Amino acid dipepetide frequency for Neisseria wadsworthii 9715

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.491AlaAla: 12.491 ± 0.206
1.38AlaCys: 1.38 ± 0.047
5.461AlaAsp: 5.461 ± 0.111
6.937AlaGlu: 6.937 ± 0.136
3.876AlaPhe: 3.876 ± 0.081
7.593AlaGly: 7.593 ± 0.136
1.868AlaHis: 1.868 ± 0.054
4.631AlaIle: 4.631 ± 0.096
5.178AlaLys: 5.178 ± 0.11
10.21AlaLeu: 10.21 ± 0.162
2.517AlaMet: 2.517 ± 0.073
3.207AlaAsn: 3.207 ± 0.089
3.553AlaPro: 3.553 ± 0.082
4.428AlaGln: 4.428 ± 0.098
4.527AlaArg: 4.527 ± 0.089
4.786AlaSer: 4.786 ± 0.104
3.971AlaThr: 3.971 ± 0.079
7.66AlaVal: 7.66 ± 0.133
1.234AlaTrp: 1.234 ± 0.041
2.823AlaTyr: 2.823 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.889CysAla: 0.889 ± 0.035
0.174CysCys: 0.174 ± 0.018
0.51CysAsp: 0.51 ± 0.032
0.53CysGlu: 0.53 ± 0.028
0.45CysPhe: 0.45 ± 0.024
1.071CysGly: 1.071 ± 0.05
0.301CysHis: 0.301 ± 0.023
0.56CysIle: 0.56 ± 0.03
0.463CysLys: 0.463 ± 0.028
1.37CysLeu: 1.37 ± 0.046
0.216CysMet: 0.216 ± 0.018
0.399CysAsn: 0.399 ± 0.025
0.473CysPro: 0.473 ± 0.027
0.343CysGln: 0.343 ± 0.023
0.573CysArg: 0.573 ± 0.031
0.623CysSer: 0.623 ± 0.032
0.467CysThr: 0.467 ± 0.027
0.627CysVal: 0.627 ± 0.031
0.126CysTrp: 0.126 ± 0.013
0.346CysTyr: 0.346 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.933AspAla: 4.933 ± 0.098
0.514AspCys: 0.514 ± 0.03
2.531AspAsp: 2.531 ± 0.08
3.418AspGlu: 3.418 ± 0.076
2.463AspPhe: 2.463 ± 0.072
3.684AspGly: 3.684 ± 0.118
0.831AspHis: 0.831 ± 0.032
3.576AspIle: 3.576 ± 0.072
3.18AspLys: 3.18 ± 0.076
5.12AspLeu: 5.12 ± 0.081
1.347AspMet: 1.347 ± 0.048
2.248AspAsn: 2.248 ± 0.062
1.877AspPro: 1.877 ± 0.056
1.421AspGln: 1.421 ± 0.048
2.21AspArg: 2.21 ± 0.059
2.714AspSer: 2.714 ± 0.069
2.84AspThr: 2.84 ± 0.08
3.494AspVal: 3.494 ± 0.07
0.864AspTrp: 0.864 ± 0.037
1.968AspTyr: 1.968 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
6.348GluAla: 6.348 ± 0.099
0.564GluCys: 0.564 ± 0.028
2.554GluAsp: 2.554 ± 0.061
3.954GluGlu: 3.954 ± 0.096
2.173GluPhe: 2.173 ± 0.062
3.7GluGly: 3.7 ± 0.087
1.678GluHis: 1.678 ± 0.056
4.004GluIle: 4.004 ± 0.073
4.047GluLys: 4.047 ± 0.084
5.618GluLeu: 5.618 ± 0.106
1.673GluMet: 1.673 ± 0.055
3.256GluAsn: 3.256 ± 0.077
2.181GluPro: 2.181 ± 0.058
3.421GluGln: 3.421 ± 0.089
3.557GluArg: 3.557 ± 0.092
3.184GluSer: 3.184 ± 0.068
3.654GluThr: 3.654 ± 0.078
3.711GluVal: 3.711 ± 0.082
0.88GluTrp: 0.88 ± 0.038
1.83GluTyr: 1.83 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
4.021PheAla: 4.021 ± 0.09
0.556PheCys: 0.556 ± 0.034
2.627PheAsp: 2.627 ± 0.054
2.347PheGlu: 2.347 ± 0.063
1.861PhePhe: 1.861 ± 0.063
3.537PheGly: 3.537 ± 0.075
0.787PheHis: 0.787 ± 0.032
2.498PheIle: 2.498 ± 0.067
2.094PheLys: 2.094 ± 0.058
3.594PheLeu: 3.594 ± 0.101
1.041PheMet: 1.041 ± 0.043
1.824PheAsn: 1.824 ± 0.051
1.471PhePro: 1.471 ± 0.05
1.469PheGln: 1.469 ± 0.043
1.864PheArg: 1.864 ± 0.062
2.933PheSer: 2.933 ± 0.08
2.28PheThr: 2.28 ± 0.06
2.663PheVal: 2.663 ± 0.064
0.58PheTrp: 0.58 ± 0.032
1.377PheTyr: 1.377 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
5.991GlyAla: 5.991 ± 0.116
0.824GlyCys: 0.824 ± 0.037
3.401GlyAsp: 3.401 ± 0.091
4.328GlyGlu: 4.328 ± 0.086
3.381GlyPhe: 3.381 ± 0.067
5.73GlyGly: 5.73 ± 0.141
1.48GlyHis: 1.48 ± 0.053
4.881GlyIle: 4.881 ± 0.097
5.305GlyLys: 5.305 ± 0.089
7.524GlyLeu: 7.524 ± 0.11
2.268GlyMet: 2.268 ± 0.061
3.223GlyAsn: 3.223 ± 0.129
1.319GlyPro: 1.319 ± 0.051
2.727GlyGln: 2.727 ± 0.064
3.848GlyArg: 3.848 ± 0.079
4.624GlySer: 4.624 ± 0.111
3.45GlyThr: 3.45 ± 0.085
5.323GlyVal: 5.323 ± 0.091
1.094GlyTrp: 1.094 ± 0.05
2.386GlyTyr: 2.386 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.958HisAla: 1.958 ± 0.047
0.279HisCys: 0.279 ± 0.02
1.081HisAsp: 1.081 ± 0.039
1.301HisGlu: 1.301 ± 0.047
1.03HisPhe: 1.03 ± 0.036
1.656HisGly: 1.656 ± 0.047
0.716HisHis: 0.716 ± 0.034
1.609HisIle: 1.609 ± 0.042
1.084HisLys: 1.084 ± 0.035
2.038HisLeu: 2.038 ± 0.064
0.523HisMet: 0.523 ± 0.028
1.039HisAsn: 1.039 ± 0.04
1.229HisPro: 1.229 ± 0.044
0.856HisGln: 0.856 ± 0.035
1.029HisArg: 1.029 ± 0.039
1.157HisSer: 1.157 ± 0.045
1.379HisThr: 1.379 ± 0.05
1.221HisVal: 1.221 ± 0.04
0.306HisTrp: 0.306 ± 0.02
0.869HisTyr: 0.869 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.855IleAla: 5.855 ± 0.099
0.671IleCys: 0.671 ± 0.029
3.467IleAsp: 3.467 ± 0.067
3.844IleGlu: 3.844 ± 0.076
2.24IlePhe: 2.24 ± 0.068
4.843IleGly: 4.843 ± 0.11
1.294IleHis: 1.294 ± 0.044
3.587IleIle: 3.587 ± 0.088
3.05IleLys: 3.05 ± 0.079
5.333IleLeu: 5.333 ± 0.108
1.4IleMet: 1.4 ± 0.044
2.758IleAsn: 2.758 ± 0.082
2.497IlePro: 2.497 ± 0.074
2.117IleGln: 2.117 ± 0.061
3.143IleArg: 3.143 ± 0.063
3.754IleSer: 3.754 ± 0.076
3.406IleThr: 3.406 ± 0.075
3.978IleVal: 3.978 ± 0.078
0.66IleTrp: 0.66 ± 0.031
1.688IleTyr: 1.688 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.244LysAla: 5.244 ± 0.104
0.331LysCys: 0.331 ± 0.026
2.647LysAsp: 2.647 ± 0.083
3.478LysGlu: 3.478 ± 0.082
1.687LysPhe: 1.687 ± 0.052
3.606LysGly: 3.606 ± 0.091
1.391LysHis: 1.391 ± 0.051
3.328LysIle: 3.328 ± 0.076
3.376LysLys: 3.376 ± 0.095
5.575LysLeu: 5.575 ± 0.097
1.643LysMet: 1.643 ± 0.052
2.686LysAsn: 2.686 ± 0.066
2.836LysPro: 2.836 ± 0.074
2.981LysGln: 2.981 ± 0.076
2.848LysArg: 2.848 ± 0.068
2.83LysSer: 2.83 ± 0.067
3.478LysThr: 3.478 ± 0.068
3.456LysVal: 3.456 ± 0.091
0.611LysTrp: 0.611 ± 0.032
1.49LysTyr: 1.49 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
10.448LeuAla: 10.448 ± 0.151
1.083LeuCys: 1.083 ± 0.039
5.065LeuAsp: 5.065 ± 0.091
5.32LeuGlu: 5.32 ± 0.098
4.11LeuPhe: 4.11 ± 0.107
6.928LeuGly: 6.928 ± 0.12
2.11LeuHis: 2.11 ± 0.062
5.715LeuIle: 5.715 ± 0.115
6.01LeuLys: 6.01 ± 0.091
10.2LeuLeu: 10.2 ± 0.192
2.654LeuMet: 2.654 ± 0.072
4.688LeuAsn: 4.688 ± 0.077
5.55LeuPro: 5.55 ± 0.101
4.207LeuGln: 4.207 ± 0.09
4.818LeuArg: 4.818 ± 0.084
6.993LeuSer: 6.993 ± 0.113
5.041LeuThr: 5.041 ± 0.08
6.105LeuVal: 6.105 ± 0.112
1.143LeuTrp: 1.143 ± 0.05
2.688LeuTyr: 2.688 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.494MetAla: 2.494 ± 0.074
0.236MetCys: 0.236 ± 0.017
1.081MetAsp: 1.081 ± 0.043
1.283MetGlu: 1.283 ± 0.045
0.949MetPhe: 0.949 ± 0.037
1.764MetGly: 1.764 ± 0.06
0.523MetHis: 0.523 ± 0.029
1.399MetIle: 1.399 ± 0.052
1.646MetLys: 1.646 ± 0.052
2.927MetLeu: 2.927 ± 0.066
0.889MetMet: 0.889 ± 0.045
1.3MetAsn: 1.3 ± 0.043
1.464MetPro: 1.464 ± 0.05
1.324MetGln: 1.324 ± 0.041
1.397MetArg: 1.397 ± 0.045
1.617MetSer: 1.617 ± 0.048
1.393MetThr: 1.393 ± 0.043
1.758MetVal: 1.758 ± 0.055
0.227MetTrp: 0.227 ± 0.019
0.539MetTyr: 0.539 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.844AsnAla: 3.844 ± 0.089
0.344AsnCys: 0.344 ± 0.025
2.144AsnAsp: 2.144 ± 0.093
2.394AsnGlu: 2.394 ± 0.059
1.379AsnPhe: 1.379 ± 0.044
3.55AsnGly: 3.55 ± 0.098
1.077AsnHis: 1.077 ± 0.047
3.131AsnIle: 3.131 ± 0.082
2.243AsnLys: 2.243 ± 0.056
4.061AsnLeu: 4.061 ± 0.089
1.086AsnMet: 1.086 ± 0.034
1.933AsnAsn: 1.933 ± 0.078
2.428AsnPro: 2.428 ± 0.061
1.88AsnGln: 1.88 ± 0.061
2.5AsnArg: 2.5 ± 0.069
2.126AsnSer: 2.126 ± 0.068
2.487AsnThr: 2.487 ± 0.07
2.677AsnVal: 2.677 ± 0.079
0.581AsnTrp: 0.581 ± 0.028
1.217AsnTyr: 1.217 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
4.091ProAla: 4.091 ± 0.092
0.36ProCys: 0.36 ± 0.023
2.541ProAsp: 2.541 ± 0.06
3.86ProGlu: 3.86 ± 0.086
1.907ProPhe: 1.907 ± 0.049
2.163ProGly: 2.163 ± 0.061
0.971ProHis: 0.971 ± 0.042
2.051ProIle: 2.051 ± 0.062
2.33ProLys: 2.33 ± 0.065
4.186ProLeu: 4.186 ± 0.099
0.987ProMet: 0.987 ± 0.038
1.807ProAsn: 1.807 ± 0.051
1.591ProPro: 1.591 ± 0.056
2.113ProGln: 2.113 ± 0.058
1.613ProArg: 1.613 ± 0.047
2.13ProSer: 2.13 ± 0.056
1.91ProThr: 1.91 ± 0.054
3.671ProVal: 3.671 ± 0.09
0.443ProTrp: 0.443 ± 0.028
1.31ProTyr: 1.31 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.903GlnAla: 4.903 ± 0.091
0.366GlnCys: 0.366 ± 0.024
1.923GlnAsp: 1.923 ± 0.055
2.493GlnGlu: 2.493 ± 0.07
1.474GlnPhe: 1.474 ± 0.053
2.696GlnGly: 2.696 ± 0.058
1.15GlnHis: 1.15 ± 0.045
2.804GlnIle: 2.804 ± 0.055
2.521GlnLys: 2.521 ± 0.068
3.498GlnLeu: 3.498 ± 0.07
1.083GlnMet: 1.083 ± 0.038
2.24GlnAsn: 2.24 ± 0.062
1.827GlnPro: 1.827 ± 0.062
2.296GlnGln: 2.296 ± 0.075
2.087GlnArg: 2.087 ± 0.06
2.583GlnSer: 2.583 ± 0.059
3.053GlnThr: 3.053 ± 0.066
2.543GlnVal: 2.543 ± 0.067
0.547GlnTrp: 0.547 ± 0.028
1.374GlnTyr: 1.374 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
4.07ArgAla: 4.07 ± 0.097
0.424ArgCys: 0.424 ± 0.029
2.47ArgAsp: 2.47 ± 0.072
3.276ArgGlu: 3.276 ± 0.086
2.597ArgPhe: 2.597 ± 0.062
2.908ArgGly: 2.908 ± 0.067
1.356ArgHis: 1.356 ± 0.041
3.276ArgIle: 3.276 ± 0.069
2.783ArgLys: 2.783 ± 0.066
5.544ArgLeu: 5.544 ± 0.101
1.479ArgMet: 1.479 ± 0.053
2.193ArgAsn: 2.193 ± 0.062
2.003ArgPro: 2.003 ± 0.055
2.53ArgGln: 2.53 ± 0.069
2.997ArgArg: 2.997 ± 0.076
2.74ArgSer: 2.74 ± 0.075
2.21ArgThr: 2.21 ± 0.062
3.306ArgVal: 3.306 ± 0.074
0.616ArgTrp: 0.616 ± 0.036
1.944ArgTyr: 1.944 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.371SerAla: 5.371 ± 0.103
0.581SerCys: 0.581 ± 0.028
3.174SerAsp: 3.174 ± 0.082
3.806SerGlu: 3.806 ± 0.078
2.407SerPhe: 2.407 ± 0.065
5.438SerGly: 5.438 ± 0.091
1.257SerHis: 1.257 ± 0.042
3.298SerIle: 3.298 ± 0.065
2.804SerLys: 2.804 ± 0.068
5.751SerLeu: 5.751 ± 0.1
1.4SerMet: 1.4 ± 0.046
2.191SerAsn: 2.191 ± 0.075
2.327SerPro: 2.327 ± 0.057
2.106SerGln: 2.106 ± 0.064
2.976SerArg: 2.976 ± 0.064
3.233SerSer: 3.233 ± 0.089
2.473SerThr: 2.473 ± 0.066
4.057SerVal: 4.057 ± 0.089
0.694SerTrp: 0.694 ± 0.035
1.753SerTyr: 1.753 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
5.271ThrAla: 5.271 ± 0.095
0.491ThrCys: 0.491 ± 0.029
2.927ThrAsp: 2.927 ± 0.077
3.106ThrGlu: 3.106 ± 0.069
2.024ThrPhe: 2.024 ± 0.055
4.481ThrGly: 4.481 ± 0.08
1.171ThrHis: 1.171 ± 0.038
2.924ThrIle: 2.924 ± 0.066
1.9ThrLys: 1.9 ± 0.052
5.881ThrLeu: 5.881 ± 0.112
1.05ThrMet: 1.05 ± 0.039
1.756ThrAsn: 1.756 ± 0.07
2.738ThrPro: 2.738 ± 0.068
2.171ThrGln: 2.171 ± 0.049
2.474ThrArg: 2.474 ± 0.059
2.414ThrSer: 2.414 ± 0.071
2.34ThrThr: 2.34 ± 0.074
4.323ThrVal: 4.323 ± 0.093
0.574ThrTrp: 0.574 ± 0.032
1.29ThrTyr: 1.29 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
6.444ValAla: 6.444 ± 0.128
0.844ValCys: 0.844 ± 0.038
3.4ValAsp: 3.4 ± 0.07
4.04ValGlu: 4.04 ± 0.083
3.201ValPhe: 3.201 ± 0.075
4.668ValGly: 4.668 ± 0.09
1.291ValHis: 1.291 ± 0.044
3.997ValIle: 3.997 ± 0.088
3.683ValLys: 3.683 ± 0.085
7.418ValLeu: 7.418 ± 0.108
1.99ValMet: 1.99 ± 0.059
2.73ValAsn: 2.73 ± 0.078
2.834ValPro: 2.834 ± 0.075
2.518ValGln: 2.518 ± 0.057
3.5ValArg: 3.5 ± 0.076
4.397ValSer: 4.397 ± 0.081
3.167ValThr: 3.167 ± 0.074
4.873ValVal: 4.873 ± 0.106
0.979ValTrp: 0.979 ± 0.036
2.104ValTyr: 2.104 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
1.051TrpAla: 1.051 ± 0.041
0.13TrpCys: 0.13 ± 0.015
0.516TrpAsp: 0.516 ± 0.026
0.551TrpGlu: 0.551 ± 0.027
0.686TrpPhe: 0.686 ± 0.034
0.756TrpGly: 0.756 ± 0.033
0.361TrpHis: 0.361 ± 0.025
0.681TrpIle: 0.681 ± 0.036
0.574TrpLys: 0.574 ± 0.033
1.89TrpLeu: 1.89 ± 0.065
0.336TrpMet: 0.336 ± 0.023
0.439TrpAsn: 0.439 ± 0.027
0.45TrpPro: 0.45 ± 0.025
1.013TrpGln: 1.013 ± 0.044
0.847TrpArg: 0.847 ± 0.04
0.599TrpSer: 0.599 ± 0.03
0.456TrpThr: 0.456 ± 0.029
0.889TrpVal: 0.889 ± 0.034
0.176TrpTrp: 0.176 ± 0.017
0.341TrpTyr: 0.341 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.611TyrAla: 2.611 ± 0.069
0.356TyrCys: 0.356 ± 0.022
1.713TyrAsp: 1.713 ± 0.074
1.723TyrGlu: 1.723 ± 0.051
1.531TyrPhe: 1.531 ± 0.057
2.337TyrGly: 2.337 ± 0.059
0.741TyrHis: 0.741 ± 0.032
1.634TyrIle: 1.634 ± 0.054
1.254TyrLys: 1.254 ± 0.052
3.138TyrLeu: 3.138 ± 0.066
0.627TyrMet: 0.627 ± 0.027
1.167TyrAsn: 1.167 ± 0.051
1.387TyrPro: 1.387 ± 0.046
1.539TyrGln: 1.539 ± 0.047
1.911TyrArg: 1.911 ± 0.053
1.663TyrSer: 1.663 ± 0.055
1.854TyrThr: 1.854 ± 0.053
1.744TyrVal: 1.744 ± 0.051
0.406TyrTrp: 0.406 ± 0.026
0.991TyrTyr: 0.991 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2553 proteins (700031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski