Amino acid dipepetide frequency for Klebsiella phage KP179

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.606AlaAla: 5.606 ± 0.485
0.557AlaCys: 0.557 ± 0.108
4.453AlaAsp: 4.453 ± 0.309
5.069AlaGlu: 5.069 ± 0.383
2.584AlaPhe: 2.584 ± 0.239
5.069AlaGly: 5.069 ± 0.448
1.352AlaHis: 1.352 ± 0.189
5.089AlaIle: 5.089 ± 0.289
5.347AlaLys: 5.347 ± 0.332
5.765AlaLeu: 5.765 ± 0.396
1.809AlaMet: 1.809 ± 0.205
3.996AlaAsn: 3.996 ± 0.278
2.743AlaPro: 2.743 ± 0.306
2.783AlaGln: 2.783 ± 0.306
3.519AlaArg: 3.519 ± 0.249
4.314AlaSer: 4.314 ± 0.3
3.678AlaThr: 3.678 ± 0.405
4.572AlaVal: 4.572 ± 0.355
1.093AlaTrp: 1.093 ± 0.157
2.505AlaTyr: 2.505 ± 0.234
0.0AlaXaa: 0.0 ± 0.0
Cys
0.656CysAla: 0.656 ± 0.118
0.159CysCys: 0.159 ± 0.056
0.795CysAsp: 0.795 ± 0.134
0.716CysGlu: 0.716 ± 0.122
0.318CysPhe: 0.318 ± 0.076
0.895CysGly: 0.895 ± 0.162
0.219CysHis: 0.219 ± 0.079
0.537CysIle: 0.537 ± 0.117
0.755CysLys: 0.755 ± 0.122
0.755CysLeu: 0.755 ± 0.105
0.318CysMet: 0.318 ± 0.078
0.477CysAsn: 0.477 ± 0.105
0.477CysPro: 0.477 ± 0.097
0.378CysGln: 0.378 ± 0.089
0.616CysArg: 0.616 ± 0.101
0.676CysSer: 0.676 ± 0.107
0.497CysThr: 0.497 ± 0.114
0.914CysVal: 0.914 ± 0.139
0.219CysTrp: 0.219 ± 0.062
0.497CysTyr: 0.497 ± 0.097
0.0CysXaa: 0.0 ± 0.0
Asp
4.87AspAla: 4.87 ± 0.367
0.616AspCys: 0.616 ± 0.111
4.175AspAsp: 4.175 ± 0.299
4.592AspGlu: 4.592 ± 0.364
3.26AspPhe: 3.26 ± 0.245
5.069AspGly: 5.069 ± 0.271
0.835AspHis: 0.835 ± 0.132
5.129AspIle: 5.129 ± 0.339
4.532AspLys: 4.532 ± 0.342
5.109AspLeu: 5.109 ± 0.32
1.988AspMet: 1.988 ± 0.183
3.041AspAsn: 3.041 ± 0.236
2.207AspPro: 2.207 ± 0.224
1.392AspGln: 1.392 ± 0.182
2.226AspArg: 2.226 ± 0.23
4.194AspSer: 4.194 ± 0.298
3.22AspThr: 3.22 ± 0.292
3.876AspVal: 3.876 ± 0.319
1.153AspTrp: 1.153 ± 0.159
3.061AspTyr: 3.061 ± 0.279
0.0AspXaa: 0.0 ± 0.0
Glu
5.328GluAla: 5.328 ± 0.404
1.034GluCys: 1.034 ± 0.182
4.135GluAsp: 4.135 ± 0.335
5.268GluGlu: 5.268 ± 0.409
3.3GluPhe: 3.3 ± 0.244
3.896GluGly: 3.896 ± 0.279
1.431GluHis: 1.431 ± 0.162
5.328GluIle: 5.328 ± 0.34
4.075GluLys: 4.075 ± 0.312
6.779GluLeu: 6.779 ± 0.465
2.425GluMet: 2.425 ± 0.226
3.578GluAsn: 3.578 ± 0.291
2.067GluPro: 2.067 ± 0.201
2.445GluGln: 2.445 ± 0.229
2.823GluArg: 2.823 ± 0.242
3.876GluSer: 3.876 ± 0.288
3.797GluThr: 3.797 ± 0.286
4.95GluVal: 4.95 ± 0.334
1.292GluTrp: 1.292 ± 0.16
3.28GluTyr: 3.28 ± 0.272
0.0GluXaa: 0.0 ± 0.0
Phe
2.823PheAla: 2.823 ± 0.296
0.517PheCys: 0.517 ± 0.094
2.902PheAsp: 2.902 ± 0.229
3.658PheGlu: 3.658 ± 0.27
1.193PhePhe: 1.193 ± 0.151
3.081PheGly: 3.081 ± 0.244
0.636PheHis: 0.636 ± 0.125
2.723PheIle: 2.723 ± 0.219
3.598PheLys: 3.598 ± 0.284
2.127PheLeu: 2.127 ± 0.195
1.372PheMet: 1.372 ± 0.187
2.604PheAsn: 2.604 ± 0.198
1.173PhePro: 1.173 ± 0.144
1.153PheGln: 1.153 ± 0.162
1.61PheArg: 1.61 ± 0.16
3.041PheSer: 3.041 ± 0.286
2.723PheThr: 2.723 ± 0.239
2.942PheVal: 2.942 ± 0.256
0.616PheTrp: 0.616 ± 0.116
1.57PheTyr: 1.57 ± 0.197
0.0PheXaa: 0.0 ± 0.0
Gly
4.433GlyAla: 4.433 ± 0.374
0.557GlyCys: 0.557 ± 0.107
4.075GlyAsp: 4.075 ± 0.274
4.393GlyGlu: 4.393 ± 0.266
2.346GlyPhe: 2.346 ± 0.215
3.558GlyGly: 3.558 ± 0.367
1.054GlyHis: 1.054 ± 0.173
4.572GlyIle: 4.572 ± 0.308
5.089GlyLys: 5.089 ± 0.34
4.89GlyLeu: 4.89 ± 0.342
1.829GlyMet: 1.829 ± 0.221
3.558GlyAsn: 3.558 ± 0.491
1.59GlyPro: 1.59 ± 0.19
2.286GlyGln: 2.286 ± 0.216
2.684GlyArg: 2.684 ± 0.226
4.175GlySer: 4.175 ± 0.297
4.334GlyThr: 4.334 ± 0.427
4.413GlyVal: 4.413 ± 0.303
1.034GlyTrp: 1.034 ± 0.148
3.161GlyTyr: 3.161 ± 0.264
0.0GlyXaa: 0.0 ± 0.0
His
0.994HisAla: 0.994 ± 0.137
0.258HisCys: 0.258 ± 0.075
1.193HisAsp: 1.193 ± 0.149
1.232HisGlu: 1.232 ± 0.161
0.954HisPhe: 0.954 ± 0.128
1.193HisGly: 1.193 ± 0.189
0.358HisHis: 0.358 ± 0.102
1.431HisIle: 1.431 ± 0.156
1.312HisLys: 1.312 ± 0.194
1.59HisLeu: 1.59 ± 0.176
0.398HisMet: 0.398 ± 0.099
0.676HisAsn: 0.676 ± 0.127
1.113HisPro: 1.113 ± 0.145
0.517HisGln: 0.517 ± 0.097
0.835HisArg: 0.835 ± 0.138
1.034HisSer: 1.034 ± 0.133
0.934HisThr: 0.934 ± 0.137
1.372HisVal: 1.372 ± 0.149
0.278HisTrp: 0.278 ± 0.075
0.795HisTyr: 0.795 ± 0.123
0.0HisXaa: 0.0 ± 0.0
Ile
4.075IleAla: 4.075 ± 0.321
0.755IleCys: 0.755 ± 0.141
4.95IleAsp: 4.95 ± 0.289
5.109IleGlu: 5.109 ± 0.374
2.485IlePhe: 2.485 ± 0.187
3.936IleGly: 3.936 ± 0.223
1.352IleHis: 1.352 ± 0.176
4.811IleIle: 4.811 ± 0.359
6.143IleLys: 6.143 ± 0.417
4.016IleLeu: 4.016 ± 0.293
2.326IleMet: 2.326 ± 0.214
4.234IleAsn: 4.234 ± 0.283
2.465IlePro: 2.465 ± 0.207
2.485IleGln: 2.485 ± 0.228
3.399IleArg: 3.399 ± 0.243
4.075IleSer: 4.075 ± 0.341
4.711IleThr: 4.711 ± 0.278
4.532IleVal: 4.532 ± 0.314
0.696IleTrp: 0.696 ± 0.125
2.246IleTyr: 2.246 ± 0.203
0.0IleXaa: 0.0 ± 0.0
Lys
5.805LysAla: 5.805 ± 0.401
0.815LysCys: 0.815 ± 0.143
4.97LysAsp: 4.97 ± 0.331
5.487LysGlu: 5.487 ± 0.344
3.936LysPhe: 3.936 ± 0.293
4.035LysGly: 4.035 ± 0.274
1.809LysHis: 1.809 ± 0.21
4.672LysIle: 4.672 ± 0.31
4.413LysLys: 4.413 ± 0.356
6.043LysLeu: 6.043 ± 0.363
2.584LysMet: 2.584 ± 0.245
3.36LysAsn: 3.36 ± 0.251
2.207LysPro: 2.207 ± 0.237
2.604LysGln: 2.604 ± 0.229
3.519LysArg: 3.519 ± 0.286
4.791LysSer: 4.791 ± 0.369
4.413LysThr: 4.413 ± 0.357
4.97LysVal: 4.97 ± 0.403
1.113LysTrp: 1.113 ± 0.136
3.081LysTyr: 3.081 ± 0.246
0.0LysXaa: 0.0 ± 0.0
Leu
5.447LeuAla: 5.447 ± 0.361
0.656LeuCys: 0.656 ± 0.13
4.85LeuAsp: 4.85 ± 0.304
5.248LeuGlu: 5.248 ± 0.368
2.624LeuPhe: 2.624 ± 0.259
3.996LeuGly: 3.996 ± 0.265
1.471LeuHis: 1.471 ± 0.158
4.791LeuIle: 4.791 ± 0.314
5.725LeuLys: 5.725 ± 0.377
4.711LeuLeu: 4.711 ± 0.304
2.326LeuMet: 2.326 ± 0.237
4.512LeuAsn: 4.512 ± 0.282
3.022LeuPro: 3.022 ± 0.219
2.624LeuGln: 2.624 ± 0.259
3.538LeuArg: 3.538 ± 0.256
4.791LeuSer: 4.791 ± 0.317
4.532LeuThr: 4.532 ± 0.307
4.373LeuVal: 4.373 ± 0.269
0.914LeuTrp: 0.914 ± 0.134
2.783LeuTyr: 2.783 ± 0.289
0.0LeuXaa: 0.0 ± 0.0
Met
2.246MetAla: 2.246 ± 0.195
0.258MetCys: 0.258 ± 0.062
1.65MetAsp: 1.65 ± 0.184
1.849MetGlu: 1.849 ± 0.234
1.332MetPhe: 1.332 ± 0.162
1.411MetGly: 1.411 ± 0.196
0.517MetHis: 0.517 ± 0.14
1.829MetIle: 1.829 ± 0.203
3.22MetLys: 3.22 ± 0.296
2.246MetLeu: 2.246 ± 0.212
0.934MetMet: 0.934 ± 0.148
1.67MetAsn: 1.67 ± 0.168
0.914MetPro: 0.914 ± 0.12
0.994MetGln: 0.994 ± 0.168
1.193MetArg: 1.193 ± 0.15
2.187MetSer: 2.187 ± 0.198
1.69MetThr: 1.69 ± 0.157
1.551MetVal: 1.551 ± 0.172
0.219MetTrp: 0.219 ± 0.068
1.034MetTyr: 1.034 ± 0.15
0.0MetXaa: 0.0 ± 0.0
Asn
3.916AsnAla: 3.916 ± 0.27
0.656AsnCys: 0.656 ± 0.115
3.459AsnAsp: 3.459 ± 0.249
3.837AsnGlu: 3.837 ± 0.283
2.028AsnPhe: 2.028 ± 0.216
4.413AsnGly: 4.413 ± 0.444
0.914AsnHis: 0.914 ± 0.122
3.578AsnIle: 3.578 ± 0.278
3.797AsnLys: 3.797 ± 0.265
4.035AsnLeu: 4.035 ± 0.342
1.332AsnMet: 1.332 ± 0.182
2.882AsnAsn: 2.882 ± 0.29
2.107AsnPro: 2.107 ± 0.237
1.729AsnGln: 1.729 ± 0.191
2.704AsnArg: 2.704 ± 0.263
3.36AsnSer: 3.36 ± 0.222
3.002AsnThr: 3.002 ± 0.21
3.479AsnVal: 3.479 ± 0.301
0.736AsnTrp: 0.736 ± 0.14
1.988AsnTyr: 1.988 ± 0.179
0.0AsnXaa: 0.0 ± 0.0
Pro
2.882ProAla: 2.882 ± 0.262
0.338ProCys: 0.338 ± 0.096
2.385ProAsp: 2.385 ± 0.199
2.803ProGlu: 2.803 ± 0.279
1.451ProPhe: 1.451 ± 0.161
2.684ProGly: 2.684 ± 0.238
0.596ProHis: 0.596 ± 0.126
2.147ProIle: 2.147 ± 0.224
2.207ProLys: 2.207 ± 0.238
2.147ProLeu: 2.147 ± 0.199
0.914ProMet: 0.914 ± 0.133
1.69ProAsn: 1.69 ± 0.212
1.014ProPro: 1.014 ± 0.158
0.994ProGln: 0.994 ± 0.149
1.431ProArg: 1.431 ± 0.202
2.306ProSer: 2.306 ± 0.205
2.326ProThr: 2.326 ± 0.266
2.525ProVal: 2.525 ± 0.156
0.736ProTrp: 0.736 ± 0.126
1.272ProTyr: 1.272 ± 0.176
0.0ProXaa: 0.0 ± 0.0
Gln
2.306GlnAla: 2.306 ± 0.208
0.219GlnCys: 0.219 ± 0.066
1.888GlnAsp: 1.888 ± 0.185
2.246GlnGlu: 2.246 ± 0.214
1.431GlnPhe: 1.431 ± 0.197
2.067GlnGly: 2.067 ± 0.208
0.716GlnHis: 0.716 ± 0.145
2.226GlnIle: 2.226 ± 0.2
2.226GlnLys: 2.226 ± 0.175
2.882GlnLeu: 2.882 ± 0.238
1.073GlnMet: 1.073 ± 0.175
1.57GlnAsn: 1.57 ± 0.181
1.093GlnPro: 1.093 ± 0.166
1.153GlnGln: 1.153 ± 0.199
1.928GlnArg: 1.928 ± 0.198
1.849GlnSer: 1.849 ± 0.217
2.028GlnThr: 2.028 ± 0.233
2.644GlnVal: 2.644 ± 0.249
0.557GlnTrp: 0.557 ± 0.109
1.511GlnTyr: 1.511 ± 0.191
0.0GlnXaa: 0.0 ± 0.0
Arg
3.121ArgAla: 3.121 ± 0.254
0.736ArgCys: 0.736 ± 0.12
2.664ArgAsp: 2.664 ± 0.235
3.618ArgGlu: 3.618 ± 0.272
1.928ArgPhe: 1.928 ± 0.195
3.22ArgGly: 3.22 ± 0.263
0.954ArgHis: 0.954 ± 0.171
3.26ArgIle: 3.26 ± 0.264
3.36ArgLys: 3.36 ± 0.303
3.161ArgLeu: 3.161 ± 0.253
0.994ArgMet: 0.994 ± 0.135
2.465ArgAsn: 2.465 ± 0.214
1.113ArgPro: 1.113 ± 0.15
1.65ArgGln: 1.65 ± 0.195
2.366ArgArg: 2.366 ± 0.239
2.445ArgSer: 2.445 ± 0.241
2.465ArgThr: 2.465 ± 0.26
2.922ArgVal: 2.922 ± 0.241
0.974ArgTrp: 0.974 ± 0.158
1.869ArgTyr: 1.869 ± 0.185
0.0ArgXaa: 0.0 ± 0.0
Ser
4.493SerAla: 4.493 ± 0.28
0.636SerCys: 0.636 ± 0.121
4.135SerAsp: 4.135 ± 0.277
4.035SerGlu: 4.035 ± 0.271
2.644SerPhe: 2.644 ± 0.228
4.711SerGly: 4.711 ± 0.323
1.054SerHis: 1.054 ± 0.135
3.976SerIle: 3.976 ± 0.312
4.87SerLys: 4.87 ± 0.364
4.512SerLeu: 4.512 ± 0.3
1.332SerMet: 1.332 ± 0.167
3.34SerAsn: 3.34 ± 0.261
2.246SerPro: 2.246 ± 0.208
1.928SerGln: 1.928 ± 0.205
2.743SerArg: 2.743 ± 0.252
4.135SerSer: 4.135 ± 0.348
3.797SerThr: 3.797 ± 0.311
4.055SerVal: 4.055 ± 0.278
0.855SerTrp: 0.855 ± 0.135
2.465SerTyr: 2.465 ± 0.213
0.0SerXaa: 0.0 ± 0.0
Thr
4.493ThrAla: 4.493 ± 0.413
0.596ThrCys: 0.596 ± 0.118
3.121ThrAsp: 3.121 ± 0.272
3.558ThrGlu: 3.558 ± 0.289
2.704ThrPhe: 2.704 ± 0.243
4.314ThrGly: 4.314 ± 0.486
1.014ThrHis: 1.014 ± 0.15
4.254ThrIle: 4.254 ± 0.283
3.717ThrLys: 3.717 ± 0.26
4.334ThrLeu: 4.334 ± 0.39
1.451ThrMet: 1.451 ± 0.18
2.763ThrAsn: 2.763 ± 0.244
2.763ThrPro: 2.763 ± 0.313
1.888ThrGln: 1.888 ± 0.192
2.684ThrArg: 2.684 ± 0.224
3.439ThrSer: 3.439 ± 0.353
3.558ThrThr: 3.558 ± 0.336
4.751ThrVal: 4.751 ± 0.364
0.875ThrTrp: 0.875 ± 0.12
2.087ThrTyr: 2.087 ± 0.221
0.0ThrXaa: 0.0 ± 0.0
Val
4.572ValAla: 4.572 ± 0.322
0.855ValCys: 0.855 ± 0.137
4.791ValAsp: 4.791 ± 0.363
5.149ValGlu: 5.149 ± 0.298
3.141ValPhe: 3.141 ± 0.252
3.399ValGly: 3.399 ± 0.335
1.073ValHis: 1.073 ± 0.147
4.652ValIle: 4.652 ± 0.305
5.805ValLys: 5.805 ± 0.353
4.135ValLeu: 4.135 ± 0.259
1.928ValMet: 1.928 ± 0.174
3.956ValAsn: 3.956 ± 0.242
2.564ValPro: 2.564 ± 0.224
2.704ValGln: 2.704 ± 0.191
2.902ValArg: 2.902 ± 0.282
3.777ValSer: 3.777 ± 0.282
3.757ValThr: 3.757 ± 0.391
4.831ValVal: 4.831 ± 0.345
1.073ValTrp: 1.073 ± 0.139
2.704ValTyr: 2.704 ± 0.215
0.0ValXaa: 0.0 ± 0.0
Trp
0.775TrpAla: 0.775 ± 0.118
0.179TrpCys: 0.179 ± 0.063
1.034TrpAsp: 1.034 ± 0.14
0.954TrpGlu: 0.954 ± 0.12
0.855TrpPhe: 0.855 ± 0.138
0.576TrpGly: 0.576 ± 0.115
0.318TrpHis: 0.318 ± 0.093
0.815TrpIle: 0.815 ± 0.139
1.57TrpLys: 1.57 ± 0.18
1.173TrpLeu: 1.173 ± 0.148
0.636TrpMet: 0.636 ± 0.098
0.895TrpAsn: 0.895 ± 0.155
0.417TrpPro: 0.417 ± 0.089
0.477TrpGln: 0.477 ± 0.091
0.636TrpArg: 0.636 ± 0.096
0.875TrpSer: 0.875 ± 0.13
0.974TrpThr: 0.974 ± 0.158
1.113TrpVal: 1.113 ± 0.147
0.318TrpTrp: 0.318 ± 0.093
0.875TrpTyr: 0.875 ± 0.116
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.061TyrAla: 3.061 ± 0.212
0.477TyrCys: 0.477 ± 0.098
2.922TyrAsp: 2.922 ± 0.222
2.286TyrGlu: 2.286 ± 0.233
1.551TyrPhe: 1.551 ± 0.18
2.505TyrGly: 2.505 ± 0.257
0.795TyrHis: 0.795 ± 0.133
2.982TyrIle: 2.982 ± 0.238
2.863TyrLys: 2.863 ± 0.224
2.525TyrLeu: 2.525 ± 0.228
0.954TyrMet: 0.954 ± 0.132
2.684TyrAsn: 2.684 ± 0.248
1.551TyrPro: 1.551 ± 0.163
1.431TyrGln: 1.431 ± 0.159
1.948TyrArg: 1.948 ± 0.212
2.624TyrSer: 2.624 ± 0.26
1.928TyrThr: 1.928 ± 0.181
2.982TyrVal: 2.982 ± 0.236
0.716TyrTrp: 0.716 ± 0.126
1.67TyrTyr: 1.67 ± 0.172
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 260 proteins (50306 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski