Amino acid dipepetide frequency for Bifidobacterium jacchi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.768AlaAla: 16.768 ± 0.307
1.095AlaCys: 1.095 ± 0.041
8.798AlaAsp: 8.798 ± 0.155
5.877AlaGlu: 5.877 ± 0.112
3.506AlaPhe: 3.506 ± 0.073
9.828AlaGly: 9.828 ± 0.163
2.346AlaHis: 2.346 ± 0.066
5.535AlaIle: 5.535 ± 0.09
4.722AlaLys: 4.722 ± 0.108
10.485AlaLeu: 10.485 ± 0.172
3.108AlaMet: 3.108 ± 0.07
3.746AlaAsn: 3.746 ± 0.086
4.392AlaPro: 4.392 ± 0.121
4.407AlaGln: 4.407 ± 0.091
6.96AlaArg: 6.96 ± 0.128
7.226AlaSer: 7.226 ± 0.141
6.772AlaThr: 6.772 ± 0.135
8.956AlaVal: 8.956 ± 0.134
1.465AlaTrp: 1.465 ± 0.049
2.776AlaTyr: 2.776 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
1.121CysAla: 1.121 ± 0.044
0.11CysCys: 0.11 ± 0.013
0.625CysAsp: 0.625 ± 0.032
0.453CysGlu: 0.453 ± 0.024
0.256CysPhe: 0.256 ± 0.022
1.013CysGly: 1.013 ± 0.039
0.191CysHis: 0.191 ± 0.014
0.393CysIle: 0.393 ± 0.026
0.196CysLys: 0.196 ± 0.018
0.677CysLeu: 0.677 ± 0.029
0.244CysMet: 0.244 ± 0.022
0.216CysAsn: 0.216 ± 0.018
0.488CysPro: 0.488 ± 0.032
0.177CysGln: 0.177 ± 0.016
0.618CysArg: 0.618 ± 0.031
0.494CysSer: 0.494 ± 0.029
0.521CysThr: 0.521 ± 0.027
0.755CysVal: 0.755 ± 0.037
0.124CysTrp: 0.124 ± 0.015
0.227CysTyr: 0.227 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
8.898AspAla: 8.898 ± 0.143
0.543AspCys: 0.543 ± 0.028
5.561AspAsp: 5.561 ± 0.098
4.765AspGlu: 4.765 ± 0.094
2.213AspPhe: 2.213 ± 0.065
6.648AspGly: 6.648 ± 0.127
1.38AspHis: 1.38 ± 0.045
3.184AspIle: 3.184 ± 0.069
2.488AspLys: 2.488 ± 0.089
5.296AspLeu: 5.296 ± 0.092
1.67AspMet: 1.67 ± 0.047
1.936AspAsn: 1.936 ± 0.057
3.453AspPro: 3.453 ± 0.07
1.892AspGln: 1.892 ± 0.062
3.998AspArg: 3.998 ± 0.087
3.787AspSer: 3.787 ± 0.081
3.35AspThr: 3.35 ± 0.071
5.23AspVal: 5.23 ± 0.085
1.003AspTrp: 1.003 ± 0.034
1.94AspTyr: 1.94 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
5.714GluAla: 5.714 ± 0.104
0.449GluCys: 0.449 ± 0.025
2.659GluAsp: 2.659 ± 0.073
2.764GluGlu: 2.764 ± 0.086
1.688GluPhe: 1.688 ± 0.057
3.679GluGly: 3.679 ± 0.083
1.591GluHis: 1.591 ± 0.049
2.588GluIle: 2.588 ± 0.064
1.867GluLys: 1.867 ± 0.061
4.939GluLeu: 4.939 ± 0.1
1.144GluMet: 1.144 ± 0.039
1.626GluAsn: 1.626 ± 0.049
2.619GluPro: 2.619 ± 0.069
2.482GluGln: 2.482 ± 0.074
4.584GluArg: 4.584 ± 0.092
3.552GluSer: 3.552 ± 0.079
3.197GluThr: 3.197 ± 0.067
3.227GluVal: 3.227 ± 0.083
0.648GluTrp: 0.648 ± 0.033
1.653GluTyr: 1.653 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
4.078PheAla: 4.078 ± 0.077
0.351PheCys: 0.351 ± 0.024
2.764PheAsp: 2.764 ± 0.072
1.619PheGlu: 1.619 ± 0.054
1.056PhePhe: 1.056 ± 0.044
3.165PheGly: 3.165 ± 0.076
0.669PheHis: 0.669 ± 0.032
1.619PheIle: 1.619 ± 0.052
1.004PheLys: 1.004 ± 0.047
2.454PheLeu: 2.454 ± 0.072
0.713PheMet: 0.713 ± 0.036
1.106PheAsn: 1.106 ± 0.042
1.248PhePro: 1.248 ± 0.041
0.818PheGln: 0.818 ± 0.034
1.701PheArg: 1.701 ± 0.051
2.064PheSer: 2.064 ± 0.057
2.162PheThr: 2.162 ± 0.058
2.539PheVal: 2.539 ± 0.068
0.383PheTrp: 0.383 ± 0.023
0.871PheTyr: 0.871 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
8.206GlyAla: 8.206 ± 0.138
0.744GlyCys: 0.744 ± 0.037
5.588GlyAsp: 5.588 ± 0.1
4.553GlyGlu: 4.553 ± 0.086
3.076GlyPhe: 3.076 ± 0.069
7.097GlyGly: 7.097 ± 0.171
1.663GlyHis: 1.663 ± 0.039
4.586GlyIle: 4.586 ± 0.096
3.663GlyLys: 3.663 ± 0.086
6.7GlyLeu: 6.7 ± 0.112
2.201GlyMet: 2.201 ± 0.058
2.982GlyAsn: 2.982 ± 0.099
2.394GlyPro: 2.394 ± 0.065
2.456GlyGln: 2.456 ± 0.072
5.428GlyArg: 5.428 ± 0.109
5.542GlySer: 5.542 ± 0.121
5.375GlyThr: 5.375 ± 0.123
6.589GlyVal: 6.589 ± 0.102
1.183GlyTrp: 1.183 ± 0.048
2.666GlyTyr: 2.666 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
2.432HisAla: 2.432 ± 0.064
0.216HisCys: 0.216 ± 0.018
1.581HisAsp: 1.581 ± 0.052
1.13HisGlu: 1.13 ± 0.04
0.578HisPhe: 0.578 ± 0.029
2.027HisGly: 2.027 ± 0.057
0.596HisHis: 0.596 ± 0.036
1.121HisIle: 1.121 ± 0.04
0.547HisLys: 0.547 ± 0.024
1.532HisLeu: 1.532 ± 0.049
0.584HisMet: 0.584 ± 0.031
0.557HisAsn: 0.557 ± 0.027
1.294HisPro: 1.294 ± 0.038
0.567HisGln: 0.567 ± 0.029
1.47HisArg: 1.47 ± 0.048
1.002HisSer: 1.002 ± 0.034
1.19HisThr: 1.19 ± 0.039
1.8HisVal: 1.8 ± 0.051
0.301HisTrp: 0.301 ± 0.02
0.592HisTyr: 0.592 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.859IleAla: 6.859 ± 0.116
0.568IleCys: 0.568 ± 0.032
4.333IleAsp: 4.333 ± 0.087
3.123IleGlu: 3.123 ± 0.075
1.18IlePhe: 1.18 ± 0.05
4.584IleGly: 4.584 ± 0.091
0.964IleHis: 0.964 ± 0.038
2.741IleIle: 2.741 ± 0.074
1.637IleLys: 1.637 ± 0.06
3.314IleLeu: 3.314 ± 0.081
1.183IleMet: 1.183 ± 0.041
1.748IleAsn: 1.748 ± 0.048
2.545IlePro: 2.545 ± 0.061
1.208IleGln: 1.208 ± 0.043
3.174IleArg: 3.174 ± 0.072
2.922IleSer: 2.922 ± 0.07
3.2IleThr: 3.2 ± 0.077
4.502IleVal: 4.502 ± 0.101
0.536IleTrp: 0.536 ± 0.028
1.146IleTyr: 1.146 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.957LysAla: 4.957 ± 0.122
0.152LysCys: 0.152 ± 0.014
2.318LysAsp: 2.318 ± 0.078
1.9LysGlu: 1.9 ± 0.06
0.904LysPhe: 0.904 ± 0.039
2.616LysGly: 2.616 ± 0.067
0.691LysHis: 0.691 ± 0.03
1.568LysIle: 1.568 ± 0.055
1.513LysLys: 1.513 ± 0.056
2.846LysLeu: 2.846 ± 0.079
0.745LysMet: 0.745 ± 0.033
1.32LysAsn: 1.32 ± 0.053
2.364LysPro: 2.364 ± 0.072
1.227LysGln: 1.227 ± 0.049
2.36LysArg: 2.36 ± 0.069
2.211LysSer: 2.211 ± 0.076
2.635LysThr: 2.635 ± 0.083
2.701LysVal: 2.701 ± 0.087
0.39LysTrp: 0.39 ± 0.025
0.985LysTyr: 0.985 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
10.163LeuAla: 10.163 ± 0.148
0.859LeuCys: 0.859 ± 0.039
6.157LeuAsp: 6.157 ± 0.107
3.973LeuGlu: 3.973 ± 0.094
2.956LeuPhe: 2.956 ± 0.077
6.509LeuGly: 6.509 ± 0.102
1.755LeuHis: 1.755 ± 0.05
4.701LeuIle: 4.701 ± 0.113
3.315LeuLys: 3.315 ± 0.079
7.417LeuLeu: 7.417 ± 0.151
2.106LeuMet: 2.106 ± 0.064
2.684LeuAsn: 2.684 ± 0.063
4.158LeuPro: 4.158 ± 0.072
2.07LeuGln: 2.07 ± 0.051
5.501LeuArg: 5.501 ± 0.109
5.318LeuSer: 5.318 ± 0.115
5.476LeuThr: 5.476 ± 0.102
6.166LeuVal: 6.166 ± 0.103
0.965LeuTrp: 0.965 ± 0.043
2.055LeuTyr: 2.055 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.638MetAla: 2.638 ± 0.061
0.231MetCys: 0.231 ± 0.017
1.236MetAsp: 1.236 ± 0.043
1.042MetGlu: 1.042 ± 0.044
0.847MetPhe: 0.847 ± 0.036
1.623MetGly: 1.623 ± 0.052
0.533MetHis: 0.533 ± 0.025
1.326MetIle: 1.326 ± 0.047
0.819MetLys: 0.819 ± 0.037
2.563MetLeu: 2.563 ± 0.071
0.726MetMet: 0.726 ± 0.036
0.905MetAsn: 0.905 ± 0.037
1.527MetPro: 1.527 ± 0.053
0.804MetGln: 0.804 ± 0.032
1.946MetArg: 1.946 ± 0.056
1.709MetSer: 1.709 ± 0.05
1.851MetThr: 1.851 ± 0.056
1.665MetVal: 1.665 ± 0.05
0.288MetTrp: 0.288 ± 0.019
0.535MetTyr: 0.535 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
4.193AsnAla: 4.193 ± 0.108
0.178AsnCys: 0.178 ± 0.018
2.24AsnAsp: 2.24 ± 0.059
1.755AsnGlu: 1.755 ± 0.049
0.787AsnPhe: 0.787 ± 0.04
3.599AsnGly: 3.599 ± 0.119
0.605AsnHis: 0.605 ± 0.028
1.428AsnIle: 1.428 ± 0.053
1.167AsnLys: 1.167 ± 0.049
2.386AsnLeu: 2.386 ± 0.061
0.738AsnMet: 0.738 ± 0.037
1.099AsnAsn: 1.099 ± 0.063
2.194AsnPro: 2.194 ± 0.06
0.91AsnGln: 0.91 ± 0.04
1.999AsnArg: 1.999 ± 0.053
1.642AsnSer: 1.642 ± 0.06
2.027AsnThr: 2.027 ± 0.058
2.555AsnVal: 2.555 ± 0.064
0.411AsnTrp: 0.411 ± 0.024
0.873AsnTyr: 0.873 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
5.384ProAla: 5.384 ± 0.131
0.348ProCys: 0.348 ± 0.024
3.559ProAsp: 3.559 ± 0.086
2.73ProGlu: 2.73 ± 0.08
1.546ProPhe: 1.546 ± 0.051
3.588ProGly: 3.588 ± 0.067
0.929ProHis: 0.929 ± 0.041
2.233ProIle: 2.233 ± 0.07
1.684ProLys: 1.684 ± 0.049
3.691ProLeu: 3.691 ± 0.075
1.022ProMet: 1.022 ± 0.037
1.605ProAsn: 1.605 ± 0.045
1.341ProPro: 1.341 ± 0.057
1.968ProGln: 1.968 ± 0.076
2.5ProArg: 2.5 ± 0.07
3.147ProSer: 3.147 ± 0.067
3.018ProThr: 3.018 ± 0.082
3.868ProVal: 3.868 ± 0.075
0.642ProTrp: 0.642 ± 0.027
1.407ProTyr: 1.407 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
3.466GlnAla: 3.466 ± 0.073
0.273GlnCys: 0.273 ± 0.018
1.383GlnAsp: 1.383 ± 0.041
1.362GlnGlu: 1.362 ± 0.047
1.035GlnPhe: 1.035 ± 0.037
2.24GlnGly: 2.24 ± 0.062
0.754GlnHis: 0.754 ± 0.035
1.816GlnIle: 1.816 ± 0.05
0.912GlnLys: 0.912 ± 0.039
3.027GlnLeu: 3.027 ± 0.074
0.875GlnMet: 0.875 ± 0.035
0.933GlnAsn: 0.933 ± 0.041
1.912GlnPro: 1.912 ± 0.082
1.6GlnGln: 1.6 ± 0.061
2.478GlnArg: 2.478 ± 0.068
2.485GlnSer: 2.485 ± 0.069
1.993GlnThr: 1.993 ± 0.056
2.304GlnVal: 2.304 ± 0.059
0.574GlnTrp: 0.574 ± 0.028
1.128GlnTyr: 1.128 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
6.147ArgAla: 6.147 ± 0.122
0.57ArgCys: 0.57 ± 0.031
4.039ArgAsp: 4.039 ± 0.085
3.718ArgGlu: 3.718 ± 0.096
2.545ArgPhe: 2.545 ± 0.065
4.144ArgGly: 4.144 ± 0.089
1.639ArgHis: 1.639 ± 0.055
4.034ArgIle: 4.034 ± 0.084
2.318ArgLys: 2.318 ± 0.077
6.104ArgLeu: 6.104 ± 0.109
2.056ArgMet: 2.056 ± 0.057
2.227ArgAsn: 2.227 ± 0.058
2.791ArgPro: 2.791 ± 0.07
2.44ArgGln: 2.44 ± 0.064
5.768ArgArg: 5.768 ± 0.146
3.759ArgSer: 3.759 ± 0.089
3.413ArgThr: 3.413 ± 0.075
4.509ArgVal: 4.509 ± 0.095
0.921ArgTrp: 0.921 ± 0.04
2.128ArgTyr: 2.128 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
7.35SerAla: 7.35 ± 0.135
0.475SerCys: 0.475 ± 0.028
4.406SerAsp: 4.406 ± 0.101
2.915SerGlu: 2.915 ± 0.066
2.038SerPhe: 2.038 ± 0.051
6.034SerGly: 6.034 ± 0.106
1.314SerHis: 1.314 ± 0.041
3.11SerIle: 3.11 ± 0.067
2.152SerLys: 2.152 ± 0.068
5.104SerLeu: 5.104 ± 0.089
1.595SerMet: 1.595 ± 0.049
2.077SerAsn: 2.077 ± 0.06
2.489SerPro: 2.489 ± 0.069
2.223SerGln: 2.223 ± 0.059
3.722SerArg: 3.722 ± 0.096
4.253SerSer: 4.253 ± 0.112
3.654SerThr: 3.654 ± 0.084
4.606SerVal: 4.606 ± 0.093
0.804SerTrp: 0.804 ± 0.034
1.642SerTyr: 1.642 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
7.164ThrAla: 7.164 ± 0.151
0.447ThrCys: 0.447 ± 0.027
4.009ThrAsp: 4.009 ± 0.083
2.595ThrGlu: 2.595 ± 0.057
2.045ThrPhe: 2.045 ± 0.063
5.466ThrGly: 5.466 ± 0.1
1.134ThrHis: 1.134 ± 0.039
3.531ThrIle: 3.531 ± 0.077
2.158ThrLys: 2.158 ± 0.065
5.629ThrLeu: 5.629 ± 0.11
1.436ThrMet: 1.436 ± 0.041
1.96ThrAsn: 1.96 ± 0.067
3.418ThrPro: 3.418 ± 0.067
1.914ThrGln: 1.914 ± 0.054
3.289ThrArg: 3.289 ± 0.071
3.46ThrSer: 3.46 ± 0.086
3.932ThrThr: 3.932 ± 0.107
5.594ThrVal: 5.594 ± 0.133
0.773ThrTrp: 0.773 ± 0.042
1.614ThrTyr: 1.614 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
8.944ValAla: 8.944 ± 0.148
0.844ValCys: 0.844 ± 0.035
5.154ValAsp: 5.154 ± 0.095
4.262ValGlu: 4.262 ± 0.09
2.658ValPhe: 2.658 ± 0.064
5.485ValGly: 5.485 ± 0.101
1.447ValHis: 1.447 ± 0.044
4.156ValIle: 4.156 ± 0.084
2.815ValLys: 2.815 ± 0.083
6.565ValLeu: 6.565 ± 0.116
1.723ValMet: 1.723 ± 0.055
2.662ValAsn: 2.662 ± 0.064
3.833ValPro: 3.833 ± 0.082
1.958ValGln: 1.958 ± 0.052
4.762ValArg: 4.762 ± 0.083
4.977ValSer: 4.977 ± 0.096
5.356ValThr: 5.356 ± 0.121
6.307ValVal: 6.307 ± 0.113
0.911ValTrp: 0.911 ± 0.037
1.843ValTyr: 1.843 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
1.149TrpAla: 1.149 ± 0.039
0.149TrpCys: 0.149 ± 0.015
0.804TrpAsp: 0.804 ± 0.029
0.518TrpGlu: 0.518 ± 0.032
0.528TrpPhe: 0.528 ± 0.027
0.837TrpGly: 0.837 ± 0.035
0.358TrpHis: 0.358 ± 0.025
0.662TrpIle: 0.662 ± 0.032
0.508TrpLys: 0.508 ± 0.026
1.318TrpLeu: 1.318 ± 0.043
0.365TrpMet: 0.365 ± 0.022
0.522TrpAsn: 0.522 ± 0.028
0.529TrpPro: 0.529 ± 0.031
0.549TrpGln: 0.549 ± 0.026
1.031TrpArg: 1.031 ± 0.042
0.889TrpSer: 0.889 ± 0.041
0.805TrpThr: 0.805 ± 0.035
0.79TrpVal: 0.79 ± 0.032
0.231TrpTrp: 0.231 ± 0.019
0.403TrpTyr: 0.403 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.138TyrAla: 3.138 ± 0.081
0.297TyrCys: 0.297 ± 0.022
2.024TyrAsp: 2.024 ± 0.057
1.614TyrGlu: 1.614 ± 0.05
0.942TyrPhe: 0.942 ± 0.038
2.51TyrGly: 2.51 ± 0.076
0.557TyrHis: 0.557 ± 0.029
1.134TyrIle: 1.134 ± 0.048
0.917TyrLys: 0.917 ± 0.036
2.259TyrLeu: 2.259 ± 0.064
0.579TyrMet: 0.579 ± 0.03
0.873TyrAsn: 0.873 ± 0.041
1.222TyrPro: 1.222 ± 0.047
0.882TyrGln: 0.882 ± 0.032
1.982TyrArg: 1.982 ± 0.061
1.522TyrSer: 1.522 ± 0.053
1.641TyrThr: 1.641 ± 0.065
2.0TyrVal: 2.0 ± 0.051
0.391TyrTrp: 0.391 ± 0.024
0.808TyrTyr: 0.808 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1942 proteins (717916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski