Amino acid dipepetide frequency for Endomicrobium proavitum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.842AlaAla: 9.842 ± 0.244
0.826AlaCys: 0.826 ± 0.051
4.662AlaAsp: 4.662 ± 0.094
4.426AlaGlu: 4.426 ± 0.127
3.61AlaPhe: 3.61 ± 0.109
7.987AlaGly: 7.987 ± 0.399
1.114AlaHis: 1.114 ± 0.055
6.077AlaIle: 6.077 ± 0.204
7.121AlaLys: 7.121 ± 0.237
8.008AlaLeu: 8.008 ± 0.162
1.546AlaMet: 1.546 ± 0.059
4.552AlaAsn: 4.552 ± 0.276
2.216AlaPro: 2.216 ± 0.082
3.519AlaGln: 3.519 ± 0.108
2.755AlaArg: 2.755 ± 0.092
5.541AlaSer: 5.541 ± 0.189
4.061AlaThr: 4.061 ± 0.304
7.488AlaVal: 7.488 ± 0.161
0.591AlaTrp: 0.591 ± 0.034
2.794AlaTyr: 2.794 ± 0.094
0.0AlaXaa: 0.0 ± 0.0
Cys
0.981CysAla: 0.981 ± 0.058
0.111CysCys: 0.111 ± 0.017
0.495CysAsp: 0.495 ± 0.037
0.555CysGlu: 0.555 ± 0.04
0.397CysPhe: 0.397 ± 0.033
1.054CysGly: 1.054 ± 0.064
0.177CysHis: 0.177 ± 0.019
0.599CysIle: 0.599 ± 0.037
0.653CysLys: 0.653 ± 0.04
0.714CysLeu: 0.714 ± 0.046
0.167CysMet: 0.167 ± 0.021
0.359CysAsn: 0.359 ± 0.032
0.453CysPro: 0.453 ± 0.034
0.163CysGln: 0.163 ± 0.021
0.346CysArg: 0.346 ± 0.03
0.624CysSer: 0.624 ± 0.043
0.323CysThr: 0.323 ± 0.028
0.733CysVal: 0.733 ± 0.046
0.058CysTrp: 0.058 ± 0.013
0.263CysTyr: 0.263 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
4.201AspAla: 4.201 ± 0.119
0.422AspCys: 0.422 ± 0.032
2.195AspAsp: 2.195 ± 0.088
2.974AspGlu: 2.974 ± 0.111
2.909AspPhe: 2.909 ± 0.079
3.723AspGly: 3.723 ± 0.106
0.534AspHis: 0.534 ± 0.036
4.896AspIle: 4.896 ± 0.107
4.466AspLys: 4.466 ± 0.152
4.126AspLeu: 4.126 ± 0.126
1.146AspMet: 1.146 ± 0.053
2.886AspAsn: 2.886 ± 0.079
1.254AspPro: 1.254 ± 0.061
0.824AspGln: 0.824 ± 0.038
1.551AspArg: 1.551 ± 0.061
2.978AspSer: 2.978 ± 0.089
2.2AspThr: 2.2 ± 0.073
3.506AspVal: 3.506 ± 0.1
0.493AspTrp: 0.493 ± 0.034
2.135AspTyr: 2.135 ± 0.089
0.0AspXaa: 0.0 ± 0.0
Glu
4.153GluAla: 4.153 ± 0.122
0.426GluCys: 0.426 ± 0.031
2.673GluAsp: 2.673 ± 0.111
3.579GluGlu: 3.579 ± 0.145
2.575GluPhe: 2.575 ± 0.097
3.331GluGly: 3.331 ± 0.111
0.899GluHis: 0.899 ± 0.051
5.971GluIle: 5.971 ± 0.19
6.067GluLys: 6.067 ± 0.222
5.138GluLeu: 5.138 ± 0.146
1.144GluMet: 1.144 ± 0.058
4.189GluAsn: 4.189 ± 0.107
1.382GluPro: 1.382 ± 0.065
1.59GluGln: 1.59 ± 0.082
2.024GluArg: 2.024 ± 0.086
3.145GluSer: 3.145 ± 0.118
3.327GluThr: 3.327 ± 0.111
3.673GluVal: 3.673 ± 0.132
0.386GluTrp: 0.386 ± 0.029
2.221GluTyr: 2.221 ± 0.092
0.0GluXaa: 0.0 ± 0.0
Phe
4.737PheAla: 4.737 ± 0.157
0.643PheCys: 0.643 ± 0.042
2.736PheAsp: 2.736 ± 0.091
2.782PheGlu: 2.782 ± 0.086
2.548PhePhe: 2.548 ± 0.116
3.544PheGly: 3.544 ± 0.112
0.58PheHis: 0.58 ± 0.04
3.959PheIle: 3.959 ± 0.128
3.514PheLys: 3.514 ± 0.088
4.301PheLeu: 4.301 ± 0.149
1.05PheMet: 1.05 ± 0.049
2.947PheAsn: 2.947 ± 0.167
1.359PhePro: 1.359 ± 0.075
1.121PheGln: 1.121 ± 0.047
1.302PheArg: 1.302 ± 0.055
3.686PheSer: 3.686 ± 0.129
3.22PheThr: 3.22 ± 0.241
3.247PheVal: 3.247 ± 0.111
0.43PheTrp: 0.43 ± 0.033
1.88PheTyr: 1.88 ± 0.073
0.0PheXaa: 0.0 ± 0.0
Gly
7.839GlyAla: 7.839 ± 0.457
0.735GlyCys: 0.735 ± 0.04
3.335GlyAsp: 3.335 ± 0.083
3.667GlyGlu: 3.667 ± 0.117
3.573GlyPhe: 3.573 ± 0.092
7.202GlyGly: 7.202 ± 0.638
1.137GlyHis: 1.137 ± 0.049
5.434GlyIle: 5.434 ± 0.127
6.14GlyLys: 6.14 ± 0.208
5.553GlyLeu: 5.553 ± 0.114
1.298GlyMet: 1.298 ± 0.054
4.562GlyAsn: 4.562 ± 0.399
1.156GlyPro: 1.156 ± 0.066
1.874GlyGln: 1.874 ± 0.061
2.287GlyArg: 2.287 ± 0.091
5.013GlySer: 5.013 ± 0.301
3.934GlyThr: 3.934 ± 0.272
5.668GlyVal: 5.668 ± 0.143
0.637GlyTrp: 0.637 ± 0.041
3.024GlyTyr: 3.024 ± 0.097
0.0GlyXaa: 0.0 ± 0.0
His
1.008HisAla: 1.008 ± 0.054
0.179HisCys: 0.179 ± 0.021
0.515HisAsp: 0.515 ± 0.036
0.664HisGlu: 0.664 ± 0.046
0.703HisPhe: 0.703 ± 0.048
1.0HisGly: 1.0 ± 0.052
0.244HisHis: 0.244 ± 0.025
1.102HisIle: 1.102 ± 0.058
1.075HisLys: 1.075 ± 0.055
1.117HisLeu: 1.117 ± 0.052
0.282HisMet: 0.282 ± 0.022
0.716HisAsn: 0.716 ± 0.04
0.624HisPro: 0.624 ± 0.046
0.319HisGln: 0.319 ± 0.027
0.503HisArg: 0.503 ± 0.039
0.95HisSer: 0.95 ± 0.042
0.689HisThr: 0.689 ± 0.037
0.72HisVal: 0.72 ± 0.041
0.098HisTrp: 0.098 ± 0.014
0.595HisTyr: 0.595 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.86IleAla: 6.86 ± 0.14
0.785IleCys: 0.785 ± 0.05
4.349IleAsp: 4.349 ± 0.115
5.186IleGlu: 5.186 ± 0.166
4.072IlePhe: 4.072 ± 0.131
5.134IleGly: 5.134 ± 0.118
0.883IleHis: 0.883 ± 0.05
6.553IleIle: 6.553 ± 0.169
7.089IleLys: 7.089 ± 0.234
6.564IleLeu: 6.564 ± 0.168
1.448IleMet: 1.448 ± 0.058
4.969IleAsn: 4.969 ± 0.177
2.63IlePro: 2.63 ± 0.099
1.574IleGln: 1.574 ± 0.056
2.371IleArg: 2.371 ± 0.079
6.092IleSer: 6.092 ± 0.137
4.852IleThr: 4.852 ± 0.189
4.838IleVal: 4.838 ± 0.127
0.534IleTrp: 0.534 ± 0.038
3.389IleTyr: 3.389 ± 0.211
0.0IleXaa: 0.0 ± 0.0
Lys
6.424LysAla: 6.424 ± 0.163
0.582LysCys: 0.582 ± 0.045
4.875LysAsp: 4.875 ± 0.172
6.246LysGlu: 6.246 ± 0.216
3.439LysPhe: 3.439 ± 0.103
4.303LysGly: 4.303 ± 0.139
1.175LysHis: 1.175 ± 0.058
8.229LysIle: 8.229 ± 0.264
9.166LysLys: 9.166 ± 0.35
6.522LysLeu: 6.522 ± 0.198
2.256LysMet: 2.256 ± 0.084
6.346LysAsn: 6.346 ± 0.187
2.379LysPro: 2.379 ± 0.114
2.431LysGln: 2.431 ± 0.098
2.757LysArg: 2.757 ± 0.116
4.821LysSer: 4.821 ± 0.157
5.493LysThr: 5.493 ± 0.138
5.163LysVal: 5.163 ± 0.158
0.584LysTrp: 0.584 ± 0.041
3.56LysTyr: 3.56 ± 0.127
0.0LysXaa: 0.0 ± 0.0
Leu
6.881LeuAla: 6.881 ± 0.16
0.799LeuCys: 0.799 ± 0.049
3.992LeuAsp: 3.992 ± 0.098
4.967LeuGlu: 4.967 ± 0.143
4.164LeuPhe: 4.164 ± 0.14
5.633LeuGly: 5.633 ± 0.139
1.148LeuHis: 1.148 ± 0.058
5.875LeuIle: 5.875 ± 0.188
8.035LeuLys: 8.035 ± 0.251
6.77LeuLeu: 6.77 ± 0.204
1.576LeuMet: 1.576 ± 0.07
4.904LeuAsn: 4.904 ± 0.123
3.114LeuPro: 3.114 ± 0.104
2.465LeuGln: 2.465 ± 0.09
3.082LeuArg: 3.082 ± 0.098
6.943LeuSer: 6.943 ± 0.131
4.798LeuThr: 4.798 ± 0.124
4.433LeuVal: 4.433 ± 0.132
0.685LeuTrp: 0.685 ± 0.049
2.951LeuTyr: 2.951 ± 0.106
0.0LeuXaa: 0.0 ± 0.0
Met
1.467MetAla: 1.467 ± 0.068
0.179MetCys: 0.179 ± 0.021
0.841MetAsp: 0.841 ± 0.044
0.993MetGlu: 0.993 ± 0.048
1.008MetPhe: 1.008 ± 0.056
1.311MetGly: 1.311 ± 0.059
0.296MetHis: 0.296 ± 0.026
1.304MetIle: 1.304 ± 0.061
1.983MetLys: 1.983 ± 0.081
1.828MetLeu: 1.828 ± 0.068
0.407MetMet: 0.407 ± 0.03
0.985MetAsn: 0.985 ± 0.05
0.983MetPro: 0.983 ± 0.053
0.714MetGln: 0.714 ± 0.044
0.753MetArg: 0.753 ± 0.051
1.601MetSer: 1.601 ± 0.056
1.046MetThr: 1.046 ± 0.041
0.985MetVal: 0.985 ± 0.051
0.15MetTrp: 0.15 ± 0.019
0.597MetTyr: 0.597 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
5.482AsnAla: 5.482 ± 0.243
0.484AsnCys: 0.484 ± 0.039
2.429AsnAsp: 2.429 ± 0.071
2.761AsnGlu: 2.761 ± 0.094
3.64AsnPhe: 3.64 ± 0.214
4.585AsnGly: 4.585 ± 0.349
0.568AsnHis: 0.568 ± 0.035
5.892AsnIle: 5.892 ± 0.16
4.779AsnLys: 4.779 ± 0.104
4.742AsnLeu: 4.742 ± 0.108
1.035AsnMet: 1.035 ± 0.049
4.216AsnAsn: 4.216 ± 0.37
2.218AsnPro: 2.218 ± 0.08
1.229AsnGln: 1.229 ± 0.063
1.722AsnArg: 1.722 ± 0.065
4.556AsnSer: 4.556 ± 0.319
3.362AsnThr: 3.362 ± 0.265
4.343AsnVal: 4.343 ± 0.164
0.436AsnTrp: 0.436 ± 0.03
2.45AsnTyr: 2.45 ± 0.117
0.0AsnXaa: 0.0 ± 0.0
Pro
2.705ProAla: 2.705 ± 0.095
0.303ProCys: 0.303 ± 0.029
1.684ProAsp: 1.684 ± 0.08
2.398ProGlu: 2.398 ± 0.116
1.503ProPhe: 1.503 ± 0.071
1.816ProGly: 1.816 ± 0.087
0.455ProHis: 0.455 ± 0.035
1.686ProIle: 1.686 ± 0.068
2.392ProLys: 2.392 ± 0.105
2.68ProLeu: 2.68 ± 0.113
0.501ProMet: 0.501 ± 0.034
1.486ProAsn: 1.486 ± 0.06
0.785ProPro: 0.785 ± 0.047
1.29ProGln: 1.29 ± 0.073
0.822ProArg: 0.822 ± 0.052
1.791ProSer: 1.791 ± 0.079
1.309ProThr: 1.309 ± 0.06
2.744ProVal: 2.744 ± 0.107
0.284ProTrp: 0.284 ± 0.025
1.252ProTyr: 1.252 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
2.17GlnAla: 2.17 ± 0.079
0.2GlnCys: 0.2 ± 0.024
1.361GlnAsp: 1.361 ± 0.054
1.811GlnGlu: 1.811 ± 0.102
1.081GlnPhe: 1.081 ± 0.049
1.789GlnGly: 1.789 ± 0.077
0.363GlnHis: 0.363 ± 0.031
2.413GlnIle: 2.413 ± 0.085
2.736GlnLys: 2.736 ± 0.11
1.947GlnLeu: 1.947 ± 0.073
0.62GlnMet: 0.62 ± 0.038
1.87GlnAsn: 1.87 ± 0.085
0.787GlnPro: 0.787 ± 0.046
0.943GlnGln: 0.943 ± 0.056
0.914GlnArg: 0.914 ± 0.059
1.951GlnSer: 1.951 ± 0.078
1.828GlnThr: 1.828 ± 0.064
1.43GlnVal: 1.43 ± 0.05
0.278GlnTrp: 0.278 ± 0.028
1.148GlnTyr: 1.148 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
2.567ArgAla: 2.567 ± 0.086
0.315ArgCys: 0.315 ± 0.025
1.576ArgAsp: 1.576 ± 0.068
2.081ArgGlu: 2.081 ± 0.09
1.563ArgPhe: 1.563 ± 0.071
2.035ArgGly: 2.035 ± 0.071
0.586ArgHis: 0.586 ± 0.037
2.667ArgIle: 2.667 ± 0.077
2.751ArgLys: 2.751 ± 0.122
2.617ArgLeu: 2.617 ± 0.095
0.781ArgMet: 0.781 ± 0.041
1.855ArgAsn: 1.855 ± 0.066
1.104ArgPro: 1.104 ± 0.057
1.079ArgGln: 1.079 ± 0.054
1.342ArgArg: 1.342 ± 0.071
1.789ArgSer: 1.789 ± 0.066
1.594ArgThr: 1.594 ± 0.062
2.187ArgVal: 2.187 ± 0.088
0.2ArgTrp: 0.2 ± 0.021
1.225ArgTyr: 1.225 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
6.71SerAla: 6.71 ± 0.18
0.58SerCys: 0.58 ± 0.039
3.352SerAsp: 3.352 ± 0.091
3.481SerGlu: 3.481 ± 0.122
3.571SerPhe: 3.571 ± 0.111
6.785SerGly: 6.785 ± 0.336
0.801SerHis: 0.801 ± 0.049
4.322SerIle: 4.322 ± 0.121
5.334SerLys: 5.334 ± 0.14
5.697SerLeu: 5.697 ± 0.126
1.198SerMet: 1.198 ± 0.045
3.681SerAsn: 3.681 ± 0.28
1.876SerPro: 1.876 ± 0.07
2.216SerGln: 2.216 ± 0.076
2.068SerArg: 2.068 ± 0.068
5.576SerSer: 5.576 ± 0.382
3.149SerThr: 3.149 ± 0.305
5.295SerVal: 5.295 ± 0.131
0.595SerTrp: 0.595 ± 0.036
2.644SerTyr: 2.644 ± 0.099
0.0SerXaa: 0.0 ± 0.0
Thr
5.364ThrAla: 5.364 ± 0.317
0.296ThrCys: 0.296 ± 0.026
2.755ThrAsp: 2.755 ± 0.089
2.496ThrGlu: 2.496 ± 0.104
2.801ThrPhe: 2.801 ± 0.226
5.159ThrGly: 5.159 ± 0.366
0.697ThrHis: 0.697 ± 0.041
4.153ThrIle: 4.153 ± 0.176
3.54ThrLys: 3.54 ± 0.116
4.677ThrLeu: 4.677 ± 0.13
0.856ThrMet: 0.856 ± 0.037
2.872ThrAsn: 2.872 ± 0.2
2.079ThrPro: 2.079 ± 0.109
1.576ThrGln: 1.576 ± 0.067
1.459ThrArg: 1.459 ± 0.056
3.654ThrSer: 3.654 ± 0.191
2.959ThrThr: 2.959 ± 0.257
4.449ThrVal: 4.449 ± 0.168
0.342ThrTrp: 0.342 ± 0.034
1.822ThrTyr: 1.822 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
5.355ValAla: 5.355 ± 0.136
0.881ValCys: 0.881 ± 0.057
2.932ValAsp: 2.932 ± 0.101
4.166ValGlu: 4.166 ± 0.104
3.786ValPhe: 3.786 ± 0.112
4.149ValGly: 4.149 ± 0.119
0.818ValHis: 0.818 ± 0.051
5.599ValIle: 5.599 ± 0.101
6.182ValLys: 6.182 ± 0.209
6.253ValLeu: 6.253 ± 0.161
1.29ValMet: 1.29 ± 0.05
4.33ValAsn: 4.33 ± 0.191
1.999ValPro: 1.999 ± 0.08
1.526ValGln: 1.526 ± 0.061
2.358ValArg: 2.358 ± 0.074
5.169ValSer: 5.169 ± 0.123
3.765ValThr: 3.765 ± 0.207
4.986ValVal: 4.986 ± 0.128
0.593ValTrp: 0.593 ± 0.034
2.659ValTyr: 2.659 ± 0.111
0.0ValXaa: 0.0 ± 0.0
Trp
0.609TrpAla: 0.609 ± 0.034
0.077TrpCys: 0.077 ± 0.014
0.424TrpAsp: 0.424 ± 0.032
0.415TrpGlu: 0.415 ± 0.03
0.399TrpPhe: 0.399 ± 0.033
0.513TrpGly: 0.513 ± 0.032
0.154TrpHis: 0.154 ± 0.017
0.597TrpIle: 0.597 ± 0.038
0.62TrpLys: 0.62 ± 0.041
0.72TrpLeu: 0.72 ± 0.043
0.179TrpMet: 0.179 ± 0.022
0.566TrpAsn: 0.566 ± 0.048
0.134TrpPro: 0.134 ± 0.018
0.359TrpGln: 0.359 ± 0.03
0.303TrpArg: 0.303 ± 0.028
0.499TrpSer: 0.499 ± 0.03
0.447TrpThr: 0.447 ± 0.036
0.459TrpVal: 0.459 ± 0.036
0.098TrpTrp: 0.098 ± 0.015
0.246TrpTyr: 0.246 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.383TyrAla: 3.383 ± 0.149
0.401TyrCys: 0.401 ± 0.03
2.237TyrAsp: 2.237 ± 0.078
2.243TyrGlu: 2.243 ± 0.093
2.246TyrPhe: 2.246 ± 0.081
3.018TyrGly: 3.018 ± 0.137
0.47TyrHis: 0.47 ± 0.037
2.842TyrIle: 2.842 ± 0.086
3.114TyrLys: 3.114 ± 0.104
3.241TyrLeu: 3.241 ± 0.098
0.651TyrMet: 0.651 ± 0.038
2.638TyrAsn: 2.638 ± 0.136
1.352TyrPro: 1.352 ± 0.069
0.829TyrGln: 0.829 ± 0.043
1.194TyrArg: 1.194 ± 0.055
2.554TyrSer: 2.554 ± 0.109
1.649TyrThr: 1.649 ± 0.071
2.448TyrVal: 2.448 ± 0.099
0.346TyrTrp: 0.346 ± 0.027
1.626TyrTyr: 1.626 ± 0.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1336 proteins (479164 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski