Amino acid dipepetide frequency for Candidatus Gracilibacteria bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.322AlaAla: 1.322 ± 0.083
0.305AlaCys: 0.305 ± 0.035
1.827AlaAsp: 1.827 ± 0.092
2.841AlaGlu: 2.841 ± 0.123
2.226AlaPhe: 2.226 ± 0.116
3.159AlaGly: 3.159 ± 0.137
0.475AlaHis: 0.475 ± 0.038
4.053AlaIle: 4.053 ± 0.127
4.11AlaLys: 4.11 ± 0.13
3.431AlaLeu: 3.431 ± 0.127
0.92AlaMet: 0.92 ± 0.063
2.252AlaAsn: 2.252 ± 0.089
0.917AlaPro: 0.917 ± 0.06
0.877AlaGln: 0.877 ± 0.054
1.463AlaArg: 1.463 ± 0.072
2.674AlaSer: 2.674 ± 0.109
1.928AlaThr: 1.928 ± 0.081
2.032AlaVal: 2.032 ± 0.089
0.284AlaTrp: 0.284 ± 0.031
1.412AlaTyr: 1.412 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.251CysAla: 0.251 ± 0.024
0.087CysCys: 0.087 ± 0.017
0.382CysAsp: 0.382 ± 0.04
0.602CysGlu: 0.602 ± 0.051
0.405CysPhe: 0.405 ± 0.038
0.505CysGly: 0.505 ± 0.046
0.127CysHis: 0.127 ± 0.024
0.549CysIle: 0.549 ± 0.043
0.646CysLys: 0.646 ± 0.053
0.569CysLeu: 0.569 ± 0.052
0.11CysMet: 0.11 ± 0.022
0.432CysAsn: 0.432 ± 0.046
0.351CysPro: 0.351 ± 0.035
0.137CysGln: 0.137 ± 0.021
0.211CysArg: 0.211 ± 0.03
0.559CysSer: 0.559 ± 0.048
0.228CysThr: 0.228 ± 0.03
0.358CysVal: 0.358 ± 0.036
0.044CysTrp: 0.044 ± 0.011
0.325CysTyr: 0.325 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
1.667AspAla: 1.667 ± 0.081
0.448AspCys: 0.448 ± 0.042
2.714AspAsp: 2.714 ± 0.104
4.244AspGlu: 4.244 ± 0.136
4.987AspPhe: 4.987 ± 0.16
3.444AspGly: 3.444 ± 0.142
0.378AspHis: 0.378 ± 0.035
5.686AspIle: 5.686 ± 0.152
5.763AspLys: 5.763 ± 0.174
6.389AspLeu: 6.389 ± 0.2
1.058AspMet: 1.058 ± 0.062
3.313AspAsn: 3.313 ± 0.117
1.131AspPro: 1.131 ± 0.077
0.76AspGln: 0.76 ± 0.051
1.643AspArg: 1.643 ± 0.069
3.608AspSer: 3.608 ± 0.134
2.028AspThr: 2.028 ± 0.082
2.577AspVal: 2.577 ± 0.105
0.331AspTrp: 0.331 ± 0.031
2.805AspTyr: 2.805 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
3.283GluAla: 3.283 ± 0.12
0.388GluCys: 0.388 ± 0.041
4.063GluAsp: 4.063 ± 0.13
7.075GluGlu: 7.075 ± 0.195
3.912GluPhe: 3.912 ± 0.136
3.293GluGly: 3.293 ± 0.111
0.783GluHis: 0.783 ± 0.059
9.592GluIle: 9.592 ± 0.205
13.167GluLys: 13.167 ± 0.305
6.761GluLeu: 6.761 ± 0.177
1.339GluMet: 1.339 ± 0.07
8.601GluAsn: 8.601 ± 0.207
1.007GluPro: 1.007 ± 0.07
2.102GluGln: 2.102 ± 0.094
2.273GluArg: 2.273 ± 0.102
3.765GluSer: 3.765 ± 0.117
3.337GluThr: 3.337 ± 0.106
4.127GluVal: 4.127 ± 0.128
0.298GluTrp: 0.298 ± 0.032
3.133GluTyr: 3.133 ± 0.097
0.0GluXaa: 0.0 ± 0.0
Phe
2.229PheAla: 2.229 ± 0.105
0.556PheCys: 0.556 ± 0.044
3.749PheAsp: 3.749 ± 0.123
5.02PheGlu: 5.02 ± 0.161
4.317PhePhe: 4.317 ± 0.177
4.274PheGly: 4.274 ± 0.171
0.592PheHis: 0.592 ± 0.045
6.356PheIle: 6.356 ± 0.225
4.823PheLys: 4.823 ± 0.146
7.236PheLeu: 7.236 ± 0.215
1.222PheMet: 1.222 ± 0.066
3.086PheAsn: 3.086 ± 0.135
1.546PhePro: 1.546 ± 0.077
1.248PheGln: 1.248 ± 0.067
1.66PheArg: 1.66 ± 0.078
5.814PheSer: 5.814 ± 0.192
2.41PheThr: 2.41 ± 0.084
3.25PheVal: 3.25 ± 0.115
0.502PheTrp: 0.502 ± 0.041
2.771PheTyr: 2.771 ± 0.108
0.0PheXaa: 0.0 ± 0.0
Gly
2.868GlyAla: 2.868 ± 0.116
0.425GlyCys: 0.425 ± 0.04
3.41GlyAsp: 3.41 ± 0.119
5.268GlyGlu: 5.268 ± 0.159
3.598GlyPhe: 3.598 ± 0.135
3.856GlyGly: 3.856 ± 0.183
0.746GlyHis: 0.746 ± 0.056
6.111GlyIle: 6.111 ± 0.157
7.059GlyLys: 7.059 ± 0.168
4.963GlyLeu: 4.963 ± 0.153
1.148GlyMet: 1.148 ± 0.086
4.625GlyAsn: 4.625 ± 0.227
1.007GlyPro: 1.007 ± 0.057
1.63GlyGln: 1.63 ± 0.079
1.851GlyArg: 1.851 ± 0.086
3.143GlySer: 3.143 ± 0.124
3.173GlyThr: 3.173 ± 0.125
3.825GlyVal: 3.825 ± 0.135
0.325GlyTrp: 0.325 ± 0.033
2.58GlyTyr: 2.58 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
0.365HisAla: 0.365 ± 0.036
0.131HisCys: 0.131 ± 0.021
0.442HisAsp: 0.442 ± 0.039
0.589HisGlu: 0.589 ± 0.044
0.723HisPhe: 0.723 ± 0.049
0.592HisGly: 0.592 ± 0.041
0.238HisHis: 0.238 ± 0.041
1.205HisIle: 1.205 ± 0.07
1.098HisLys: 1.098 ± 0.061
1.021HisLeu: 1.021 ± 0.061
0.197HisMet: 0.197 ± 0.026
0.76HisAsn: 0.76 ± 0.054
0.348HisPro: 0.348 ± 0.038
0.271HisGln: 0.271 ± 0.028
0.422HisArg: 0.422 ± 0.035
0.847HisSer: 0.847 ± 0.051
0.522HisThr: 0.522 ± 0.045
0.271HisVal: 0.271 ± 0.035
0.074HisTrp: 0.074 ± 0.016
0.572HisTyr: 0.572 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
3.909IleAla: 3.909 ± 0.133
0.696IleCys: 0.696 ± 0.051
5.917IleAsp: 5.917 ± 0.159
8.116IleGlu: 8.116 ± 0.174
7.935IlePhe: 7.935 ± 0.304
6.506IleGly: 6.506 ± 0.178
1.051IleHis: 1.051 ± 0.061
10.767IleIle: 10.767 ± 0.266
10.526IleLys: 10.526 ± 0.216
10.439IleLeu: 10.439 ± 0.27
1.714IleMet: 1.714 ± 0.08
6.637IleAsn: 6.637 ± 0.191
2.768IlePro: 2.768 ± 0.103
1.998IleGln: 1.998 ± 0.078
2.376IleArg: 2.376 ± 0.095
7.932IleSer: 7.932 ± 0.189
4.411IleThr: 4.411 ± 0.146
5.067IleVal: 5.067 ± 0.129
0.542IleTrp: 0.542 ± 0.043
4.204IleTyr: 4.204 ± 0.123
0.0IleXaa: 0.0 ± 0.0
Lys
3.996LysAla: 3.996 ± 0.118
0.572LysCys: 0.572 ± 0.051
6.463LysAsp: 6.463 ± 0.159
10.027LysGlu: 10.027 ± 0.247
5.164LysPhe: 5.164 ± 0.139
5.308LysGly: 5.308 ± 0.138
0.987LysHis: 0.987 ± 0.059
13.408LysIle: 13.408 ± 0.286
13.073LysLys: 13.073 ± 0.312
8.424LysLeu: 8.424 ± 0.204
2.242LysMet: 2.242 ± 0.095
10.984LysAsn: 10.984 ± 0.226
1.673LysPro: 1.673 ± 0.072
3.106LysGln: 3.106 ± 0.123
3.166LysArg: 3.166 ± 0.119
6.342LysSer: 6.342 ± 0.154
5.479LysThr: 5.479 ± 0.151
5.552LysVal: 5.552 ± 0.135
0.502LysTrp: 0.502 ± 0.04
5.325LysTyr: 5.325 ± 0.152
0.0LysXaa: 0.0 ± 0.0
Leu
3.989LeuAla: 3.989 ± 0.125
0.465LeuCys: 0.465 ± 0.038
5.583LeuAsp: 5.583 ± 0.156
9.194LeuGlu: 9.194 ± 0.243
5.191LeuPhe: 5.191 ± 0.189
5.576LeuGly: 5.576 ± 0.146
0.924LeuHis: 0.924 ± 0.056
7.453LeuIle: 7.453 ± 0.202
10.948LeuLys: 10.948 ± 0.265
7.109LeuLeu: 7.109 ± 0.19
1.369LeuMet: 1.369 ± 0.076
6.145LeuAsn: 6.145 ± 0.125
2.537LeuPro: 2.537 ± 0.109
2.366LeuGln: 2.366 ± 0.1
2.654LeuArg: 2.654 ± 0.111
6.774LeuSer: 6.774 ± 0.166
4.307LeuThr: 4.307 ± 0.139
4.548LeuVal: 4.548 ± 0.13
0.469LeuTrp: 0.469 ± 0.042
2.915LeuTyr: 2.915 ± 0.101
0.0LeuXaa: 0.0 ± 0.0
Met
0.85MetAla: 0.85 ± 0.048
0.077MetCys: 0.077 ± 0.015
0.887MetAsp: 0.887 ± 0.05
1.325MetGlu: 1.325 ± 0.068
1.068MetPhe: 1.068 ± 0.099
1.125MetGly: 1.125 ± 0.064
0.231MetHis: 0.231 ± 0.026
1.791MetIle: 1.791 ± 0.093
2.44MetLys: 2.44 ± 0.086
1.543MetLeu: 1.543 ± 0.083
0.432MetMet: 0.432 ± 0.043
1.081MetAsn: 1.081 ± 0.073
0.459MetPro: 0.459 ± 0.039
0.623MetGln: 0.623 ± 0.064
0.656MetArg: 0.656 ± 0.049
1.131MetSer: 1.131 ± 0.059
0.917MetThr: 0.917 ± 0.062
0.877MetVal: 0.877 ± 0.059
0.074MetTrp: 0.074 ± 0.015
0.556MetTyr: 0.556 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
2.196AsnAla: 2.196 ± 0.088
0.529AsnCys: 0.529 ± 0.048
3.099AsnAsp: 3.099 ± 0.113
4.18AsnGlu: 4.18 ± 0.105
5.506AsnPhe: 5.506 ± 0.171
4.679AsnGly: 4.679 ± 0.195
0.86AsnHis: 0.86 ± 0.059
8.916AsnIle: 8.916 ± 0.206
7.166AsnLys: 7.166 ± 0.165
7.541AsnLeu: 7.541 ± 0.167
1.526AsnMet: 1.526 ± 0.104
4.917AsnAsn: 4.917 ± 0.182
2.426AsnPro: 2.426 ± 0.111
2.045AsnGln: 2.045 ± 0.116
1.724AsnArg: 1.724 ± 0.078
5.231AsnSer: 5.231 ± 0.177
3.116AsnThr: 3.116 ± 0.111
2.785AsnVal: 2.785 ± 0.123
0.519AsnTrp: 0.519 ± 0.066
3.625AsnTyr: 3.625 ± 0.129
0.0AsnXaa: 0.0 ± 0.0
Pro
1.027ProAla: 1.027 ± 0.064
0.124ProCys: 0.124 ± 0.02
1.446ProAsp: 1.446 ± 0.074
2.406ProGlu: 2.406 ± 0.107
1.302ProPhe: 1.302 ± 0.068
1.379ProGly: 1.379 ± 0.066
0.392ProHis: 0.392 ± 0.042
2.139ProIle: 2.139 ± 0.078
2.483ProLys: 2.483 ± 0.096
1.841ProLeu: 1.841 ± 0.087
0.372ProMet: 0.372 ± 0.036
1.449ProAsn: 1.449 ± 0.072
0.569ProPro: 0.569 ± 0.079
0.479ProGln: 0.479 ± 0.041
0.629ProArg: 0.629 ± 0.046
1.456ProSer: 1.456 ± 0.084
1.202ProThr: 1.202 ± 0.068
1.289ProVal: 1.289 ± 0.079
0.154ProTrp: 0.154 ± 0.023
1.027ProTyr: 1.027 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
1.272GlnAla: 1.272 ± 0.079
0.124GlnCys: 0.124 ± 0.023
1.309GlnAsp: 1.309 ± 0.07
2.49GlnGlu: 2.49 ± 0.109
0.817GlnPhe: 0.817 ± 0.053
1.007GlnGly: 1.007 ± 0.079
0.208GlnHis: 0.208 ± 0.029
2.547GlnIle: 2.547 ± 0.09
3.514GlnLys: 3.514 ± 0.112
1.603GlnLeu: 1.603 ± 0.076
0.438GlnMet: 0.438 ± 0.041
2.299GlnAsn: 2.299 ± 0.1
0.422GlnPro: 0.422 ± 0.043
0.452GlnGln: 0.452 ± 0.049
0.807GlnArg: 0.807 ± 0.053
1.205GlnSer: 1.205 ± 0.062
1.279GlnThr: 1.279 ± 0.068
1.285GlnVal: 1.285 ± 0.074
0.084GlnTrp: 0.084 ± 0.015
0.756GlnTyr: 0.756 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
1.312ArgAla: 1.312 ± 0.075
0.154ArgCys: 0.154 ± 0.023
1.476ArgAsp: 1.476 ± 0.079
2.801ArgGlu: 2.801 ± 0.11
1.543ArgPhe: 1.543 ± 0.066
1.851ArgGly: 1.851 ± 0.088
0.325ArgHis: 0.325 ± 0.036
2.845ArgIle: 2.845 ± 0.106
3.474ArgLys: 3.474 ± 0.117
2.423ArgLeu: 2.423 ± 0.102
0.512ArgMet: 0.512 ± 0.042
2.169ArgAsn: 2.169 ± 0.091
0.609ArgPro: 0.609 ± 0.052
0.813ArgGln: 0.813 ± 0.047
0.934ArgArg: 0.934 ± 0.056
1.225ArgSer: 1.225 ± 0.064
1.258ArgThr: 1.258 ± 0.064
1.533ArgVal: 1.533 ± 0.087
0.151ArgTrp: 0.151 ± 0.023
1.222ArgTyr: 1.222 ± 0.074
0.0ArgXaa: 0.0 ± 0.0
Ser
2.537SerAla: 2.537 ± 0.099
0.559SerCys: 0.559 ± 0.049
3.836SerAsp: 3.836 ± 0.116
5.208SerGlu: 5.208 ± 0.151
4.448SerPhe: 4.448 ± 0.141
5.077SerGly: 5.077 ± 0.159
0.803SerHis: 0.803 ± 0.057
6.707SerIle: 6.707 ± 0.19
6.61SerLys: 6.61 ± 0.163
6.182SerLeu: 6.182 ± 0.15
1.218SerMet: 1.218 ± 0.068
4.097SerAsn: 4.097 ± 0.17
1.546SerPro: 1.546 ± 0.078
1.757SerGln: 1.757 ± 0.083
1.868SerArg: 1.868 ± 0.072
5.071SerSer: 5.071 ± 0.194
2.664SerThr: 2.664 ± 0.108
3.216SerVal: 3.216 ± 0.094
0.569SerTrp: 0.569 ± 0.054
2.905SerTyr: 2.905 ± 0.107
0.0SerXaa: 0.0 ± 0.0
Thr
1.821ThrAla: 1.821 ± 0.082
0.361ThrCys: 0.361 ± 0.041
2.346ThrAsp: 2.346 ± 0.103
3.464ThrGlu: 3.464 ± 0.106
2.353ThrPhe: 2.353 ± 0.094
3.524ThrGly: 3.524 ± 0.124
0.546ThrHis: 0.546 ± 0.046
4.478ThrIle: 4.478 ± 0.138
4.686ThrLys: 4.686 ± 0.12
3.728ThrLeu: 3.728 ± 0.109
0.706ThrMet: 0.706 ± 0.052
3.136ThrAsn: 3.136 ± 0.115
1.533ThrPro: 1.533 ± 0.098
1.104ThrGln: 1.104 ± 0.065
1.362ThrArg: 1.362 ± 0.067
3.022ThrSer: 3.022 ± 0.122
2.376ThrThr: 2.376 ± 0.105
2.169ThrVal: 2.169 ± 0.096
0.284ThrTrp: 0.284 ± 0.037
1.988ThrTyr: 1.988 ± 0.097
0.0ThrXaa: 0.0 ± 0.0
Val
2.129ValAla: 2.129 ± 0.096
0.445ValCys: 0.445 ± 0.045
2.885ValAsp: 2.885 ± 0.103
4.04ValGlu: 4.04 ± 0.129
3.246ValPhe: 3.246 ± 0.12
3.631ValGly: 3.631 ± 0.12
0.485ValHis: 0.485 ± 0.048
4.344ValIle: 4.344 ± 0.134
4.873ValLys: 4.873 ± 0.113
4.739ValLeu: 4.739 ± 0.137
0.79ValMet: 0.79 ± 0.058
3.109ValAsn: 3.109 ± 0.121
1.198ValPro: 1.198 ± 0.067
0.964ValGln: 0.964 ± 0.062
1.489ValArg: 1.489 ± 0.075
3.722ValSer: 3.722 ± 0.141
2.303ValThr: 2.303 ± 0.121
2.754ValVal: 2.754 ± 0.122
0.318ValTrp: 0.318 ± 0.028
2.229ValTyr: 2.229 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.187TrpAla: 0.187 ± 0.027
0.04TrpCys: 0.04 ± 0.013
0.485TrpAsp: 0.485 ± 0.06
0.492TrpGlu: 0.492 ± 0.041
0.308TrpPhe: 0.308 ± 0.035
0.452TrpGly: 0.452 ± 0.048
0.074TrpHis: 0.074 ± 0.015
0.455TrpIle: 0.455 ± 0.037
0.636TrpLys: 0.636 ± 0.05
0.428TrpLeu: 0.428 ± 0.036
0.124TrpMet: 0.124 ± 0.02
0.462TrpAsn: 0.462 ± 0.08
0.11TrpPro: 0.11 ± 0.019
0.208TrpGln: 0.208 ± 0.028
0.184TrpArg: 0.184 ± 0.027
0.361TrpSer: 0.361 ± 0.035
0.201TrpThr: 0.201 ± 0.029
0.251TrpVal: 0.251 ± 0.032
0.064TrpTrp: 0.064 ± 0.013
0.295TrpTyr: 0.295 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.299TyrAla: 1.299 ± 0.068
0.392TyrCys: 0.392 ± 0.036
2.657TyrAsp: 2.657 ± 0.138
2.918TyrGlu: 2.918 ± 0.093
3.611TyrPhe: 3.611 ± 0.129
2.373TyrGly: 2.373 ± 0.103
0.462TyrHis: 0.462 ± 0.039
4.11TyrIle: 4.11 ± 0.12
4.702TyrLys: 4.702 ± 0.135
4.143TyrLeu: 4.143 ± 0.12
0.703TyrMet: 0.703 ± 0.044
3.029TyrAsn: 3.029 ± 0.117
1.004TyrPro: 1.004 ± 0.058
0.977TyrGln: 0.977 ± 0.06
1.258TyrArg: 1.258 ± 0.071
2.995TyrSer: 2.995 ± 0.117
1.851TyrThr: 1.851 ± 0.081
1.928TyrVal: 1.928 ± 0.085
0.231TyrTrp: 0.231 ± 0.031
2.098TyrTyr: 2.098 ± 0.093
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1051 proteins (298787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski