Amino acid dipepetide frequency for Lachnospiraceae bacterium 3_1_57FAA_CT1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.315AlaAla: 8.315 ± 0.082	1.268AlaCys: 1.268 ± 0.025	4.53AlaAsp: 4.53 ± 0.051	5.657AlaGlu: 5.657 ± 0.066	3.382AlaPhe: 3.382 ± 0.046	6.892AlaGly: 6.892 ± 0.07	1.03AlaHis: 1.03 ± 0.021	4.049AlaIle: 4.049 ± 0.043	3.435AlaLys: 3.435 ± 0.045	7.001AlaLeu: 7.001 ± 0.067	2.243AlaMet: 2.243 ± 0.032	2.156AlaAsn: 2.156 ± 0.034	2.218AlaPro: 2.218 ± 0.037	2.34AlaGln: 2.34 ± 0.036	3.123AlaArg: 3.123 ± 0.036	3.954AlaSer: 3.954 ± 0.045	2.377AlaThr: 2.377 ± 0.037	6.633AlaVal: 6.633 ± 0.066	0.774AlaTrp: 0.774 ± 0.018	2.822AlaTyr: 2.822 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.069CysAla: 1.069 ± 0.022	0.334CysCys: 0.334 ± 0.012	0.839CysAsp: 0.839 ± 0.019	0.941CysGlu: 0.941 ± 0.023	0.763CysPhe: 0.763 ± 0.017	1.611CysGly: 1.611 ± 0.031	0.314CysHis: 0.314 ± 0.012	1.172CysIle: 1.172 ± 0.023	0.677CysLys: 0.677 ± 0.018	1.407CysLeu: 1.407 ± 0.026	0.518CysMet: 0.518 ± 0.016	0.512CysAsn: 0.512 ± 0.016	0.659CysPro: 0.659 ± 0.017	0.396CysGln: 0.396 ± 0.014	1.075CysArg: 1.075 ± 0.025	1.027CysSer: 1.027 ± 0.022	0.759CysThr: 0.759 ± 0.021	1.006CysVal: 1.006 ± 0.021	0.176CysTrp: 0.176 ± 0.009	0.693CysTyr: 0.693 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.739AspAla: 3.739 ± 0.045	0.933AspCys: 0.933 ± 0.02	2.526AspAsp: 2.526 ± 0.039	4.167AspGlu: 4.167 ± 0.039	2.85AspPhe: 2.85 ± 0.036	4.723AspGly: 4.723 ± 0.055	0.726AspHis: 0.726 ± 0.021	4.362AspIle: 4.362 ± 0.042	3.316AspLys: 3.316 ± 0.04	4.18AspLeu: 4.18 ± 0.041	1.898AspMet: 1.898 ± 0.031	2.247AspAsn: 2.247 ± 0.033	1.887AspPro: 1.887 ± 0.026	1.141AspGln: 1.141 ± 0.022	2.626AspArg: 2.626 ± 0.043	3.314AspSer: 3.314 ± 0.041	3.071AspThr: 3.071 ± 0.037	3.224AspVal: 3.224 ± 0.041	0.852AspTrp: 0.852 ± 0.021	2.895AspTyr: 2.895 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.884GluAla: 5.884 ± 0.058	0.87GluCys: 0.87 ± 0.022	4.346GluAsp: 4.346 ± 0.044	8.294GluGlu: 8.294 ± 0.079	2.549GluPhe: 2.549 ± 0.033	5.059GluGly: 5.059 ± 0.052	1.227GluHis: 1.227 ± 0.023	5.118GluIle: 5.118 ± 0.049	6.693GluLys: 6.693 ± 0.069	6.694GluLeu: 6.694 ± 0.066	2.4GluMet: 2.4 ± 0.033	4.163GluAsn: 4.163 ± 0.048	2.11GluPro: 2.11 ± 0.031	2.953GluGln: 2.953 ± 0.038	3.643GluArg: 3.643 ± 0.047	3.59GluSer: 3.59 ± 0.047	3.774GluThr: 3.774 ± 0.037	3.939GluVal: 3.939 ± 0.042	0.883GluTrp: 0.883 ± 0.021	3.263GluTyr: 3.263 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.043PheAla: 3.043 ± 0.043	0.889PheCys: 0.889 ± 0.019	2.435PheAsp: 2.435 ± 0.034	2.56PheGlu: 2.56 ± 0.035	2.278PhePhe: 2.278 ± 0.036	3.128PheGly: 3.128 ± 0.041	0.933PheHis: 0.933 ± 0.021	2.875PheIle: 2.875 ± 0.042	1.81PheLys: 1.81 ± 0.031	4.805PheLeu: 4.805 ± 0.056	1.301PheMet: 1.301 ± 0.028	1.554PheAsn: 1.554 ± 0.029	1.675PhePro: 1.675 ± 0.03	1.44PheGln: 1.44 ± 0.025	2.391PheArg: 2.391 ± 0.033	3.262PheSer: 3.262 ± 0.04	2.663PheThr: 2.663 ± 0.036	2.783PheVal: 2.783 ± 0.037	0.585PheTrp: 0.585 ± 0.015	2.065PheTyr: 2.065 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	4.724GlyAla: 4.724 ± 0.053	1.484GlyCys: 1.484 ± 0.029	3.492GlyAsp: 3.492 ± 0.039	5.331GlyGlu: 5.331 ± 0.052	3.332GlyPhe: 3.332 ± 0.037	5.033GlyGly: 5.033 ± 0.066	1.161GlyHis: 1.161 ± 0.024	6.203GlyIle: 6.203 ± 0.06	5.432GlyLys: 5.432 ± 0.052	6.374GlyLeu: 6.374 ± 0.056	2.715GlyMet: 2.715 ± 0.034	3.339GlyAsn: 3.339 ± 0.046	1.447GlyPro: 1.447 ± 0.032	2.205GlyGln: 2.205 ± 0.031	3.576GlyArg: 3.576 ± 0.043	4.312GlySer: 4.312 ± 0.054	4.048GlyThr: 4.048 ± 0.05	4.413GlyVal: 4.413 ± 0.05	0.901GlyTrp: 0.901 ± 0.024	3.458GlyTyr: 3.458 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.046HisAla: 1.046 ± 0.025	0.291HisCys: 0.291 ± 0.01	0.852HisAsp: 0.852 ± 0.021	1.03HisGlu: 1.03 ± 0.024	0.955HisPhe: 0.955 ± 0.023	1.245HisGly: 1.245 ± 0.025	0.387HisHis: 0.387 ± 0.018	1.353HisIle: 1.353 ± 0.027	0.842HisLys: 0.842 ± 0.019	1.475HisLeu: 1.475 ± 0.027	0.57HisMet: 0.57 ± 0.015	0.682HisAsn: 0.682 ± 0.017	0.867HisPro: 0.867 ± 0.022	0.488HisGln: 0.488 ± 0.016	0.769HisArg: 0.769 ± 0.021	0.969HisSer: 0.969 ± 0.024	0.908HisThr: 0.908 ± 0.021	1.031HisVal: 1.031 ± 0.021	0.243HisTrp: 0.243 ± 0.011	0.858HisTyr: 0.858 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.004IleAla: 5.004 ± 0.055	1.338IleCys: 1.338 ± 0.022	3.495IleAsp: 3.495 ± 0.044	3.744IleGlu: 3.744 ± 0.041	3.069IlePhe: 3.069 ± 0.044	4.56IleGly: 4.56 ± 0.056	1.322IleHis: 1.322 ± 0.025	4.779IleIle: 4.779 ± 0.062	3.306IleLys: 3.306 ± 0.039	7.314IleLeu: 7.314 ± 0.07	2.004IleMet: 2.004 ± 0.037	2.78IleAsn: 2.78 ± 0.034	3.388IlePro: 3.388 ± 0.043	2.202IleGln: 2.202 ± 0.028	4.057IleArg: 4.057 ± 0.041	4.776IleSer: 4.776 ± 0.051	4.058IleThr: 4.058 ± 0.044	4.12IleVal: 4.12 ± 0.051	0.836IleTrp: 0.836 ± 0.019	2.871IleTyr: 2.871 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.621LysAla: 4.621 ± 0.054	0.628LysCys: 0.628 ± 0.014	3.444LysAsp: 3.444 ± 0.04	6.324LysGlu: 6.324 ± 0.061	1.624LysPhe: 1.624 ± 0.031	4.12LysGly: 4.12 ± 0.037	0.827LysHis: 0.827 ± 0.023	3.973LysIle: 3.973 ± 0.044	5.372LysLys: 5.372 ± 0.059	4.879LysLeu: 4.879 ± 0.052	1.875LysMet: 1.875 ± 0.029	3.136LysAsn: 3.136 ± 0.042	1.94LysPro: 1.94 ± 0.027	2.182LysGln: 2.182 ± 0.034	2.812LysArg: 2.812 ± 0.037	2.897LysSer: 2.897 ± 0.037	3.164LysThr: 3.164 ± 0.041	3.405LysVal: 3.405 ± 0.042	0.695LysTrp: 0.695 ± 0.018	2.631LysTyr: 2.631 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	6.897LeuAla: 6.897 ± 0.062	1.682LeuCys: 1.682 ± 0.027	5.066LeuAsp: 5.066 ± 0.047	6.712LeuGlu: 6.712 ± 0.069	4.594LeuPhe: 4.594 ± 0.061	5.758LeuGly: 5.758 ± 0.061	1.719LeuHis: 1.719 ± 0.03	6.031LeuIle: 6.031 ± 0.069	5.681LeuLys: 5.681 ± 0.053	10.197LeuLeu: 10.197 ± 0.088	2.751LeuMet: 2.751 ± 0.035	3.732LeuAsn: 3.732 ± 0.043	4.191LeuPro: 4.191 ± 0.048	3.24LeuGln: 3.24 ± 0.04	4.135LeuArg: 4.135 ± 0.045	6.703LeuSer: 6.703 ± 0.064	5.244LeuThr: 5.244 ± 0.048	5.36LeuVal: 5.36 ± 0.056	1.045LeuTrp: 1.045 ± 0.021	3.983LeuTyr: 3.983 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.469MetAla: 2.469 ± 0.037	0.362MetCys: 0.362 ± 0.012	1.964MetAsp: 1.964 ± 0.029	2.934MetGlu: 2.934 ± 0.038	1.004MetPhe: 1.004 ± 0.021	2.117MetGly: 2.117 ± 0.032	0.449MetHis: 0.449 ± 0.016	1.975MetIle: 1.975 ± 0.034	2.45MetLys: 2.45 ± 0.034	2.975MetLeu: 2.975 ± 0.035	0.886MetMet: 0.886 ± 0.023	1.546MetAsn: 1.546 ± 0.029	1.251MetPro: 1.251 ± 0.021	1.117MetGln: 1.117 ± 0.022	1.292MetArg: 1.292 ± 0.027	1.671MetSer: 1.671 ± 0.03	1.654MetThr: 1.654 ± 0.025	1.822MetVal: 1.822 ± 0.033	0.263MetTrp: 0.263 ± 0.012	0.989MetTyr: 0.989 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.932AsnAla: 2.932 ± 0.038	0.643AsnCys: 0.643 ± 0.018	1.942AsnAsp: 1.942 ± 0.029	2.648AsnGlu: 2.648 ± 0.035	1.659AsnPhe: 1.659 ± 0.027	3.605AsnGly: 3.605 ± 0.039	0.753AsnHis: 0.753 ± 0.018	3.084AsnIle: 3.084 ± 0.039	2.238AsnLys: 2.238 ± 0.033	3.536AsnLeu: 3.536 ± 0.038	1.345AsnMet: 1.345 ± 0.025	1.736AsnAsn: 1.736 ± 0.025	2.047AsnPro: 2.047 ± 0.032	1.39AsnGln: 1.39 ± 0.024	2.181AsnArg: 2.181 ± 0.032	2.489AsnSer: 2.489 ± 0.037	2.442AsnThr: 2.442 ± 0.031	2.494AsnVal: 2.494 ± 0.039	0.506AsnTrp: 0.506 ± 0.015	1.932AsnTyr: 1.932 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	2.897ProAla: 2.897 ± 0.037	0.515ProCys: 0.515 ± 0.017	2.744ProAsp: 2.744 ± 0.038	3.953ProGlu: 3.953 ± 0.048	1.846ProPhe: 1.846 ± 0.026	2.816ProGly: 2.816 ± 0.041	0.683ProHis: 0.683 ± 0.016	1.851ProIle: 1.851 ± 0.033	1.463ProLys: 1.463 ± 0.027	3.21ProLeu: 3.21 ± 0.038	0.972ProMet: 0.972 ± 0.023	1.156ProAsn: 1.156 ± 0.022	0.883ProPro: 0.883 ± 0.019	1.112ProGln: 1.112 ± 0.022	1.168ProArg: 1.168 ± 0.024	1.998ProSer: 1.998 ± 0.035	1.41ProThr: 1.41 ± 0.03	3.407ProVal: 3.407 ± 0.038	0.463ProTrp: 0.463 ± 0.017	1.593ProTyr: 1.593 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	2.619GlnAla: 2.619 ± 0.037	0.385GlnCys: 0.385 ± 0.012	1.701GlnAsp: 1.701 ± 0.031	2.955GlnGlu: 2.955 ± 0.04	1.255GlnPhe: 1.255 ± 0.022	2.031GlnGly: 2.031 ± 0.034	0.441GlnHis: 0.441 ± 0.014	2.442GlnIle: 2.442 ± 0.031	2.482GlnLys: 2.482 ± 0.036	3.123GlnLeu: 3.123 ± 0.041	1.149GlnMet: 1.149 ± 0.023	1.482GlnAsn: 1.482 ± 0.024	1.045GlnPro: 1.045 ± 0.025	1.199GlnGln: 1.199 ± 0.03	1.354GlnArg: 1.354 ± 0.024	1.643GlnSer: 1.643 ± 0.031	1.718GlnThr: 1.718 ± 0.029	1.985GlnVal: 1.985 ± 0.033	0.396GlnTrp: 0.396 ± 0.013	1.394GlnTyr: 1.394 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	2.792ArgAla: 2.792 ± 0.039	0.64ArgCys: 0.64 ± 0.019	2.505ArgAsp: 2.505 ± 0.028	4.433ArgGlu: 4.433 ± 0.048	2.181ArgPhe: 2.181 ± 0.03	2.509ArgGly: 2.509 ± 0.036	0.818ArgHis: 0.818 ± 0.021	3.903ArgIle: 3.903 ± 0.048	3.607ArgLys: 3.607 ± 0.044	4.782ArgLeu: 4.782 ± 0.051	1.712ArgMet: 1.712 ± 0.027	2.209ArgAsn: 2.209 ± 0.031	1.536ArgPro: 1.536 ± 0.028	1.974ArgGln: 1.974 ± 0.031	2.574ArgArg: 2.574 ± 0.039	2.342ArgSer: 2.342 ± 0.036	2.348ArgThr: 2.348 ± 0.031	2.654ArgVal: 2.654 ± 0.036	0.494ArgTrp: 0.494 ± 0.014	2.081ArgTyr: 2.081 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	4.264SerAla: 4.264 ± 0.047	0.991SerCys: 0.991 ± 0.022	3.207SerAsp: 3.207 ± 0.034	3.679SerGlu: 3.679 ± 0.045	3.123SerPhe: 3.123 ± 0.039	5.216SerGly: 5.216 ± 0.065	1.124SerHis: 1.124 ± 0.024	4.008SerIle: 4.008 ± 0.049	2.524SerLys: 2.524 ± 0.036	5.871SerLeu: 5.871 ± 0.057	1.855SerMet: 1.855 ± 0.03	2.023SerAsn: 2.023 ± 0.029	2.045SerPro: 2.045 ± 0.032	1.881SerGln: 1.881 ± 0.029	3.276SerArg: 3.276 ± 0.038	3.693SerSer: 3.693 ± 0.053	2.624SerThr: 2.624 ± 0.035	4.244SerVal: 4.244 ± 0.05	0.762SerTrp: 0.762 ± 0.02	2.616SerTyr: 2.616 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.664ThrAla: 4.664 ± 0.054	0.658ThrCys: 0.658 ± 0.018	3.154ThrAsp: 3.154 ± 0.037	3.892ThrGlu: 3.892 ± 0.051	2.139ThrPhe: 2.139 ± 0.032	4.731ThrGly: 4.731 ± 0.056	0.795ThrHis: 0.795 ± 0.019	3.577ThrIle: 3.577 ± 0.04	2.295ThrLys: 2.295 ± 0.031	4.808ThrLeu: 4.808 ± 0.046	1.377ThrMet: 1.377 ± 0.024	1.756ThrAsn: 1.756 ± 0.03	2.187ThrPro: 2.187 ± 0.031	1.516ThrGln: 1.516 ± 0.028	2.013ThrArg: 2.013 ± 0.029	2.643ThrSer: 2.643 ± 0.037	2.275ThrThr: 2.275 ± 0.034	4.07ThrVal: 4.07 ± 0.047	0.537ThrTrp: 0.537 ± 0.015	2.064ThrTyr: 2.064 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	3.679ValAla: 3.679 ± 0.048	1.152ValCys: 1.152 ± 0.025	3.283ValAsp: 3.283 ± 0.042	4.103ValGlu: 4.103 ± 0.047	3.209ValPhe: 3.209 ± 0.043	3.703ValGly: 3.703 ± 0.047	1.013ValHis: 1.013 ± 0.024	4.665ValIle: 4.665 ± 0.058	3.959ValLys: 3.959 ± 0.042	6.66ValLeu: 6.66 ± 0.059	1.979ValMet: 1.979 ± 0.031	2.811ValAsn: 2.811 ± 0.042	2.662ValPro: 2.662 ± 0.034	1.893ValGln: 1.893 ± 0.03	3.089ValArg: 3.089 ± 0.038	4.549ValSer: 4.549 ± 0.05	3.812ValThr: 3.812 ± 0.049	3.96ValVal: 3.96 ± 0.047	0.799ValTrp: 0.799 ± 0.021	2.722ValTyr: 2.722 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.669TrpAla: 0.669 ± 0.019	0.203TrpCys: 0.203 ± 0.009	0.726TrpAsp: 0.726 ± 0.019	0.97TrpGlu: 0.97 ± 0.019	0.524TrpPhe: 0.524 ± 0.015	0.84TrpGly: 0.84 ± 0.021	0.259TrpHis: 0.259 ± 0.011	0.74TrpIle: 0.74 ± 0.018	0.915TrpLys: 0.915 ± 0.02	1.132TrpLeu: 1.132 ± 0.026	0.388TrpMet: 0.388 ± 0.013	0.779TrpAsn: 0.779 ± 0.019	0.34TrpPro: 0.34 ± 0.014	0.5TrpGln: 0.5 ± 0.015	0.449TrpArg: 0.449 ± 0.015	0.632TrpSer: 0.632 ± 0.017	0.514TrpThr: 0.514 ± 0.015	0.608TrpVal: 0.608 ± 0.015	0.17TrpTrp: 0.17 ± 0.009	0.519TrpTyr: 0.519 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.875TyrAla: 2.875 ± 0.038	0.682TyrCys: 0.682 ± 0.018	2.424TyrAsp: 2.424 ± 0.034	3.126TyrGlu: 3.126 ± 0.035	2.138TyrPhe: 2.138 ± 0.036	3.283TyrGly: 3.283 ± 0.038	0.881TyrHis: 0.881 ± 0.019	2.862TyrIle: 2.862 ± 0.042	2.048TyrLys: 2.048 ± 0.03	4.295TyrLeu: 4.295 ± 0.048	1.254TyrMet: 1.254 ± 0.022	1.805TyrAsn: 1.805 ± 0.026	1.76TyrPro: 1.76 ± 0.028	1.632TyrGln: 1.632 ± 0.025	2.491TyrArg: 2.491 ± 0.035	2.562TyrSer: 2.562 ± 0.034	2.29TyrThr: 2.29 ± 0.034	2.545TyrVal: 2.545 ± 0.037	0.498TyrTrp: 0.498 ± 0.015	2.082TyrTyr: 2.082 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6505 proteins (2265984 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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