Amino acid dipepetide frequency for Flavobacterium oncorhynchi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.034AlaAla: 5.034 ± 0.096	0.531AlaCys: 0.531 ± 0.021	3.617AlaAsp: 3.617 ± 0.059	4.179AlaGlu: 4.179 ± 0.074	3.444AlaPhe: 3.444 ± 0.052	4.465AlaGly: 4.465 ± 0.073	0.993AlaHis: 0.993 ± 0.029	5.307AlaIle: 5.307 ± 0.067	5.305AlaLys: 5.305 ± 0.101	6.209AlaLeu: 6.209 ± 0.068	1.475AlaMet: 1.475 ± 0.036	3.678AlaAsn: 3.678 ± 0.058	1.989AlaPro: 1.989 ± 0.044	2.557AlaGln: 2.557 ± 0.05	1.843AlaArg: 1.843 ± 0.043	4.456AlaSer: 4.456 ± 0.067	3.537AlaThr: 3.537 ± 0.07	4.667AlaVal: 4.667 ± 0.068	0.644AlaTrp: 0.644 ± 0.022	2.492AlaTyr: 2.492 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.432CysAla: 0.432 ± 0.019	0.112CysCys: 0.112 ± 0.009	0.409CysAsp: 0.409 ± 0.018	0.447CysGlu: 0.447 ± 0.021	0.437CysPhe: 0.437 ± 0.019	0.602CysGly: 0.602 ± 0.025	0.181CysHis: 0.181 ± 0.015	0.615CysIle: 0.615 ± 0.022	0.5CysLys: 0.5 ± 0.02	0.628CysLeu: 0.628 ± 0.025	0.141CysMet: 0.141 ± 0.01	0.416CysAsn: 0.416 ± 0.022	0.333CysPro: 0.333 ± 0.019	0.209CysGln: 0.209 ± 0.014	0.188CysArg: 0.188 ± 0.012	0.576CysSer: 0.576 ± 0.026	0.492CysThr: 0.492 ± 0.024	0.416CysVal: 0.416 ± 0.017	0.078CysTrp: 0.078 ± 0.007	0.304CysTyr: 0.304 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.659AspAla: 3.659 ± 0.063	0.394AspCys: 0.394 ± 0.023	2.601AspAsp: 2.601 ± 0.054	3.387AspGlu: 3.387 ± 0.05	3.659AspPhe: 3.659 ± 0.051	3.54AspGly: 3.54 ± 0.066	0.795AspHis: 0.795 ± 0.027	3.969AspIle: 3.969 ± 0.057	4.467AspLys: 4.467 ± 0.058	5.319AspLeu: 5.319 ± 0.07	1.004AspMet: 1.004 ± 0.031	3.111AspAsn: 3.111 ± 0.045	1.768AspPro: 1.768 ± 0.041	1.592AspGln: 1.592 ± 0.031	1.717AspArg: 1.717 ± 0.036	3.089AspSer: 3.089 ± 0.053	2.45AspThr: 2.45 ± 0.043	3.38AspVal: 3.38 ± 0.046	0.745AspTrp: 0.745 ± 0.023	2.724AspTyr: 2.724 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.111GluAla: 4.111 ± 0.077	0.337GluCys: 0.337 ± 0.016	3.053GluAsp: 3.053 ± 0.053	4.146GluGlu: 4.146 ± 0.078	2.835GluPhe: 2.835 ± 0.053	3.316GluGly: 3.316 ± 0.055	0.977GluHis: 0.977 ± 0.029	5.633GluIle: 5.633 ± 0.07	6.399GluLys: 6.399 ± 0.081	5.535GluLeu: 5.535 ± 0.066	1.595GluMet: 1.595 ± 0.034	4.947GluAsn: 4.947 ± 0.059	1.512GluPro: 1.512 ± 0.034	2.058GluGln: 2.058 ± 0.042	2.193GluArg: 2.193 ± 0.043	3.355GluSer: 3.355 ± 0.052	3.764GluThr: 3.764 ± 0.058	3.941GluVal: 3.941 ± 0.054	0.618GluTrp: 0.618 ± 0.02	2.313GluTyr: 2.313 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.35PheAla: 3.35 ± 0.053	0.458PheCys: 0.458 ± 0.019	3.237PheAsp: 3.237 ± 0.05	3.402PheGlu: 3.402 ± 0.053	2.909PhePhe: 2.909 ± 0.062	3.734PheGly: 3.734 ± 0.061	0.791PheHis: 0.791 ± 0.024	3.931PheIle: 3.931 ± 0.064	3.848PheLys: 3.848 ± 0.058	4.858PheLeu: 4.858 ± 0.072	1.182PheMet: 1.182 ± 0.03	3.216PheAsn: 3.216 ± 0.057	1.794PhePro: 1.794 ± 0.042	1.656PheGln: 1.656 ± 0.036	1.6PheArg: 1.6 ± 0.033	4.271PheSer: 4.271 ± 0.064	3.276PheThr: 3.276 ± 0.054	3.214PheVal: 3.214 ± 0.049	0.603PheTrp: 0.603 ± 0.022	2.372PheTyr: 2.372 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.121GlyAla: 4.121 ± 0.074	0.584GlyCys: 0.584 ± 0.028	3.135GlyAsp: 3.135 ± 0.05	3.306GlyGlu: 3.306 ± 0.056	3.754GlyPhe: 3.754 ± 0.046	4.523GlyGly: 4.523 ± 0.095	1.019GlyHis: 1.019 ± 0.035	5.402GlyIle: 5.402 ± 0.061	5.305GlyLys: 5.305 ± 0.069	5.64GlyLeu: 5.64 ± 0.068	1.487GlyMet: 1.487 ± 0.034	3.87GlyAsn: 3.87 ± 0.065	1.329GlyPro: 1.329 ± 0.035	1.901GlyGln: 1.901 ± 0.044	1.927GlyArg: 1.927 ± 0.042	4.147GlySer: 4.147 ± 0.069	4.312GlyThr: 4.312 ± 0.091	4.197GlyVal: 4.197 ± 0.059	0.762GlyTrp: 0.762 ± 0.025	2.848GlyTyr: 2.848 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.883HisAla: 0.883 ± 0.029	0.169HisCys: 0.169 ± 0.012	0.818HisAsp: 0.818 ± 0.031	0.899HisGlu: 0.899 ± 0.026	1.165HisPhe: 1.165 ± 0.032	0.984HisGly: 0.984 ± 0.032	0.416HisHis: 0.416 ± 0.017	1.25HisIle: 1.25 ± 0.037	1.101HisLys: 1.101 ± 0.03	1.587HisLeu: 1.587 ± 0.034	0.284HisMet: 0.284 ± 0.014	0.987HisAsn: 0.987 ± 0.027	0.74HisPro: 0.74 ± 0.023	0.621HisGln: 0.621 ± 0.024	0.535HisArg: 0.535 ± 0.019	0.972HisSer: 0.972 ± 0.029	0.852HisThr: 0.852 ± 0.026	0.767HisVal: 0.767 ± 0.023	0.188HisTrp: 0.188 ± 0.012	0.762HisTyr: 0.762 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.826IleAla: 5.826 ± 0.073	0.685IleCys: 0.685 ± 0.027	4.677IleAsp: 4.677 ± 0.063	5.389IleGlu: 5.389 ± 0.076	3.67IlePhe: 3.67 ± 0.064	5.156IleGly: 5.156 ± 0.081	1.304IleHis: 1.304 ± 0.035	6.102IleIle: 6.102 ± 0.072	6.078IleLys: 6.078 ± 0.074	7.222IleLeu: 7.222 ± 0.095	1.429IleMet: 1.429 ± 0.033	4.748IleAsn: 4.748 ± 0.062	3.226IlePro: 3.226 ± 0.05	2.688IleGln: 2.688 ± 0.042	2.405IleArg: 2.405 ± 0.043	5.721IleSer: 5.721 ± 0.063	5.072IleThr: 5.072 ± 0.074	4.869IleVal: 4.869 ± 0.071	0.733IleTrp: 0.733 ± 0.027	2.799IleTyr: 2.799 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	5.458LysAla: 5.458 ± 0.089	0.382LysCys: 0.382 ± 0.019	4.532LysAsp: 4.532 ± 0.062	6.071LysGlu: 6.071 ± 0.084	3.252LysPhe: 3.252 ± 0.051	4.808LysGly: 4.808 ± 0.07	1.25LysHis: 1.25 ± 0.032	7.049LysIle: 7.049 ± 0.076	7.406LysLys: 7.406 ± 0.088	6.759LysLeu: 6.759 ± 0.064	2.248LysMet: 2.248 ± 0.042	5.947LysAsn: 5.947 ± 0.07	2.669LysPro: 2.669 ± 0.046	2.737LysGln: 2.737 ± 0.048	2.555LysArg: 2.555 ± 0.042	4.869LysSer: 4.869 ± 0.07	5.4LysThr: 5.4 ± 0.068	4.916LysVal: 4.916 ± 0.066	0.904LysTrp: 0.904 ± 0.023	3.241LysTyr: 3.241 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.886LeuAla: 5.886 ± 0.078	0.7LeuCys: 0.7 ± 0.023	4.769LeuAsp: 4.769 ± 0.061	5.713LeuGlu: 5.713 ± 0.07	5.042LeuPhe: 5.042 ± 0.076	5.622LeuGly: 5.622 ± 0.074	1.476LeuHis: 1.476 ± 0.03	6.743LeuIle: 6.743 ± 0.086	7.876LeuLys: 7.876 ± 0.084	8.454LeuLeu: 8.454 ± 0.106	1.974LeuMet: 1.974 ± 0.042	5.786LeuAsn: 5.786 ± 0.068	3.594LeuPro: 3.594 ± 0.053	3.161LeuGln: 3.161 ± 0.05	2.874LeuArg: 2.874 ± 0.052	6.648LeuSer: 6.648 ± 0.083	5.222LeuThr: 5.222 ± 0.075	5.22LeuVal: 5.22 ± 0.067	0.795LeuTrp: 0.795 ± 0.025	3.297LeuTyr: 3.297 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.54MetAla: 1.54 ± 0.04	0.142MetCys: 0.142 ± 0.01	0.98MetAsp: 0.98 ± 0.028	1.236MetGlu: 1.236 ± 0.031	0.866MetPhe: 0.866 ± 0.026	1.299MetGly: 1.299 ± 0.031	0.393MetHis: 0.393 ± 0.018	1.579MetIle: 1.579 ± 0.04	2.321MetLys: 2.321 ± 0.039	1.812MetLeu: 1.812 ± 0.043	0.552MetMet: 0.552 ± 0.021	1.367MetAsn: 1.367 ± 0.028	0.839MetPro: 0.839 ± 0.025	0.804MetGln: 0.804 ± 0.027	0.776MetArg: 0.776 ± 0.024	1.418MetSer: 1.418 ± 0.031	1.174MetThr: 1.174 ± 0.032	1.224MetVal: 1.224 ± 0.031	0.167MetTrp: 0.167 ± 0.01	0.705MetTyr: 0.705 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	4.155AsnAla: 4.155 ± 0.066	0.477AsnCys: 0.477 ± 0.021	3.279AsnAsp: 3.279 ± 0.051	3.923AsnGlu: 3.923 ± 0.056	3.346AsnPhe: 3.346 ± 0.059	4.284AsnGly: 4.284 ± 0.071	1.051AsnHis: 1.051 ± 0.031	4.877AsnIle: 4.877 ± 0.063	4.728AsnLys: 4.728 ± 0.058	5.654AsnLeu: 5.654 ± 0.079	1.17AsnMet: 1.17 ± 0.03	4.043AsnAsn: 4.043 ± 0.072	2.974AsnPro: 2.974 ± 0.045	2.342AsnGln: 2.342 ± 0.044	2.084AsnArg: 2.084 ± 0.046	4.214AsnSer: 4.214 ± 0.071	3.796AsnThr: 3.796 ± 0.064	3.782AsnVal: 3.782 ± 0.058	0.833AsnTrp: 0.833 ± 0.03	2.957AsnTyr: 2.957 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	2.324ProAla: 2.324 ± 0.044	0.193ProCys: 0.193 ± 0.012	1.945ProAsp: 1.945 ± 0.042	2.736ProGlu: 2.736 ± 0.044	1.952ProPhe: 1.952 ± 0.037	1.967ProGly: 1.967 ± 0.048	0.508ProHis: 0.508 ± 0.02	2.725ProIle: 2.725 ± 0.048	2.707ProLys: 2.707 ± 0.045	2.906ProLeu: 2.906 ± 0.049	0.691ProMet: 0.691 ± 0.019	2.332ProAsn: 2.332 ± 0.049	0.768ProPro: 0.768 ± 0.028	1.124ProGln: 1.124 ± 0.029	0.899ProArg: 0.899 ± 0.025	2.221ProSer: 2.221 ± 0.042	1.997ProThr: 1.997 ± 0.05	2.484ProVal: 2.484 ± 0.048	0.319ProTrp: 0.319 ± 0.014	1.419ProTyr: 1.419 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	1.953GlnAla: 1.953 ± 0.043	0.171GlnCys: 0.171 ± 0.012	1.644GlnAsp: 1.644 ± 0.036	2.171GlnGlu: 2.171 ± 0.042	1.713GlnPhe: 1.713 ± 0.037	1.696GlnGly: 1.696 ± 0.039	0.529GlnHis: 0.529 ± 0.019	2.82GlnIle: 2.82 ± 0.046	3.253GlnLys: 3.253 ± 0.05	3.25GlnLeu: 3.25 ± 0.05	0.756GlnMet: 0.756 ± 0.027	2.512GlnAsn: 2.512 ± 0.042	1.049GlnPro: 1.049 ± 0.028	1.308GlnGln: 1.308 ± 0.039	1.082GlnArg: 1.082 ± 0.029	2.034GlnSer: 2.034 ± 0.041	2.101GlnThr: 2.101 ± 0.045	1.809GlnVal: 1.809 ± 0.039	0.378GlnTrp: 0.378 ± 0.02	1.429GlnTyr: 1.429 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.94ArgAla: 1.94 ± 0.044	0.19ArgCys: 0.19 ± 0.013	1.531ArgAsp: 1.531 ± 0.031	1.992ArgGlu: 1.992 ± 0.04	1.812ArgPhe: 1.812 ± 0.041	1.723ArgGly: 1.723 ± 0.038	0.517ArgHis: 0.517 ± 0.021	2.748ArgIle: 2.748 ± 0.053	2.581ArgLys: 2.581 ± 0.047	2.864ArgLeu: 2.864 ± 0.049	0.813ArgMet: 0.813 ± 0.025	2.04ArgAsn: 2.04 ± 0.043	1.012ArgPro: 1.012 ± 0.031	0.948ArgGln: 0.948 ± 0.023	1.087ArgArg: 1.087 ± 0.033	1.766ArgSer: 1.766 ± 0.039	1.759ArgThr: 1.759 ± 0.034	1.889ArgVal: 1.889 ± 0.038	0.375ArgTrp: 0.375 ± 0.018	1.406ArgTyr: 1.406 ± 0.03	0.001ArgXaa: 0.001 ± 0.001
Ser	4.174SerAla: 4.174 ± 0.065	0.673SerCys: 0.673 ± 0.025	3.638SerAsp: 3.638 ± 0.049	3.814SerGlu: 3.814 ± 0.054	4.022SerPhe: 4.022 ± 0.061	4.72SerGly: 4.72 ± 0.066	1.054SerHis: 1.054 ± 0.026	5.397SerIle: 5.397 ± 0.066	5.344SerLys: 5.344 ± 0.063	6.033SerLeu: 6.033 ± 0.073	1.252SerMet: 1.252 ± 0.028	4.084SerAsn: 4.084 ± 0.063	2.047SerPro: 2.047 ± 0.039	2.281SerGln: 2.281 ± 0.042	1.922SerArg: 1.922 ± 0.042	4.32SerSer: 4.32 ± 0.073	3.832SerThr: 3.832 ± 0.069	4.061SerVal: 4.061 ± 0.059	0.703SerTrp: 0.703 ± 0.025	2.85SerTyr: 2.85 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.528ThrAla: 4.528 ± 0.083	0.355ThrCys: 0.355 ± 0.02	3.214ThrAsp: 3.214 ± 0.051	3.369ThrGlu: 3.369 ± 0.051	3.214ThrPhe: 3.214 ± 0.05	4.136ThrGly: 4.136 ± 0.082	0.886ThrHis: 0.886 ± 0.026	5.22ThrIle: 5.22 ± 0.068	4.319ThrLys: 4.319 ± 0.063	5.262ThrLeu: 5.262 ± 0.06	0.908ThrMet: 0.908 ± 0.028	3.509ThrAsn: 3.509 ± 0.064	2.603ThrPro: 2.603 ± 0.053	1.933ThrGln: 1.933 ± 0.04	1.588ThrArg: 1.588 ± 0.031	3.872ThrSer: 3.872 ± 0.059	3.922ThrThr: 3.922 ± 0.086	4.008ThrVal: 4.008 ± 0.087	0.591ThrTrp: 0.591 ± 0.022	2.408ThrTyr: 2.408 ± 0.054	0.001ThrXaa: 0.001 ± 0.001
Val	3.902ValAla: 3.902 ± 0.057	0.524ValCys: 0.524 ± 0.024	3.326ValAsp: 3.326 ± 0.046	3.529ValGlu: 3.529 ± 0.052	3.51ValPhe: 3.51 ± 0.059	3.655ValGly: 3.655 ± 0.063	0.914ValHis: 0.914 ± 0.024	4.852ValIle: 4.852 ± 0.06	4.736ValLys: 4.736 ± 0.066	6.139ValLeu: 6.139 ± 0.077	1.266ValMet: 1.266 ± 0.032	3.817ValAsn: 3.817 ± 0.057	2.226ValPro: 2.226 ± 0.044	1.836ValGln: 1.836 ± 0.04	1.859ValArg: 1.859 ± 0.036	4.691ValSer: 4.691 ± 0.069	3.777ValThr: 3.777 ± 0.08	4.105ValVal: 4.105 ± 0.064	0.601ValTrp: 0.601 ± 0.023	2.471ValTyr: 2.471 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.652TrpAla: 0.652 ± 0.022	0.108TrpCys: 0.108 ± 0.009	0.589TrpAsp: 0.589 ± 0.024	0.634TrpGlu: 0.634 ± 0.023	0.602TrpPhe: 0.602 ± 0.024	0.674TrpGly: 0.674 ± 0.023	0.209TrpHis: 0.209 ± 0.012	0.781TrpIle: 0.781 ± 0.029	0.881TrpLys: 0.881 ± 0.025	0.964TrpLeu: 0.964 ± 0.03	0.277TrpMet: 0.277 ± 0.015	0.789TrpAsn: 0.789 ± 0.024	0.243TrpPro: 0.243 ± 0.015	0.411TrpGln: 0.411 ± 0.019	0.397TrpArg: 0.397 ± 0.016	0.697TrpSer: 0.697 ± 0.026	0.602TrpThr: 0.602 ± 0.024	0.563TrpVal: 0.563 ± 0.02	0.161TrpTrp: 0.161 ± 0.012	0.462TrpTyr: 0.462 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.495TyrAla: 2.495 ± 0.047	0.331TyrCys: 0.331 ± 0.015	2.376TyrAsp: 2.376 ± 0.038	2.292TyrGlu: 2.292 ± 0.045	2.499TyrPhe: 2.499 ± 0.048	2.664TyrGly: 2.664 ± 0.052	0.715TyrHis: 0.715 ± 0.023	2.802TyrIle: 2.802 ± 0.043	3.295TyrLys: 3.295 ± 0.051	3.756TyrLeu: 3.756 ± 0.053	0.689TyrMet: 0.689 ± 0.024	2.772TyrAsn: 2.772 ± 0.05	1.505TyrPro: 1.505 ± 0.036	1.493TyrGln: 1.493 ± 0.037	1.46TyrArg: 1.46 ± 0.033	2.884TyrSer: 2.884 ± 0.05	2.512TyrThr: 2.512 ± 0.053	2.222TyrVal: 2.222 ± 0.042	0.498TyrTrp: 0.498 ± 0.019	1.908TyrTyr: 1.908 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3969 proteins (1381088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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