Amino acid dipepetide frequency for Flaviaesturariibacter flavus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.167AlaAla: 11.167 ± 0.151	0.898AlaCys: 0.898 ± 0.028	4.639AlaAsp: 4.639 ± 0.076	4.878AlaGlu: 4.878 ± 0.09	4.113AlaPhe: 4.113 ± 0.056	8.599AlaGly: 8.599 ± 0.138	1.698AlaHis: 1.698 ± 0.042	5.051AlaIle: 5.051 ± 0.081	3.395AlaLys: 3.395 ± 0.074	9.39AlaLeu: 9.39 ± 0.138	1.722AlaMet: 1.722 ± 0.041	3.507AlaAsn: 3.507 ± 0.085	4.386AlaPro: 4.386 ± 0.092	3.869AlaGln: 3.869 ± 0.06	5.3AlaArg: 5.3 ± 0.094	5.43AlaSer: 5.43 ± 0.142	6.047AlaThr: 6.047 ± 0.18	6.235AlaVal: 6.235 ± 0.096	1.123AlaTrp: 1.123 ± 0.034	2.952AlaTyr: 2.952 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.802CysAla: 0.802 ± 0.032	0.138CysCys: 0.138 ± 0.013	0.407CysAsp: 0.407 ± 0.021	0.383CysGlu: 0.383 ± 0.021	0.403CysPhe: 0.403 ± 0.021	0.852CysGly: 0.852 ± 0.037	0.208CysHis: 0.208 ± 0.013	0.536CysIle: 0.536 ± 0.025	0.313CysLys: 0.313 ± 0.017	0.807CysLeu: 0.807 ± 0.03	0.168CysMet: 0.168 ± 0.014	0.371CysAsn: 0.371 ± 0.022	0.429CysPro: 0.429 ± 0.022	0.231CysGln: 0.231 ± 0.017	0.542CysArg: 0.542 ± 0.027	0.703CysSer: 0.703 ± 0.039	0.646CysThr: 0.646 ± 0.033	0.542CysVal: 0.542 ± 0.025	0.112CysTrp: 0.112 ± 0.01	0.306CysTyr: 0.306 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.008AspAla: 5.008 ± 0.08	0.383AspCys: 0.383 ± 0.02	2.363AspAsp: 2.363 ± 0.051	2.959AspGlu: 2.959 ± 0.065	2.57AspPhe: 2.57 ± 0.05	4.082AspGly: 4.082 ± 0.078	0.929AspHis: 0.929 ± 0.025	3.014AspIle: 3.014 ± 0.066	2.395AspLys: 2.395 ± 0.054	4.743AspLeu: 4.743 ± 0.083	0.943AspMet: 0.943 ± 0.031	2.116AspAsn: 2.116 ± 0.059	2.487AspPro: 2.487 ± 0.046	1.383AspGln: 1.383 ± 0.039	2.95AspArg: 2.95 ± 0.055	2.977AspSer: 2.977 ± 0.066	2.764AspThr: 2.764 ± 0.066	3.401AspVal: 3.401 ± 0.054	0.742AspTrp: 0.742 ± 0.028	2.027AspTyr: 2.027 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.417GluAla: 5.417 ± 0.109	0.338GluCys: 0.338 ± 0.02	2.465GluAsp: 2.465 ± 0.056	3.821GluGlu: 3.821 ± 0.087	2.002GluPhe: 2.002 ± 0.051	4.213GluGly: 4.213 ± 0.081	1.151GluHis: 1.151 ± 0.036	2.902GluIle: 2.902 ± 0.073	3.623GluLys: 3.623 ± 0.075	5.893GluLeu: 5.893 ± 0.116	1.2GluMet: 1.2 ± 0.041	2.218GluAsn: 2.218 ± 0.048	1.886GluPro: 1.886 ± 0.05	2.474GluGln: 2.474 ± 0.059	3.692GluArg: 3.692 ± 0.081	2.669GluSer: 2.669 ± 0.06	2.752GluThr: 2.752 ± 0.05	3.831GluVal: 3.831 ± 0.082	0.793GluTrp: 0.793 ± 0.03	1.804GluTyr: 1.804 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.936PheAla: 3.936 ± 0.062	0.435PheCys: 0.435 ± 0.021	2.629PheAsp: 2.629 ± 0.049	2.403PheGlu: 2.403 ± 0.054	2.351PhePhe: 2.351 ± 0.061	3.562PheGly: 3.562 ± 0.061	0.841PheHis: 0.841 ± 0.032	2.481PheIle: 2.481 ± 0.055	1.638PheLys: 1.638 ± 0.045	4.214PheLeu: 4.214 ± 0.087	0.929PheMet: 0.929 ± 0.03	2.307PheAsn: 2.307 ± 0.062	1.83PhePro: 1.83 ± 0.044	1.386PheGln: 1.386 ± 0.042	2.915PheArg: 2.915 ± 0.06	3.265PheSer: 3.265 ± 0.057	3.23PheThr: 3.23 ± 0.075	2.898PheVal: 2.898 ± 0.049	0.595PheTrp: 0.595 ± 0.027	1.693PheTyr: 1.693 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	7.591GlyAla: 7.591 ± 0.129	0.928GlyCys: 0.928 ± 0.055	3.679GlyAsp: 3.679 ± 0.069	3.55GlyGlu: 3.55 ± 0.076	3.654GlyPhe: 3.654 ± 0.06	6.707GlyGly: 6.707 ± 0.154	1.49GlyHis: 1.49 ± 0.04	5.011GlyIle: 5.011 ± 0.074	4.28GlyLys: 4.28 ± 0.075	6.897GlyLeu: 6.897 ± 0.1	1.859GlyMet: 1.859 ± 0.048	3.861GlyAsn: 3.861 ± 0.091	2.351GlyPro: 2.351 ± 0.052	2.66GlyGln: 2.66 ± 0.054	4.449GlyArg: 4.449 ± 0.07	5.427GlySer: 5.427 ± 0.133	5.775GlyThr: 5.775 ± 0.181	5.065GlyVal: 5.065 ± 0.084	1.145GlyTrp: 1.145 ± 0.036	2.989GlyTyr: 2.989 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.462HisAla: 1.462 ± 0.039	0.235HisCys: 0.235 ± 0.017	0.925HisAsp: 0.925 ± 0.037	1.035HisGlu: 1.035 ± 0.03	1.228HisPhe: 1.228 ± 0.032	1.303HisGly: 1.303 ± 0.035	0.598HisHis: 0.598 ± 0.026	1.175HisIle: 1.175 ± 0.036	0.759HisLys: 0.759 ± 0.029	2.014HisLeu: 2.014 ± 0.051	0.376HisMet: 0.376 ± 0.016	0.782HisAsn: 0.782 ± 0.03	1.262HisPro: 1.262 ± 0.035	0.716HisGln: 0.716 ± 0.026	1.261HisArg: 1.261 ± 0.039	1.133HisSer: 1.133 ± 0.037	1.083HisThr: 1.083 ± 0.03	1.119HisVal: 1.119 ± 0.034	0.296HisTrp: 0.296 ± 0.016	0.947HisTyr: 0.947 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.276IleAla: 5.276 ± 0.079	0.568IleCys: 0.568 ± 0.028	3.434IleAsp: 3.434 ± 0.061	3.177IleGlu: 3.177 ± 0.077	2.201IlePhe: 2.201 ± 0.051	4.383IleGly: 4.383 ± 0.074	1.064IleHis: 1.064 ± 0.032	3.034IleIle: 3.034 ± 0.065	2.251IleLys: 2.251 ± 0.055	4.547IleLeu: 4.547 ± 0.086	0.919IleMet: 0.919 ± 0.028	2.703IleAsn: 2.703 ± 0.054	2.6IlePro: 2.6 ± 0.049	1.668IleGln: 1.668 ± 0.037	3.729IleArg: 3.729 ± 0.061	3.447IleSer: 3.447 ± 0.062	3.708IleThr: 3.708 ± 0.085	3.711IleVal: 3.711 ± 0.063	0.542IleTrp: 0.542 ± 0.021	1.855IleTyr: 1.855 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.436LysAla: 4.436 ± 0.082	0.257LysCys: 0.257 ± 0.015	2.629LysAsp: 2.629 ± 0.052	3.433LysGlu: 3.433 ± 0.083	1.539LysPhe: 1.539 ± 0.041	3.804LysGly: 3.804 ± 0.067	0.882LysHis: 0.882 ± 0.03	2.544LysIle: 2.544 ± 0.057	3.367LysLys: 3.367 ± 0.089	4.05LysLeu: 4.05 ± 0.077	1.285LysMet: 1.285 ± 0.036	2.117LysAsn: 2.117 ± 0.051	2.312LysPro: 2.312 ± 0.05	1.844LysGln: 1.844 ± 0.044	2.487LysArg: 2.487 ± 0.054	2.386LysSer: 2.386 ± 0.055	2.806LysThr: 2.806 ± 0.06	3.253LysVal: 3.253 ± 0.06	0.599LysTrp: 0.599 ± 0.019	1.606LysTyr: 1.606 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	8.718LeuAla: 8.718 ± 0.105	0.976LeuCys: 0.976 ± 0.034	4.521LeuAsp: 4.521 ± 0.063	5.2LeuGlu: 5.2 ± 0.099	4.62LeuPhe: 4.62 ± 0.092	6.501LeuGly: 6.501 ± 0.087	2.215LeuHis: 2.215 ± 0.058	4.361LeuIle: 4.361 ± 0.082	4.632LeuLys: 4.632 ± 0.084	11.288LeuLeu: 11.288 ± 0.203	1.964LeuMet: 1.964 ± 0.047	3.904LeuAsn: 3.904 ± 0.059	4.992LeuPro: 4.992 ± 0.085	4.606LeuGln: 4.606 ± 0.077	6.494LeuArg: 6.494 ± 0.102	6.076LeuSer: 6.076 ± 0.076	5.329LeuThr: 5.329 ± 0.093	6.566LeuVal: 6.566 ± 0.087	1.008LeuTrp: 1.008 ± 0.034	2.989LeuTyr: 2.989 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.885MetAla: 1.885 ± 0.035	0.116MetCys: 0.116 ± 0.01	0.975MetAsp: 0.975 ± 0.033	1.287MetGlu: 1.287 ± 0.042	0.582MetPhe: 0.582 ± 0.021	1.472MetGly: 1.472 ± 0.039	0.421MetHis: 0.421 ± 0.017	1.118MetIle: 1.118 ± 0.034	1.639MetLys: 1.639 ± 0.042	1.859MetLeu: 1.859 ± 0.05	0.557MetMet: 0.557 ± 0.024	1.108MetAsn: 1.108 ± 0.032	1.104MetPro: 1.104 ± 0.032	0.927MetGln: 0.927 ± 0.028	1.261MetArg: 1.261 ± 0.037	1.164MetSer: 1.164 ± 0.034	1.15MetThr: 1.15 ± 0.033	1.264MetVal: 1.264 ± 0.037	0.192MetTrp: 0.192 ± 0.013	0.546MetTyr: 0.546 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.915AsnAla: 3.915 ± 0.089	0.419AsnCys: 0.419 ± 0.031	2.241AsnAsp: 2.241 ± 0.046	2.376AsnGlu: 2.376 ± 0.053	2.013AsnPhe: 2.013 ± 0.045	4.134AsnGly: 4.134 ± 0.114	0.751AsnHis: 0.751 ± 0.025	2.698AsnIle: 2.698 ± 0.052	1.939AsnLys: 1.939 ± 0.057	3.791AsnLeu: 3.791 ± 0.066	0.854AsnMet: 0.854 ± 0.025	2.359AsnAsn: 2.359 ± 0.071	2.576AsnPro: 2.576 ± 0.068	1.321AsnGln: 1.321 ± 0.039	2.427AsnArg: 2.427 ± 0.048	2.537AsnSer: 2.537 ± 0.074	2.996AsnThr: 2.996 ± 0.094	2.947AsnVal: 2.947 ± 0.066	0.707AsnTrp: 0.707 ± 0.025	1.852AsnTyr: 1.852 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	5.387ProAla: 5.387 ± 0.127	0.279ProCys: 0.279 ± 0.016	2.638ProAsp: 2.638 ± 0.05	3.122ProGlu: 3.122 ± 0.064	2.079ProPhe: 2.079 ± 0.043	4.076ProGly: 4.076 ± 0.076	0.839ProHis: 0.839 ± 0.031	1.999ProIle: 1.999 ± 0.041	1.903ProLys: 1.903 ± 0.049	3.964ProLeu: 3.964 ± 0.072	0.901ProMet: 0.901 ± 0.027	1.823ProAsn: 1.823 ± 0.044	1.579ProPro: 1.579 ± 0.054	1.691ProGln: 1.691 ± 0.041	2.057ProArg: 2.057 ± 0.044	2.34ProSer: 2.34 ± 0.058	2.268ProThr: 2.268 ± 0.072	4.278ProVal: 4.278 ± 0.077	0.503ProTrp: 0.503 ± 0.021	1.603ProTyr: 1.603 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.106GlnAla: 3.106 ± 0.058	0.244GlnCys: 0.244 ± 0.015	1.584GlnAsp: 1.584 ± 0.037	2.186GlnGlu: 2.186 ± 0.053	1.548GlnPhe: 1.548 ± 0.041	2.48GlnGly: 2.48 ± 0.049	0.87GlnHis: 0.87 ± 0.029	1.669GlnIle: 1.669 ± 0.043	2.12GlnLys: 2.12 ± 0.045	4.253GlnLeu: 4.253 ± 0.06	0.902GlnMet: 0.902 ± 0.028	1.471GlnAsn: 1.471 ± 0.038	1.877GlnPro: 1.877 ± 0.045	2.154GlnGln: 2.154 ± 0.059	2.293GlnArg: 2.293 ± 0.046	1.973GlnSer: 1.973 ± 0.036	1.935GlnThr: 1.935 ± 0.051	2.814GlnVal: 2.814 ± 0.053	0.584GlnTrp: 0.584 ± 0.025	1.446GlnTyr: 1.446 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.543ArgAla: 4.543 ± 0.072	0.436ArgCys: 0.436 ± 0.022	2.933ArgAsp: 2.933 ± 0.058	3.363ArgGlu: 3.363 ± 0.077	3.071ArgPhe: 3.071 ± 0.058	3.487ArgGly: 3.487 ± 0.069	1.265ArgHis: 1.265 ± 0.036	3.935ArgIle: 3.935 ± 0.065	3.151ArgLys: 3.151 ± 0.058	5.908ArgLeu: 5.908 ± 0.089	1.514ArgMet: 1.514 ± 0.041	2.878ArgAsn: 2.878 ± 0.058	2.455ArgPro: 2.455 ± 0.053	2.409ArgGln: 2.409 ± 0.054	3.935ArgArg: 3.935 ± 0.086	3.453ArgSer: 3.453 ± 0.067	3.146ArgThr: 3.146 ± 0.054	3.812ArgVal: 3.812 ± 0.063	0.843ArgTrp: 0.843 ± 0.029	2.592ArgTyr: 2.592 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	5.585SerAla: 5.585 ± 0.126	0.612SerCys: 0.612 ± 0.027	2.897SerAsp: 2.897 ± 0.058	2.967SerGlu: 2.967 ± 0.061	3.275SerPhe: 3.275 ± 0.067	5.92SerGly: 5.92 ± 0.148	0.955SerHis: 0.955 ± 0.03	3.39SerIle: 3.39 ± 0.053	2.346SerLys: 2.346 ± 0.059	5.779SerLeu: 5.779 ± 0.071	1.25SerMet: 1.25 ± 0.038	2.755SerAsn: 2.755 ± 0.084	2.481SerPro: 2.481 ± 0.065	1.714SerGln: 1.714 ± 0.038	2.975SerArg: 2.975 ± 0.055	3.704SerSer: 3.704 ± 0.097	3.71SerThr: 3.71 ± 0.11	4.447SerVal: 4.447 ± 0.084	0.935SerTrp: 0.935 ± 0.031	2.219SerTyr: 2.219 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	6.139ThrAla: 6.139 ± 0.167	0.468ThrCys: 0.468 ± 0.023	3.169ThrAsp: 3.169 ± 0.064	2.907ThrGlu: 2.907 ± 0.057	2.712ThrPhe: 2.712 ± 0.068	5.793ThrGly: 5.793 ± 0.154	1.041ThrHis: 1.041 ± 0.033	3.759ThrIle: 3.759 ± 0.077	2.066ThrLys: 2.066 ± 0.051	5.747ThrLeu: 5.747 ± 0.089	0.964ThrMet: 0.964 ± 0.031	2.549ThrAsn: 2.549 ± 0.1	3.446ThrPro: 3.446 ± 0.108	1.863ThrGln: 1.863 ± 0.048	2.933ThrArg: 2.933 ± 0.062	3.422ThrSer: 3.422 ± 0.115	4.02ThrThr: 4.02 ± 0.176	5.16ThrVal: 5.16 ± 0.17	0.827ThrTrp: 0.827 ± 0.032	2.345ThrTyr: 2.345 ± 0.081	0.0ThrXaa: 0.0 ± 0.0
Val	6.293ValAla: 6.293 ± 0.082	0.726ValCys: 0.726 ± 0.03	3.444ValAsp: 3.444 ± 0.068	3.477ValGlu: 3.477 ± 0.065	3.112ValPhe: 3.112 ± 0.056	4.362ValGly: 4.362 ± 0.059	1.432ValHis: 1.432 ± 0.037	3.667ValIle: 3.667 ± 0.058	3.367ValLys: 3.367 ± 0.07	7.171ValLeu: 7.171 ± 0.096	1.334ValMet: 1.334 ± 0.036	3.428ValAsn: 3.428 ± 0.079	3.321ValPro: 3.321 ± 0.061	2.678ValGln: 2.678 ± 0.049	4.161ValArg: 4.161 ± 0.075	4.509ValSer: 4.509 ± 0.096	4.763ValThr: 4.763 ± 0.173	4.906ValVal: 4.906 ± 0.086	0.744ValTrp: 0.744 ± 0.027	2.389ValTyr: 2.389 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.9TrpAla: 0.9 ± 0.026	0.121TrpCys: 0.121 ± 0.01	0.665TrpAsp: 0.665 ± 0.028	0.665TrpGlu: 0.665 ± 0.028	0.564TrpPhe: 0.564 ± 0.025	0.884TrpGly: 0.884 ± 0.032	0.281TrpHis: 0.281 ± 0.016	0.7TrpIle: 0.7 ± 0.026	0.804TrpLys: 0.804 ± 0.031	1.275TrpLeu: 1.275 ± 0.035	0.382TrpMet: 0.382 ± 0.02	0.726TrpAsn: 0.726 ± 0.028	0.402TrpPro: 0.402 ± 0.02	0.589TrpGln: 0.589 ± 0.026	0.782TrpArg: 0.782 ± 0.027	0.882TrpSer: 0.882 ± 0.03	0.827TrpThr: 0.827 ± 0.03	0.854TrpVal: 0.854 ± 0.029	0.247TrpTrp: 0.247 ± 0.016	0.495TrpTyr: 0.495 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.833TyrAla: 2.833 ± 0.049	0.323TyrCys: 0.323 ± 0.017	1.999TyrAsp: 1.999 ± 0.051	1.954TyrGlu: 1.954 ± 0.045	1.903TyrPhe: 1.903 ± 0.047	2.752TyrGly: 2.752 ± 0.05	0.78TyrHis: 0.78 ± 0.026	1.771TyrIle: 1.771 ± 0.04	1.647TyrLys: 1.647 ± 0.041	3.37TyrLeu: 3.37 ± 0.065	0.605TyrMet: 0.605 ± 0.024	1.867TyrAsn: 1.867 ± 0.042	1.555TyrPro: 1.555 ± 0.037	1.326TyrGln: 1.326 ± 0.036	2.489TyrArg: 2.489 ± 0.049	2.418TyrSer: 2.418 ± 0.059	2.374TyrThr: 2.374 ± 0.074	2.179TyrVal: 2.179 ± 0.045	0.511TyrTrp: 0.511 ± 0.023	1.602TyrTyr: 1.602 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3213 proteins (1136354 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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