101
8.076LysGlu: 8.076 ± 0.126
1.989LysPhe: 1.989 ± 0.063
4.551LysGly: 4.551 ± 0.099
1.157LysHis: 1.157 ± 0.04
5.552LysIle: 5.552 ± 0.099
7.586LysLys: 7.586 ± 0.128
5.672LysLeu: 5.672 ± 0.087
2.56LysMet: 2.56 ± 0.058
3.891LysAsn: 3.891 ± 0.077
1.943LysPro: 1.943 ± 0.053
2.276LysGln: 2.276 ± 0.055
3.256LysArg: 3.256 ± 0.074
3.382LysSer: 3.382 ± 0.073
3.866LysThr: 3.866 ± 0.07
5.166LysVal: 5.166 ± 0.095
0.561LysTrp: 0.561 ± 0.029
3.131LysTyr: 3.131 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
6.592LeuAla: 6.592 ± 0.107
1.266LeuCys: 1.266 ± 0.045
5.098LeuAsp: 5.098 ± 0.086
6.481LeuGlu: 6.481 ± 0.098
3.324LeuPhe: 3.324 ± 0.078
6.151LeuGly: 6.151 ± 0.113
1.6LeuHis: 1.6 ± 0.051
6.145LeuIle: 6.145 ± 0.12
6.718LeuLys: 6.718 ± 0.106
7.722LeuLeu: 7.722 ± 0.119
2.65LeuMet: 2.65 ± 0.059
3.722LeuAsn: 3.722 ± 0.076
3.329LeuPro: 3.329 ± 0.078
2.576LeuGln: 2.576 ± 0.062
3.367LeuArg: 3.367 ± 0.074
5.272LeuSer: 5.272 ± 0.092
4.972LeuThr: 4.972 ± 0.094
5.619LeuVal: 5.619 ± 0.104
0.651LeuTrp: 0.651 ± 0.034
3.153LeuTyr: 3.153 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
2.557MetAla: 2.557 ± 0.067
0.415MetCys: 0.415 ± 0.024
1.992MetAsp: 1.992 ± 0.06
2.765MetGlu: 2.765 ± 0.054
1.003MetPhe: 1.003 ± 0.04
2.233MetGly: 2.233 ± 0.064
0.551MetHis: 0.551 ± 0.028
2.632MetIle: 2.632 ± 0.066
3.033MetLys: 3.033 ± 0.069
2.806MetLeu: 2.806 ± 0.076
1.097MetMet: 1.097 ± 0.041
1.798MetAsn: 1.798 ± 0.051
1.185MetPro: 1.185 ± 0.038
1.153MetGln: 1.153 ± 0.042
1.331MetArg: 1.331 ± 0.049
1.821MetSer: 1.821 ± 0.05
1.898MetThr: 1.898 ± 0.055
2.114MetVal: 2.114 ± 0.056
0.233MetTrp: 0.233 ± 0.021
1.025MetTyr: 1.025 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.938AsnAla: 2.938 ± 0.059
0.549AsnCys: 0.549 ± 0.028
2.086AsnAsp: 2.086 ± 0.047
2.834AsnGlu: 2.834 ± 0.064
1.407AsnPhe: 1.407 ± 0.05
3.258AsnGly: 3.258 ± 0.077
0.852AsnHis: 0.852 ± 0.034
3.32AsnIle: 3.32 ± 0.071
2.654AsnLys: 2.654 ± 0.067
3.697AsnLeu: 3.697 ± 0.063
1.425AsnMet: 1.425 ± 0.047
1.641AsnAsn: 1.641 ± 0.054
1.895AsnPro: 1.895 ± 0.048
1.484AsnGln: 1.484 ± 0.052
1.809AsnArg: 1.809 ± 0.052
2.082AsnSer: 2.082 ± 0.064
2.302AsnThr: 2.302 ± 0.066
2.958AsnVal: 2.958 ± 0.064
0.38AsnTrp: 0.38 ± 0.026
1.756AsnTyr: 1.756 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.35ProAla: 2.35 ± 0.063
0.461ProCys: 0.461 ± 0.025
2.241ProAsp: 2.241 ± 0.062
3.427ProGlu: 3.427 ± 0.086
1.341ProPhe: 1.341 ± 0.049
2.451ProGly: 2.451 ± 0.063
0.555ProHis: 0.555 ± 0.027
2.049ProIle: 2.049 ± 0.062
2.083ProLys: 2.083 ± 0.051
2.732ProLeu: 2.732 ± 0.06
0.929ProMet: 0.929 ± 0.035
1.141ProAsn: 1.141 ± 0.036
0.614ProPro: 0.614 ± 0.034
0.877ProGln: 0.877 ± 0.041
0.891ProArg: 0.891 ± 0.036
1.661ProSer: 1.661 ± 0.056
1.431ProThr: 1.431 ± 0.044
3.127ProVal: 3.127 ± 0.062
0.3ProTrp: 0.3 ± 0.02
1.407ProTyr: 1.407 ± 0.053
0.001ProXaa: 0.001 ± 0.002
Gln
2.258GlnAla: 2.258 ± 0.059
0.377GlnCys: 0.377 ± 0.02
1.544GlnAsp: 1.544 ± 0.049
2.672GlnGlu: 2.672 ± 0.062
1.086GlnPhe: 1.086 ± 0.038
1.945GlnGly: 1.945 ± 0.059
0.436GlnHis: 0.436 ± 0.029
2.816GlnIle: 2.816 ± 0.062
2.903GlnLys: 2.903 ± 0.074
2.52GlnLeu: 2.52 ± 0.055
1.281GlnMet: 1.281 ± 0.047
1.558GlnAsn: 1.558 ± 0.053
0.808GlnPro: 0.808 ± 0.038
1.013GlnGln: 1.013 ± 0.041
1.175GlnArg: 1.175 ± 0.039
1.518GlnSer: 1.518 ± 0.051
1.661GlnThr: 1.661 ± 0.048
2.057GlnVal: 2.057 ± 0.051
0.215GlnTrp: 0.215 ± 0.016
1.228GlnTyr: 1.228 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.441ArgAla: 2.441 ± 0.064
0.533ArgCys: 0.533 ± 0.029
2.015ArgAsp: 2.015 ± 0.058
3.555ArgGlu: 3.555 ± 0.091
1.591ArgPhe: 1.591 ± 0.05
2.395ArgGly: 2.395 ± 0.063
0.782ArgHis: 0.782 ± 0.037
3.511ArgIle: 3.511 ± 0.075
3.698ArgLys: 3.698 ± 0.073
3.629ArgLeu: 3.629 ± 0.085
1.664ArgMet: 1.664 ± 0.053
1.868ArgAsn: 1.868 ± 0.06
1.325ArgPro: 1.325 ± 0.046
1.525ArgGln: 1.525 ± 0.052
2.08ArgArg: 2.08 ± 0.063
2.061ArgSer: 2.061 ± 0.052
2.251ArgThr: 2.251 ± 0.055
2.578ArgVal: 2.578 ± 0.065
0.334ArgTrp: 0.334 ± 0.025
1.815ArgTyr: 1.815 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
3.837SerAla: 3.837 ± 0.068
0.768SerCys: 0.768 ± 0.032
3.017SerAsp: 3.017 ± 0.082
3.692SerGlu: 3.692 ± 0.072
2.272SerPhe: 2.272 ± 0.054
4.601SerGly: 4.601 ± 0.082
0.92SerHis: 0.92 ± 0.032
3.869SerIle: 3.869 ± 0.091
3.552SerLys: 3.552 ± 0.079
4.512SerLeu: 4.512 ± 0.087
1.806SerMet: 1.806 ± 0.051
1.926SerAsn: 1.926 ± 0.062
1.481SerPro: 1.481 ± 0.046
1.634SerGln: 1.634 ± 0.049
2.444SerArg: 2.444 ± 0.054
3.136SerSer: 3.136 ± 0.094
2.666SerThr: 2.666 ± 0.063
4.221SerVal: 4.221 ± 0.09
0.446SerTrp: 0.446 ± 0.024
2.236SerTyr: 2.236 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
4.255ThrAla: 4.255 ± 0.09
0.665ThrCys: 0.665 ± 0.033
3.349ThrAsp: 3.349 ± 0.077
3.891ThrGlu: 3.891 ± 0.077
2.204ThrPhe: 2.204 ± 0.054
5.042ThrGly: 5.042 ± 0.091
0.941ThrHis: 0.941 ± 0.037
3.835ThrIle: 3.835 ± 0.075
3.32ThrLys: 3.32 ± 0.078
4.578ThrLeu: 4.578 ± 0.087
1.575ThrMet: 1.575 ± 0.044
1.906ThrAsn: 1.906 ± 0.056
2.124ThrPro: 2.124 ± 0.069
1.406ThrGln: 1.406 ± 0.046
1.964ThrArg: 1.964 ± 0.055
2.938ThrSer: 2.938 ± 0.082
3.049ThrThr: 3.049 ± 0.073
4.339ThrVal: 4.339 ± 0.084
0.445ThrTrp: 0.445 ± 0.027
2.167ThrTyr: 2.167 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
5.104ValAla: 5.104 ± 0.094
1.273ValCys: 1.273 ± 0.043
3.931ValAsp: 3.931 ± 0.082
4.957ValGlu: 4.957 ± 0.085
3.009ValPhe: 3.009 ± 0.073
4.777ValGly: 4.777 ± 0.07
1.26ValHis: 1.26 ± 0.043
5.865ValIle: 5.865 ± 0.088
5.111ValLys: 5.111 ± 0.09
6.69ValLeu: 6.69 ± 0.106
2.354ValMet: 2.354 ± 0.058
2.922ValAsn: 2.922 ± 0.074
2.506ValPro: 2.506 ± 0.061
2.083ValGln: 2.083 ± 0.054
2.866ValArg: 2.866 ± 0.062
4.396ValSer: 4.396 ± 0.094
4.436ValThr: 4.436 ± 0.083
5.306ValVal: 5.306 ± 0.098
0.604ValTrp: 0.604 ± 0.031
2.697ValTyr: 2.697 ± 0.075
0.001ValXaa: 0.001 ± 0.001
Trp
0.501TrpAla: 0.501 ± 0.027
0.127TrpCys: 0.127 ± 0.015
0.428TrpAsp: 0.428 ± 0.027
0.57TrpGlu: 0.57 ± 0.028
0.342TrpPhe: 0.342 ± 0.027
0.626TrpGly: 0.626 ± 0.033
0.137TrpHis: 0.137 ± 0.015
0.66TrpIle: 0.66 ± 0.036
0.816TrpLys: 0.816 ± 0.044
0.713TrpLeu: 0.713 ± 0.034
0.325TrpMet: 0.325 ± 0.022
0.452TrpAsn: 0.452 ± 0.028
0.199TrpPro: 0.199 ± 0.02
0.337TrpGln: 0.337 ± 0.022
0.308TrpArg: 0.308 ± 0.019
0.362TrpSer: 0.362 ± 0.025
0.364TrpThr: 0.364 ± 0.025
0.436TrpVal: 0.436 ± 0.028
0.099TrpTrp: 0.099 ± 0.013
0.334TrpTyr: 0.334 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.721TyrAla: 2.721 ± 0.068
0.576TyrCys: 0.576 ± 0.027
2.528TyrAsp: 2.528 ± 0.064
3.156TyrGlu: 3.156 ± 0.069
1.641TyrPhe: 1.641 ± 0.048
3.028TyrGly: 3.028 ± 0.07
0.954TyrHis: 0.954 ± 0.039
2.868TyrIle: 2.868 ± 0.068
2.464TyrLys: 2.464 ± 0.062
3.604TyrLeu: 3.604 ± 0.071
1.206TyrMet: 1.206 ± 0.047
1.706TyrAsn: 1.706 ± 0.054
1.513TyrPro: 1.513 ± 0.042
1.628TyrGln: 1.628 ± 0.048
1.918TyrArg: 1.918 ± 0.053
2.116TyrSer: 2.116 ± 0.052
2.267TyrThr: 2.267 ± 0.071
2.675TyrVal: 2.675 ± 0.066
0.303TyrTrp: 0.303 ± 0.023
1.898TyrTyr: 1.898 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.003XaaGly: 0.003 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.001XaaLys: 0.001 ± 0.001
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.006XaaXaa: 0.006 ± 0.004
Statistics based on 2196 proteins (679263 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski