Amino acid dipepetide frequency for Roseococcus sp. SYP-B2431

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.391AlaAla: 23.391 ± 0.231
1.237AlaCys: 1.237 ± 0.031
6.299AlaAsp: 6.299 ± 0.066
9.552AlaGlu: 9.552 ± 0.097
4.388AlaPhe: 4.388 ± 0.063
13.451AlaGly: 13.451 ± 0.109
2.4AlaHis: 2.4 ± 0.045
5.969AlaIle: 5.969 ± 0.077
3.029AlaLys: 3.029 ± 0.058
16.451AlaLeu: 16.451 ± 0.155
4.344AlaMet: 4.344 ± 0.059
2.56AlaAsn: 2.56 ± 0.053
7.94AlaPro: 7.94 ± 0.1
4.759AlaGln: 4.759 ± 0.06
12.109AlaArg: 12.109 ± 0.111
6.301AlaSer: 6.301 ± 0.066
6.422AlaThr: 6.422 ± 0.078
9.409AlaVal: 9.409 ± 0.096
2.124AlaTrp: 2.124 ± 0.041
2.21AlaTyr: 2.21 ± 0.033
0.0AlaXaa: 0.0 ± 0.0
Cys
1.125CysAla: 1.125 ± 0.027
0.113CysCys: 0.113 ± 0.009
0.47CysAsp: 0.47 ± 0.02
0.397CysGlu: 0.397 ± 0.018
0.315CysPhe: 0.315 ± 0.015
0.941CysGly: 0.941 ± 0.029
0.213CysHis: 0.213 ± 0.013
0.364CysIle: 0.364 ± 0.015
0.124CysLys: 0.124 ± 0.01
0.835CysLeu: 0.835 ± 0.022
0.16CysMet: 0.16 ± 0.011
0.188CysAsn: 0.188 ± 0.012
0.485CysPro: 0.485 ± 0.019
0.188CysGln: 0.188 ± 0.011
0.702CysArg: 0.702 ± 0.025
0.392CysSer: 0.392 ± 0.017
0.444CysThr: 0.444 ± 0.018
0.609CysVal: 0.609 ± 0.021
0.118CysTrp: 0.118 ± 0.01
0.169CysTyr: 0.169 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.759AspAla: 6.759 ± 0.072
0.418AspCys: 0.418 ± 0.018
2.103AspAsp: 2.103 ± 0.042
2.647AspGlu: 2.647 ± 0.041
1.921AspPhe: 1.921 ± 0.036
4.772AspGly: 4.772 ± 0.063
1.065AspHis: 1.065 ± 0.029
2.333AspIle: 2.333 ± 0.042
0.866AspLys: 0.866 ± 0.03
5.194AspLeu: 5.194 ± 0.071
1.151AspMet: 1.151 ± 0.031
0.883AspAsn: 0.883 ± 0.028
3.753AspPro: 3.753 ± 0.048
1.298AspGln: 1.298 ± 0.03
4.189AspArg: 4.189 ± 0.063
1.819AspSer: 1.819 ± 0.039
2.061AspThr: 2.061 ± 0.034
3.4AspVal: 3.4 ± 0.052
0.962AspTrp: 0.962 ± 0.025
1.035AspTyr: 1.035 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
9.769GluAla: 9.769 ± 0.095
0.34GluCys: 0.34 ± 0.015
2.35GluAsp: 2.35 ± 0.042
3.462GluGlu: 3.462 ± 0.057
1.695GluPhe: 1.695 ± 0.036
5.154GluGly: 5.154 ± 0.074
1.061GluHis: 1.061 ± 0.026
2.859GluIle: 2.859 ± 0.047
1.509GluLys: 1.509 ± 0.044
5.436GluLeu: 5.436 ± 0.062
1.651GluMet: 1.651 ± 0.036
1.213GluAsn: 1.213 ± 0.028
2.871GluPro: 2.871 ± 0.049
1.884GluGln: 1.884 ± 0.037
5.138GluArg: 5.138 ± 0.071
2.149GluSer: 2.149 ± 0.043
2.988GluThr: 2.988 ± 0.051
4.195GluVal: 4.195 ± 0.058
0.816GluTrp: 0.816 ± 0.026
0.808GluTyr: 0.808 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
4.71PheAla: 4.71 ± 0.063
0.394PheCys: 0.394 ± 0.018
2.166PheAsp: 2.166 ± 0.039
1.841PheGlu: 1.841 ± 0.041
1.183PhePhe: 1.183 ± 0.03
3.585PheGly: 3.585 ± 0.059
0.766PheHis: 0.766 ± 0.023
1.105PheIle: 1.105 ± 0.033
0.549PheLys: 0.549 ± 0.021
3.527PheLeu: 3.527 ± 0.055
0.611PheMet: 0.611 ± 0.019
0.834PheAsn: 0.834 ± 0.024
1.805PhePro: 1.805 ± 0.035
1.007PheGln: 1.007 ± 0.027
2.616PheArg: 2.616 ± 0.045
1.83PheSer: 1.83 ± 0.04
1.819PheThr: 1.819 ± 0.037
2.439PheVal: 2.439 ± 0.041
0.543PheTrp: 0.543 ± 0.021
0.645PheTyr: 0.645 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
11.595GlyAla: 11.595 ± 0.105
0.887GlyCys: 0.887 ± 0.025
3.897GlyAsp: 3.897 ± 0.056
5.017GlyGlu: 5.017 ± 0.061
3.982GlyPhe: 3.982 ± 0.059
8.815GlyGly: 8.815 ± 0.107
2.1GlyHis: 2.1 ± 0.04
4.265GlyIle: 4.265 ± 0.064
2.283GlyLys: 2.283 ± 0.048
10.305GlyLeu: 10.305 ± 0.094
2.659GlyMet: 2.659 ± 0.037
1.939GlyAsn: 1.939 ± 0.041
4.707GlyPro: 4.707 ± 0.055
3.145GlyGln: 3.145 ± 0.053
7.835GlyArg: 7.835 ± 0.091
4.653GlySer: 4.653 ± 0.062
5.037GlyThr: 5.037 ± 0.08
6.464GlyVal: 6.464 ± 0.066
1.737GlyTrp: 1.737 ± 0.039
1.998GlyTyr: 1.998 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.712HisAla: 2.712 ± 0.045
0.215HisCys: 0.215 ± 0.012
1.004HisAsp: 1.004 ± 0.025
0.971HisGlu: 0.971 ± 0.026
0.749HisPhe: 0.749 ± 0.024
2.088HisGly: 2.088 ± 0.042
0.56HisHis: 0.56 ± 0.021
0.803HisIle: 0.803 ± 0.027
0.305HisLys: 0.305 ± 0.017
2.257HisLeu: 2.257 ± 0.042
0.458HisMet: 0.458 ± 0.019
0.407HisAsn: 0.407 ± 0.018
1.623HisPro: 1.623 ± 0.035
0.523HisGln: 0.523 ± 0.02
1.67HisArg: 1.67 ± 0.036
0.816HisSer: 0.816 ± 0.023
0.741HisThr: 0.741 ± 0.022
1.577HisVal: 1.577 ± 0.036
0.378HisTrp: 0.378 ± 0.017
0.429HisTyr: 0.429 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.725IleAla: 6.725 ± 0.076
0.458IleCys: 0.458 ± 0.016
2.254IleAsp: 2.254 ± 0.043
2.881IleGlu: 2.881 ± 0.052
1.318IlePhe: 1.318 ± 0.03
4.559IleGly: 4.559 ± 0.061
0.803IleHis: 0.803 ± 0.026
1.419IleIle: 1.419 ± 0.032
0.706IleLys: 0.706 ± 0.025
4.244IleLeu: 4.244 ± 0.069
0.777IleMet: 0.777 ± 0.022
0.932IleAsn: 0.932 ± 0.028
2.531IlePro: 2.531 ± 0.043
1.119IleGln: 1.119 ± 0.03
3.491IleArg: 3.491 ± 0.054
2.079IleSer: 2.079 ± 0.042
2.228IleThr: 2.228 ± 0.046
3.206IleVal: 3.206 ± 0.051
0.527IleTrp: 0.527 ± 0.021
0.769IleTyr: 0.769 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
2.934LysAla: 2.934 ± 0.054
0.113LysCys: 0.113 ± 0.01
1.019LysAsp: 1.019 ± 0.028
1.002LysGlu: 1.002 ± 0.028
0.579LysPhe: 0.579 ± 0.02
1.844LysGly: 1.844 ± 0.039
0.432LysHis: 0.432 ± 0.018
0.981LysIle: 0.981 ± 0.034
0.657LysLys: 0.657 ± 0.033
2.51LysLeu: 2.51 ± 0.05
0.478LysMet: 0.478 ± 0.019
0.448LysAsn: 0.448 ± 0.019
1.471LysPro: 1.471 ± 0.034
0.568LysGln: 0.568 ± 0.023
1.756LysArg: 1.756 ± 0.04
1.025LysSer: 1.025 ± 0.026
1.037LysThr: 1.037 ± 0.032
1.609LysVal: 1.609 ± 0.04
0.263LysTrp: 0.263 ± 0.016
0.346LysTyr: 0.346 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
17.248LeuAla: 17.248 ± 0.16
0.955LeuCys: 0.955 ± 0.028
6.013LeuAsp: 6.013 ± 0.069
5.391LeuGlu: 5.391 ± 0.07
3.232LeuPhe: 3.232 ± 0.056
9.856LeuGly: 9.856 ± 0.088
2.145LeuHis: 2.145 ± 0.037
4.074LeuIle: 4.074 ± 0.055
2.374LeuLys: 2.374 ± 0.049
11.515LeuLeu: 11.515 ± 0.139
2.393LeuMet: 2.393 ± 0.041
2.201LeuAsn: 2.201 ± 0.039
7.273LeuPro: 7.273 ± 0.083
2.649LeuGln: 2.649 ± 0.04
9.628LeuArg: 9.628 ± 0.103
5.448LeuSer: 5.448 ± 0.064
5.246LeuThr: 5.246 ± 0.075
7.647LeuVal: 7.647 ± 0.086
1.265LeuTrp: 1.265 ± 0.035
1.63LeuTyr: 1.63 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.629MetAla: 3.629 ± 0.052
0.153MetCys: 0.153 ± 0.01
1.197MetAsp: 1.197 ± 0.031
1.346MetGlu: 1.346 ± 0.03
0.637MetPhe: 0.637 ± 0.02
2.076MetGly: 2.076 ± 0.039
0.418MetHis: 0.418 ± 0.016
1.102MetIle: 1.102 ± 0.029
0.697MetLys: 0.697 ± 0.023
2.766MetLeu: 2.766 ± 0.05
0.605MetMet: 0.605 ± 0.021
0.659MetAsn: 0.659 ± 0.02
1.791MetPro: 1.791 ± 0.036
0.813MetGln: 0.813 ± 0.022
2.182MetArg: 2.182 ± 0.043
1.446MetSer: 1.446 ± 0.03
1.583MetThr: 1.583 ± 0.033
1.719MetVal: 1.719 ± 0.035
0.206MetTrp: 0.206 ± 0.013
0.244MetTyr: 0.244 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.771AsnAla: 2.771 ± 0.046
0.192AsnCys: 0.192 ± 0.011
0.974AsnAsp: 0.974 ± 0.032
0.927AsnGlu: 0.927 ± 0.023
0.804AsnPhe: 0.804 ± 0.025
1.925AsnGly: 1.925 ± 0.044
0.464AsnHis: 0.464 ± 0.019
1.076AsnIle: 1.076 ± 0.033
0.374AsnLys: 0.374 ± 0.017
2.396AsnLeu: 2.396 ± 0.047
0.498AsnMet: 0.498 ± 0.018
0.545AsnAsn: 0.545 ± 0.022
1.723AsnPro: 1.723 ± 0.035
0.556AsnGln: 0.556 ± 0.022
1.806AsnArg: 1.806 ± 0.032
0.917AsnSer: 0.917 ± 0.032
1.06AsnThr: 1.06 ± 0.03
1.511AsnVal: 1.511 ± 0.036
0.339AsnTrp: 0.339 ± 0.016
0.445AsnTyr: 0.445 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
8.889ProAla: 8.889 ± 0.101
0.37ProCys: 0.37 ± 0.017
3.704ProAsp: 3.704 ± 0.055
4.633ProGlu: 4.633 ± 0.06
2.094ProPhe: 2.094 ± 0.037
6.542ProGly: 6.542 ± 0.075
1.297ProHis: 1.297 ± 0.034
2.324ProIle: 2.324 ± 0.045
1.143ProLys: 1.143 ± 0.033
5.664ProLeu: 5.664 ± 0.058
1.523ProMet: 1.523 ± 0.031
1.328ProAsn: 1.328 ± 0.035
4.213ProPro: 4.213 ± 0.092
1.776ProGln: 1.776 ± 0.035
4.447ProArg: 4.447 ± 0.072
2.941ProSer: 2.941 ± 0.05
2.538ProThr: 2.538 ± 0.047
4.71ProVal: 4.71 ± 0.06
0.919ProTrp: 0.919 ± 0.026
1.216ProTyr: 1.216 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
4.748GlnAla: 4.748 ± 0.059
0.171GlnCys: 0.171 ± 0.011
1.384GlnAsp: 1.384 ± 0.032
1.563GlnGlu: 1.563 ± 0.039
0.826GlnPhe: 0.826 ± 0.025
2.908GlnGly: 2.908 ± 0.045
0.603GlnHis: 0.603 ± 0.02
1.344GlnIle: 1.344 ± 0.03
0.654GlnLys: 0.654 ± 0.025
2.767GlnLeu: 2.767 ± 0.047
0.75GlnMet: 0.75 ± 0.023
0.654GlnAsn: 0.654 ± 0.022
1.957GlnPro: 1.957 ± 0.038
1.158GlnGln: 1.158 ± 0.039
2.688GlnArg: 2.688 ± 0.046
1.384GlnSer: 1.384 ± 0.03
1.316GlnThr: 1.316 ± 0.031
2.319GlnVal: 2.319 ± 0.045
0.361GlnTrp: 0.361 ± 0.016
0.454GlnTyr: 0.454 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
10.989ArgAla: 10.989 ± 0.099
0.65ArgCys: 0.65 ± 0.022
4.25ArgAsp: 4.25 ± 0.059
4.891ArgGlu: 4.891 ± 0.069
3.199ArgPhe: 3.199 ± 0.051
6.63ArgGly: 6.63 ± 0.069
1.979ArgHis: 1.979 ± 0.037
4.225ArgIle: 4.225 ± 0.056
1.667ArgLys: 1.667 ± 0.037
9.948ArgLeu: 9.948 ± 0.105
2.33ArgMet: 2.33 ± 0.043
1.899ArgAsn: 1.899 ± 0.036
5.157ArgPro: 5.157 ± 0.061
2.65ArgGln: 2.65 ± 0.048
7.855ArgArg: 7.855 ± 0.089
3.676ArgSer: 3.676 ± 0.056
3.374ArgThr: 3.374 ± 0.052
5.57ArgVal: 5.57 ± 0.067
1.239ArgTrp: 1.239 ± 0.032
1.465ArgTyr: 1.465 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
5.896SerAla: 5.896 ± 0.076
0.395SerCys: 0.395 ± 0.017
2.034SerAsp: 2.034 ± 0.042
2.277SerGlu: 2.277 ± 0.046
1.947SerPhe: 1.947 ± 0.038
5.096SerGly: 5.096 ± 0.065
0.945SerHis: 0.945 ± 0.025
2.04SerIle: 2.04 ± 0.034
0.916SerLys: 0.916 ± 0.029
5.121SerLeu: 5.121 ± 0.059
1.143SerMet: 1.143 ± 0.029
0.979SerAsn: 0.979 ± 0.028
2.986SerPro: 2.986 ± 0.049
1.283SerGln: 1.283 ± 0.031
3.744SerArg: 3.744 ± 0.053
2.333SerSer: 2.333 ± 0.051
2.348SerThr: 2.348 ± 0.047
3.319SerVal: 3.319 ± 0.054
0.829SerTrp: 0.829 ± 0.022
1.018SerTyr: 1.018 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
6.309ThrAla: 6.309 ± 0.07
0.39ThrCys: 0.39 ± 0.016
2.37ThrAsp: 2.37 ± 0.043
2.633ThrGlu: 2.633 ± 0.044
1.549ThrPhe: 1.549 ± 0.035
4.936ThrGly: 4.936 ± 0.072
1.014ThrHis: 1.014 ± 0.029
2.218ThrIle: 2.218 ± 0.042
0.912ThrLys: 0.912 ± 0.029
5.657ThrLeu: 5.657 ± 0.078
1.111ThrMet: 1.111 ± 0.027
1.022ThrAsn: 1.022 ± 0.029
3.585ThrPro: 3.585 ± 0.051
1.412ThrGln: 1.412 ± 0.037
3.611ThrArg: 3.611 ± 0.051
2.326ThrSer: 2.326 ± 0.046
2.452ThrThr: 2.452 ± 0.046
3.737ThrVal: 3.737 ± 0.052
0.62ThrTrp: 0.62 ± 0.022
0.889ThrTyr: 0.889 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
10.217ValAla: 10.217 ± 0.096
0.569ValCys: 0.569 ± 0.017
3.35ValAsp: 3.35 ± 0.057
4.368ValGlu: 4.368 ± 0.061
2.388ValPhe: 2.388 ± 0.046
5.262ValGly: 5.262 ± 0.069
1.276ValHis: 1.276 ± 0.028
3.298ValIle: 3.298 ± 0.053
1.637ValLys: 1.637 ± 0.042
8.045ValLeu: 8.045 ± 0.084
1.866ValMet: 1.866 ± 0.037
1.762ValAsn: 1.762 ± 0.035
4.521ValPro: 4.521 ± 0.061
2.166ValGln: 2.166 ± 0.043
4.966ValArg: 4.966 ± 0.063
3.532ValSer: 3.532 ± 0.051
4.438ValThr: 4.438 ± 0.059
5.934ValVal: 5.934 ± 0.07
0.88ValTrp: 0.88 ± 0.023
1.014ValTyr: 1.014 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.589TrpAla: 1.589 ± 0.039
0.151TrpCys: 0.151 ± 0.012
0.703TrpAsp: 0.703 ± 0.022
0.651TrpGlu: 0.651 ± 0.021
0.566TrpPhe: 0.566 ± 0.022
1.074TrpGly: 1.074 ± 0.03
0.377TrpHis: 0.377 ± 0.017
0.616TrpIle: 0.616 ± 0.019
0.36TrpLys: 0.36 ± 0.017
1.798TrpLeu: 1.798 ± 0.04
0.413TrpMet: 0.413 ± 0.017
0.453TrpAsn: 0.453 ± 0.018
0.944TrpPro: 0.944 ± 0.029
0.573TrpGln: 0.573 ± 0.021
1.537TrpArg: 1.537 ± 0.038
0.729TrpSer: 0.729 ± 0.022
0.772TrpThr: 0.772 ± 0.026
0.843TrpVal: 0.843 ± 0.021
0.265TrpTrp: 0.265 ± 0.014
0.254TrpTyr: 0.254 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.342TyrAla: 2.342 ± 0.043
0.184TyrCys: 0.184 ± 0.013
1.088TyrAsp: 1.088 ± 0.031
0.897TyrGlu: 0.897 ± 0.026
0.604TyrPhe: 0.604 ± 0.022
1.806TyrGly: 1.806 ± 0.039
0.367TyrHis: 0.367 ± 0.018
0.609TyrIle: 0.609 ± 0.023
0.313TyrLys: 0.313 ± 0.014
1.743TyrLeu: 1.743 ± 0.037
0.347TyrMet: 0.347 ± 0.015
0.398TyrAsn: 0.398 ± 0.018
0.937TyrPro: 0.937 ± 0.024
0.478TyrGln: 0.478 ± 0.017
1.672TyrArg: 1.672 ± 0.033
0.853TyrSer: 0.853 ± 0.026
0.852TyrThr: 0.852 ± 0.026
1.272TyrVal: 1.272 ± 0.028
0.275TyrTrp: 0.275 ± 0.015
0.37TyrTyr: 0.37 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4416 proteins (1429663 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski