Amino acid dipepetide frequency for Paraburkholderia sp. BL23I1N1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.014AlaAla: 17.014 ± 0.13	1.305AlaCys: 1.305 ± 0.025	6.482AlaAsp: 6.482 ± 0.056	6.02AlaGlu: 6.02 ± 0.062	4.312AlaPhe: 4.312 ± 0.047	10.069AlaGly: 10.069 ± 0.081	2.76AlaHis: 2.76 ± 0.033	5.786AlaIle: 5.786 ± 0.061	3.784AlaLys: 3.784 ± 0.051	13.729AlaLeu: 13.729 ± 0.095	3.266AlaMet: 3.266 ± 0.04	3.431AlaAsn: 3.431 ± 0.04	5.653AlaPro: 5.653 ± 0.059	5.222AlaGln: 5.222 ± 0.053	8.447AlaArg: 8.447 ± 0.055	7.561AlaSer: 7.561 ± 0.065	6.543AlaThr: 6.543 ± 0.054	8.883AlaVal: 8.883 ± 0.067	1.671AlaTrp: 1.671 ± 0.032	2.745AlaTyr: 2.745 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.259CysAla: 1.259 ± 0.022	0.145CysCys: 0.145 ± 0.008	0.56CysAsp: 0.56 ± 0.015	0.519CysGlu: 0.519 ± 0.016	0.349CysPhe: 0.349 ± 0.011	1.051CysGly: 1.051 ± 0.024	0.273CysHis: 0.273 ± 0.011	0.439CysIle: 0.439 ± 0.013	0.252CysLys: 0.252 ± 0.01	0.832CysLeu: 0.832 ± 0.019	0.222CysMet: 0.222 ± 0.009	0.265CysAsn: 0.265 ± 0.011	0.451CysPro: 0.451 ± 0.016	0.243CysGln: 0.243 ± 0.011	0.65CysArg: 0.65 ± 0.018	0.552CysSer: 0.552 ± 0.015	0.505CysThr: 0.505 ± 0.015	0.846CysVal: 0.846 ± 0.019	0.133CysTrp: 0.133 ± 0.007	0.231CysTyr: 0.231 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.199AspAla: 7.199 ± 0.068	0.481AspCys: 0.481 ± 0.013	2.968AspAsp: 2.968 ± 0.039	3.312AspGlu: 3.312 ± 0.039	1.956AspPhe: 1.956 ± 0.029	4.397AspGly: 4.397 ± 0.047	1.195AspHis: 1.195 ± 0.022	2.505AspIle: 2.505 ± 0.035	1.527AspLys: 1.527 ± 0.027	5.091AspLeu: 5.091 ± 0.05	1.195AspMet: 1.195 ± 0.023	1.375AspAsn: 1.375 ± 0.027	2.861AspPro: 2.861 ± 0.032	1.654AspGln: 1.654 ± 0.025	3.335AspArg: 3.335 ± 0.039	2.66AspSer: 2.66 ± 0.033	2.843AspThr: 2.843 ± 0.032	4.286AspVal: 4.286 ± 0.038	0.887AspTrp: 0.887 ± 0.023	1.511AspTyr: 1.511 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.446GluAla: 6.446 ± 0.073	0.432GluCys: 0.432 ± 0.013	2.099GluAsp: 2.099 ± 0.032	2.432GluGlu: 2.432 ± 0.037	1.791GluPhe: 1.791 ± 0.033	3.342GluGly: 3.342 ± 0.04	1.424GluHis: 1.424 ± 0.025	2.757GluIle: 2.757 ± 0.037	1.828GluLys: 1.828 ± 0.03	5.422GluLeu: 5.422 ± 0.056	1.204GluMet: 1.204 ± 0.021	1.418GluAsn: 1.418 ± 0.025	2.479GluPro: 2.479 ± 0.031	2.37GluGln: 2.37 ± 0.035	4.688GluArg: 4.688 ± 0.053	2.677GluSer: 2.677 ± 0.038	2.91GluThr: 2.91 ± 0.034	3.56GluVal: 3.56 ± 0.044	0.726GluTrp: 0.726 ± 0.018	1.124GluTyr: 1.124 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.656PheAla: 4.656 ± 0.048	0.443PheCys: 0.443 ± 0.014	2.662PheAsp: 2.662 ± 0.032	2.047PheGlu: 2.047 ± 0.029	1.49PhePhe: 1.49 ± 0.03	3.767PheGly: 3.767 ± 0.044	0.754PheHis: 0.754 ± 0.018	1.623PheIle: 1.623 ± 0.028	1.079PheLys: 1.079 ± 0.024	3.034PheLeu: 3.034 ± 0.041	0.839PheMet: 0.839 ± 0.018	1.257PheAsn: 1.257 ± 0.025	1.588PhePro: 1.588 ± 0.025	1.009PheGln: 1.009 ± 0.019	2.081PheArg: 2.081 ± 0.03	2.398PheSer: 2.398 ± 0.03	1.989PheThr: 1.989 ± 0.028	3.098PheVal: 3.098 ± 0.035	0.51PheTrp: 0.51 ± 0.015	1.004PheTyr: 1.004 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	9.163GlyAla: 9.163 ± 0.07	0.888GlyCys: 0.888 ± 0.02	3.805GlyAsp: 3.805 ± 0.041	4.189GlyGlu: 4.189 ± 0.043	3.413GlyPhe: 3.413 ± 0.041	6.754GlyGly: 6.754 ± 0.083	1.934GlyHis: 1.934 ± 0.03	4.286GlyIle: 4.286 ± 0.04	3.173GlyLys: 3.173 ± 0.04	7.848GlyLeu: 7.848 ± 0.069	2.215GlyMet: 2.215 ± 0.032	2.498GlyAsn: 2.498 ± 0.04	2.92GlyPro: 2.92 ± 0.034	2.771GlyGln: 2.771 ± 0.036	5.098GlyArg: 5.098 ± 0.052	4.845GlySer: 4.845 ± 0.055	4.733GlyThr: 4.733 ± 0.063	6.702GlyVal: 6.702 ± 0.057	1.375GlyTrp: 1.375 ± 0.026	2.453GlyTyr: 2.453 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	3.077HisAla: 3.077 ± 0.038	0.287HisCys: 0.287 ± 0.011	1.349HisAsp: 1.349 ± 0.022	1.204HisGlu: 1.204 ± 0.023	0.982HisPhe: 0.982 ± 0.019	2.165HisGly: 2.165 ± 0.028	0.657HisHis: 0.657 ± 0.017	0.944HisIle: 0.944 ± 0.019	0.57HisLys: 0.57 ± 0.021	2.192HisLeu: 2.192 ± 0.027	0.547HisMet: 0.547 ± 0.015	0.553HisAsn: 0.553 ± 0.019	1.441HisPro: 1.441 ± 0.025	0.707HisGln: 0.707 ± 0.018	1.547HisArg: 1.547 ± 0.025	1.15HisSer: 1.15 ± 0.023	1.132HisThr: 1.132 ± 0.022	1.749HisVal: 1.749 ± 0.026	0.396HisTrp: 0.396 ± 0.015	0.678HisTyr: 0.678 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.93IleAla: 6.93 ± 0.064	0.495IleCys: 0.495 ± 0.015	3.437IleAsp: 3.437 ± 0.038	3.241IleGlu: 3.241 ± 0.04	1.524IlePhe: 1.524 ± 0.025	4.753IleGly: 4.753 ± 0.046	0.928IleHis: 0.928 ± 0.021	1.676IleIle: 1.676 ± 0.03	1.412IleLys: 1.412 ± 0.026	3.468IleLeu: 3.468 ± 0.04	0.786IleMet: 0.786 ± 0.02	1.455IleAsn: 1.455 ± 0.029	2.182IlePro: 2.182 ± 0.033	1.3IleGln: 1.3 ± 0.024	2.891IleArg: 2.891 ± 0.033	2.683IleSer: 2.683 ± 0.037	2.516IleThr: 2.516 ± 0.035	4.39IleVal: 4.39 ± 0.046	0.532IleTrp: 0.532 ± 0.016	1.067IleTyr: 1.067 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.637LysAla: 3.637 ± 0.045	0.186LysCys: 0.186 ± 0.01	1.503LysAsp: 1.503 ± 0.029	1.409LysGlu: 1.409 ± 0.026	0.908LysPhe: 0.908 ± 0.017	2.17LysGly: 2.17 ± 0.033	0.759LysHis: 0.759 ± 0.026	1.596LysIle: 1.596 ± 0.025	1.275LysLys: 1.275 ± 0.028	3.422LysLeu: 3.422 ± 0.044	0.789LysMet: 0.789 ± 0.02	0.924LysAsn: 0.924 ± 0.02	2.008LysPro: 2.008 ± 0.035	1.362LysGln: 1.362 ± 0.026	2.477LysArg: 2.477 ± 0.039	1.813LysSer: 1.813 ± 0.028	1.948LysThr: 1.948 ± 0.03	2.388LysVal: 2.388 ± 0.037	0.396LysTrp: 0.396 ± 0.012	0.727LysTyr: 0.727 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.451LeuAla: 13.451 ± 0.098	1.058LeuCys: 1.058 ± 0.022	5.801LeuAsp: 5.801 ± 0.049	4.971LeuGlu: 4.971 ± 0.058	3.605LeuPhe: 3.605 ± 0.042	8.025LeuGly: 8.025 ± 0.076	2.28LeuHis: 2.28 ± 0.036	4.809LeuIle: 4.809 ± 0.048	3.483LeuLys: 3.483 ± 0.04	9.924LeuLeu: 9.924 ± 0.087	2.32LeuMet: 2.32 ± 0.035	2.943LeuAsn: 2.943 ± 0.035	5.6LeuPro: 5.6 ± 0.052	3.397LeuGln: 3.397 ± 0.037	6.914LeuArg: 6.914 ± 0.056	6.449LeuSer: 6.449 ± 0.05	5.746LeuThr: 5.746 ± 0.054	7.274LeuVal: 7.274 ± 0.068	1.125LeuTrp: 1.125 ± 0.024	2.212LeuTyr: 2.212 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.567MetAla: 2.567 ± 0.033	0.199MetCys: 0.199 ± 0.009	0.977MetAsp: 0.977 ± 0.022	0.942MetGlu: 0.942 ± 0.02	0.784MetPhe: 0.784 ± 0.019	1.548MetGly: 1.548 ± 0.03	0.583MetHis: 0.583 ± 0.014	1.162MetIle: 1.162 ± 0.021	1.065MetLys: 1.065 ± 0.021	2.681MetLeu: 2.681 ± 0.032	0.593MetMet: 0.593 ± 0.017	0.984MetAsn: 0.984 ± 0.02	1.453MetPro: 1.453 ± 0.022	1.036MetGln: 1.036 ± 0.019	1.808MetArg: 1.808 ± 0.026	1.77MetSer: 1.77 ± 0.026	1.664MetThr: 1.664 ± 0.024	1.557MetVal: 1.557 ± 0.029	0.218MetTrp: 0.218 ± 0.009	0.423MetTyr: 0.423 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.748AsnAla: 3.748 ± 0.043	0.297AsnCys: 0.297 ± 0.011	1.517AsnAsp: 1.517 ± 0.028	1.403AsnGlu: 1.403 ± 0.027	1.059AsnPhe: 1.059 ± 0.023	2.782AsnGly: 2.782 ± 0.042	0.587AsnHis: 0.587 ± 0.015	1.285AsnIle: 1.285 ± 0.025	0.714AsnLys: 0.714 ± 0.016	2.837AsnLeu: 2.837 ± 0.039	0.598AsnMet: 0.598 ± 0.017	0.88AsnAsn: 0.88 ± 0.022	1.875AsnPro: 1.875 ± 0.026	0.994AsnGln: 0.994 ± 0.025	1.944AsnArg: 1.944 ± 0.023	1.516AsnSer: 1.516 ± 0.033	1.594AsnThr: 1.594 ± 0.034	2.32AsnVal: 2.32 ± 0.036	0.449AsnTrp: 0.449 ± 0.015	0.796AsnTyr: 0.796 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.383ProAla: 6.383 ± 0.058	0.373ProCys: 0.373 ± 0.012	3.163ProAsp: 3.163 ± 0.037	2.952ProGlu: 2.952 ± 0.036	1.933ProPhe: 1.933 ± 0.027	4.098ProGly: 4.098 ± 0.044	1.251ProHis: 1.251 ± 0.025	2.13ProIle: 2.13 ± 0.03	1.472ProLys: 1.472 ± 0.027	5.122ProLeu: 5.122 ± 0.051	1.123ProMet: 1.123 ± 0.021	1.482ProAsn: 1.482 ± 0.025	2.406ProPro: 2.406 ± 0.042	1.907ProGln: 1.907 ± 0.032	2.838ProArg: 2.838 ± 0.04	2.939ProSer: 2.939 ± 0.037	2.578ProThr: 2.578 ± 0.033	4.308ProVal: 4.308 ± 0.046	0.649ProTrp: 0.649 ± 0.015	1.224ProTyr: 1.224 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.436GlnAla: 4.436 ± 0.057	0.293GlnCys: 0.293 ± 0.012	1.384GlnAsp: 1.384 ± 0.026	1.357GlnGlu: 1.357 ± 0.031	1.353GlnPhe: 1.353 ± 0.026	2.515GlnGly: 2.515 ± 0.03	0.96GlnHis: 0.96 ± 0.02	2.071GlnIle: 2.071 ± 0.028	1.155GlnLys: 1.155 ± 0.023	3.846GlnLeu: 3.846 ± 0.042	1.043GlnMet: 1.043 ± 0.021	1.011GlnAsn: 1.011 ± 0.024	2.028GlnPro: 2.028 ± 0.029	1.97GlnGln: 1.97 ± 0.038	2.9GlnArg: 2.9 ± 0.039	2.199GlnSer: 2.199 ± 0.029	2.151GlnThr: 2.151 ± 0.03	2.528GlnVal: 2.528 ± 0.033	0.576GlnTrp: 0.576 ± 0.016	0.922GlnTyr: 0.922 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.832ArgAla: 7.832 ± 0.06	0.647ArgCys: 0.647 ± 0.016	3.682ArgAsp: 3.682 ± 0.04	4.171ArgGlu: 4.171 ± 0.047	2.939ArgPhe: 2.939 ± 0.034	4.503ArgGly: 4.503 ± 0.048	1.841ArgHis: 1.841 ± 0.024	3.569ArgIle: 3.569 ± 0.034	2.163ArgLys: 2.163 ± 0.034	7.133ArgLeu: 7.133 ± 0.066	1.805ArgMet: 1.805 ± 0.026	1.976ArgAsn: 1.976 ± 0.032	3.013ArgPro: 3.013 ± 0.04	2.571ArgGln: 2.571 ± 0.035	5.303ArgArg: 5.303 ± 0.057	3.664ArgSer: 3.664 ± 0.039	3.507ArgThr: 3.507 ± 0.036	5.166ArgVal: 5.166 ± 0.05	1.058ArgTrp: 1.058 ± 0.024	1.973ArgTyr: 1.973 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.206SerAla: 7.206 ± 0.062	0.49SerCys: 0.49 ± 0.014	2.88SerAsp: 2.88 ± 0.037	2.665SerGlu: 2.665 ± 0.038	2.348SerPhe: 2.348 ± 0.033	5.537SerGly: 5.537 ± 0.058	1.304SerHis: 1.304 ± 0.023	2.934SerIle: 2.934 ± 0.035	1.81SerLys: 1.81 ± 0.026	5.897SerLeu: 5.897 ± 0.058	1.471SerMet: 1.471 ± 0.028	1.813SerAsn: 1.813 ± 0.034	2.944SerPro: 2.944 ± 0.033	1.944SerGln: 1.944 ± 0.029	3.809SerArg: 3.809 ± 0.039	3.751SerSer: 3.751 ± 0.052	3.393SerThr: 3.393 ± 0.043	4.537SerVal: 4.537 ± 0.039	0.721SerTrp: 0.721 ± 0.019	1.411SerTyr: 1.411 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.206ThrAla: 6.206 ± 0.063	0.461ThrCys: 0.461 ± 0.014	2.703ThrAsp: 2.703 ± 0.039	2.444ThrGlu: 2.444 ± 0.035	2.059ThrPhe: 2.059 ± 0.034	4.913ThrGly: 4.913 ± 0.05	1.317ThrHis: 1.317 ± 0.02	2.669ThrIle: 2.669 ± 0.039	1.332ThrLys: 1.332 ± 0.026	6.557ThrLeu: 6.557 ± 0.048	1.232ThrMet: 1.232 ± 0.022	1.465ThrAsn: 1.465 ± 0.033	3.594ThrPro: 3.594 ± 0.041	2.048ThrGln: 2.048 ± 0.031	3.621ThrArg: 3.621 ± 0.04	3.204ThrSer: 3.204 ± 0.046	3.11ThrThr: 3.11 ± 0.046	4.529ThrVal: 4.529 ± 0.043	0.73ThrTrp: 0.73 ± 0.017	1.342ThrTyr: 1.342 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	9.48ValAla: 9.48 ± 0.068	0.858ValCys: 0.858 ± 0.019	4.258ValAsp: 4.258 ± 0.045	4.118ValGlu: 4.118 ± 0.044	2.931ValPhe: 2.931 ± 0.034	5.577ValGly: 5.577 ± 0.056	1.594ValHis: 1.594 ± 0.026	3.808ValIle: 3.808 ± 0.044	2.51ValLys: 2.51 ± 0.038	7.871ValLeu: 7.871 ± 0.065	1.919ValMet: 1.919 ± 0.033	2.305ValAsn: 2.305 ± 0.036	3.907ValPro: 3.907 ± 0.04	2.598ValGln: 2.598 ± 0.033	5.051ValArg: 5.051 ± 0.05	4.841ValSer: 4.841 ± 0.048	4.657ValThr: 4.657 ± 0.048	6.206ValVal: 6.206 ± 0.058	0.98ValTrp: 0.98 ± 0.019	1.739ValTyr: 1.739 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.165TrpAla: 1.165 ± 0.023	0.159TrpCys: 0.159 ± 0.009	0.627TrpAsp: 0.627 ± 0.017	0.511TrpGlu: 0.511 ± 0.015	0.552TrpPhe: 0.552 ± 0.015	0.886TrpGly: 0.886 ± 0.02	0.404TrpHis: 0.404 ± 0.015	0.733TrpIle: 0.733 ± 0.017	0.439TrpLys: 0.439 ± 0.015	1.884TrpLeu: 1.884 ± 0.035	0.371TrpMet: 0.371 ± 0.012	0.483TrpAsn: 0.483 ± 0.015	0.648TrpPro: 0.648 ± 0.015	0.661TrpGln: 0.661 ± 0.017	1.183TrpArg: 1.183 ± 0.025	0.836TrpSer: 0.836 ± 0.018	0.719TrpThr: 0.719 ± 0.017	0.943TrpVal: 0.943 ± 0.021	0.226TrpTrp: 0.226 ± 0.01	0.32TrpTyr: 0.32 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.831TyrAla: 2.831 ± 0.036	0.279TyrCys: 0.279 ± 0.01	1.382TyrAsp: 1.382 ± 0.025	1.221TyrGlu: 1.221 ± 0.02	1.043TyrPhe: 1.043 ± 0.019	2.21TyrGly: 2.21 ± 0.033	0.522TyrHis: 0.522 ± 0.015	0.886TyrIle: 0.886 ± 0.02	0.656TyrLys: 0.656 ± 0.016	2.596TyrLeu: 2.596 ± 0.039	0.473TyrMet: 0.473 ± 0.014	0.678TyrAsn: 0.678 ± 0.02	1.279TyrPro: 1.279 ± 0.027	0.934TyrGln: 0.934 ± 0.019	1.93TyrArg: 1.93 ± 0.034	1.357TyrSer: 1.357 ± 0.025	1.297TyrThr: 1.297 ± 0.026	1.936TyrVal: 1.936 ± 0.028	0.393TyrTrp: 0.393 ± 0.012	0.692TyrTyr: 0.692 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7914 proteins (2467661 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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