Amino acid dipepetide frequency for Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.399AlaAla: 5.399 ± 0.118	0.945AlaCys: 0.945 ± 0.049	3.311AlaAsp: 3.311 ± 0.082	4.149AlaGlu: 4.149 ± 0.094	3.021AlaPhe: 3.021 ± 0.082	4.606AlaGly: 4.606 ± 0.1	1.771AlaHis: 1.771 ± 0.06	5.006AlaIle: 5.006 ± 0.111	4.202AlaLys: 4.202 ± 0.093	8.858AlaLeu: 8.858 ± 0.182	1.821AlaMet: 1.821 ± 0.062	2.616AlaAsn: 2.616 ± 0.074	2.426AlaPro: 2.426 ± 0.075	3.711AlaGln: 3.711 ± 0.089	3.861AlaArg: 3.861 ± 0.087	4.545AlaSer: 4.545 ± 0.102	3.238AlaThr: 3.238 ± 0.092	4.29AlaVal: 4.29 ± 0.101	0.847AlaTrp: 0.847 ± 0.038	2.096AlaTyr: 2.096 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.733CysAla: 0.733 ± 0.044	0.163CysCys: 0.163 ± 0.016	0.62CysAsp: 0.62 ± 0.039	0.572CysGlu: 0.572 ± 0.03	0.593CysPhe: 0.593 ± 0.032	0.738CysGly: 0.738 ± 0.037	0.427CysHis: 0.427 ± 0.033	0.77CysIle: 0.77 ± 0.042	0.459CysLys: 0.459 ± 0.03	1.274CysLeu: 1.274 ± 0.049	0.225CysMet: 0.225 ± 0.022	0.304CysAsn: 0.304 ± 0.024	0.44CysPro: 0.44 ± 0.03	0.504CysGln: 0.504 ± 0.032	0.572CysArg: 0.572 ± 0.033	0.781CysSer: 0.781 ± 0.041	0.422CysThr: 0.422 ± 0.026	0.649CysVal: 0.649 ± 0.033	0.17CysTrp: 0.17 ± 0.016	0.364CysTyr: 0.364 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	3.4AspAla: 3.4 ± 0.09	0.486AspCys: 0.486 ± 0.031	2.417AspAsp: 2.417 ± 0.081	3.093AspGlu: 3.093 ± 0.089	2.567AspPhe: 2.567 ± 0.077	2.798AspGly: 2.798 ± 0.094	1.263AspHis: 1.263 ± 0.055	4.326AspIle: 4.326 ± 0.098	3.345AspLys: 3.345 ± 0.088	5.092AspLeu: 5.092 ± 0.113	1.258AspMet: 1.258 ± 0.049	2.182AspAsn: 2.182 ± 0.078	2.148AspPro: 2.148 ± 0.072	2.062AspGln: 2.062 ± 0.069	2.319AspArg: 2.319 ± 0.081	3.007AspSer: 3.007 ± 0.102	2.546AspThr: 2.546 ± 0.081	2.944AspVal: 2.944 ± 0.07	0.722AspTrp: 0.722 ± 0.037	1.728AspTyr: 1.728 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.304GluAla: 4.304 ± 0.095	0.502GluCys: 0.502 ± 0.032	2.541GluAsp: 2.541 ± 0.078	3.741GluGlu: 3.741 ± 0.118	2.146GluPhe: 2.146 ± 0.069	3.8GluGly: 3.8 ± 0.104	1.428GluHis: 1.428 ± 0.048	4.529GluIle: 4.529 ± 0.107	5.973GluLys: 5.973 ± 0.133	5.896GluLeu: 5.896 ± 0.105	1.735GluMet: 1.735 ± 0.057	3.38GluAsn: 3.38 ± 0.093	1.883GluPro: 1.883 ± 0.07	2.944GluGln: 2.944 ± 0.081	3.386GluArg: 3.386 ± 0.105	3.336GluSer: 3.336 ± 0.077	3.184GluThr: 3.184 ± 0.078	3.414GluVal: 3.414 ± 0.096	0.666GluTrp: 0.666 ± 0.039	1.649GluTyr: 1.649 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.36PheAla: 2.36 ± 0.077	0.668PheCys: 0.668 ± 0.04	2.453PheAsp: 2.453 ± 0.069	2.207PheGlu: 2.207 ± 0.071	2.532PhePhe: 2.532 ± 0.089	2.534PheGly: 2.534 ± 0.084	0.99PheHis: 0.99 ± 0.04	3.556PheIle: 3.556 ± 0.103	2.432PheLys: 2.432 ± 0.072	4.524PheLeu: 4.524 ± 0.117	1.224PheMet: 1.224 ± 0.046	2.307PheAsn: 2.307 ± 0.067	1.522PhePro: 1.522 ± 0.056	1.422PheGln: 1.422 ± 0.051	1.855PheArg: 1.855 ± 0.056	4.242PheSer: 4.242 ± 0.099	2.214PheThr: 2.214 ± 0.076	2.319PheVal: 2.319 ± 0.074	0.557PheTrp: 0.557 ± 0.037	1.651PheTyr: 1.651 ± 0.058	0.004PheXaa: 0.004 ± 0.003
Gly	4.501GlyAla: 4.501 ± 0.114	0.775GlyCys: 0.775 ± 0.037	3.096GlyAsp: 3.096 ± 0.102	3.854GlyGlu: 3.854 ± 0.107	2.837GlyPhe: 2.837 ± 0.069	4.272GlyGly: 4.272 ± 0.128	1.778GlyHis: 1.778 ± 0.059	4.947GlyIle: 4.947 ± 0.111	4.317GlyLys: 4.317 ± 0.107	6.404GlyLeu: 6.404 ± 0.106	1.862GlyMet: 1.862 ± 0.068	2.344GlyAsn: 2.344 ± 0.091	1.46GlyPro: 1.46 ± 0.052	2.65GlyGln: 2.65 ± 0.065	3.13GlyArg: 3.13 ± 0.078	3.581GlySer: 3.581 ± 0.089	2.987GlyThr: 2.987 ± 0.091	4.242GlyVal: 4.242 ± 0.102	0.843GlyTrp: 0.843 ± 0.042	2.196GlyTyr: 2.196 ± 0.068	0.002GlyXaa: 0.002 ± 0.002
His	1.644HisAla: 1.644 ± 0.057	0.381HisCys: 0.381 ± 0.027	1.072HisAsp: 1.072 ± 0.048	1.122HisGlu: 1.122 ± 0.043	1.542HisPhe: 1.542 ± 0.055	1.347HisGly: 1.347 ± 0.049	1.179HisHis: 1.179 ± 0.054	1.922HisIle: 1.922 ± 0.056	1.254HisLys: 1.254 ± 0.048	3.107HisLeu: 3.107 ± 0.082	0.561HisMet: 0.561 ± 0.034	0.852HisAsn: 0.852 ± 0.041	1.485HisPro: 1.485 ± 0.059	1.772HisGln: 1.772 ± 0.049	1.495HisArg: 1.495 ± 0.057	1.653HisSer: 1.653 ± 0.057	1.108HisThr: 1.108 ± 0.051	1.213HisVal: 1.213 ± 0.043	0.427HisTrp: 0.427 ± 0.029	1.038HisTyr: 1.038 ± 0.044	0.0HisXaa: 0.0 ± 0.0
Ile	5.265IleAla: 5.265 ± 0.108	0.85IleCys: 0.85 ± 0.041	4.274IleAsp: 4.274 ± 0.086	5.106IleGlu: 5.106 ± 0.112	3.493IlePhe: 3.493 ± 0.116	4.538IleGly: 4.538 ± 0.107	1.835IleHis: 1.835 ± 0.055	4.608IleIle: 4.608 ± 0.113	5.376IleLys: 5.376 ± 0.12	7.199IleLeu: 7.199 ± 0.136	1.492IleMet: 1.492 ± 0.058	3.963IleAsn: 3.963 ± 0.102	3.07IlePro: 3.07 ± 0.071	3.307IleGln: 3.307 ± 0.07	3.439IleArg: 3.439 ± 0.086	5.417IleSer: 5.417 ± 0.124	3.959IleThr: 3.959 ± 0.101	3.557IleVal: 3.557 ± 0.089	0.695IleTrp: 0.695 ± 0.037	2.208IleTyr: 2.208 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	4.813LysAla: 4.813 ± 0.104	0.407LysCys: 0.407 ± 0.027	3.116LysAsp: 3.116 ± 0.086	4.76LysGlu: 4.76 ± 0.097	1.837LysPhe: 1.837 ± 0.067	4.127LysGly: 4.127 ± 0.114	1.37LysHis: 1.37 ± 0.052	5.75LysIle: 5.75 ± 0.112	7.195LysLys: 7.195 ± 0.14	5.726LysLeu: 5.726 ± 0.13	1.976LysMet: 1.976 ± 0.058	5.349LysAsn: 5.349 ± 0.141	2.353LysPro: 2.353 ± 0.073	2.778LysGln: 2.778 ± 0.074	3.293LysArg: 3.293 ± 0.089	4.224LysSer: 4.224 ± 0.099	4.199LysThr: 4.199 ± 0.106	3.616LysVal: 3.616 ± 0.086	0.622LysTrp: 0.622 ± 0.038	1.69LysTyr: 1.69 ± 0.057	0.007LysXaa: 0.007 ± 0.004
Leu	7.676LeuAla: 7.676 ± 0.152	1.311LeuCys: 1.311 ± 0.052	4.887LeuAsp: 4.887 ± 0.106	5.901LeuGlu: 5.901 ± 0.115	4.615LeuPhe: 4.615 ± 0.129	6.159LeuGly: 6.159 ± 0.12	2.312LeuHis: 2.312 ± 0.063	7.665LeuIle: 7.665 ± 0.147	7.704LeuLys: 7.704 ± 0.136	11.337LeuLeu: 11.337 ± 0.216	2.852LeuMet: 2.852 ± 0.074	6.007LeuAsn: 6.007 ± 0.106	4.762LeuPro: 4.762 ± 0.114	3.925LeuGln: 3.925 ± 0.097	5.133LeuArg: 5.133 ± 0.102	9.214LeuSer: 9.214 ± 0.148	5.9LeuThr: 5.9 ± 0.1	5.346LeuVal: 5.346 ± 0.106	1.097LeuTrp: 1.097 ± 0.055	2.88LeuTyr: 2.88 ± 0.092	0.002LeuXaa: 0.002 ± 0.002
Met	2.214MetAla: 2.214 ± 0.071	0.195MetCys: 0.195 ± 0.021	1.045MetAsp: 1.045 ± 0.039	1.211MetGlu: 1.211 ± 0.047	0.745MetPhe: 0.745 ± 0.038	1.631MetGly: 1.631 ± 0.058	0.507MetHis: 0.507 ± 0.028	2.015MetIle: 2.015 ± 0.063	1.885MetLys: 1.885 ± 0.055	2.63MetLeu: 2.63 ± 0.072	0.918MetMet: 0.918 ± 0.048	1.49MetAsn: 1.49 ± 0.048	1.152MetPro: 1.152 ± 0.052	0.976MetGln: 0.976 ± 0.036	1.351MetArg: 1.351 ± 0.047	1.808MetSer: 1.808 ± 0.064	1.799MetThr: 1.799 ± 0.053	1.47MetVal: 1.47 ± 0.054	0.161MetTrp: 0.161 ± 0.016	0.457MetTyr: 0.457 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.159AsnAla: 3.159 ± 0.079	0.381AsnCys: 0.381 ± 0.024	2.507AsnAsp: 2.507 ± 0.081	2.918AsnGlu: 2.918 ± 0.08	1.915AsnPhe: 1.915 ± 0.075	2.644AsnGly: 2.644 ± 0.098	1.403AsnHis: 1.403 ± 0.045	3.931AsnIle: 3.931 ± 0.092	3.543AsnLys: 3.543 ± 0.097	4.595AsnLeu: 4.595 ± 0.099	1.142AsnMet: 1.142 ± 0.049	2.451AsnAsn: 2.451 ± 0.091	2.182AsnPro: 2.182 ± 0.059	2.507AsnGln: 2.507 ± 0.084	2.421AsnArg: 2.421 ± 0.061	2.685AsnSer: 2.685 ± 0.089	2.785AsnThr: 2.785 ± 0.075	2.36AsnVal: 2.36 ± 0.078	0.579AsnTrp: 0.579 ± 0.032	1.292AsnTyr: 1.292 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	2.489ProAla: 2.489 ± 0.073	0.4ProCys: 0.4 ± 0.028	2.503ProAsp: 2.503 ± 0.071	3.202ProGlu: 3.202 ± 0.071	1.844ProPhe: 1.844 ± 0.066	2.121ProGly: 2.121 ± 0.066	1.11ProHis: 1.11 ± 0.048	2.517ProIle: 2.517 ± 0.077	2.494ProLys: 2.494 ± 0.07	4.292ProLeu: 4.292 ± 0.103	0.958ProMet: 0.958 ± 0.04	1.576ProAsn: 1.576 ± 0.059	1.572ProPro: 1.572 ± 0.065	1.658ProGln: 1.658 ± 0.05	1.428ProArg: 1.428 ± 0.053	2.678ProSer: 2.678 ± 0.063	1.901ProThr: 1.901 ± 0.06	2.805ProVal: 2.805 ± 0.069	0.468ProTrp: 0.468 ± 0.031	1.315ProTyr: 1.315 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	3.514GlnAla: 3.514 ± 0.077	0.404GlnCys: 0.404 ± 0.033	1.826GlnAsp: 1.826 ± 0.058	2.578GlnGlu: 2.578 ± 0.072	1.615GlnPhe: 1.615 ± 0.061	2.88GlnGly: 2.88 ± 0.087	1.204GlnHis: 1.204 ± 0.056	3.254GlnIle: 3.254 ± 0.076	4.161GlnLys: 4.161 ± 0.097	4.733GlnLeu: 4.733 ± 0.11	1.097GlnMet: 1.097 ± 0.038	2.314GlnAsn: 2.314 ± 0.066	1.703GlnPro: 1.703 ± 0.061	2.407GlnGln: 2.407 ± 0.083	2.419GlnArg: 2.419 ± 0.078	2.88GlnSer: 2.88 ± 0.073	2.366GlnThr: 2.366 ± 0.082	2.541GlnVal: 2.541 ± 0.076	0.631GlnTrp: 0.631 ± 0.036	1.453GlnTyr: 1.453 ± 0.066	0.0GlnXaa: 0.0 ± 0.0
Arg	3.554ArgAla: 3.554 ± 0.079	0.557ArgCys: 0.557 ± 0.038	2.559ArgAsp: 2.559 ± 0.066	3.152ArgGlu: 3.152 ± 0.091	2.46ArgPhe: 2.46 ± 0.066	2.789ArgGly: 2.789 ± 0.089	1.608ArgHis: 1.608 ± 0.055	3.545ArgIle: 3.545 ± 0.093	2.802ArgLys: 2.802 ± 0.069	5.673ArgLeu: 5.673 ± 0.11	1.267ArgMet: 1.267 ± 0.044	1.774ArgAsn: 1.774 ± 0.06	1.908ArgPro: 1.908 ± 0.064	2.7ArgGln: 2.7 ± 0.075	2.864ArgArg: 2.864 ± 0.094	2.727ArgSer: 2.727 ± 0.074	2.303ArgThr: 2.303 ± 0.062	3.025ArgVal: 3.025 ± 0.089	0.65ArgTrp: 0.65 ± 0.035	1.783ArgTyr: 1.783 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	5.019SerAla: 5.019 ± 0.11	0.679SerCys: 0.679 ± 0.036	3.722SerAsp: 3.722 ± 0.088	4.386SerGlu: 4.386 ± 0.104	2.932SerPhe: 2.932 ± 0.08	4.931SerGly: 4.931 ± 0.114	1.917SerHis: 1.917 ± 0.05	4.735SerIle: 4.735 ± 0.106	3.539SerLys: 3.539 ± 0.092	7.676SerLeu: 7.676 ± 0.13	1.637SerMet: 1.637 ± 0.056	2.51SerAsn: 2.51 ± 0.084	2.709SerPro: 2.709 ± 0.071	3.118SerGln: 3.118 ± 0.074	3.027SerArg: 3.027 ± 0.069	4.735SerSer: 4.735 ± 0.107	3.561SerThr: 3.561 ± 0.093	4.36SerVal: 4.36 ± 0.086	0.722SerTrp: 0.722 ± 0.038	1.781SerTyr: 1.781 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	3.838ThrAla: 3.838 ± 0.089	0.486ThrCys: 0.486 ± 0.032	2.809ThrAsp: 2.809 ± 0.077	3.307ThrGlu: 3.307 ± 0.077	2.124ThrPhe: 2.124 ± 0.064	4.058ThrGly: 4.058 ± 0.13	1.487ThrHis: 1.487 ± 0.049	3.105ThrIle: 3.105 ± 0.087	2.732ThrLys: 2.732 ± 0.075	6.689ThrLeu: 6.689 ± 0.12	0.997ThrMet: 0.997 ± 0.046	1.776ThrAsn: 1.776 ± 0.066	2.626ThrPro: 2.626 ± 0.082	2.78ThrGln: 2.78 ± 0.082	2.335ThrArg: 2.335 ± 0.065	3.175ThrSer: 3.175 ± 0.078	2.659ThrThr: 2.659 ± 0.08	3.479ThrVal: 3.479 ± 0.092	0.527ThrTrp: 0.527 ± 0.032	1.244ThrTyr: 1.244 ± 0.051	0.002ThrXaa: 0.002 ± 0.002
Val	4.077ValAla: 4.077 ± 0.1	0.64ValCys: 0.64 ± 0.035	2.905ValAsp: 2.905 ± 0.072	3.18ValGlu: 3.18 ± 0.084	2.678ValPhe: 2.678 ± 0.073	3.475ValGly: 3.475 ± 0.089	1.263ValHis: 1.263 ± 0.049	4.758ValIle: 4.758 ± 0.11	3.677ValLys: 3.677 ± 0.101	6.003ValLeu: 6.003 ± 0.108	1.676ValMet: 1.676 ± 0.055	2.764ValAsn: 2.764 ± 0.081	2.223ValPro: 2.223 ± 0.06	2.049ValGln: 2.049 ± 0.074	2.748ValArg: 2.748 ± 0.086	4.31ValSer: 4.31 ± 0.109	3.368ValThr: 3.368 ± 0.101	3.631ValVal: 3.631 ± 0.089	0.584ValTrp: 0.584 ± 0.036	1.592ValTyr: 1.592 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.784TrpAla: 0.784 ± 0.041	0.155TrpCys: 0.155 ± 0.017	0.454TrpAsp: 0.454 ± 0.025	0.534TrpGlu: 0.534 ± 0.031	0.493TrpPhe: 0.493 ± 0.028	0.632TrpGly: 0.632 ± 0.034	0.334TrpHis: 0.334 ± 0.025	0.817TrpIle: 0.817 ± 0.037	0.62TrpLys: 0.62 ± 0.036	1.528TrpLeu: 1.528 ± 0.062	0.375TrpMet: 0.375 ± 0.027	0.418TrpAsn: 0.418 ± 0.029	0.47TrpPro: 0.47 ± 0.034	0.709TrpGln: 0.709 ± 0.036	0.795TrpArg: 0.795 ± 0.042	0.684TrpSer: 0.684 ± 0.034	0.466TrpThr: 0.466 ± 0.03	0.763TrpVal: 0.763 ± 0.036	0.132TrpTrp: 0.132 ± 0.016	0.363TrpTyr: 0.363 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.976TyrAla: 1.976 ± 0.061	0.391TyrCys: 0.391 ± 0.025	1.585TyrAsp: 1.585 ± 0.057	1.465TyrGlu: 1.465 ± 0.05	1.579TyrPhe: 1.579 ± 0.064	1.99TyrGly: 1.99 ± 0.066	0.99TyrHis: 0.99 ± 0.045	1.897TyrIle: 1.897 ± 0.072	1.497TyrLys: 1.497 ± 0.048	3.447TyrLeu: 3.447 ± 0.088	0.59TyrMet: 0.59 ± 0.034	1.02TyrAsn: 1.02 ± 0.042	1.238TyrPro: 1.238 ± 0.044	1.999TyrGln: 1.999 ± 0.057	1.824TyrArg: 1.824 ± 0.058	2.014TyrSer: 2.014 ± 0.06	1.27TyrThr: 1.27 ± 0.048	1.576TyrVal: 1.576 ± 0.05	0.427TyrTrp: 0.427 ± 0.032	1.035TyrTyr: 1.035 ± 0.042	0.005TyrXaa: 0.005 ± 0.006
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.005XaaGly: 0.005 ± 0.004	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.002	0.004XaaLeu: 0.004 ± 0.004	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.002	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.004XaaArg: 0.004 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.002	0.023XaaXaa: 0.023 ± 0.024

Statistics based on 2045 proteins (559690 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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