Amino acid dipepetide frequency for Defluviimonas denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.491AlaAla: 19.491 ± 0.182	1.08AlaCys: 1.08 ± 0.035	7.241AlaAsp: 7.241 ± 0.077	8.876AlaGlu: 8.876 ± 0.106	4.576AlaPhe: 4.576 ± 0.057	12.081AlaGly: 12.081 ± 0.112	2.366AlaHis: 2.366 ± 0.047	6.178AlaIle: 6.178 ± 0.082	4.003AlaLys: 4.003 ± 0.066	14.734AlaLeu: 14.734 ± 0.133	4.027AlaMet: 4.027 ± 0.055	2.591AlaAsn: 2.591 ± 0.05	6.644AlaPro: 6.644 ± 0.106	3.839AlaGln: 3.839 ± 0.059	9.97AlaArg: 9.97 ± 0.121	5.16AlaSer: 5.16 ± 0.059	6.527AlaThr: 6.527 ± 0.079	9.026AlaVal: 9.026 ± 0.092	1.523AlaTrp: 1.523 ± 0.038	2.566AlaTyr: 2.566 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.06CysAla: 1.06 ± 0.031	0.099CysCys: 0.099 ± 0.01	0.595CysAsp: 0.595 ± 0.022	0.388CysGlu: 0.388 ± 0.019	0.353CysPhe: 0.353 ± 0.018	0.954CysGly: 0.954 ± 0.029	0.295CysHis: 0.295 ± 0.018	0.371CysIle: 0.371 ± 0.016	0.201CysLys: 0.201 ± 0.012	0.868CysLeu: 0.868 ± 0.028	0.151CysMet: 0.151 ± 0.012	0.215CysAsn: 0.215 ± 0.015	0.517CysPro: 0.517 ± 0.022	0.198CysGln: 0.198 ± 0.012	0.571CysArg: 0.571 ± 0.019	0.396CysSer: 0.396 ± 0.017	0.449CysThr: 0.449 ± 0.019	0.6CysVal: 0.6 ± 0.024	0.124CysTrp: 0.124 ± 0.009	0.229CysTyr: 0.229 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.165AspAla: 7.165 ± 0.084	0.555AspCys: 0.555 ± 0.023	3.124AspAsp: 3.124 ± 0.06	3.26AspGlu: 3.26 ± 0.062	2.261AspPhe: 2.261 ± 0.044	5.703AspGly: 5.703 ± 0.092	1.423AspHis: 1.423 ± 0.037	2.819AspIle: 2.819 ± 0.051	1.542AspLys: 1.542 ± 0.036	6.68AspLeu: 6.68 ± 0.08	1.638AspMet: 1.638 ± 0.036	1.132AspAsn: 1.132 ± 0.028	3.87AspPro: 3.87 ± 0.059	1.726AspGln: 1.726 ± 0.034	4.815AspArg: 4.815 ± 0.071	1.97AspSer: 1.97 ± 0.044	2.818AspThr: 2.818 ± 0.052	3.714AspVal: 3.714 ± 0.052	1.325AspTrp: 1.325 ± 0.035	1.625AspTyr: 1.625 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.088GluAla: 8.088 ± 0.106	0.343GluCys: 0.343 ± 0.017	3.209GluAsp: 3.209 ± 0.061	3.42GluGlu: 3.42 ± 0.069	1.653GluPhe: 1.653 ± 0.043	5.278GluGly: 5.278 ± 0.07	0.991GluHis: 0.991 ± 0.03	3.371GluIle: 3.371 ± 0.053	2.116GluLys: 2.116 ± 0.046	4.534GluLeu: 4.534 ± 0.064	1.711GluMet: 1.711 ± 0.04	1.393GluAsn: 1.393 ± 0.033	2.359GluPro: 2.359 ± 0.045	1.484GluGln: 1.484 ± 0.04	4.219GluArg: 4.219 ± 0.067	1.944GluSer: 1.944 ± 0.04	3.544GluThr: 3.544 ± 0.053	4.569GluVal: 4.569 ± 0.06	0.689GluTrp: 0.689 ± 0.026	0.957GluTyr: 0.957 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.782PheAla: 4.782 ± 0.069	0.397PheCys: 0.397 ± 0.019	2.852PheAsp: 2.852 ± 0.048	1.888PheGlu: 1.888 ± 0.041	1.411PhePhe: 1.411 ± 0.035	3.723PheGly: 3.723 ± 0.052	0.748PheHis: 0.748 ± 0.025	1.614PheIle: 1.614 ± 0.038	0.81PheLys: 0.81 ± 0.026	3.579PheLeu: 3.579 ± 0.062	0.739PheMet: 0.739 ± 0.026	0.968PheAsn: 0.968 ± 0.029	1.655PhePro: 1.655 ± 0.037	0.931PheGln: 0.931 ± 0.028	2.355PheArg: 2.355 ± 0.048	1.974PheSer: 1.974 ± 0.042	2.1PheThr: 2.1 ± 0.043	2.617PheVal: 2.617 ± 0.052	0.608PheTrp: 0.608 ± 0.024	0.91PheTyr: 0.91 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.468GlyAla: 11.468 ± 0.098	0.903GlyCys: 0.903 ± 0.029	4.93GlyAsp: 4.93 ± 0.075	4.699GlyGlu: 4.699 ± 0.058	3.835GlyPhe: 3.835 ± 0.059	8.311GlyGly: 8.311 ± 0.118	1.967GlyHis: 1.967 ± 0.039	4.732GlyIle: 4.732 ± 0.067	3.26GlyLys: 3.26 ± 0.06	9.546GlyLeu: 9.546 ± 0.104	2.791GlyMet: 2.791 ± 0.08	2.087GlyAsn: 2.087 ± 0.052	3.994GlyPro: 3.994 ± 0.063	3.231GlyGln: 3.231 ± 0.054	6.605GlyArg: 6.605 ± 0.08	3.984GlySer: 3.984 ± 0.063	4.934GlyThr: 4.934 ± 0.08	6.511GlyVal: 6.511 ± 0.078	1.625GlyTrp: 1.625 ± 0.042	2.324GlyTyr: 2.324 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.322HisAla: 2.322 ± 0.042	0.243HisCys: 0.243 ± 0.014	1.294HisAsp: 1.294 ± 0.031	1.011HisGlu: 1.011 ± 0.028	0.77HisPhe: 0.77 ± 0.029	1.952HisGly: 1.952 ± 0.043	0.537HisHis: 0.537 ± 0.026	0.874HisIle: 0.874 ± 0.026	0.447HisLys: 0.447 ± 0.018	2.199HisLeu: 2.199 ± 0.048	0.519HisMet: 0.519 ± 0.021	0.42HisAsn: 0.42 ± 0.016	1.429HisPro: 1.429 ± 0.036	0.509HisGln: 0.509 ± 0.02	1.437HisArg: 1.437 ± 0.034	0.846HisSer: 0.846 ± 0.027	0.746HisThr: 0.746 ± 0.028	1.495HisVal: 1.495 ± 0.038	0.383HisTrp: 0.383 ± 0.018	0.536HisTyr: 0.536 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.541IleAla: 7.541 ± 0.08	0.594IleCys: 0.594 ± 0.02	3.408IleAsp: 3.408 ± 0.059	3.219IleGlu: 3.219 ± 0.058	1.726IlePhe: 1.726 ± 0.041	5.0IleGly: 5.0 ± 0.073	0.912IleHis: 0.912 ± 0.028	1.93IleIle: 1.93 ± 0.045	1.13IleLys: 1.13 ± 0.034	4.982IleLeu: 4.982 ± 0.068	0.946IleMet: 0.946 ± 0.031	1.176IleAsn: 1.176 ± 0.034	2.316IlePro: 2.316 ± 0.047	0.979IleGln: 0.979 ± 0.028	3.48IleArg: 3.48 ± 0.056	2.607IleSer: 2.607 ± 0.045	2.596IleThr: 2.596 ± 0.047	3.963IleVal: 3.963 ± 0.065	0.7IleTrp: 0.7 ± 0.024	1.056IleTyr: 1.056 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.116LysAla: 4.116 ± 0.068	0.169LysCys: 0.169 ± 0.012	1.765LysAsp: 1.765 ± 0.043	1.494LysGlu: 1.494 ± 0.04	0.837LysPhe: 0.837 ± 0.026	3.01LysGly: 3.01 ± 0.052	0.537LysHis: 0.537 ± 0.022	1.669LysIle: 1.669 ± 0.043	1.176LysLys: 1.176 ± 0.041	2.844LysLeu: 2.844 ± 0.049	0.797LysMet: 0.797 ± 0.025	0.71LysAsn: 0.71 ± 0.026	1.752LysPro: 1.752 ± 0.046	0.733LysGln: 0.733 ± 0.027	2.149LysArg: 2.149 ± 0.052	1.592LysSer: 1.592 ± 0.04	1.892LysThr: 1.892 ± 0.041	2.438LysVal: 2.438 ± 0.053	0.387LysTrp: 0.387 ± 0.017	0.602LysTyr: 0.602 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.77LeuAla: 13.77 ± 0.147	0.933LeuCys: 0.933 ± 0.025	5.928LeuAsp: 5.928 ± 0.075	4.54LeuGlu: 4.54 ± 0.07	3.455LeuPhe: 3.455 ± 0.058	8.799LeuGly: 8.799 ± 0.091	1.884LeuHis: 1.884 ± 0.039	5.413LeuIle: 5.413 ± 0.074	3.375LeuLys: 3.375 ± 0.056	8.907LeuLeu: 8.907 ± 0.111	2.698LeuMet: 2.698 ± 0.046	2.525LeuAsn: 2.525 ± 0.046	5.989LeuPro: 5.989 ± 0.08	2.304LeuGln: 2.304 ± 0.041	7.251LeuArg: 7.251 ± 0.088	6.515LeuSer: 6.515 ± 0.077	6.435LeuThr: 6.435 ± 0.071	6.724LeuVal: 6.724 ± 0.082	1.479LeuTrp: 1.479 ± 0.036	2.112LeuTyr: 2.112 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.737MetAla: 3.737 ± 0.05	0.166MetCys: 0.166 ± 0.013	1.29MetAsp: 1.29 ± 0.032	1.363MetGlu: 1.363 ± 0.034	0.74MetPhe: 0.74 ± 0.024	2.34MetGly: 2.34 ± 0.052	0.407MetHis: 0.407 ± 0.017	1.494MetIle: 1.494 ± 0.037	1.082MetLys: 1.082 ± 0.03	2.491MetLeu: 2.491 ± 0.039	0.754MetMet: 0.754 ± 0.029	0.769MetAsn: 0.769 ± 0.03	1.513MetPro: 1.513 ± 0.039	0.844MetGln: 0.844 ± 0.027	1.974MetArg: 1.974 ± 0.041	1.63MetSer: 1.63 ± 0.048	2.163MetThr: 2.163 ± 0.044	1.897MetVal: 1.897 ± 0.042	0.227MetTrp: 0.227 ± 0.013	0.31MetTyr: 0.31 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.992AsnAla: 2.992 ± 0.044	0.251AsnCys: 0.251 ± 0.015	1.278AsnAsp: 1.278 ± 0.04	0.991AsnGlu: 0.991 ± 0.029	0.89AsnPhe: 0.89 ± 0.029	2.212AsnGly: 2.212 ± 0.045	0.445AsnHis: 0.445 ± 0.021	1.169AsnIle: 1.169 ± 0.031	0.573AsnLys: 0.573 ± 0.026	2.273AsnLeu: 2.273 ± 0.047	0.663AsnMet: 0.663 ± 0.022	0.535AsnAsn: 0.535 ± 0.024	1.727AsnPro: 1.727 ± 0.043	0.594AsnGln: 0.594 ± 0.02	1.691AsnArg: 1.691 ± 0.038	0.952AsnSer: 0.952 ± 0.03	1.217AsnThr: 1.217 ± 0.038	1.702AsnVal: 1.702 ± 0.038	0.398AsnTrp: 0.398 ± 0.018	0.588AsnTyr: 0.588 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.869ProAla: 6.869 ± 0.093	0.341ProCys: 0.341 ± 0.017	4.01ProAsp: 4.01 ± 0.064	4.142ProGlu: 4.142 ± 0.076	2.094ProPhe: 2.094 ± 0.045	5.082ProGly: 5.082 ± 0.062	1.065ProHis: 1.065 ± 0.027	2.077ProIle: 2.077 ± 0.038	1.695ProLys: 1.695 ± 0.042	4.759ProLeu: 4.759 ± 0.058	1.381ProMet: 1.381 ± 0.034	1.179ProAsn: 1.179 ± 0.032	2.359ProPro: 2.359 ± 0.049	1.514ProGln: 1.514 ± 0.035	2.987ProArg: 2.987 ± 0.066	2.314ProSer: 2.314 ± 0.043	2.382ProThr: 2.382 ± 0.047	4.71ProVal: 4.71 ± 0.07	0.695ProTrp: 0.695 ± 0.025	1.199ProTyr: 1.199 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.612GlnAla: 3.612 ± 0.057	0.198GlnCys: 0.198 ± 0.012	1.485GlnAsp: 1.485 ± 0.032	1.284GlnGlu: 1.284 ± 0.036	0.923GlnPhe: 0.923 ± 0.029	2.582GlnGly: 2.582 ± 0.053	0.5GlnHis: 0.5 ± 0.02	1.802GlnIle: 1.802 ± 0.039	1.006GlnLys: 1.006 ± 0.03	2.294GlnLeu: 2.294 ± 0.046	0.969GlnMet: 0.969 ± 0.029	0.761GlnAsn: 0.761 ± 0.025	1.456GlnPro: 1.456 ± 0.031	0.842GlnGln: 0.842 ± 0.03	2.008GlnArg: 2.008 ± 0.038	1.554GlnSer: 1.554 ± 0.036	1.562GlnThr: 1.562 ± 0.034	2.14GlnVal: 2.14 ± 0.041	0.34GlnTrp: 0.34 ± 0.017	0.498GlnTyr: 0.498 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.309ArgAla: 9.309 ± 0.106	0.477ArgCys: 0.477 ± 0.02	4.539ArgAsp: 4.539 ± 0.061	3.748ArgGlu: 3.748 ± 0.069	2.8ArgPhe: 2.8 ± 0.046	5.005ArgGly: 5.005 ± 0.064	1.67ArgHis: 1.67 ± 0.04	4.056ArgIle: 4.056 ± 0.057	2.352ArgLys: 2.352 ± 0.049	7.906ArgLeu: 7.906 ± 0.096	2.102ArgMet: 2.102 ± 0.042	1.606ArgAsn: 1.606 ± 0.034	3.896ArgPro: 3.896 ± 0.07	2.314ArgGln: 2.314 ± 0.049	5.598ArgArg: 5.598 ± 0.084	3.094ArgSer: 3.094 ± 0.053	3.062ArgThr: 3.062 ± 0.047	4.892ArgVal: 4.892 ± 0.068	1.029ArgTrp: 1.029 ± 0.027	1.646ArgTyr: 1.646 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.755SerAla: 5.755 ± 0.08	0.439SerCys: 0.439 ± 0.022	2.842SerAsp: 2.842 ± 0.046	2.327SerGlu: 2.327 ± 0.045	2.109SerPhe: 2.109 ± 0.045	5.296SerGly: 5.296 ± 0.079	0.999SerHis: 0.999 ± 0.026	2.23SerIle: 2.23 ± 0.042	1.268SerLys: 1.268 ± 0.031	4.628SerLeu: 4.628 ± 0.071	1.135SerMet: 1.135 ± 0.031	1.099SerAsn: 1.099 ± 0.033	2.429SerPro: 2.429 ± 0.039	1.284SerGln: 1.284 ± 0.033	3.075SerArg: 3.075 ± 0.053	2.151SerSer: 2.151 ± 0.051	2.31SerThr: 2.31 ± 0.046	3.656SerVal: 3.656 ± 0.052	0.621SerTrp: 0.621 ± 0.025	1.28SerTyr: 1.28 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.664ThrAla: 6.664 ± 0.075	0.492ThrCys: 0.492 ± 0.022	3.173ThrAsp: 3.173 ± 0.052	2.851ThrGlu: 2.851 ± 0.046	1.971ThrPhe: 1.971 ± 0.042	5.827ThrGly: 5.827 ± 0.083	1.051ThrHis: 1.051 ± 0.03	2.7ThrIle: 2.7 ± 0.062	1.387ThrLys: 1.387 ± 0.034	6.161ThrLeu: 6.161 ± 0.069	1.202ThrMet: 1.202 ± 0.029	1.157ThrAsn: 1.157 ± 0.036	3.405ThrPro: 3.405 ± 0.055	1.328ThrGln: 1.328 ± 0.034	3.581ThrArg: 3.581 ± 0.06	2.535ThrSer: 2.535 ± 0.05	2.845ThrThr: 2.845 ± 0.055	4.461ThrVal: 4.461 ± 0.066	0.701ThrTrp: 0.701 ± 0.022	1.204ThrTyr: 1.204 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.711ValAla: 9.711 ± 0.108	0.589ValCys: 0.589 ± 0.022	3.843ValAsp: 3.843 ± 0.06	4.535ValGlu: 4.535 ± 0.07	2.8ValPhe: 2.8 ± 0.046	5.373ValGly: 5.373 ± 0.073	1.296ValHis: 1.296 ± 0.032	4.167ValIle: 4.167 ± 0.062	2.241ValLys: 2.241 ± 0.048	7.564ValLeu: 7.564 ± 0.088	2.122ValMet: 2.122 ± 0.045	1.822ValAsn: 1.822 ± 0.039	3.729ValPro: 3.729 ± 0.058	1.933ValGln: 1.933 ± 0.041	4.404ValArg: 4.404 ± 0.057	3.812ValSer: 3.812 ± 0.061	5.155ValThr: 5.155 ± 0.077	5.562ValVal: 5.562 ± 0.078	1.052ValTrp: 1.052 ± 0.033	1.512ValTyr: 1.512 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.49TrpAla: 1.49 ± 0.035	0.134TrpCys: 0.134 ± 0.011	0.766TrpAsp: 0.766 ± 0.029	0.651TrpGlu: 0.651 ± 0.024	0.572TrpPhe: 0.572 ± 0.022	1.059TrpGly: 1.059 ± 0.032	0.357TrpHis: 0.357 ± 0.017	0.722TrpIle: 0.722 ± 0.022	0.465TrpLys: 0.465 ± 0.02	1.728TrpLeu: 1.728 ± 0.042	0.39TrpMet: 0.39 ± 0.019	0.414TrpAsn: 0.414 ± 0.019	0.773TrpPro: 0.773 ± 0.025	0.6TrpGln: 0.6 ± 0.025	1.236TrpArg: 1.236 ± 0.036	0.798TrpSer: 0.798 ± 0.027	0.842TrpThr: 0.842 ± 0.027	0.974TrpVal: 0.974 ± 0.029	0.223TrpTrp: 0.223 ± 0.013	0.312TrpTyr: 0.312 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.557TyrAla: 2.557 ± 0.041	0.231TyrCys: 0.231 ± 0.013	1.593TyrAsp: 1.593 ± 0.032	1.184TyrGlu: 1.184 ± 0.032	0.887TyrPhe: 0.887 ± 0.027	2.147TyrGly: 2.147 ± 0.039	0.521TyrHis: 0.521 ± 0.021	0.872TyrIle: 0.872 ± 0.03	0.538TyrLys: 0.538 ± 0.021	2.357TyrLeu: 2.357 ± 0.042	0.456TyrMet: 0.456 ± 0.021	0.584TyrAsn: 0.584 ± 0.024	1.044TyrPro: 1.044 ± 0.032	0.628TyrGln: 0.628 ± 0.025	1.698TyrArg: 1.698 ± 0.039	1.104TyrSer: 1.104 ± 0.028	1.116TyrThr: 1.116 ± 0.031	1.571TyrVal: 1.571 ± 0.037	0.379TyrTrp: 0.379 ± 0.02	0.572TyrTyr: 0.572 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4024 proteins (1248739 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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